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The map label for this gene is acdA [H]

Identifier: 121610468

GI number: 121610468

Start: 3912693

End: 3913853

Strand: Direct

Name: acdA [H]

Synonym: Veis_3538

Alternate gene names: 121610468

Gene position: 3912693-3913853 (Clockwise)

Preceding gene: 121610462

Following gene: 121610469

Centisome position: 70.29

GC content: 68.22

Gene sequence:

>1161_bases
ATGGACTTTGAACTCACCGAAGAACAACGCGCCTTTGCCAAGAGCGCGCACGACTTTGCCCGGGCCGAATTTGCGCCCCA
TGCCGCGCAGTGGGACGAGCAGGCCATCTTCCCCAGAGCGGCGATTGCCAAGGCCGGCGCGCTCGGCTTTTGCGGCCTGT
ATGCCTGCGAGGCCGCCGGCGGCCTGGCCCTGCCCCGGCTCGATGCCACGCTGGTGTTCGAGGAACTGGCGGCCATCGAT
CCATCGACCACCGCCTTCATCTCCATCCACAACATGGCGACCTGGATGCTCGGCCGCTGGGCCACGCCCGCAGTGCGCGA
CCACTGGGGCCCGCTGCTGACCCGGGGCGAGAAACTGGCCTCCTACTGCCTGACGGAGCCTGGCGCAGGCTCGGACGCCG
CCGCGCTCACGACGCGGGCCGAGCGGGTCGGCAGCGACTATGTGATCAACGGCAGCAAAGCCTTCATCTCGGGCGCCGGC
AGCACCGACATGCTGGTGTTGATGGCGCGCACCGGCGCTGCCGGCGCCGGCGGCATCAGCGCCTTTGCCGTGCCCGCCGA
CACCCCCGGCATCAGCTACGGCAAGAAAGAGCGCAAGCTGGGCTGGAACAGCCAGCCCACGCGCAGCATTGGCTTGGAGC
AGTTGCGCATCCCTGCCGAGCACCTGCTCGGCCGCGTCGGCGAGGGCTTCAAGATCGCGATGCAGGGGCTCGACGGCGGG
CGCATCAACATCGCCAGTTGCTCGGTCGGCGCAGCGCAAGGCGCGCTGCAGGCAGCCCGGCAGTACATGCAGCAGCGCCG
GCAGTTCGGCCAGCCGCTGGCCAGCTTTCAGGCGTTGCAGTTCAAACTGGCCGACATGGCCACCGAACTGGTCGCCGCGC
GCCAGATGGTGCGCCTGGCGGCCAGCAAGCTCGACACCGGCGCGCCCGACGCCAGCACCTATTGCGCGATGGCCAAGCGC
TTTGCCACCGACATCGGCTTTGCCGTCTGCAACGAGGCGCTGCAACTGCACGGCGGCTACGGCTACATCCGCGAGTACCC
GATCGAGCGCCTGCTGCGCGACACCCGCGTGCACCAGATACTGGAAGGCAGCAACGAAATCATGCGCCTGATCATTGCGC
GGCGCATACTCGATGGCGCCTGCGGCGATACCATCCGCTAG

Upstream 100 bases:

>100_bases
GGCGGATGGCGCGCCGCATCATGGAAAACGGCTATGGCCGCCGTGCATGGATGCCGCATATGATGGCCGACGCCCTGCGC
ACCTGTGCCGAAAACGCCCC

Downstream 100 bases:

>100_bases
CCACGCAACCACGCTGCGCCAGCCAGAACCGGAACACACCCAGCCAGCGCTGAGTCGGCCATTGTTTCGATAGCCGTCTG
CGCAACATCCACCCGCACCC

Product: butyryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MDFELTEEQRAFAKSAHDFARAEFAPHAAQWDEQAIFPRAAIAKAGALGFCGLYACEAAGGLALPRLDATLVFEELAAID
PSTTAFISIHNMATWMLGRWATPAVRDHWGPLLTRGEKLASYCLTEPGAGSDAAALTTRAERVGSDYVINGSKAFISGAG
STDMLVLMARTGAAGAGGISAFAVPADTPGISYGKKERKLGWNSQPTRSIGLEQLRIPAEHLLGRVGEGFKIAMQGLDGG
RINIASCSVGAAQGALQAARQYMQQRRQFGQPLASFQALQFKLADMATELVAARQMVRLAASKLDTGAPDASTYCAMAKR
FATDIGFAVCNEALQLHGGYGYIREYPIERLLRDTRVHQILEGSNEIMRLIIARRILDGACGDTIR

Sequences:

>Translated_386_residues
MDFELTEEQRAFAKSAHDFARAEFAPHAAQWDEQAIFPRAAIAKAGALGFCGLYACEAAGGLALPRLDATLVFEELAAID
PSTTAFISIHNMATWMLGRWATPAVRDHWGPLLTRGEKLASYCLTEPGAGSDAAALTTRAERVGSDYVINGSKAFISGAG
STDMLVLMARTGAAGAGGISAFAVPADTPGISYGKKERKLGWNSQPTRSIGLEQLRIPAEHLLGRVGEGFKIAMQGLDGG
RINIASCSVGAAQGALQAARQYMQQRRQFGQPLASFQALQFKLADMATELVAARQMVRLAASKLDTGAPDASTYCAMAKR
FATDIGFAVCNEALQLHGGYGYIREYPIERLLRDTRVHQILEGSNEIMRLIIARRILDGACGDTIR
>Mature_386_residues
MDFELTEEQRAFAKSAHDFARAEFAPHAAQWDEQAIFPRAAIAKAGALGFCGLYACEAAGGLALPRLDATLVFEELAAID
PSTTAFISIHNMATWMLGRWATPAVRDHWGPLLTRGEKLASYCLTEPGAGSDAAALTTRAERVGSDYVINGSKAFISGAG
STDMLVLMARTGAAGAGGISAFAVPADTPGISYGKKERKLGWNSQPTRSIGLEQLRIPAEHLLGRVGEGFKIAMQGLDGG
RINIASCSVGAAQGALQAARQYMQQRRQFGQPLASFQALQFKLADMATELVAARQMVRLAASKLDTGAPDASTYCAMAKR
FATDIGFAVCNEALQLHGGYGYIREYPIERLLRDTRVHQILEGSNEIMRLIIARRILDGACGDTIR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=54.9597855227882, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=41.2698412698413, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=37.6315789473684, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=37.6315789473684, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=36.096256684492, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=34.3915343915344, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=36.1581920903955, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=33.5106382978723, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI4557235, Length=282, Percent_Identity=36.5248226950355, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI76496475, Length=282, Percent_Identity=36.5248226950355, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI226958414, Length=333, Percent_Identity=34.2342342342342, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI4503943, Length=390, Percent_Identity=27.4358974358974, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=27.4725274725275, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI38505218, Length=282, Percent_Identity=28.3687943262411, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=29.2682926829268, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=29.2682926829268, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=30.6068601583113, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=29.1338582677165, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87082384, Length=292, Percent_Identity=31.5068493150685, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081702, Length=317, Percent_Identity=23.6593059936909, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=51.0928961748634, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=36.6492146596859, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=35.6955380577428, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=34.9081364829396, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17508101, Length=375, Percent_Identity=33.6, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=33.6898395721925, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=34.5714285714286, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=33.4210526315789, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=36.4620938628159, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71985192, Length=296, Percent_Identity=32.4324324324324, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=36.0869565217391, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17534353, Length=387, Percent_Identity=27.906976744186, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17505929, Length=376, Percent_Identity=29.7872340425532, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=27.7333333333333, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=27.7372262773723, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=28.4722222222222, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=27.6859504132231, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24660351, Length=392, Percent_Identity=37.2448979591837, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=36.8983957219251, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=37.1352785145889, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=33.4224598930481, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=34.4736842105263, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI281363737, Length=282, Percent_Identity=33.6879432624113, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI19920834, Length=389, Percent_Identity=28.7917737789203, Blast_Score=141, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41359; Mature: 41359

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFELTEEQRAFAKSAHDFARAEFAPHAAQWDEQAIFPRAAIAKAGALGFCGLYACEAAG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHCCCHHHHHHCCCHHHHHHHHHHHCC
GLALPRLDATLVFEELAAIDPSTTAFISIHNMATWMLGRWATPAVRDHWGPLLTRGEKLA
CCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHH
SYCLTEPGAGSDAAALTTRAERVGSDYVINGSKAFISGAGSTDMLVLMARTGAAGAGGIS
HHHCCCCCCCCCHHHHHHHHHHCCCCEEECCCEEEEECCCCCCEEEEEEECCCCCCCCCE
AFAVPADTPGISYGKKERKLGWNSQPTRSIGLEQLRIPAEHLLGRVGEGFKIAMQGLDGG
EEEECCCCCCCCCCCHHHCCCCCCCCCHHHCHHHHCCCHHHHHHHCCCCCEEEEECCCCC
RINIASCSVGAAQGALQAARQYMQQRRQFGQPLASFQALQFKLADMATELVAARQMVRLA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASKLDTGAPDASTYCAMAKRFATDIGFAVCNEALQLHGGYGYIREYPIERLLRDTRVHQI
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LEGSNEIMRLIIARRILDGACGDTIR
HHCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDFELTEEQRAFAKSAHDFARAEFAPHAAQWDEQAIFPRAAIAKAGALGFCGLYACEAAG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHCCCHHHHHHCCCHHHHHHHHHHHCC
GLALPRLDATLVFEELAAIDPSTTAFISIHNMATWMLGRWATPAVRDHWGPLLTRGEKLA
CCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHH
SYCLTEPGAGSDAAALTTRAERVGSDYVINGSKAFISGAGSTDMLVLMARTGAAGAGGIS
HHHCCCCCCCCCHHHHHHHHHHCCCCEEECCCEEEEECCCCCCEEEEEEECCCCCCCCCE
AFAVPADTPGISYGKKERKLGWNSQPTRSIGLEQLRIPAEHLLGRVGEGFKIAMQGLDGG
EEEECCCCCCCCCCCHHHCCCCCCCCCHHHCHHHHCCCHHHHHHHCCCCCEEEEECCCCC
RINIASCSVGAAQGALQAARQYMQQRRQFGQPLASFQALQFKLADMATELVAARQMVRLA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASKLDTGAPDASTYCAMAKRFATDIGFAVCNEALQLHGGYGYIREYPIERLLRDTRVHQI
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LEGSNEIMRLIIARRILDGACGDTIR
HHCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]