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The map label for this gene is hutH [H]

Identifier: 121610572

GI number: 121610572

Start: 4029505

End: 4031067

Strand: Direct

Name: hutH [H]

Synonym: Veis_3645

Alternate gene names: 121610572

Gene position: 4029505-4031067 (Clockwise)

Preceding gene: 121610571

Following gene: 121610573

Centisome position: 72.39

GC content: 71.15

Gene sequence:

>1563_bases
ATGACCGAATCCAACACTTCCCCACTGCTGCTGCAACCCGGCCATGTCACCCTGGCCGGGCTGCGCCGCATCCATGCCGG
CCCGGTACGACTGGCGCTGGACGCACCGGCCCGGGCGGCCATGCAGGCCGCGCAGGCGGCGGTGCAGCGCATCGTGGCGG
CAGACCGGGTGGTCTATGGCATCAACACCGGTTTTGGCAAGCTGGCCAGCACCAGGATTGCTGCCGAGCACCTGACCGAG
TTGCAGCGCCGCCTGGTGCTGTCGCACAGCGCGGGCACCGGGCCGGCGCTGCCCGACGCGGTGGTGCGCCTGGTGCTGGC
CACCAAGGCCGTGGGCCTGGCGCGCGGCCACTCCGGCATCCGCCCCGAGATCGTCGATGCGCTGCTGGCGCTGGCCAGTG
CCGAGGTGCTGCCGGTGATTCCGGCCAAAGGCTCGGTCGGGGCCTCGGGGGATCTGGCGCCGCTGGCGCATCTGGCCTGC
GTGCTGATCGGGCAGGGGCAGGCCCAATGCAACGGCACGCTGGTGCCGGGCGCCGAGGCGATGCGCGCCATCGGTTGCCA
GCCCTTCGTGCTCGGCCCGAAGGAGGGGCTGGCGCTGCTCAACGGCACGCAGGTGTCGACCGCGCTGGCGCTGGCGGGCC
TGTTCGGCGCCGAGAACCTGCTGGCCGCTGCGCTGGTGGCCGGCGCGCTATCGCTGGAGGCCATCAAAGGCTCGGTCTGG
CCGCTGGATGCGCGCATCCATGAAGCCCGCGGCCAAGCCGGGCAAATCGCCGTGGCCGCCGCGTTGCGCGCGCTGCTCGA
AGGCAGCGCCATCGCCGCTTCGCACCCGCACTGTGGCCGCGTGCAAGACCCCTACTCGATCCGCTGTATGCCGCAGGTGC
TGGGCGCTTGCCTGGACAACCTGCACCACGCGGCGCGCGTGCTCGTCATCGAAGCCAATGCGGCATCGGACAACCCGCTG
GTCTTTGCCGCAGCGCAGGGCGGCCCGGGTGCGGACGAGGTGATCTCCGGCGGCAACTTCCACGCCGAGCCGGTGGCCTT
TGCTGCCGACATCATGGCGCTGGCGGTGGCCGAGATCGGCGCCATGTCCGAACGGCGCCTGGCGCTGCTGCTCGACACCG
GCCTGTCGGCACTGCCGGCCTTTCTGGTGCGCGACAGCGGCATGAACTCGGGCTTCATGATGGCGCAGGTCACCGCCGCT
GCGCTGGCGAGCGAGAACAAATCGCTGGCCCACCCGGCCAGTGTCGACAGCCTGCCCACATCGGCGAACCAGGAAGACCA
TGTGTCCATGGCCACCTTCGGCGCGCGCCGCCTGGCCGAGATGATCGACAACACGGCGACGGTGGTGGGCATCGAGGCCA
TGGCGGCGGCGCAGGGCATGGAGTTCGATCGCAGCCTGCGCTCGACGCCGCTGCTCGAAGGGCAGTGGGCCGCGATTCGC
GAGCGCGTGGCCTTTCTGGAGCAAGACCGCTGCCTGGCGCCCGATATAGCCGCCATGCGGCTGTGGGCGCAGCAATCCGG
GTGGCCCGCGCCGCTGTTGCAGTGCCTGCCCAGCCATGCCTGA

Upstream 100 bases:

>100_bases
ACCGCCTGGGCAGCCGCTTTCGCGCGGACGGCAATCCGCTGGCCGGCTGAGCGGGTGGCCGCAGTTGCCTGGCATGGCGC
GTAAGGACAGGATCGATGCG

Downstream 100 bases:

>100_bases
GCCTTGCATCGGCCACCTGCGCCCAATGAGACCCGCCACCAGCCCCCCCATGAGGCCCGCCATGACCGCCAATGACCCCC
GCCACGACGCCACGCGCGTG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTESNTSPLLLQPGHVTLAGLRRIHAGPVRLALDAPARAAMQAAQAAVQRIVAADRVVYGINTGFGKLASTRIAAEHLTE
LQRRLVLSHSAGTGPALPDAVVRLVLATKAVGLARGHSGIRPEIVDALLALASAEVLPVIPAKGSVGASGDLAPLAHLAC
VLIGQGQAQCNGTLVPGAEAMRAIGCQPFVLGPKEGLALLNGTQVSTALALAGLFGAENLLAAALVAGALSLEAIKGSVW
PLDARIHEARGQAGQIAVAAALRALLEGSAIAASHPHCGRVQDPYSIRCMPQVLGACLDNLHHAARVLVIEANAASDNPL
VFAAAQGGPGADEVISGGNFHAEPVAFAADIMALAVAEIGAMSERRLALLLDTGLSALPAFLVRDSGMNSGFMMAQVTAA
ALASENKSLAHPASVDSLPTSANQEDHVSMATFGARRLAEMIDNTATVVGIEAMAAAQGMEFDRSLRSTPLLEGQWAAIR
ERVAFLEQDRCLAPDIAAMRLWAQQSGWPAPLLQCLPSHA

Sequences:

>Translated_520_residues
MTESNTSPLLLQPGHVTLAGLRRIHAGPVRLALDAPARAAMQAAQAAVQRIVAADRVVYGINTGFGKLASTRIAAEHLTE
LQRRLVLSHSAGTGPALPDAVVRLVLATKAVGLARGHSGIRPEIVDALLALASAEVLPVIPAKGSVGASGDLAPLAHLAC
VLIGQGQAQCNGTLVPGAEAMRAIGCQPFVLGPKEGLALLNGTQVSTALALAGLFGAENLLAAALVAGALSLEAIKGSVW
PLDARIHEARGQAGQIAVAAALRALLEGSAIAASHPHCGRVQDPYSIRCMPQVLGACLDNLHHAARVLVIEANAASDNPL
VFAAAQGGPGADEVISGGNFHAEPVAFAADIMALAVAEIGAMSERRLALLLDTGLSALPAFLVRDSGMNSGFMMAQVTAA
ALASENKSLAHPASVDSLPTSANQEDHVSMATFGARRLAEMIDNTATVVGIEAMAAAQGMEFDRSLRSTPLLEGQWAAIR
ERVAFLEQDRCLAPDIAAMRLWAQQSGWPAPLLQCLPSHA
>Mature_519_residues
TESNTSPLLLQPGHVTLAGLRRIHAGPVRLALDAPARAAMQAAQAAVQRIVAADRVVYGINTGFGKLASTRIAAEHLTEL
QRRLVLSHSAGTGPALPDAVVRLVLATKAVGLARGHSGIRPEIVDALLALASAEVLPVIPAKGSVGASGDLAPLAHLACV
LIGQGQAQCNGTLVPGAEAMRAIGCQPFVLGPKEGLALLNGTQVSTALALAGLFGAENLLAAALVAGALSLEAIKGSVWP
LDARIHEARGQAGQIAVAAALRALLEGSAIAASHPHCGRVQDPYSIRCMPQVLGACLDNLHHAARVLVIEANAASDNPLV
FAAAQGGPGADEVISGGNFHAEPVAFAADIMALAVAEIGAMSERRLALLLDTGLSALPAFLVRDSGMNSGFMMAQVTAAA
LASENKSLAHPASVDSLPTSANQEDHVSMATFGARRLAEMIDNTATVVGIEAMAAAQGMEFDRSLRSTPLLEGQWAAIRE
RVAFLEQDRCLAPDIAAMRLWAQQSGWPAPLLQCLPSHA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=507, Percent_Identity=43.7869822485207, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17567831, Length=519, Percent_Identity=41.8111753371869, Blast_Score=348, Evalue=3e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53464; Mature: 53333

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00488 PAL_HISTIDASE ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESNTSPLLLQPGHVTLAGLRRIHAGPVRLALDAPARAAMQAAQAAVQRIVAADRVVYG
CCCCCCCCEEEECCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEE
INTGFGKLASTRIAAEHLTELQRRLVLSHSAGTGPALPDAVVRLVLATKAVGLARGHSGI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
RPEIVDALLALASAEVLPVIPAKGSVGASGDLAPLAHLACVLIGQGQAQCNGTLVPGAEA
CHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCHHH
MRAIGCQPFVLGPKEGLALLNGTQVSTALALAGLFGAENLLAAALVAGALSLEAIKGSVW
HHHHCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLDARIHEARGQAGQIAVAAALRALLEGSAIAASHPHCGRVQDPYSIRCMPQVLGACLDN
CCHHHHHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEEHHHHHHHHHHH
LHHAARVLVIEANAASDNPLVFAAAQGGPGADEVISGGNFHAEPVAFAADIMALAVAEIG
HHHHEEEEEEEECCCCCCCEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHC
AMSERRLALLLDTGLSALPAFLVRDSGMNSGFMMAQVTAAALASENKSLAHPASVDSLPT
CCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SANQEDHVSMATFGARRLAEMIDNTATVVGIEAMAAAQGMEFDRSLRSTPLLEGQWAAIR
CCCCCCCHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHCCCHHHHHHHCCCCCCCHHHHHH
ERVAFLEQDRCLAPDIAAMRLWAQQSGWPAPLLQCLPSHA
HHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCC
>Mature Secondary Structure 
TESNTSPLLLQPGHVTLAGLRRIHAGPVRLALDAPARAAMQAAQAAVQRIVAADRVVYG
CCCCCCCEEEECCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEE
INTGFGKLASTRIAAEHLTELQRRLVLSHSAGTGPALPDAVVRLVLATKAVGLARGHSGI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
RPEIVDALLALASAEVLPVIPAKGSVGASGDLAPLAHLACVLIGQGQAQCNGTLVPGAEA
CHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCHHH
MRAIGCQPFVLGPKEGLALLNGTQVSTALALAGLFGAENLLAAALVAGALSLEAIKGSVW
HHHHCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLDARIHEARGQAGQIAVAAALRALLEGSAIAASHPHCGRVQDPYSIRCMPQVLGACLDN
CCHHHHHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEEHHHHHHHHHHH
LHHAARVLVIEANAASDNPLVFAAAQGGPGADEVISGGNFHAEPVAFAADIMALAVAEIG
HHHHEEEEEEEECCCCCCCEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHC
AMSERRLALLLDTGLSALPAFLVRDSGMNSGFMMAQVTAAALASENKSLAHPASVDSLPT
CCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SANQEDHVSMATFGARRLAEMIDNTATVVGIEAMAAAQGMEFDRSLRSTPLLEGQWAAIR
CCCCCCCHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHCCCHHHHHHHCCCCCCCHHHHHH
ERVAFLEQDRCLAPDIAAMRLWAQQSGWPAPLLQCLPSHA
HHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA