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The map label for this gene is gbpR [H]

Identifier: 121611112

GI number: 121611112

Start: 4622321

End: 4623289

Strand: Direct

Name: gbpR [H]

Synonym: Veis_4196

Alternate gene names: 121611112

Gene position: 4622321-4623289 (Clockwise)

Preceding gene: 121611109

Following gene: 121611116

Centisome position: 83.03

GC content: 66.67

Gene sequence:

>969_bases
ATGATCGAGCGTTCAGAAGGCATCTCCTGGGCGCGGGGCATCAAGGTCCGGCATCTGGAATCCTTTCTGGTGCTGGACGA
GGCGGGCACGCTGACCGAAGCGGCGGCGCGGCTGCACATGACGCAATCTGCCATGTCGCACTGGCTGGCAGAACTCGAAC
GCGTGGCGGGCACGCCGCTGGTGGTGCGCGGGCGCAAGGTGCAGCTGACGCCTGCGGGGCATCTGCTCAAGCGGCTGGCC
ATCACCGTGCTGGGCGACATCGTCCGCACCGGCCGCGAGATGCATGCGGTGGCCGCGGGACGTGTGCCGCGTCTGAACGT
GGGCAGCGTCTGGGCCGGCATCGCCGGCGGCCTGCCCGAAGCCGTGACCGCGTTCCAGCAGCGCCATGCCGACGTGGCCG
TGTCCATTCACGACGGGCTGTTCGACGACCTGCTCAAGGGCTTGGACACGCGTGCCATGGATGCCGTGATCGGCGTTCTG
GATGCCAGGGCGCACCAGCCGCAGTTGGCGCATCACGTGCTCTTCGACGACCAGGTGAGCATCGTCATCGGCCAGGGCAG
CAAGCACTGGCACAGCGAGCAGCCGCTGGGCTTTGCAGACGTGCTGCGCGAGCAATGGGTGATGCCGCCCCTTGGCACGC
TCACCCGCATCCAGATGGATGCCTACCTCATCGAGCAACAGGCCTCGTGGCTGGTGCCCAAGGCAGAAACCGCCTCGCTG
GCCATGATGCAGGCCCTGCTGCACAAGGGCGACTATGTCGGCGTGTGCGCGGAATCCATGGCGGACTACATGGCCTCGCT
GGGGCTGTTCCGGAAGGTCGCCATCGATTCGAACATCCGCTTCGGCCCGATCACCGTGGTGTGGAACCGCGAGCACGTCT
CGGCAACGCTCATGGACTTCATTGATTGCCTGAAGGCGCATGTGCGGGGCTTGCCTGCCGCACAGGTGCAGGAGGCGCCC
CGCGCTTAG

Upstream 100 bases:

>100_bases
GGATTCCTCTGAGGGTCTGACATAAAAGATGAAGTAATTTTCATGACAACCCTGTCATCCGCCTAGTGAAAATGCAAAAT
GGAAGCATGAAGGTTTACTC

Downstream 100 bases:

>100_bases
CGGCCCGCGAAGGCAAGTGCCTCAGTTCGAATTGGAAGCCTCGTAGACCACCACTGCCGCGGCCAGGTCCTCCAAGGCGG
TCCCCACCGCCTTGAAGACG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Galactose-binding protein regulator; GBP regulator [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MIERSEGISWARGIKVRHLESFLVLDEAGTLTEAAARLHMTQSAMSHWLAELERVAGTPLVVRGRKVQLTPAGHLLKRLA
ITVLGDIVRTGREMHAVAAGRVPRLNVGSVWAGIAGGLPEAVTAFQQRHADVAVSIHDGLFDDLLKGLDTRAMDAVIGVL
DARAHQPQLAHHVLFDDQVSIVIGQGSKHWHSEQPLGFADVLREQWVMPPLGTLTRIQMDAYLIEQQASWLVPKAETASL
AMMQALLHKGDYVGVCAESMADYMASLGLFRKVAIDSNIRFGPITVVWNREHVSATLMDFIDCLKAHVRGLPAAQVQEAP
RA

Sequences:

>Translated_322_residues
MIERSEGISWARGIKVRHLESFLVLDEAGTLTEAAARLHMTQSAMSHWLAELERVAGTPLVVRGRKVQLTPAGHLLKRLA
ITVLGDIVRTGREMHAVAAGRVPRLNVGSVWAGIAGGLPEAVTAFQQRHADVAVSIHDGLFDDLLKGLDTRAMDAVIGVL
DARAHQPQLAHHVLFDDQVSIVIGQGSKHWHSEQPLGFADVLREQWVMPPLGTLTRIQMDAYLIEQQASWLVPKAETASL
AMMQALLHKGDYVGVCAESMADYMASLGLFRKVAIDSNIRFGPITVVWNREHVSATLMDFIDCLKAHVRGLPAAQVQEAP
RA
>Mature_322_residues
MIERSEGISWARGIKVRHLESFLVLDEAGTLTEAAARLHMTQSAMSHWLAELERVAGTPLVVRGRKVQLTPAGHLLKRLA
ITVLGDIVRTGREMHAVAAGRVPRLNVGSVWAGIAGGLPEAVTAFQQRHADVAVSIHDGLFDDLLKGLDTRAMDAVIGVL
DARAHQPQLAHHVLFDDQVSIVIGQGSKHWHSEQPLGFADVLREQWVMPPLGTLTRIQMDAYLIEQQASWLVPKAETASL
AMMQALLHKGDYVGVCAESMADYMASLGLFRKVAIDSNIRFGPITVVWNREHVSATLMDFIDCLKAHVRGLPAAQVQEAP
RA

Specific function: Does not seem to be required for sbpA expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081904, Length=245, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788887, Length=293, Percent_Identity=24.2320819112628, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789506, Length=287, Percent_Identity=22.6480836236934, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI157672245, Length=207, Percent_Identity=26.0869565217391, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787806, Length=176, Percent_Identity=26.1363636363636, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35218; Mature: 35218

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERSEGISWARGIKVRHLESFLVLDEAGTLTEAAARLHMTQSAMSHWLAELERVAGTPL
CCCCCCCCHHHHCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VVRGRKVQLTPAGHLLKRLAITVLGDIVRTGREMHAVAAGRVPRLNVGSVWAGIAGGLPE
EEECCEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHCCCHH
AVTAFQQRHADVAVSIHDGLFDDLLKGLDTRAMDAVIGVLDARAHQPQLAHHVLFDDQVS
HHHHHHHHCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHEECCCEE
IVIGQGSKHWHSEQPLGFADVLREQWVMPPLGTLTRIQMDAYLIEQQASWLVPKAETASL
EEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AMMQALLHKGDYVGVCAESMADYMASLGLFRKVAIDSNIRFGPITVVWNREHVSATLMDF
HHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHH
IDCLKAHVRGLPAAQVQEAPRA
HHHHHHHHCCCCHHHHHCCCCC
>Mature Secondary Structure
MIERSEGISWARGIKVRHLESFLVLDEAGTLTEAAARLHMTQSAMSHWLAELERVAGTPL
CCCCCCCCHHHHCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VVRGRKVQLTPAGHLLKRLAITVLGDIVRTGREMHAVAAGRVPRLNVGSVWAGIAGGLPE
EEECCEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHCCCHH
AVTAFQQRHADVAVSIHDGLFDDLLKGLDTRAMDAVIGVLDARAHQPQLAHHVLFDDQVS
HHHHHHHHCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHEECCCEE
IVIGQGSKHWHSEQPLGFADVLREQWVMPPLGTLTRIQMDAYLIEQQASWLVPKAETASL
EEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AMMQALLHKGDYVGVCAESMADYMASLGLFRKVAIDSNIRFGPITVVWNREHVSATLMDF
HHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHH
IDCLKAHVRGLPAAQVQEAPRA
HHHHHHHHCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10361275 [H]