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The map label for this gene is mmsB [H]

Identifier: 121610469

GI number: 121610469

Start: 3913985

End: 3914884

Strand: Direct

Name: mmsB [H]

Synonym: Veis_3539

Alternate gene names: 121610469

Gene position: 3913985-3914884 (Clockwise)

Preceding gene: 121610468

Following gene: 121610470

Centisome position: 70.31

GC content: 68.67

Gene sequence:

>900_bases
ATGTCGATTGCATTCATCGGACTGGGCCACATGGGCGGCCCCATGGCCTTGAACCTGCAACGGGCGGGCCATGCCGTGCA
GGGGTTTGACCTGTCACCGGCCGCGCGCGCACAACTGGCCGCCGCAGGCTTGCCGATCGCCGCCGATGCCGCCGCGTCGG
TGCAGGGAGCGGATATCGTCATCAGCATGCTGCCGGCCAACGCGCATGTCGAGGCGCTGTACCTGGGCCACGGCGGGCAG
GCGGGACTGTTGCCGCAACTGGCAGCCGACACGCTGGTGATCGACTGCTCGACCATCGCCGCCAGCAGCGCGCGCAAGGT
GGCAGACGCGGCCTTGGCGCAGCAGCGCGGCCTGCGGTTCATCGACGCCCCCGTCTCGGGCGGCACCGGGGGCGCCGTGG
CAGGCACGCTGACCTTCATCGTCGGCGGTGACGAGCAGGCGCTGGAGCAGGCCCGTCCGGTGCTGGAAAAAATGGGCCAG
AACATCTTCCACGCCGGCGGCGTGGGCACGGGCCAGACGGCCAAAATCTGCAACAACATGCTGCTGGGCATCCTGATGGC
AGGCACCAGCGAAGCGCTTGCGCTGGGCCTGGCCAATGGCCTGGACCCGCGCGTGCTCAGCGACATCATGCGCGGCAGTT
CGGGCAGCAACTGGGTGCTGGAAAAGTACAACCCCATGCCCGGCGTGATGGCCTCGGCCCCGGCCTCCAAAGGCTACGCC
GGCGGCTTTGGCACCGACCTGATGCTCAAGGACCTGGGCCTGGCGCAAGACAGCGCAACCGCCGTGCAGGCAGCGACCCC
GCTGGGCAGTCTGGCGCGCAACCTGTACGCCGCGCACAGCCTGGCGGGCAACGGCGCGCTGGATTTTTCCAGCATCATCC
GGATGCTGCAAAAGCGGTGA

Upstream 100 bases:

>100_bases
GAACACACCCAGCCAGCGCTGAGTCGGCCATTGTTTCGATAGCCGTCTGCGCAACATCCACCCGCACCCTATCCATATTC
ATCACCAGGAGACTGTCGAG

Downstream 100 bases:

>100_bases
TGCGCGGCGCCCTGGCCCCCCCAGTCGCTTGCGGCTTCCGTTGCGTCGCTTGCGGCTTCCACCCCGTCGCCGGCGACTTC
TGTCCCGCCATTGCCATTGC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSIAFIGLGHMGGPMALNLQRAGHAVQGFDLSPAARAQLAAAGLPIAADAAASVQGADIVISMLPANAHVEALYLGHGGQ
AGLLPQLAADTLVIDCSTIAASSARKVADAALAQQRGLRFIDAPVSGGTGGAVAGTLTFIVGGDEQALEQARPVLEKMGQ
NIFHAGGVGTGQTAKICNNMLLGILMAGTSEALALGLANGLDPRVLSDIMRGSSGSNWVLEKYNPMPGVMASAPASKGYA
GGFGTDLMLKDLGLAQDSATAVQAATPLGSLARNLYAAHSLAGNGALDFSSIIRMLQKR

Sequences:

>Translated_299_residues
MSIAFIGLGHMGGPMALNLQRAGHAVQGFDLSPAARAQLAAAGLPIAADAAASVQGADIVISMLPANAHVEALYLGHGGQ
AGLLPQLAADTLVIDCSTIAASSARKVADAALAQQRGLRFIDAPVSGGTGGAVAGTLTFIVGGDEQALEQARPVLEKMGQ
NIFHAGGVGTGQTAKICNNMLLGILMAGTSEALALGLANGLDPRVLSDIMRGSSGSNWVLEKYNPMPGVMASAPASKGYA
GGFGTDLMLKDLGLAQDSATAVQAATPLGSLARNLYAAHSLAGNGALDFSSIIRMLQKR
>Mature_298_residues
SIAFIGLGHMGGPMALNLQRAGHAVQGFDLSPAARAQLAAAGLPIAADAAASVQGADIVISMLPANAHVEALYLGHGGQA
GLLPQLAADTLVIDCSTIAASSARKVADAALAQQRGLRFIDAPVSGGTGGAVAGTLTFIVGGDEQALEQARPVLEKMGQN
IFHAGGVGTGQTAKICNNMLLGILMAGTSEALALGLANGLDPRVLSDIMRGSSGSNWVLEKYNPMPGVMASAPASKGYAG
GFGTDLMLKDLGLAQDSATAVQAATPLGSLARNLYAAHSLAGNGALDFSSIIRMLQKR

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=298, Percent_Identity=44.6308724832215, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI40556376, Length=298, Percent_Identity=26.8456375838926, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI145693186, Length=298, Percent_Identity=33.8926174496644, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1786719, Length=297, Percent_Identity=32.996632996633, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1790315, Length=297, Percent_Identity=34.3434343434343, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1789092, Length=297, Percent_Identity=32.996632996633, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557316, Length=299, Percent_Identity=43.8127090301003, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24655230, Length=298, Percent_Identity=44.9664429530201, Blast_Score=237, Evalue=6e-63,
Organism=Drosophila melanogaster, GI19922568, Length=298, Percent_Identity=44.9664429530201, Blast_Score=237, Evalue=6e-63,
Organism=Drosophila melanogaster, GI28574115, Length=296, Percent_Identity=21.9594594594595, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30066; Mature: 29935

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAFIGLGHMGGPMALNLQRAGHAVQGFDLSPAARAQLAAAGLPIAADAAASVQGADIV
CEEEEEEECCCCCCEEEEHHHCCCEECCCCCCHHHHHHHHHCCCCEECCCCCCCCCCEEE
ISMLPANAHVEALYLGHGGQAGLLPQLAADTLVIDCSTIAASSARKVADAALAQQRGLRF
EEEECCCCCEEEEEECCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEE
IDAPVSGGTGGAVAGTLTFIVGGDEQALEQARPVLEKMGQNIFHAGGVGTGQTAKICNNM
EECCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHH
LLGILMAGTSEALALGLANGLDPRVLSDIMRGSSGSNWVLEKYNPMPGVMASAPASKGYA
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCCCHHCCCCCCCCC
GGFGTDLMLKDLGLAQDSATAVQAATPLGSLARNLYAAHSLAGNGALDFSSIIRMLQKR
CCCCHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SIAFIGLGHMGGPMALNLQRAGHAVQGFDLSPAARAQLAAAGLPIAADAAASVQGADIV
EEEEEEECCCCCCEEEEHHHCCCEECCCCCCHHHHHHHHHCCCCEECCCCCCCCCCEEE
ISMLPANAHVEALYLGHGGQAGLLPQLAADTLVIDCSTIAASSARKVADAALAQQRGLRF
EEEECCCCCEEEEEECCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEE
IDAPVSGGTGGAVAGTLTFIVGGDEQALEQARPVLEKMGQNIFHAGGVGTGQTAKICNNM
EECCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHH
LLGILMAGTSEALALGLANGLDPRVLSDIMRGSSGSNWVLEKYNPMPGVMASAPASKGYA
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCCCHHCCCCCCCCC
GGFGTDLMLKDLGLAQDSATAVQAATPLGSLARNLYAAHSLAGNGALDFSSIIRMLQKR
CCCCHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]