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The map label for this gene is fadA [H]

Identifier: 121611109

GI number: 121611109

Start: 4617990

End: 4619171

Strand: Direct

Name: fadA [H]

Synonym: Veis_4193

Alternate gene names: 121611109

Gene position: 4617990-4619171 (Clockwise)

Preceding gene: 121611108

Following gene: 121611112

Centisome position: 82.96

GC content: 69.37

Gene sequence:

>1182_bases
ATGACCATCGATGCCGTCATCGTTTCCACCGCACGAACGCCCATCGGCAAGGCCTACCGCGGCGCCTTCAACGACACGCA
TGGTGCCGTGCTCGGCGCGCACGCCGTGCGCCATGCCGTCGAACGCGCCGGGCTGGCCCCCGACGAGATCGAGGACGTGA
TCATGGGAACGGCCCGCCCCGAGGGCAGCACGGGCATGAACATCGGCCGCATCGTCGCGCTGCGCGCCGGGCTGCCGAAA
CACACGGCGGGCGTGACGGTGAACCGCTTCTGCAGCTCGGGCCTGCAGGCCATTGCGATGGGCGCGCACAGCATTCTGTG
CGACGGTGTGCCCGCGGTGGTGGCAGGCGGGCTCGACGCCGTGAGCCTCACGGTCAACACGGACACCAACACCTACCGCC
AGCGCGACTCGTGGCTGGAGCAGCATGTGCCGGGCCTGTACCAGACCATGATCCAGACCGCCGAGAGCGTGGCCACGCGC
TACGGCATCGGTCGCGAGCAGCAAGACGCTTACGGCCTGCGCAGCCAGCAGCGGGCGGTGGCCGCGCGCGACGCCGACGC
CTTCGCGCAAGAGATCTCGCCCATCGAGGTGCGCAAGCTCGTGGCCGGCAAGGACGGCGCACCCGACACGCACGAGGACA
TCACGCTGACGCACGACGAAGGTCTACGCAGCACGTCGACGCAGCAGTTGGCGGCCCTCAAGCCGGTGATCGAAGGCGGC
CATATCACGGCAGGCAATGCGAGCCAACTTTCCGATGGCACCTCCGCCTGCGTGCTGATGAACAGCCGGCTGGCCGAGCA
GCGCAACCTCACGCCGCTGGGCATCTTCCGCGGCTTTGCCGTGGCCGGCTGCGAGCCCGACGAGATGGGCATCGGCCCGG
TGTTTGCGGTGCCGCGCCTGCTCGCGCGCTGCGGCGTGCGCGCCGACGACGTCGGTCTGTGGGAACTCAACGAAGCCTTC
GCCGTGCAGGTGCTCTACTGTCGCGACCGGCTGGGCATTCCGGACGAGCGCCTGAACATCCACGGCGGCGCGATCGCAAT
GGGCCACCCGTTCGGCATGTCGGGCTCGCGGCTCGTGGGCCACGCGCTGATCGCCGGCAAGGCGCTCGGCGTGCGCCATG
TGGTCGTCACGATGTGCGTGGGCGGCGGGATGGGCGCAGCGGGGTTGTTCGAAGTTGTTTGA

Upstream 100 bases:

>100_bases
GCCATCGAAGGCGTCGCCGCTGCGCGCGGCAAGCGGGCGCCGAACTGGCAGCAGGTCATCGCCGCGCGCGATTGAAGAGA
ACACATTTTAAGGGGGCGGC

Downstream 100 bases:

>100_bases
GCACTGCGCCCCGCGTGCGCAACCGCTCCTCGGGGCGCGAGTGGACTGAAAACCTCTTGGTTTGTCAGTACAGCCTGCCA
AGGCGCATTCCTCTGCGCTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTIDAVIVSTARTPIGKAYRGAFNDTHGAVLGAHAVRHAVERAGLAPDEIEDVIMGTARPEGSTGMNIGRIVALRAGLPK
HTAGVTVNRFCSSGLQAIAMGAHSILCDGVPAVVAGGLDAVSLTVNTDTNTYRQRDSWLEQHVPGLYQTMIQTAESVATR
YGIGREQQDAYGLRSQQRAVAARDADAFAQEISPIEVRKLVAGKDGAPDTHEDITLTHDEGLRSTSTQQLAALKPVIEGG
HITAGNASQLSDGTSACVLMNSRLAEQRNLTPLGIFRGFAVAGCEPDEMGIGPVFAVPRLLARCGVRADDVGLWELNEAF
AVQVLYCRDRLGIPDERLNIHGGAIAMGHPFGMSGSRLVGHALIAGKALGVRHVVVTMCVGGGMGAAGLFEVV

Sequences:

>Translated_393_residues
MTIDAVIVSTARTPIGKAYRGAFNDTHGAVLGAHAVRHAVERAGLAPDEIEDVIMGTARPEGSTGMNIGRIVALRAGLPK
HTAGVTVNRFCSSGLQAIAMGAHSILCDGVPAVVAGGLDAVSLTVNTDTNTYRQRDSWLEQHVPGLYQTMIQTAESVATR
YGIGREQQDAYGLRSQQRAVAARDADAFAQEISPIEVRKLVAGKDGAPDTHEDITLTHDEGLRSTSTQQLAALKPVIEGG
HITAGNASQLSDGTSACVLMNSRLAEQRNLTPLGIFRGFAVAGCEPDEMGIGPVFAVPRLLARCGVRADDVGLWELNEAF
AVQVLYCRDRLGIPDERLNIHGGAIAMGHPFGMSGSRLVGHALIAGKALGVRHVVVTMCVGGGMGAAGLFEVV
>Mature_392_residues
TIDAVIVSTARTPIGKAYRGAFNDTHGAVLGAHAVRHAVERAGLAPDEIEDVIMGTARPEGSTGMNIGRIVALRAGLPKH
TAGVTVNRFCSSGLQAIAMGAHSILCDGVPAVVAGGLDAVSLTVNTDTNTYRQRDSWLEQHVPGLYQTMIQTAESVATRY
GIGREQQDAYGLRSQQRAVAARDADAFAQEISPIEVRKLVAGKDGAPDTHEDITLTHDEGLRSTSTQQLAALKPVIEGGH
ITAGNASQLSDGTSACVLMNSRLAEQRNLTPLGIFRGFAVAGCEPDEMGIGPVFAVPRLLARCGVRADDVGLWELNEAFA
VQVLYCRDRLGIPDERLNIHGGAIAMGHPFGMSGSRLVGHALIAGKALGVRHVVVTMCVGGGMGAAGLFEVV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=40.153452685422, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=36.75, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=35.1620947630923, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=34.010152284264, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4504327, Length=437, Percent_Identity=28.8329519450801, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI194353979, Length=88, Percent_Identity=48.8636363636364, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=37.378640776699, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=37.6847290640394, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=36.6834170854271, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=37.3762376237624, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788683, Length=406, Percent_Identity=30.5418719211823, Blast_Score=151, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=398, Percent_Identity=33.9195979899498, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=37.2839506172839, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=30.25, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17551802, Length=435, Percent_Identity=26.8965517241379, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17535917, Length=362, Percent_Identity=27.9005524861878, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=34.6437346437346, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6325229, Length=416, Percent_Identity=32.2115384615385, Blast_Score=189, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=34.7290640394089, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24655093, Length=407, Percent_Identity=36.8550368550369, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=34.0740740740741, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137578, Length=437, Percent_Identity=29.0617848970252, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41212; Mature: 41080

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDAVIVSTARTPIGKAYRGAFNDTHGAVLGAHAVRHAVERAGLAPDEIEDVIMGTARP
CCCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
EGSTGMNIGRIVALRAGLPKHTAGVTVNRFCSSGLQAIAMGAHSILCDGVPAVVAGGLDA
CCCCCCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEE
VSLTVNTDTNTYRQRDSWLEQHVPGLYQTMIQTAESVATRYGIGREQQDAYGLRSQQRAV
EEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHH
AARDADAFAQEISPIEVRKLVAGKDGAPDTHEDITLTHDEGLRSTSTQQLAALKPVIEGG
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCC
HITAGNASQLSDGTSACVLMNSRLAEQRNLTPLGIFRGFAVAGCEPDEMGIGPVFAVPRL
EEECCCHHHCCCCCCEEEEEHHHHHHHHCCCHHHHHHCCEECCCCCCCCCCCHHHHHHHH
LARCGVRADDVGLWELNEAFAVQVLYCRDRLGIPDERLNIHGGAIAMGHPFGMSGSRLVG
HHHCCCCCCCCCEEECCHHHEEEEEEECCCCCCCCCCEEECCCEEEECCCCCCCCCHHHH
HALIAGKALGVRHVVVTMCVGGGMGAAGLFEVV
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
TIDAVIVSTARTPIGKAYRGAFNDTHGAVLGAHAVRHAVERAGLAPDEIEDVIMGTARP
CCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
EGSTGMNIGRIVALRAGLPKHTAGVTVNRFCSSGLQAIAMGAHSILCDGVPAVVAGGLDA
CCCCCCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEE
VSLTVNTDTNTYRQRDSWLEQHVPGLYQTMIQTAESVATRYGIGREQQDAYGLRSQQRAV
EEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHH
AARDADAFAQEISPIEVRKLVAGKDGAPDTHEDITLTHDEGLRSTSTQQLAALKPVIEGG
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCC
HITAGNASQLSDGTSACVLMNSRLAEQRNLTPLGIFRGFAVAGCEPDEMGIGPVFAVPRL
EEECCCHHHCCCCCCEEEEEHHHHHHHHCCCHHHHHHCCEECCCCCCCCCCCHHHHHHHH
LARCGVRADDVGLWELNEAFAVQVLYCRDRLGIPDERLNIHGGAIAMGHPFGMSGSRLVG
HHHCCCCCCCCCEEECCHHHEEEEEEECCCCCCCCCCEEECCCEEEECCCCCCCCCHHHH
HALIAGKALGVRHVVVTMCVGGGMGAAGLFEVV
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]