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The map label for this gene is hisB

Identifier: 121611289

GI number: 121611289

Start: 4826247

End: 4826879

Strand: Direct

Name: hisB

Synonym: Veis_4375

Alternate gene names: 121611289

Gene position: 4826247-4826879 (Clockwise)

Preceding gene: 121611288

Following gene: 121611290

Centisome position: 86.7

GC content: 67.61

Gene sequence:

>633_bases
ATGACCTCCTCCGCCCTCGTGCCCTCGGGCCTGCCCGGTTCGCTCGACCGCATCGCCGAGGTCAGCCGCAACACCGCCGA
GACCCGCGTCAGCGTGCGCGTCAACCTCGACGGCACCGGCCAGGCCAAGCTGCGCACCGGCATCGGTTTCTTTGACCATA
TGCTCGATCAAACCGCCCGCCACGGGCTGATCGACCTGGATGTCGACTGCGCCGGCGACCTGCACATCGACGGCCACCAC
ACGGTCGAGGACGTGGGCATCACGCTGGGCCAGGCGCTGGCGCGGGCCATGGGCGACAAAAAAGGCATCTGCCGCTACGC
CCATGCCTATGTGCCGCTGGACGAGGCGCTCTCGCGCGTGGTGGTCGATATCTCGGGCCGCCCGGGGCTGCACCTGCATA
TCCCGTTCAGCGCCGGCCGCATTGGCGACTTCGACACCCAACTGACCCACGAATTCTTCCAGGGCTTCGTGAACCACGCG
GGCATCACGCTGCACATCGACAACCTCAAGGGCGTCAACGCGCACCACCAGTGCGAGTCCGTGTTCAAGGCCTTTGCCCG
CGCGCTGCGCGCGGCGCTCGAACGCGACCCCCGCTCGGCGGGCCGCATCGCCTCGACCAAAGGCTCTTTGTAA

Upstream 100 bases:

>100_bases
ACGTTTCTACAATGCACCCCTTGCTGAGCAACTGCCTGCGCCTGACGGTCGGCAGTGCCGACGACAACGCACAAATGCTG
GCTGCACTCCAGGCCTCTTC

Downstream 100 bases:

>100_bases
AGTGCTGTGAACCGTGTTGATTTCCGTGATTGAATCCGGGCACTGAGCGCTTTCGACACACGCTGGCTGCCATGAATACG
CAAGCAAAAACCGTCGCCGT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTSSALVPSGLPGSLDRIAEVSRNTAETRVSVRVNLDGTGQAKLRTGIGFFDHMLDQTARHGLIDLDVDCAGDLHIDGHH
TVEDVGITLGQALARAMGDKKGICRYAHAYVPLDEALSRVVVDISGRPGLHLHIPFSAGRIGDFDTQLTHEFFQGFVNHA
GITLHIDNLKGVNAHHQCESVFKAFARALRAALERDPRSAGRIASTKGSL

Sequences:

>Translated_210_residues
MTSSALVPSGLPGSLDRIAEVSRNTAETRVSVRVNLDGTGQAKLRTGIGFFDHMLDQTARHGLIDLDVDCAGDLHIDGHH
TVEDVGITLGQALARAMGDKKGICRYAHAYVPLDEALSRVVVDISGRPGLHLHIPFSAGRIGDFDTQLTHEFFQGFVNHA
GITLHIDNLKGVNAHHQCESVFKAFARALRAALERDPRSAGRIASTKGSL
>Mature_209_residues
TSSALVPSGLPGSLDRIAEVSRNTAETRVSVRVNLDGTGQAKLRTGIGFFDHMLDQTARHGLIDLDVDCAGDLHIDGHHT
VEDVGITLGQALARAMGDKKGICRYAHAYVPLDEALSRVVVDISGRPGLHLHIPFSAGRIGDFDTQLTHEFFQGFVNHAG
ITLHIDNLKGVNAHHQCESVFKAFARALRAALERDPRSAGRIASTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=48.7179487179487, Blast_Score=188, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=219, Percent_Identity=39.2694063926941, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_VEREI (A1WR21)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_999096.1
- ProteinModelPortal:   A1WR21
- SMR:   A1WR21
- STRING:   A1WR21
- GeneID:   4691905
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_4375
- NMPDR:   fig|391735.5.peg.4006
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   A1WR21
- BioCyc:   VEIS391735:VEIS_4375-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22591; Mature: 22460

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSALVPSGLPGSLDRIAEVSRNTAETRVSVRVNLDGTGQAKLRTGIGFFDHMLDQTAR
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
HGLIDLDVDCAGDLHIDGHHTVEDVGITLGQALARAMGDKKGICRYAHAYVPLDEALSRV
CCEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHH
VVDISGRPGLHLHIPFSAGRIGDFDTQLTHEFFQGFVNHAGITLHIDNLKGVNAHHQCES
EEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
VFKAFARALRAALERDPRSAGRIASTKGSL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSSALVPSGLPGSLDRIAEVSRNTAETRVSVRVNLDGTGQAKLRTGIGFFDHMLDQTAR
CCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
HGLIDLDVDCAGDLHIDGHHTVEDVGITLGQALARAMGDKKGICRYAHAYVPLDEALSRV
CCEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHH
VVDISGRPGLHLHIPFSAGRIGDFDTQLTHEFFQGFVNHAGITLHIDNLKGVNAHHQCES
EEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
VFKAFARALRAALERDPRSAGRIASTKGSL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA