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The map label for this gene is fadE23 [H]

Identifier: 121639023

GI number: 121639023

Start: 3459837

End: 3461042

Strand: Direct

Name: fadE23 [H]

Synonym: BCG_3163

Alternate gene names: 121639023

Gene position: 3459837-3461042 (Clockwise)

Preceding gene: 121639022

Following gene: 121639024

Centisome position: 79.09

GC content: 62.52

Gene sequence:

>1206_bases
ATGGCAATAAATCTGGAACTGCCGCGCAAGCTGCAGGCGATCATCGTCAAGACCCATCAGGGCGCTGCGGAGATGATGCG
GCCGATAGCCCGCAAGTACGACCTGAAGGAACATGCCTACCCGGTCGAACTCGACACCCTGATCAATTTGTTCGAGGGCG
CCGCCGAATCGTTCAACTTTGCCGGAGCCCATTCGCTTCGCGACGAGGACGAAGGCAAGGACGAAAACCACAACGGTGCC
AACATGGCCGCCGTGGTACAGACGATGGAGGCCAGCTGGGGCGACGTCGCGATGATGCTGTCGCTGCCCTATCAGGGGCT
GGGTAACGCAGCCATCTCCGCGGTAGCCACCGACGAGCAGCTGGAGCGGCTGGGCAAAGTGTGGGCAGCGATGGCCATCA
CCGAACCGGAATTCGGATCGGACTCGGCGGCAGTGTCGACGACCGCCACCCTCGACGGCGACGAGTACGTGATCAACGGC
GAGAAGATCTTTGTCACCGCCGGTTCCCGCGCCACCCACATCGTGGTCTGGGCCACGCTGGACAAATCCTTGGGCCGCCC
GGCGATTAAGTCGTTCATCGTGCCCCGTGAGCATCCCGGCGTGACCGTCGAACGACTTGAACACAAACTCGGCATCAAGG
GTTCTGATACTGCGGTGATCCGGTTCGACAACGCCCGTATCCCCAAGGGCAACCTACTTGGGAACCCGGAAATCGAGGTC
GGCAAGGGCTTTGCCGGGGTGATGGAGACCTTCGACAACACCCGGCCGATTGTGGCCGCCATGGCCGTCGGGATCGGCCG
TGCCGCACTGGAGGAAATCCGTAGTGTCCTCACCGGGGCCGGCGTGGAGATCTCCTACGACAAGCCCTCACACACCCAGA
GCGCCGCGGCCGCCGAGTTCCTGCGGATGGAGGCCGACTGGGAGGCCAGCTACCTACTGTCCCTGCGCGCAGCCTGGCAG
GCCGACAACAACATCCCCAACTCCAAAGAAGCCTCGATGAGCAAGGCCAAGGCGGGCCGGATGGCCAGCGACGTCACCTG
CAAAACCGTCGAATTGGCAGGAACTACCGGGTATTCCGAGCAATCACTGCTGGAGAAGTGGGCCCGCGACTCCAAGATCC
TGGACATCTTCGAGGGCACCCAGCAGATCCAGCAGCTGGTGGTCGCACGCCGACTGTTGGGCCTGTCGTCGTCCGAGCTC
AAATAG

Upstream 100 bases:

>100_bases
ACACCAAGGAGCATCCGGTTGAGCGCTGGTACCGCGACCTGCGAGCCATCGGCGTCGCCGAGGGCGTTGTTGTCATCTAG
AACGAGCTGAAAGATCAATC

Downstream 100 bases:

>100_bases
CCTCGGCGAGCAGACGTCAAAGCCCCCGAATTTCAGTGAAATCGGGGGCTTTTGCGTCTGCTGGCGCCCGTCTGCACCCC
CGCCAGTAGGCTGGTCGGCA

Product: putative acyl-CoA dehydrogenase fadE23

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGA
NMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVING
EKIFVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEV
GKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQ
ADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSEL
K

Sequences:

>Translated_401_residues
MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGA
NMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVING
EKIFVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEV
GKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQ
ADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSEL
K
>Mature_400_residues
AINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGAN
MAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGE
KIFVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEVG
KGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQA
DNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=402, Percent_Identity=31.8407960199005, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI187960098, Length=402, Percent_Identity=31.592039800995, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4557231, Length=402, Percent_Identity=31.592039800995, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4501859, Length=263, Percent_Identity=30.4182509505703, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI21361497, Length=399, Percent_Identity=28.8220551378446, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=27.8215223097113, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=27.8215223097113, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4501857, Length=305, Percent_Identity=26.5573770491803, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI226958412, Length=272, Percent_Identity=27.2058823529412, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI226958414, Length=272, Percent_Identity=27.2058823529412, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI7656849, Length=268, Percent_Identity=24.6268656716418, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4503943, Length=299, Percent_Identity=22.0735785953177, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI48976061, Length=277, Percent_Identity=25.2707581227437, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI211971008, Length=277, Percent_Identity=25.2707581227437, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786223, Length=284, Percent_Identity=27.112676056338, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081958, Length=266, Percent_Identity=28.1954887218045, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17569725, Length=351, Percent_Identity=33.3333333333333, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17534899, Length=345, Percent_Identity=33.6231884057971, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17570075, Length=272, Percent_Identity=36.7647058823529, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17508101, Length=291, Percent_Identity=32.6460481099656, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17506239, Length=267, Percent_Identity=32.5842696629214, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71985184, Length=328, Percent_Identity=29.5731707317073, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71990804, Length=263, Percent_Identity=29.6577946768061, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=26.0162601626016, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17538396, Length=307, Percent_Identity=24.7557003257329, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI32563615, Length=144, Percent_Identity=36.1111111111111, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17533517, Length=276, Percent_Identity=25, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71985192, Length=209, Percent_Identity=33.9712918660287, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17505929, Length=298, Percent_Identity=23.489932885906, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17551932, Length=268, Percent_Identity=26.865671641791, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71982178, Length=156, Percent_Identity=29.4871794871795, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17534353, Length=279, Percent_Identity=25.089605734767, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356377, Length=272, Percent_Identity=37.1323529411765, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24660351, Length=317, Percent_Identity=36.2776025236593, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24646207, Length=379, Percent_Identity=30.0791556728232, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24666513, Length=292, Percent_Identity=31.5068493150685, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI281363737, Length=312, Percent_Identity=29.4871794871795, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21355753, Length=314, Percent_Identity=27.3885350318471, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920834, Length=306, Percent_Identity=25.8169934640523, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281365206, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585193, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585195, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585191, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43345; Mature: 43213

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNF
CEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCC
AGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCHHH
LERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATL
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCCEEEEEECCCCEEEEEEEEC
DKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEV
CCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEEE
GKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEF
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHH
LRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSE
HHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCH
QSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNF
EECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCC
AGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCHHH
LERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATL
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCCEEEEEECCCCEEEEEEEEC
DKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEV
CCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEEE
GKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEF
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHH
LRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSE
HHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCH
QSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]