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The map label for this gene is hutU [H]

Identifier: 121610573

GI number: 121610573

Start: 4031129

End: 4032850

Strand: Direct

Name: hutU [H]

Synonym: Veis_3646

Alternate gene names: 121610573

Gene position: 4031129-4032850 (Clockwise)

Preceding gene: 121610572

Following gene: 121610574

Centisome position: 72.41

GC content: 68.7

Gene sequence:

>1722_bases
ATGACCGCCAATGACCCCCGCCACGACGCCACGCGCGTGATCCGCGCCCCGCGCGGCAGCCAGCTCAGTTGCAAGAGCTG
GCTCACCGAAGCGGCCTACCGCATGCTCCAGAACAACCTGGACGCCGAAGTGGCCGAGCGCCCGCAAGACCTGGTGGTGT
ACGGCGGCATCGGCCGCGCCGCGCGCAACTGGCAGTGCTATGACCAAATCCTGGCCACGCTCAGGGAACTGAACGACGAC
GAGACCCTGCTGGTGCAGTCCGGCAAACCGGTGGGCGTTTTCCAGACCCATGCCGACGCGCCGCGCGTGCTGCTGGCCAA
TTCCAACCTGGTGCCCCGGTGGGCGAATTGGGAGCATTTCAGCGCGCTCGACCAAAAGGGCTTGTTCATGTACGGCCAGA
TGACGGCGGGCAGTTGGATCTACATCGGCAGCCAAGGCATCGTGCAAGGCACCTACGAGACCTTTGCCGCCGCCGGACGC
CAGCATTACGGCGGCTCGCTGGCAGGCCGGTGGATTTTGAGCGCCGGGCTGGGCGGCATGGGCGGCGCGCAGCCGCTGGC
CGCCAGCTTTGCCGGCGCAGTGTCGCTGACCATCGAATGCCGGCAAAGCAGCATCGACGCCCGGCTGCGCACCGGCTATC
TGGACCGGCAGGCGCGCGATATCGACCACGCCATCGAATGCCTGCGCCAGCACCTGGCGGCCCAAGAGGCGGTGTCGATC
GCACTGCTGGGCAACGCCGCCGAGCTGCTGCCCGAACTGCTGCGGCGGGCGCAGGCCGGGGGCCTGAAGCCCGATCTGGT
CACCGACCAGACCTCGGCGCACGACCTGGTCAACGGCTACCTGCCCGGCGGCTGGACGCTGGCGCAGTGGCACGCCGCAC
AGCAGGATGCGGGCCGGCATGCGCAGCTCAGACAGGCAGCGGCGCGCTCGTGCGCCGTCCATGTGCAGGCCATGCTGGAC
TTTCAGGCCATGGGCATTCCGGTCGTCGACTATGGCAACAACATCCGCCAGGTGGCGTTCGATGAGGGCGTGAAAAATGC
GTTCGACATCCCCGGCTTCGTGCCGGCCTATATCCGCCCGCTGTTTTGCGCAGGCAAAGGGCCGTTTCGCTGGGTGGCGC
TGTCGGGCGACCCGCAGGACATCGACAAGACCGACGCCAGGATCAAGGCCCTGTTCCCGGAAAACCGGCATCTGCACCGC
TGGCTGGACATGGCGCGCGCACGCATCCGCTTTCAGGGCCTGCCCGCGCGCATCTGCTGGCTGGGCCTGGGCGAGCGCCA
CATCGCCGGCCTGGCCTTCAACGCCATGGTCAAGAGCGGCGAACTCAAGGCACCGATCGTCATTGGCCGCGACCACCTGG
ACACCGGCTCCGTGGCCAGCCCGAACCGCGAGACCGAGGGCATGCTCGACGGCACCGATGCCGTGAGCGACTGGCCGCTG
CTCAACGCGCTGCTGAACACCGCCGGTGGCGCCACCTGGGTCAGCCTGCACCATGGCGGCGGCGTCGGCATGGGCTACTC
GCAGCACGCCGGCATGGTCATCGTGGCCGACGGCAGCGATGCCGCAGCCAGGCGCCTGGCGCGCGTGCTGGTCAACGACA
GCGGCAGCGGCGTGATGCGCCATGCCGATGCCGGCTACGCGCTGGCGCTGCAAACGGCCAACGAGCAAGGGCTGCAACTG
CCGATGGCCCGTTCGGCCTGCGCCGACGGCGCAGCACGATGA

Upstream 100 bases:

>100_bases
CCCGCGCCGCTGTTGCAGTGCCTGCCCAGCCATGCCTGAGCCTTGCATCGGCCACCTGCGCCCAATGAGACCCGCCACCA
GCCCCCCCATGAGGCCCGCC

Downstream 100 bases:

>100_bases
GAAACCGGTTTCCCCACCCCGCCCAAGAACCCCCGCCCATGAACCCGCCCCGCCTGGCGCCCGCCATCGGCCGCACTCCC
TTCATCCCGCCCCCCTGCCC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTANDPRHDATRVIRAPRGSQLSCKSWLTEAAYRMLQNNLDAEVAERPQDLVVYGGIGRAARNWQCYDQILATLRELNDD
ETLLVQSGKPVGVFQTHADAPRVLLANSNLVPRWANWEHFSALDQKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAAAGR
QHYGGSLAGRWILSAGLGGMGGAQPLAASFAGAVSLTIECRQSSIDARLRTGYLDRQARDIDHAIECLRQHLAAQEAVSI
ALLGNAAELLPELLRRAQAGGLKPDLVTDQTSAHDLVNGYLPGGWTLAQWHAAQQDAGRHAQLRQAAARSCAVHVQAMLD
FQAMGIPVVDYGNNIRQVAFDEGVKNAFDIPGFVPAYIRPLFCAGKGPFRWVALSGDPQDIDKTDARIKALFPENRHLHR
WLDMARARIRFQGLPARICWLGLGERHIAGLAFNAMVKSGELKAPIVIGRDHLDTGSVASPNRETEGMLDGTDAVSDWPL
LNALLNTAGGATWVSLHHGGGVGMGYSQHAGMVIVADGSDAAARRLARVLVNDSGSGVMRHADAGYALALQTANEQGLQL
PMARSACADGAAR

Sequences:

>Translated_573_residues
MTANDPRHDATRVIRAPRGSQLSCKSWLTEAAYRMLQNNLDAEVAERPQDLVVYGGIGRAARNWQCYDQILATLRELNDD
ETLLVQSGKPVGVFQTHADAPRVLLANSNLVPRWANWEHFSALDQKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAAAGR
QHYGGSLAGRWILSAGLGGMGGAQPLAASFAGAVSLTIECRQSSIDARLRTGYLDRQARDIDHAIECLRQHLAAQEAVSI
ALLGNAAELLPELLRRAQAGGLKPDLVTDQTSAHDLVNGYLPGGWTLAQWHAAQQDAGRHAQLRQAAARSCAVHVQAMLD
FQAMGIPVVDYGNNIRQVAFDEGVKNAFDIPGFVPAYIRPLFCAGKGPFRWVALSGDPQDIDKTDARIKALFPENRHLHR
WLDMARARIRFQGLPARICWLGLGERHIAGLAFNAMVKSGELKAPIVIGRDHLDTGSVASPNRETEGMLDGTDAVSDWPL
LNALLNTAGGATWVSLHHGGGVGMGYSQHAGMVIVADGSDAAARRLARVLVNDSGSGVMRHADAGYALALQTANEQGLQL
PMARSACADGAAR
>Mature_572_residues
TANDPRHDATRVIRAPRGSQLSCKSWLTEAAYRMLQNNLDAEVAERPQDLVVYGGIGRAARNWQCYDQILATLRELNDDE
TLLVQSGKPVGVFQTHADAPRVLLANSNLVPRWANWEHFSALDQKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAAAGRQ
HYGGSLAGRWILSAGLGGMGGAQPLAASFAGAVSLTIECRQSSIDARLRTGYLDRQARDIDHAIECLRQHLAAQEAVSIA
LLGNAAELLPELLRRAQAGGLKPDLVTDQTSAHDLVNGYLPGGWTLAQWHAAQQDAGRHAQLRQAAARSCAVHVQAMLDF
QAMGIPVVDYGNNIRQVAFDEGVKNAFDIPGFVPAYIRPLFCAGKGPFRWVALSGDPQDIDKTDARIKALFPENRHLHRW
LDMARARIRFQGLPARICWLGLGERHIAGLAFNAMVKSGELKAPIVIGRDHLDTGSVASPNRETEGMLDGTDAVSDWPLL
NALLNTAGGATWVSLHHGGGVGMGYSQHAGMVIVADGSDAAARRLARVLVNDSGSGVMRHADAGYALALQTANEQGLQLP
MARSACADGAAR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=571, Percent_Identity=33.4500875656743, Blast_Score=279, Evalue=6e-75,
Organism=Homo sapiens, GI260306182, Length=631, Percent_Identity=31.2202852614897, Blast_Score=253, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI71997891, Length=585, Percent_Identity=34.5299145299145, Blast_Score=307, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61725; Mature: 61593

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANDPRHDATRVIRAPRGSQLSCKSWLTEAAYRMLQNNLDAEVAERPQDLVVYGGIGRA
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEECCCCCC
ARNWQCYDQILATLRELNDDETLLVQSGKPVGVFQTHADAPRVLLANSNLVPRWANWEHF
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHH
SALDQKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAAAGRQHYGGSLAGRWILSAGLGGM
HHHCCCCEEEEEEECCCCEEEECCCCCEECHHHHHHHCCCHHCCCCHHHHHHHHCCCCCC
GGAQPLAASFAGAVSLTIECRQSSIDARLRTGYLDRQARDIDHAIECLRQHLAAQEAVSI
CCCCHHHHHHCCEEEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
ALLGNAAELLPELLRRAQAGGLKPDLVTDQTSAHDLVNGYLPGGWTLAQWHAAQQDAGRH
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCHH
AQLRQAAARSCAVHVQAMLDFQAMGIPVVDYGNNIRQVAFDEGVKNAFDIPGFVPAYIRP
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHCCCHHCCCCCCCHHHHHH
LFCAGKGPFRWVALSGDPQDIDKTDARIKALFPENRHLHRWLDMARARIRFQGLPARICW
HHCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEECCCCEEEEE
LGLGERHIAGLAFNAMVKSGELKAPIVIGRDHLDTGSVASPNRETEGMLDGTDAVSDWPL
ECCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LNALLNTAGGATWVSLHHGGGVGMGYSQHAGMVIVADGSDAAARRLARVLVNDSGSGVMR
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEE
HADAGYALALQTANEQGLQLPMARSACADGAAR
ECCCCEEEEEEECCCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
TANDPRHDATRVIRAPRGSQLSCKSWLTEAAYRMLQNNLDAEVAERPQDLVVYGGIGRA
CCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEECCCCCC
ARNWQCYDQILATLRELNDDETLLVQSGKPVGVFQTHADAPRVLLANSNLVPRWANWEHF
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHH
SALDQKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAAAGRQHYGGSLAGRWILSAGLGGM
HHHCCCCEEEEEEECCCCEEEECCCCCEECHHHHHHHCCCHHCCCCHHHHHHHHCCCCCC
GGAQPLAASFAGAVSLTIECRQSSIDARLRTGYLDRQARDIDHAIECLRQHLAAQEAVSI
CCCCHHHHHHCCEEEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
ALLGNAAELLPELLRRAQAGGLKPDLVTDQTSAHDLVNGYLPGGWTLAQWHAAQQDAGRH
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCHH
AQLRQAAARSCAVHVQAMLDFQAMGIPVVDYGNNIRQVAFDEGVKNAFDIPGFVPAYIRP
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHCCCHHCCCCCCCHHHHHH
LFCAGKGPFRWVALSGDPQDIDKTDARIKALFPENRHLHRWLDMARARIRFQGLPARICW
HHCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEECCCCEEEEE
LGLGERHIAGLAFNAMVKSGELKAPIVIGRDHLDTGSVASPNRETEGMLDGTDAVSDWPL
ECCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LNALLNTAGGATWVSLHHGGGVGMGYSQHAGMVIVADGSDAAARRLARVLVNDSGSGVMR
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEE
HADAGYALALQTANEQGLQLPMARSACADGAAR
ECCCCEEEEEEECCCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]