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The map label for this gene is lon [H]

Identifier: 121611287

GI number: 121611287

Start: 4822066

End: 4824516

Strand: Direct

Name: lon [H]

Synonym: Veis_4373

Alternate gene names: 121611287

Gene position: 4822066-4824516 (Clockwise)

Preceding gene: 121611286

Following gene: 121611288

Centisome position: 86.62

GC content: 63.48

Gene sequence:

>2451_bases
ATGCCCGGATATACCCCCCTGCCAGCCATCGCCCTGAACCTGCCGCTGTTGCCGCTGCGCGATGTGGTGGTGTTCCCCCA
CATGGTCATCCCGCTGTTCGTCGGCCGCCCCAAGAGCATCAAGGCGCTGGAAAAAGCGATGGAGGCCGACCGCCGCATCA
TGCTGGTGGCGCAGAAAGCGGCGGCCAAGGACGAGCCCTCGGTGTCGGACATGTTCGATGTCGGCTGCGTCTCGACCATC
TTGCAGATGCTCAAGCTGCCCGACGGCACGGTCAAGGTGCTGGTCGAAGGCCAGCAGCGTGCCCAGGTGGCAGCGATCGA
AGACGCCCAGACCCATTTCACGGCCACCGTGACACCGGTCGAGGCGAGCAAGCCCGGCGAGACCGAGACCCGCATGCCCT
CCCGGGAGATAGAAGCCCTGCGCCGCGCGGTAATGCAGCAGTTTGACCAATACGTCAAGATCAACAAGAAGATTCCGCCG
GAGATCCTGACCTCGATCGCCAGCATCGATGATCCCGGCCGCCTGGCCGACACCATTGCCGCCCATCTGCCGCTCAAGCT
GGAAAACAAACAGTTGGTGCTGGACCTGGCCGACGTGAAAGCCCGTCTGGAATACCTGTTCGAGCAGCTCGACCGCGAGG
TCGACATCCTGAACGTGGACCGGAAAATCCGCGGGCGCGTGAAGCGCCAGATGGAAAAGAACCAGCGCGACTTCTACCTG
AACGAGCAGGTCAAGGCCATACAAAAGGAACTCGGCGAGGGCGAAGAAGGCGCCGACATCGACGAGATCGAGAAAAAAAT
CAAACTCGCCAAGATGCCCGCCGAAGCGCGCAAGAAGGCCGATGGCGAGCTCAAAAAACTCAAGCTGATGTCGCCCATGT
CTGCCGAGGCGACCGTGGTGCGCAACTACATCGACGTGCTCTCCAACCTGCCCTGGAGCAAGAAAACCAAGATCAAGTAC
GACCTGGTCAATGCCGAGGAGGTGCTCAACGCCGACCACTTCGGCCTGGACAAGGTCAAGGACCGCATCCTGGAATACCT
GGCCGTGCAGCAGCGCGTGGACAAGGTCAAAGCGCCGATCCTGTGTCTGGTCGGCCCGCCCGGCGTGGGCAAGACCTCGC
TGGGCCAGTCGATCGCCCGGGCCACCGGCCGCAAATATGTGCGCATGGCCCTGGGCGGCATGCGCGACGAGGCCGAGATT
CGCGGCCACCGCCGCACCTACATCGGCGCGCTGCCGGGCAAGGTGCTGCAAAGCCTGTCCAAGGTCGGCACGCGCAACCC
GCTGTTCCTGCTCGACGAGATCGACAAACTGGGCACCGACTTCCGGGGCGACCCCGCCAGTGCGCTGCTGGAGGTGCTGG
ATCCGGAACAGAACCACACCTTCGGCGACCACTATGTGGAGGTCGACTTCGACCTCTCGGACGTGATGTTCGTCGCCACC
TCGAACTCGATGAGCATCCCGCCCGCGTTGCTCGACCGCATGGAAGTCATCCGCCTGTCGGGCTACACCGAGGACGAAAA
GATCAGCATCGCGATGAAGTACCTGCTGCCCAAGCAGCTCAAGAACAATGGCGTCAAGGACGAGGAACTGCTGGTCACCG
AGGCCGCCGTGCGCGACATGGTGCGCTACTACACCCGCGAGGCCGGCGTGCGCTCGCTCGAACGCGAGCTGTCCAAGATC
TGCCGCAAACTGGTCAAGGGCCTGCAACTCAAGAAGCTCGAACCGCAGGTGGTGCTGACAGCCGACAACCTGCCCGACTA
CCTGGGCGTGCACAAATACACCTACGGCCGCGCCGAACTGCAAAACCAGGTCGGGCAGGTGGTGGGCCTGGCCTGGACCG
AAGTCGGCGGCGACCTGCTGACCATCGAAGTGGCCACCATGCCCGGCAAGGGCGTGATCACGCGCACCGGCTCGCTCGGC
GATGTGATGAAGGAATCCGTCGAGGCGGCACGCACGGTGGTGCGCAGCCGCTCGCGCATGCTCGGCATCAAGGATGAGAC
CTTCGAGAAGCGCGACATCCATATCCATGTGCCGGACGGCGCCACGCCCAAAGACGGCCCGAGCGCCGGCGCCGCGATGA
CCACGGCGTTCGTTTCGGCCCTCACCGGCATCCCCGTGCGCGGCGATGTGGCGATGACCGGCGAAATCACGCTGCGCGGC
GAAGTCACGGCCATTGGTGGCCTGAAGGAAAAACTGCTGGCCGCATTGCGCGGCGGCATCAAGACCGTGCTGATCCCCCA
GGAAAATGTCAAGGACTTGCAGGAAATTCCGGACAACGTCAAAAACGGCCTGGAGATCGTGCCCGTGCGCTGGATCGACA
AGGTGCTGGAAGTGGCGCTGGAACGCAAGCCCGTGCCGCTGACAGACGAAGAAGTGACCGTGATGGTCGCCGCCGCTGCG
GCAGACAAGACCGTGGCCGCAGCGGTGCTCACCGATGGCCTGAAGCATTGA

Upstream 100 bases:

>100_bases
TTGCTGCCCGCAGCCCCTGCACCCCGGATACAGTTGCCGTGCAAGGGATTGAAAAACCCCGCTTGCGGGCCATATTCCAC
AGAGCACTTTGAGGACTCCC

Downstream 100 bases:

>100_bases
CGCCCCATTTTTTCCAGGCACCCCAAAAAAACACGCTACAATCGAAGCCATCGCGGCCAACTGCATTTACAATGCAAGGC
TTCGGTAGAGCGCTGGCGAT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 816; Mature: 815

Protein sequence:

>816_residues
MPGYTPLPAIALNLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEKAMEADRRIMLVAQKAAAKDEPSVSDMFDVGCVSTI
LQMLKLPDGTVKVLVEGQQRAQVAAIEDAQTHFTATVTPVEASKPGETETRMPSREIEALRRAVMQQFDQYVKINKKIPP
EILTSIASIDDPGRLADTIAAHLPLKLENKQLVLDLADVKARLEYLFEQLDREVDILNVDRKIRGRVKRQMEKNQRDFYL
NEQVKAIQKELGEGEEGADIDEIEKKIKLAKMPAEARKKADGELKKLKLMSPMSAEATVVRNYIDVLSNLPWSKKTKIKY
DLVNAEEVLNADHFGLDKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATGRKYVRMALGGMRDEAEI
RGHRRTYIGALPGKVLQSLSKVGTRNPLFLLDEIDKLGTDFRGDPASALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVAT
SNSMSIPPALLDRMEVIRLSGYTEDEKISIAMKYLLPKQLKNNGVKDEELLVTEAAVRDMVRYYTREAGVRSLERELSKI
CRKLVKGLQLKKLEPQVVLTADNLPDYLGVHKYTYGRAELQNQVGQVVGLAWTEVGGDLLTIEVATMPGKGVITRTGSLG
DVMKESVEAARTVVRSRSRMLGIKDETFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRG
EVTAIGGLKEKLLAALRGGIKTVLIPQENVKDLQEIPDNVKNGLEIVPVRWIDKVLEVALERKPVPLTDEEVTVMVAAAA
ADKTVAAAVLTDGLKH

Sequences:

>Translated_816_residues
MPGYTPLPAIALNLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEKAMEADRRIMLVAQKAAAKDEPSVSDMFDVGCVSTI
LQMLKLPDGTVKVLVEGQQRAQVAAIEDAQTHFTATVTPVEASKPGETETRMPSREIEALRRAVMQQFDQYVKINKKIPP
EILTSIASIDDPGRLADTIAAHLPLKLENKQLVLDLADVKARLEYLFEQLDREVDILNVDRKIRGRVKRQMEKNQRDFYL
NEQVKAIQKELGEGEEGADIDEIEKKIKLAKMPAEARKKADGELKKLKLMSPMSAEATVVRNYIDVLSNLPWSKKTKIKY
DLVNAEEVLNADHFGLDKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATGRKYVRMALGGMRDEAEI
RGHRRTYIGALPGKVLQSLSKVGTRNPLFLLDEIDKLGTDFRGDPASALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVAT
SNSMSIPPALLDRMEVIRLSGYTEDEKISIAMKYLLPKQLKNNGVKDEELLVTEAAVRDMVRYYTREAGVRSLERELSKI
CRKLVKGLQLKKLEPQVVLTADNLPDYLGVHKYTYGRAELQNQVGQVVGLAWTEVGGDLLTIEVATMPGKGVITRTGSLG
DVMKESVEAARTVVRSRSRMLGIKDETFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRG
EVTAIGGLKEKLLAALRGGIKTVLIPQENVKDLQEIPDNVKNGLEIVPVRWIDKVLEVALERKPVPLTDEEVTVMVAAAA
ADKTVAAAVLTDGLKH
>Mature_815_residues
PGYTPLPAIALNLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEKAMEADRRIMLVAQKAAAKDEPSVSDMFDVGCVSTIL
QMLKLPDGTVKVLVEGQQRAQVAAIEDAQTHFTATVTPVEASKPGETETRMPSREIEALRRAVMQQFDQYVKINKKIPPE
ILTSIASIDDPGRLADTIAAHLPLKLENKQLVLDLADVKARLEYLFEQLDREVDILNVDRKIRGRVKRQMEKNQRDFYLN
EQVKAIQKELGEGEEGADIDEIEKKIKLAKMPAEARKKADGELKKLKLMSPMSAEATVVRNYIDVLSNLPWSKKTKIKYD
LVNAEEVLNADHFGLDKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATGRKYVRMALGGMRDEAEIR
GHRRTYIGALPGKVLQSLSKVGTRNPLFLLDEIDKLGTDFRGDPASALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVATS
NSMSIPPALLDRMEVIRLSGYTEDEKISIAMKYLLPKQLKNNGVKDEELLVTEAAVRDMVRYYTREAGVRSLERELSKIC
RKLVKGLQLKKLEPQVVLTADNLPDYLGVHKYTYGRAELQNQVGQVVGLAWTEVGGDLLTIEVATMPGKGVITRTGSLGD
VMKESVEAARTVVRSRSRMLGIKDETFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRGE
VTAIGGLKEKLLAALRGGIKTVLIPQENVKDLQEIPDNVKNGLEIVPVRWIDKVLEVALERKPVPLTDEEVTVMVAAAAA
DKTVAAAVLTDGLKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=45.3900709219858, Blast_Score=501, Evalue=1e-141,
Organism=Homo sapiens, GI21396489, Length=835, Percent_Identity=34.7305389221557, Blast_Score=470, Evalue=1e-132,
Organism=Escherichia coli, GI1786643, Length=774, Percent_Identity=66.7958656330749, Blast_Score=1053, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=695, Percent_Identity=38.8489208633094, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17556486, Length=543, Percent_Identity=39.7790055248619, Blast_Score=420, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=711, Percent_Identity=41.2095639943741, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221513036, Length=629, Percent_Identity=42.6073131955485, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=629, Percent_Identity=42.6073131955485, Blast_Score=495, Evalue=1e-140,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90005; Mature: 89874

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGYTPLPAIALNLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEKAMEADRRIMLVAQKA
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEHH
AAKDEPSVSDMFDVGCVSTILQMLKLPDGTVKVLVEGQQRAQVAAIEDAQTHFTATVTPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHEEEECCCCCEEEEEEEEC
EASKPGETETRMPSREIEALRRAVMQQFDQYVKINKKIPPEILTSIASIDDPGRLADTIA
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHH
AHLPLKLENKQLVLDLADVKARLEYLFEQLDREVDILNVDRKIRGRVKRQMEKNQRDFYL
HHCCEEECCCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCH
NEQVKAIQKELGEGEEGADIDEIEKKIKLAKMPAEARKKADGELKKLKLMSPMSAEATVV
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHCCCCCHHHHHH
RNYIDVLSNLPWSKKTKIKYDLVNAEEVLNADHFGLDKVKDRILEYLAVQQRVDKVKAPI
HHHHHHHHCCCCCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
LCLVGPPGVGKTSLGQSIARATGRKYVRMALGGMRDEAEIRGHRRTYIGALPGKVLQSLS
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHEEECCCHHHHHHHH
KVGTRNPLFLLDEIDKLGTDFRGDPASALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVAT
HHCCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEE
SNSMSIPPALLDRMEVIRLSGYTEDEKISIAMKYLLPKQLKNNGVKDEELLVTEAAVRDM
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VRYYTREAGVRSLERELSKICRKLVKGLQLKKLEPQVVLTADNLPDYLGVHKYTYGRAEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEECCCCHHHCCHHCCCCHHHH
QNQVGQVVGLAWTEVGGDLLTIEVATMPGKGVITRTGSLGDVMKESVEAARTVVRSRSRM
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LGIKDETFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRG
CCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEE
EVTAIGGLKEKLLAALRGGIKTVLIPQENVKDLQEIPDNVKNGLEIVPVRWIDKVLEVAL
EEEECCCHHHHHHHHHHCCCEEEEECCHHHHHHHHCCHHHHCCCEEEEHHHHHHHHHHHH
ERKPVPLTDEEVTVMVAAAAADKTVAAAVLTDGLKH
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
PGYTPLPAIALNLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEKAMEADRRIMLVAQKA
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEHH
AAKDEPSVSDMFDVGCVSTILQMLKLPDGTVKVLVEGQQRAQVAAIEDAQTHFTATVTPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHEEEECCCCCEEEEEEEEC
EASKPGETETRMPSREIEALRRAVMQQFDQYVKINKKIPPEILTSIASIDDPGRLADTIA
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHH
AHLPLKLENKQLVLDLADVKARLEYLFEQLDREVDILNVDRKIRGRVKRQMEKNQRDFYL
HHCCEEECCCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCH
NEQVKAIQKELGEGEEGADIDEIEKKIKLAKMPAEARKKADGELKKLKLMSPMSAEATVV
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHCCCCCHHHHHH
RNYIDVLSNLPWSKKTKIKYDLVNAEEVLNADHFGLDKVKDRILEYLAVQQRVDKVKAPI
HHHHHHHHCCCCCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
LCLVGPPGVGKTSLGQSIARATGRKYVRMALGGMRDEAEIRGHRRTYIGALPGKVLQSLS
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHEEECCCHHHHHHHH
KVGTRNPLFLLDEIDKLGTDFRGDPASALLEVLDPEQNHTFGDHYVEVDFDLSDVMFVAT
HHCCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEE
SNSMSIPPALLDRMEVIRLSGYTEDEKISIAMKYLLPKQLKNNGVKDEELLVTEAAVRDM
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VRYYTREAGVRSLERELSKICRKLVKGLQLKKLEPQVVLTADNLPDYLGVHKYTYGRAEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEECCCCHHHCCHHCCCCHHHH
QNQVGQVVGLAWTEVGGDLLTIEVATMPGKGVITRTGSLGDVMKESVEAARTVVRSRSRM
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LGIKDETFEKRDIHIHVPDGATPKDGPSAGAAMTTAFVSALTGIPVRGDVAMTGEITLRG
CCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEE
EVTAIGGLKEKLLAALRGGIKTVLIPQENVKDLQEIPDNVKNGLEIVPVRWIDKVLEVAL
EEEECCCHHHHHHHHHHCCCEEEEECCHHHHHHHHCCHHHHCCCEEEEHHHHHHHHHHHH
ERKPVPLTDEEVTVMVAAAAADKTVAAAVLTDGLKH
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]