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The map label for this gene is tyrS [H]

Identifier: 121609599

GI number: 121609599

Start: 2988218

End: 2989450

Strand: Direct

Name: tyrS [H]

Synonym: Veis_2645

Alternate gene names: 121609599

Gene position: 2988218-2989450 (Clockwise)

Preceding gene: 121609596

Following gene: 121609601

Centisome position: 53.68

GC content: 66.5

Gene sequence:

>1233_bases
ATGAATCAATCTGCTGTTACCACTGCCCCGGTGTCCGATGGGGTCAGGCAGGCCCTGGAAATCTCGCTGCGCGGCGCGCA
TGAACTGCTGCCGCAGGACGAATGGGTCAAAAAGCTCGTGCGCTCGGAGGCCACCGGCCAGCCGCTGCGCATCAAACTGG
GGCTGGACCCCACGGCGCCGGACATCCACCTCGGCCACACGGTGGTGCTCAACAAACTGCGGCAGTTGCAAGACCTGGGG
CACCAGGTGATTTTTCTGATCGGCGACTTCACCAGCCTGATCGGCGACCCCTCGGGCCGCAACCACACGCGCCCGGCGCT
CACGCCCGAGCAGATCCAGGCCAACGCCGAGACCTACTACCGCCAGGCCAGCCTGGTGCTGGACCCCGCCCGCACCGAGA
TCCGCTACAACAGCGAATGGAGCGAGCCCCTGGGCGCGCAGGGCATGATCCGGCTGGCCGCCATGTACACCGTGGCGCGG
ATGATGGAGCGCGAGGACTTCCACAAGCGCTACACCACGGGCCAGTCGATTTCGGTGCACGAGTTTTTGTACCCGCTGAT
GCAGGGCTATGACTCCGTGGCCTTGAAGAGCGACCTGGAGCTCGGCGGCACCGACCAGAAGTTCAACCTGCTGATGGGGC
GCCACCTGCAGCACGAGCATGGCCAGGAGCCGCAATGCGTGCTCACGATGCCGCTGCTGGTCGGGCTCGATGGCGTGGAC
AAGATGTCCAAGTCGAAGAACAACTACATCGCCATCACCGAAAGCGCCAACACCATGTACGCCAAGCTGCTGTCGATACC
GGACACATTGATGTGGGACTGGTACCCGCTGCTGTCCTGGCGCTCGCTGGCCGGGATTGCCGCGCTCAAGGCCGAAGTCG
CCGGGGGCCGCAACCCCAAGGACGCCAAGGTGCTGCTGGCCAAGGAAATCACCGCGCGCTTTCACGGCGCAGCGGCAGCC
GACGCCGCCGAGCAGGACTTCATCGTCCGCAGCCAGGGCGGCGTGCCCGACGCGATTGCGGCCTTGACCCTGTCGGGCGC
GCCGCTGGGCATTGGCGTGCTGCTGCGGCAGGCCGGACTGGCGCCATCGACCAGCGAGGCCCACCGGCTGATCGACGGCA
ACGGCGTGCGCGTGGACGGCAGCCTGGTCAGCGACAAGGGCCTGAAGCTCGGCGCCGGCACCTACGTGCTGCAGGTCGGC
AAGCGCAGGTTTGCCCGCGTGACCCTGGGTTGA

Upstream 100 bases:

>100_bases
CGTGAAAACAGGCGGAAACGGCGGGCCCACTAGAATCCGCCTGCGCAATGTGGGCCGGAGTATAGCCGCGCCTGCGGCCT
GTGCATCTGAACAAACCCGT

Downstream 100 bases:

>100_bases
CGGGCCATGAAAATGGCTCGTAGCGCCCGATCCTGATTCGCCGACGGCGATCAAAAAAAGCAGCATTCACGGCCGCCGCA
GGGCCAGGCAAAAGCTCAGT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MNQSAVTTAPVSDGVRQALEISLRGAHELLPQDEWVKKLVRSEATGQPLRIKLGLDPTAPDIHLGHTVVLNKLRQLQDLG
HQVIFLIGDFTSLIGDPSGRNHTRPALTPEQIQANAETYYRQASLVLDPARTEIRYNSEWSEPLGAQGMIRLAAMYTVAR
MMEREDFHKRYTTGQSISVHEFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQHEHGQEPQCVLTMPLLVGLDGVD
KMSKSKNNYIAITESANTMYAKLLSIPDTLMWDWYPLLSWRSLAGIAALKAEVAGGRNPKDAKVLLAKEITARFHGAAAA
DAAEQDFIVRSQGGVPDAIAALTLSGAPLGIGVLLRQAGLAPSTSEAHRLIDGNGVRVDGSLVSDKGLKLGAGTYVLQVG
KRRFARVTLG

Sequences:

>Translated_410_residues
MNQSAVTTAPVSDGVRQALEISLRGAHELLPQDEWVKKLVRSEATGQPLRIKLGLDPTAPDIHLGHTVVLNKLRQLQDLG
HQVIFLIGDFTSLIGDPSGRNHTRPALTPEQIQANAETYYRQASLVLDPARTEIRYNSEWSEPLGAQGMIRLAAMYTVAR
MMEREDFHKRYTTGQSISVHEFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQHEHGQEPQCVLTMPLLVGLDGVD
KMSKSKNNYIAITESANTMYAKLLSIPDTLMWDWYPLLSWRSLAGIAALKAEVAGGRNPKDAKVLLAKEITARFHGAAAA
DAAEQDFIVRSQGGVPDAIAALTLSGAPLGIGVLLRQAGLAPSTSEAHRLIDGNGVRVDGSLVSDKGLKLGAGTYVLQVG
KRRFARVTLG
>Mature_410_residues
MNQSAVTTAPVSDGVRQALEISLRGAHELLPQDEWVKKLVRSEATGQPLRIKLGLDPTAPDIHLGHTVVLNKLRQLQDLG
HQVIFLIGDFTSLIGDPSGRNHTRPALTPEQIQANAETYYRQASLVLDPARTEIRYNSEWSEPLGAQGMIRLAAMYTVAR
MMEREDFHKRYTTGQSISVHEFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQHEHGQEPQCVLTMPLLVGLDGVD
KMSKSKNNYIAITESANTMYAKLLSIPDTLMWDWYPLLSWRSLAGIAALKAEVAGGRNPKDAKVLLAKEITARFHGAAAA
DAAEQDFIVRSQGGVPDAIAALTLSGAPLGIGVLLRQAGLAPSTSEAHRLIDGNGVRVDGSLVSDKGLKLGAGTYVLQVG
KRRFARVTLG

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=405, Percent_Identity=26.1728395061728, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1787925, Length=392, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI25145802, Length=209, Percent_Identity=29.6650717703349, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325160, Length=338, Percent_Identity=26.6272189349112, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130383, Length=437, Percent_Identity=27.0022883295195, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 44670; Mature: 44670

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQSAVTTAPVSDGVRQALEISLRGAHELLPQDEWVKKLVRSEATGQPLRIKLGLDPTAP
CCCCCEEECCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCCC
DIHLGHTVVLNKLRQLQDLGHQVIFLIGDFTSLIGDPSGRNHTRPALTPEQIQANAETYY
CCCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHH
RQASLVLDPARTEIRYNSEWSEPLGAQGMIRLAAMYTVARMMEREDFHKRYTTGQSISVH
HHHHEEECCCHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQHEHGQEPQCVLTMPLLVGLDGVD
HHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCHH
KMSKSKNNYIAITESANTMYAKLLSIPDTLMWDWYPLLSWRSLAGIAALKAEVAGGRNPK
HHHCCCCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAKVLLAKEITARFHGAAAADAAEQDFIVRSQGGVPDAIAALTLSGAPLGIGVLLRQAGL
HHHEEHHHHHHHHHCCCHHCCCCCCCEEEECCCCCCHHHHHEEECCCCHHHHHHHHHCCC
APSTSEAHRLIDGNGVRVDGSLVSDKGLKLGAGTYVLQVGKRRFARVTLG
CCCCHHHHHEECCCCEEECCCEECCCCCEECCCHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MNQSAVTTAPVSDGVRQALEISLRGAHELLPQDEWVKKLVRSEATGQPLRIKLGLDPTAP
CCCCCEEECCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCCC
DIHLGHTVVLNKLRQLQDLGHQVIFLIGDFTSLIGDPSGRNHTRPALTPEQIQANAETYY
CCCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHH
RQASLVLDPARTEIRYNSEWSEPLGAQGMIRLAAMYTVARMMEREDFHKRYTTGQSISVH
HHHHEEECCCHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQHEHGQEPQCVLTMPLLVGLDGVD
HHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCHH
KMSKSKNNYIAITESANTMYAKLLSIPDTLMWDWYPLLSWRSLAGIAALKAEVAGGRNPK
HHHCCCCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAKVLLAKEITARFHGAAAADAAEQDFIVRSQGGVPDAIAALTLSGAPLGIGVLLRQAGL
HHHEEHHHHHHHHHCCCHHCCCCCCCEEEECCCCCCHHHHHEEECCCCHHHHHHHHHCCC
APSTSEAHRLIDGNGVRVDGSLVSDKGLKLGAGTYVLQVGKRRFARVTLG
CCCCHHHHHEECCCCEEECCCEECCCCCEECCCHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA