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The map label for this gene is rppH

Identifier: 121609350

GI number: 121609350

Start: 2707317

End: 2707982

Strand: Direct

Name: rppH

Synonym: Veis_2393

Alternate gene names: 121609350

Gene position: 2707317-2707982 (Clockwise)

Preceding gene: 121609347

Following gene: 121609351

Centisome position: 48.63

GC content: 63.66

Gene sequence:

>666_bases
ATGCTTGACCGGGACGGCTTTCGGCCGAACGTCGGCATCGTCTTGCTCAACCAGAAAAACCAGGTGTTCTGGGGCAAACG
AATACGCACCCATAGCTGGCAGTTTCCACAGGGGGGCATTGACCGGGGCGAAACCCCCGAGCAAGCCATGTTCCGGGAAC
TGCACGAAGAGGTGGGGTTGTTGCCCGACCATGTGCGCGTGGTGGCCCGCACCCGGGACTGGCTGCGCTACGAGGTGCCT
GACCGGTATGTCCGCCGCGATGCTCGCGGACACTACAAGGGCCAGAAACAAATCTGGTATCTGCTGCAACTGGTCGGACA
TGACTGGAATTTGAACCTGCGCGCCACCAACCACCCGGAGTTCGACGCCTGGCGCTGGAACGACTACTGGGTTCCGCTGG
ACGTGGTGATCGAGTTCAAGCGCAGCGTCTATGCGCTGGCGCTCACCGAACTGGCGCGCTATCTGCCACGCCATGAACCG
CGCAACCGCTATCTGCGCAGCGGCATGCGCACGCGCGACGGCGAGCATGCGGGCCTGTTCCTCACCAGGGTCATGTCCCC
CAAGCCCGGCATACAACTGCCGCCGGGTGCCTGTTTCGACCCGATTCCGCCGACCGGCATGCCGGATGAGCGCGAGGGGT
TGCCGTTCACGGCCATGCCACGCTGA

Upstream 100 bases:

>100_bases
GGCTTTCATCGGGATCAATGGCGAACGAGGCGGGCCGCCCACTTGCCGCAGCGCAGGCGCGGTGCATAATGGGCGCAGTT
TAAAAATTTGGGGTTCGATT

Downstream 100 bases:

>100_bases
TGCCCGCCGCGCCCGCAGGGCTTGCCGGCCTCTTTCGGCAGACCGCACACCGATTACGACCCCGCCGATGGCCTGAATGG
GCCTGCGGCGAGCGCCACCC

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MLDRDGFRPNVGIVLLNQKNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGLLPDHVRVVARTRDWLRYEVP
DRYVRRDARGHYKGQKQIWYLLQLVGHDWNLNLRATNHPEFDAWRWNDYWVPLDVVIEFKRSVYALALTELARYLPRHEP
RNRYLRSGMRTRDGEHAGLFLTRVMSPKPGIQLPPGACFDPIPPTGMPDEREGLPFTAMPR

Sequences:

>Translated_221_residues
MLDRDGFRPNVGIVLLNQKNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGLLPDHVRVVARTRDWLRYEVP
DRYVRRDARGHYKGQKQIWYLLQLVGHDWNLNLRATNHPEFDAWRWNDYWVPLDVVIEFKRSVYALALTELARYLPRHEP
RNRYLRSGMRTRDGEHAGLFLTRVMSPKPGIQLPPGACFDPIPPTGMPDEREGLPFTAMPR
>Mature_221_residues
MLDRDGFRPNVGIVLLNQKNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGLLPDHVRVVARTRDWLRYEVP
DRYVRRDARGHYKGQKQIWYLLQLVGHDWNLNLRATNHPEFDAWRWNDYWVPLDVVIEFKRSVYALALTELARYLPRHEP
RNRYLRSGMRTRDGEHAGLFLTRVMSPKPGIQLPPGACFDPIPPTGMPDEREGLPFTAMPR

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=152, Percent_Identity=55.2631578947368, Blast_Score=181, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_VEREI (A1WKI2)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_997157.1
- ProteinModelPortal:   A1WKI2
- SMR:   A1WKI2
- STRING:   A1WKI2
- GeneID:   4692344
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_2393
- NMPDR:   fig|391735.5.peg.2261
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   A1WKI2
- ProtClustDB:   PRK00714
- BioCyc:   VEIS391735:VEIS_2393-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 26091; Mature: 26091

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRDGFRPNVGIVLLNQKNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGL
CCCCCCCCCCCCEEEECCCCCEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPDHVRVVARTRDWLRYEVPDRYVRRDARGHYKGQKQIWYLLQLVGHDWNLNLRATNHPE
CHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCC
FDAWRWNDYWVPLDVVIEFKRSVYALALTELARYLPRHEPRNRYLRSGMRTRDGEHAGLF
CCCEECCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHEE
LTRVMSPKPGIQLPPGACFDPIPPTGMPDEREGLPFTAMPR
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDRDGFRPNVGIVLLNQKNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGL
CCCCCCCCCCCCEEEECCCCCEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPDHVRVVARTRDWLRYEVPDRYVRRDARGHYKGQKQIWYLLQLVGHDWNLNLRATNHPE
CHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCC
FDAWRWNDYWVPLDVVIEFKRSVYALALTELARYLPRHEPRNRYLRSGMRTRDGEHAGLF
CCCEECCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHEE
LTRVMSPKPGIQLPPGACFDPIPPTGMPDEREGLPFTAMPR
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA