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The map label for this gene is hutC [H]

Identifier: 121610571

GI number: 121610571

Start: 4028684

End: 4029454

Strand: Direct

Name: hutC [H]

Synonym: Veis_3644

Alternate gene names: 121610571

Gene position: 4028684-4029454 (Clockwise)

Preceding gene: 121610570

Following gene: 121610572

Centisome position: 72.37

GC content: 70.04

Gene sequence:

>771_bases
ATGAGCACCCACCCCTCCCACTCCTCCCGCCGCCGCGCTGCCCCGGCGCCCGCCATGGCGCTGTACGAGCAGGTCAAGGA
CTTCATTGCGCGCAGGATCCAGCAGGGCCTTTGGCGCACGGGCGACCGCCTGCCGTCCGAGAACGAGTTGGTCAGCCAGT
TCGGCATCTCGCGCATGACGGTCAACCGCGCGCTGCGCGAGTTGGTGCAACAGGGCCGCATCGTGCGCGTGGCCGGCGTG
GGCAGCTTTGTCGCCGAAGACCGGCCCCAGTCGACCTTGCTGCAAATTGCCAACCTGGCCAGCGAGATCCGCCAGCGCGG
CCACGACTACCGCTGCGACCTGCTGGCCGTGGAGCGCGTCCCGGCCACGCTGGAGGTGGCTGCGGCGCTGGAGTTGCGCA
CCGGAGCGTCGGTATTCCACTCGCTGTGCATACACCGCGAGGACGGCGTGCCGGTGCAACTGGAAGACCGCCATGTGAAC
CCGCGCCAGGTGCCCGGGTTCGCCGCGCAGGACTTTGCCCGGATGCCGCCCTCCGAATACCTGGTGCGCAACGTGCCGTT
CGACCAGATCGAGCATGTGGTCGATGCCGTGATGCCCGGCGCCAGGCAGGCTGCGCTGCTGGAAATGTCGCCGCAGGAGC
CTTGCCTGCTGCTGACGCGGCGCACCTGGTCGCGCGCGGTGCCGATCACCGTGGTGCGCTGCCTGCATCCGGCCACCCGC
TACCGCCTGGGCAGCCGCTTTCGCGCGGACGGCAATCCGCTGGCCGGCTGA

Upstream 100 bases:

>100_bases
CGCATTCATTGCGCTCAAGGCGCGCCTGACCGAAGAGATTCGCGCCGAGGCCATGGCGGCGGGCTGGCACTGAGGTTGGG
CCCTTTTTCAGCTTTCGCCG

Downstream 100 bases:

>100_bases
GCGGGTGGCCGCAGTTGCCTGGCATGGCGCGTAAGGACAGGATCGATGCGATGACCGAATCCAACACTTCCCCACTGCTG
CTGCAACCCGGCCATGTCAC

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSTHPSHSSRRRAAPAPAMALYEQVKDFIARRIQQGLWRTGDRLPSENELVSQFGISRMTVNRALRELVQQGRIVRVAGV
GSFVAEDRPQSTLLQIANLASEIRQRGHDYRCDLLAVERVPATLEVAAALELRTGASVFHSLCIHREDGVPVQLEDRHVN
PRQVPGFAAQDFARMPPSEYLVRNVPFDQIEHVVDAVMPGARQAALLEMSPQEPCLLLTRRTWSRAVPITVVRCLHPATR
YRLGSRFRADGNPLAG

Sequences:

>Translated_256_residues
MSTHPSHSSRRRAAPAPAMALYEQVKDFIARRIQQGLWRTGDRLPSENELVSQFGISRMTVNRALRELVQQGRIVRVAGV
GSFVAEDRPQSTLLQIANLASEIRQRGHDYRCDLLAVERVPATLEVAAALELRTGASVFHSLCIHREDGVPVQLEDRHVN
PRQVPGFAAQDFARMPPSEYLVRNVPFDQIEHVVDAVMPGARQAALLEMSPQEPCLLLTRRTWSRAVPITVVRCLHPATR
YRLGSRFRADGNPLAG
>Mature_255_residues
STHPSHSSRRRAAPAPAMALYEQVKDFIARRIQQGLWRTGDRLPSENELVSQFGISRMTVNRALRELVQQGRIVRVAGVG
SFVAEDRPQSTLLQIANLASEIRQRGHDYRCDLLAVERVPATLEVAAALELRTGASVFHSLCIHREDGVPVQLEDRHVNP
RQVPGFAAQDFARMPPSEYLVRNVPFDQIEHVVDAVMPGARQAALLEMSPQEPCLLLTRRTWSRAVPITVVRCLHPATRY
RLGSRFRADGNPLAG

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=200, Percent_Identity=29, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082252, Length=147, Percent_Identity=27.2108843537415, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790540, Length=159, Percent_Identity=30.8176100628931, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28621; Mature: 28490

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHPSHSSRRRAAPAPAMALYEQVKDFIARRIQQGLWRTGDRLPSENELVSQFGISRMT
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHH
VNRALRELVQQGRIVRVAGVGSFVAEDRPQSTLLQIANLASEIRQRGHDYRCDLLAVERV
HHHHHHHHHHCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHC
PATLEVAAALELRTGASVFHSLCIHREDGVPVQLEDRHVNPRQVPGFAAQDFARMPPSEY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHCCCHHH
LVRNVPFDQIEHVVDAVMPGARQAALLEMSPQEPCLLLTRRTWSRAVPITVVRCLHPATR
HHHCCCHHHHHHHHHHHCCCCHHHHEEECCCCCCEEEEEHHHHHCCHHHHHHHHHCHHHH
YRLGSRFRADGNPLAG
HHHCCCCCCCCCCCCC
>Mature Secondary Structure 
STHPSHSSRRRAAPAPAMALYEQVKDFIARRIQQGLWRTGDRLPSENELVSQFGISRMT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHH
VNRALRELVQQGRIVRVAGVGSFVAEDRPQSTLLQIANLASEIRQRGHDYRCDLLAVERV
HHHHHHHHHHCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHC
PATLEVAAALELRTGASVFHSLCIHREDGVPVQLEDRHVNPRQVPGFAAQDFARMPPSEY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHCCCHHH
LVRNVPFDQIEHVVDAVMPGARQAALLEMSPQEPCLLLTRRTWSRAVPITVVRCLHPATR
HHHCCCHHHHHHHHHHHCCCCHHHHEEECCCCCCEEEEEHHHHHCCHHHHHHHHHCHHHH
YRLGSRFRADGNPLAG
HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]