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The map label for this gene is prrA [H]

Identifier: 121636826

GI number: 121636826

Start: 1036326

End: 1037036

Strand: Reverse

Name: prrA [H]

Synonym: BCG_0955c

Alternate gene names: 121636826

Gene position: 1037036-1036326 (Counterclockwise)

Preceding gene: 121636827

Following gene: 121636825

Centisome position: 23.71

GC content: 66.81

Gene sequence:

>711_bases
ATGGGCGGCATGGACACTGGTGTGACCTCACCTCGGGTGTTGGTCGTCGACGACGACTCCGATGTGCTCGCCTCGCTGGA
ACGCGGCTTACGGCTGTCCGGATTCGAGGTAGCGACCGCGGTGGACGGCGCCGAGGCCTTGCGCAGCGCCACCGAGAACC
GGCCGGACGCGATCGTGCTCGACATCAACATGCCAGTGCTCGATGGAGTCAGCGTCGTGACGGCACTACGCGCGATGGAC
AACGACGTCCCGGTCTGTGTGCTATCCGCACGCAGCTCTGTCGATGACCGAGTGGCCGGATTGGAGGCCGGCGCCGACGA
TTACCTGGTGAAACCGTTCGTGCTGGCCGAGCTGGTGGCACGGGTGAAGGCGCTGCTGCGCCGCCGCGGCTCCACTGCAA
CGTCGTCCTCGGAAACCATCACGGTGGGCCCGCTGGAGGTGGACATCCCCGGCCGGCGGGCCCGGGTCAACGGCGTCGAC
GTCGACCTGACCAAGCGCGAATTCGACCTGCTCGCGGTGCTGGCCGAGCACAAGACCGCGGTGCTCTCCCGAGCGCAACT
CCTGGAATTGGTGTGGGGCTACGACTTCGCCGCCGACACCAACGTGGTGGACGTCTTCATCGGGTACCTGCGGCGCAAAC
TGGAGGCCGGCGGTGGCCCTAGGCTGCTGCATACCGTCCGCGGAGTCGGATTCGTGCTGCGTATGCAGTGA

Upstream 100 bases:

>100_bases
TCGCACAAAATCGGCGGTTTTGATGCGACTCTGTGTCTGCTCGCCCAGCACGCGACCCGGCGGCTCACCCTCCCACCCTG
CTGGACGGTAATCAGGCAAA

Downstream 100 bases:

>100_bases
CGGGGCATGCATGAATATTCTGTCGCGGATCTTCGCCCGTACGCCCTCGCTGCGAACCCGGGTGGTGGTCGCGACGGCGA
TCGGCGCCGCGATCCCGGTA

Product: two component response transcriptional regulatory protein prrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVLDINMPVLDGVSVVTALRAMD
NDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVD
VDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ

Sequences:

>Translated_236_residues
MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVLDINMPVLDGVSVVTALRAMD
NDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVD
VDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ
>Mature_235_residues
GGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVLDINMPVLDGVSVVTALRAMDN
DVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVDV
DLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=39.1891891891892, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=38.7387387387387, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35.4545454545455, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=36.5638766519824, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=38.1818181818182, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=37.1681415929204, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=39.4736842105263, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=37.6106194690265, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.0472103004292, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=30.3030303030303, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.4561403508772, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788550, Length=157, Percent_Identity=32.484076433121, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=38.7387387387387, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=140, Percent_Identity=32.8571428571429, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=26.8398268398268, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=31.858407079646, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=143, Percent_Identity=27.972027972028, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25254; Mature: 25123

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVL
CCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEE
DINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVA
EECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
RVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTA
HHHHHHHHCCCCCCCCCCEEEECCEEEECCCCEEEECCCCEEECHHHHHHHHHHHHHHHH
VLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEC
>Mature Secondary Structure 
GGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVL
CCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEE
DINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVA
EECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
RVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTA
HHHHHHHHCCCCCCCCCCEEEECCEEEECCCCEEEECCCCEEECHHHHHHHHHHHHHHHH
VLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]