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The map label for this gene is ilvD [H]

Identifier: 121610470

GI number: 121610470

Start: 3915027

End: 3916736

Strand: Direct

Name: ilvD [H]

Synonym: Veis_3540

Alternate gene names: 121610470

Gene position: 3915027-3916736 (Clockwise)

Preceding gene: 121610469

Following gene: 121610471

Centisome position: 70.33

GC content: 67.95

Gene sequence:

>1710_bases
ATGAAAAGACGATCGCAGCACTGGTTCGGTGGCACGGGCAAAGACGCCTTCATCCACCGCAGTTGGATGAAAAACCATGG
CCTGCCCGACGACGCCTTCGACGGCCGGCCAGTGATCGGCATCTGCAACACCTTCTCCGAATTCACGCCCTGCAACGCGC
ATTTTCGCGGCCTCATCGAGCACATCAAGGCGGGCGTGCTCGAAGCCGGCGGCCTGCCGCTGGAGTTTCCGGTCTTTTCC
TGCGGCGAATCCAACCTGCGCCCGACGGCCATGCTGTTTCGCAACCTGGCCTCGATGGATGTCGAGGAGGCGATTCGCGG
CAACCCGATGGACGCCGTGGTGCTGATGGCCGGCTGCGACAAGACCACGCCCGCGCTGGTCATGGGCGCGGCCTCGTGCG
ATCTGCCGGCCATCGTCATCTCCGGCGGGCCGATGCTCAACGGTCGTTTCCAAGGCCGCGCGATCGGCTCGGGCACCGAC
GTATGGAAATTCTCCGAAGACCTGCGCGCCGGCGTGATGAGCGCACAGGCATTCGCCGCTGCCGAAAGCGCCATGTCGCG
CTCGCCCGGTCACTGCATGACCATGGGCACGGCCTCGACCATGGCCTCGATGGTGGAGGCGCTGGGCATCGCCCTGCCGG
GCAATGCGGCCTACCCGGCGGTCGACGCGCACCGCAACCGCCTGGCCCGGATGACCGGCCGGCGCAGCGTCGAGCTGGTC
CACGAAGACCTGCGGCTGTCCCGGATACTCCAGCCGCAAGCCTTCGCCAACGCCATCCGGGTCAATGGGGCGATCGGCGG
CTCGACCAACGCCGTGGTGCATCTGCTGGCCATTGCCGGGCGCATCGGCACGCCGCTGACCCTGGACGACTGGGACCGCC
TCGGCCGCGATGTGCCGACCATCCTGGACCTGATGCCCTCGGGCCGCTTCCTGATGGAGGACTTCTGCTACGCCGGCGGC
ATACCCGCCGTCATGAAGGAAATCAGCCATCTGCTCGAACTGCAAGCCATGACGGTCAGCGGCAAAAGCGTGCGCGAGAA
CATCGCCGATGCCTGCAACCACAACCCCGAGGTGATCCGCCCTCTCGATCGGGCGCTGACGCCGCAGGGCGGCATCGCGG
TGCTGCGCGGCAACCTGGCGCCCGCCGGCGCCATCATCAAGCCGTCTGCCGCCACGCCCGCGCTGATGCAGCATCGCGGC
CGCGCCGTCGTGTTCGAGGACATCGACCACTACAAGCGCAGCATCGACGACCCGGCGCTGGACATCGACGAAAACTGCAT
CATGGTGCTCAAGAACTGCGGCCCCAAAGGCTACCCCGGCATGGCCGAGGTCGGCAACATGGCGCTGCCGGAAAAGCTGC
TGCGGCGCGGCCTGCGCGACATGGTGCGCATCTCGGATGCCCGCATGTCCGGCACCGCGTTCGGCACCGTGGTGCTGCAT
GTGGCGCCAGAAGCCGCCGTCGGCGGCCCGCTGGCGCTGGTGCGCAGCGGCGACATGATCGAACTCGATGTTCCGGCACG
CCGGCTGCACCTGGATGTCGCGCCGGCCGAGTTGCAGGCACGCCGCAGCCGTTGGCGCGCGCCGGCCGCCGCCATGTCCG
GCGGCTACCAGGGCCTGTACGTCGAGCGCGTGATGCAGGCCGACAGCGGCGCCGACCTGGACTTCCTGGTCGGTTGTCGC
GGCCATGCCATCCCGCGTGAAAGCCATTGA

Upstream 100 bases:

>100_bases
GCGTCGCTTGCGGCTTCCACCCCGTCGCCGGCGACTTCTGTCCCGCCATTGCCATTGCCGGCGCGACCCCCAAAGTGAAC
ATCCCGAAGGAGCAACAACG

Downstream 100 bases:

>100_bases
GAGCGGCCATGCAGAAATACCGGCCCGAAGACCTGCACGGCATCCACGCCATCGTCTACGCCTTGTTCGACGCCGACGAG
CGACTGGACCGCGCAGCCAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MKRRSQHWFGGTGKDAFIHRSWMKNHGLPDDAFDGRPVIGICNTFSEFTPCNAHFRGLIEHIKAGVLEAGGLPLEFPVFS
CGESNLRPTAMLFRNLASMDVEEAIRGNPMDAVVLMAGCDKTTPALVMGAASCDLPAIVISGGPMLNGRFQGRAIGSGTD
VWKFSEDLRAGVMSAQAFAAAESAMSRSPGHCMTMGTASTMASMVEALGIALPGNAAYPAVDAHRNRLARMTGRRSVELV
HEDLRLSRILQPQAFANAIRVNGAIGGSTNAVVHLLAIAGRIGTPLTLDDWDRLGRDVPTILDLMPSGRFLMEDFCYAGG
IPAVMKEISHLLELQAMTVSGKSVRENIADACNHNPEVIRPLDRALTPQGGIAVLRGNLAPAGAIIKPSAATPALMQHRG
RAVVFEDIDHYKRSIDDPALDIDENCIMVLKNCGPKGYPGMAEVGNMALPEKLLRRGLRDMVRISDARMSGTAFGTVVLH
VAPEAAVGGPLALVRSGDMIELDVPARRLHLDVAPAELQARRSRWRAPAAAMSGGYQGLYVERVMQADSGADLDFLVGCR
GHAIPRESH

Sequences:

>Translated_569_residues
MKRRSQHWFGGTGKDAFIHRSWMKNHGLPDDAFDGRPVIGICNTFSEFTPCNAHFRGLIEHIKAGVLEAGGLPLEFPVFS
CGESNLRPTAMLFRNLASMDVEEAIRGNPMDAVVLMAGCDKTTPALVMGAASCDLPAIVISGGPMLNGRFQGRAIGSGTD
VWKFSEDLRAGVMSAQAFAAAESAMSRSPGHCMTMGTASTMASMVEALGIALPGNAAYPAVDAHRNRLARMTGRRSVELV
HEDLRLSRILQPQAFANAIRVNGAIGGSTNAVVHLLAIAGRIGTPLTLDDWDRLGRDVPTILDLMPSGRFLMEDFCYAGG
IPAVMKEISHLLELQAMTVSGKSVRENIADACNHNPEVIRPLDRALTPQGGIAVLRGNLAPAGAIIKPSAATPALMQHRG
RAVVFEDIDHYKRSIDDPALDIDENCIMVLKNCGPKGYPGMAEVGNMALPEKLLRRGLRDMVRISDARMSGTAFGTVVLH
VAPEAAVGGPLALVRSGDMIELDVPARRLHLDVAPAELQARRSRWRAPAAAMSGGYQGLYVERVMQADSGADLDFLVGCR
GHAIPRESH
>Mature_569_residues
MKRRSQHWFGGTGKDAFIHRSWMKNHGLPDDAFDGRPVIGICNTFSEFTPCNAHFRGLIEHIKAGVLEAGGLPLEFPVFS
CGESNLRPTAMLFRNLASMDVEEAIRGNPMDAVVLMAGCDKTTPALVMGAASCDLPAIVISGGPMLNGRFQGRAIGSGTD
VWKFSEDLRAGVMSAQAFAAAESAMSRSPGHCMTMGTASTMASMVEALGIALPGNAAYPAVDAHRNRLARMTGRRSVELV
HEDLRLSRILQPQAFANAIRVNGAIGGSTNAVVHLLAIAGRIGTPLTLDDWDRLGRDVPTILDLMPSGRFLMEDFCYAGG
IPAVMKEISHLLELQAMTVSGKSVRENIADACNHNPEVIRPLDRALTPQGGIAVLRGNLAPAGAIIKPSAATPALMQHRG
RAVVFEDIDHYKRSIDDPALDIDENCIMVLKNCGPKGYPGMAEVGNMALPEKLLRRGLRDMVRISDARMSGTAFGTVVLH
VAPEAAVGGPLALVRSGDMIELDVPARRLHLDVAPAELQARRSRWRAPAAAMSGGYQGLYVERVMQADSGADLDFLVGCR
GHAIPRESH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=558, Percent_Identity=31.0035842293907, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI2367371, Length=463, Percent_Identity=32.829373650108, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786464, Length=449, Percent_Identity=32.5167037861915, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788157, Length=582, Percent_Identity=27.4914089347079, Blast_Score=158, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6322476, Length=545, Percent_Identity=29.7247706422018, Blast_Score=234, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60942; Mature: 60942

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRSQHWFGGTGKDAFIHRSWMKNHGLPDDAFDGRPVIGICNTFSEFTPCNAHFRGLIE
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHCCCCCHHHHHHHH
HIKAGVLEAGGLPLEFPVFSCGESNLRPTAMLFRNLASMDVEEAIRGNPMDAVVLMAGCD
HHHHHHHHCCCCCEECCEECCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECCC
KTTPALVMGAASCDLPAIVISGGPMLNGRFQGRAIGSGTDVWKFSEDLRAGVMSAQAFAA
CCCCHHEEECCCCCCCEEEEECCCEECCEECCEECCCCCCHHHHHHHHHHHHHHHHHHHH
AESAMSRSPGHCMTMGTASTMASMVEALGIALPGNAAYPAVDAHRNRLARMTGRRSVELV
HHHHHCCCCCCEEEECHHHHHHHHHHHHCEECCCCCCCCCHHHHHHHHHHHHCCCHHHHH
HEDLRLSRILQPQAFANAIRVNGAIGGSTNAVVHLLAIAGRIGTPLTLDDWDRLGRDVPT
HHHHHHHHHCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHCCCHHH
ILDLMPSGRFLMEDFCYAGGIPAVMKEISHLLELQAMTVSGKSVRENIADACNHNPEVIR
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
PLDRALTPQGGIAVLRGNLAPAGAIIKPSAATPALMQHRGRAVVFEDIDHYKRSIDDPAL
HHHHHCCCCCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEEHHHHHHHHCCCCCCC
DIDENCIMVLKNCGPKGYPGMAEVGNMALPEKLLRRGLRDMVRISDARMSGTAFGTVVLH
CCCCCHHHHEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VAPEAAVGGPLALVRSGDMIELDVPARRLHLDVAPAELQARRSRWRAPAAAMSGGYQGLY
ECCCCCCCCCEEEEECCCEEEEECCCEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHH
VERVMQADSGADLDFLVGCRGHAIPRESH
HHHHHHCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKRRSQHWFGGTGKDAFIHRSWMKNHGLPDDAFDGRPVIGICNTFSEFTPCNAHFRGLIE
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHCCCCCHHHHHHHH
HIKAGVLEAGGLPLEFPVFSCGESNLRPTAMLFRNLASMDVEEAIRGNPMDAVVLMAGCD
HHHHHHHHCCCCCEECCEECCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECCC
KTTPALVMGAASCDLPAIVISGGPMLNGRFQGRAIGSGTDVWKFSEDLRAGVMSAQAFAA
CCCCHHEEECCCCCCCEEEEECCCEECCEECCEECCCCCCHHHHHHHHHHHHHHHHHHHH
AESAMSRSPGHCMTMGTASTMASMVEALGIALPGNAAYPAVDAHRNRLARMTGRRSVELV
HHHHHCCCCCCEEEECHHHHHHHHHHHHCEECCCCCCCCCHHHHHHHHHHHHCCCHHHHH
HEDLRLSRILQPQAFANAIRVNGAIGGSTNAVVHLLAIAGRIGTPLTLDDWDRLGRDVPT
HHHHHHHHHCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHCCCHHH
ILDLMPSGRFLMEDFCYAGGIPAVMKEISHLLELQAMTVSGKSVRENIADACNHNPEVIR
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
PLDRALTPQGGIAVLRGNLAPAGAIIKPSAATPALMQHRGRAVVFEDIDHYKRSIDDPAL
HHHHHCCCCCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEEHHHHHHHHCCCCCCC
DIDENCIMVLKNCGPKGYPGMAEVGNMALPEKLLRRGLRDMVRISDARMSGTAFGTVVLH
CCCCCHHHHEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VAPEAAVGGPLALVRSGDMIELDVPARRLHLDVAPAELQARRSRWRAPAAAMSGGYQGLY
ECCCCCCCCCEEEEECCCEEEEECCCEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHH
VERVMQADSGADLDFLVGCRGHAIPRESH
HHHHHHCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA