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The map label for this gene is accD3

Identifier: 121636827

GI number: 121636827

Start: 1037167

End: 1038654

Strand: Reverse

Name: accD3

Synonym: BCG_0956c

Alternate gene names: 121636827

Gene position: 1038654-1037167 (Counterclockwise)

Preceding gene: 121636836

Following gene: 121636826

Centisome position: 23.74

GC content: 69.42

Gene sequence:

>1488_bases
GTGAGTCGTATCACGACCGACCAACTGCGGCACGCGGTGCTAGACCGGGGATCTTTCGTCAGCTGGGATAGCGAGCCGCT
GGCGGTGCCGGTAGCCGACTCCTATGCGCGGGAGCTGGCCGCCGCTCGGGCGGCCACCGGCGCGGACGAATCGGTGCAGA
CCGGTGAGGGACGCGTATTCGGGCGGCGGGTGGCCGTGGTGGCCTGTGAGTTCGACTTCCTGGGCGGCTCGATTGGGGTG
GCAGCGGCCGAACGGATCACCGCCGCCGTCGAGCGGGCGACCGCCGAGCGGCTGCCGCTACTGGCGTCACCAAGCTCGGG
AGGCACCCGCATGCAAGAAGGCACGGTCGCGTTTCTGCAGATGGTGAAGATCGCTGCGGCCATCCAGCTGCACAACCAGG
CGCGCCTGCCCTACCTGGTCTATTTGCGCCATCCGACCACGGGTGGAGTTTTCGCGTCGTGGGGCTCGCTGGGGCATCTC
ACCGTCGCCGAGCCGGGCGCCCTGATCGGCTTTCTGGGACCACGGGTCTATGAGTTGCTCTATGGCGACCCCTTCCCATC
CGGCGTCCAAACCGCCGAGAATCTACGGCGGCATGGGATCATCGACGGCGTCGTTGCACTGGACCGGCTACGACCGATGC
TGGATCGTGCGTTGACGGTGCTCATCGACGCTCCCGAACCGCTTCCGGCACCGCAGACGCCCGCGCCCGTACCCGATGTG
CCCACGTGGGACTCGGTGGTGGCATCGCGCCGGCCGGACCGGCCGGGCGTCAGGCAGCTACTGCGACACGGCGCCACCGA
CCGGGTGTTGTTGTCAGGAACCGATCAAGGCGAAGCGGCGACCACGCTGCTGGCGCTGGCCCGCTTTGGCGGCCAACCCA
CGGTGGTCCTCGGCCAGCAAAGGGCAGTAGGCGGCGGGGGAAGCACTGTCGGGCCCGCTGCGTTACGCGAAGCCCGACGC
GGGATGGCGCTCGCCGCCGAGCTGTGCCTGCCGCTGGTGCTGGTCATTGACGCGGCCGGACCCGCGTTGTCGGCCGCAGC
CGAACAGGGCGGGCTGGCCGGCCAGATCGCGCATTGCCTGGCCGAGCTCGTCACGCTGGATACCCCGACCGTGTCGATCC
TGCTGGGCCAGGGCAGCGGCGGGCCGGCGCTGGCGATGTTGCCCGCCGACCGGGTGCTGGCCGCACTCCACGGCTGGCTG
GCGCCCTTGCCTCCCGAAGGAGCCAGCGCGATCGTGTTCCGAGACACTGCTCATGCCGCCGAACTCGCTGCCGCCCAAGG
CATCCGGTCGGCCGACCTACTGAAGTCGGGGATTGTCGACACCATCGTGCCGGAGTACCCCGACGCCGCAGACGAGCCGA
TCGAGTTCGCCCTACGACTGTCGAACGCCATCGCCGCCGAAGTGCACGCGTTACGGAAGATACCGGCCCCGGAACGCCTC
GCGACTCGGTTGCAACGCTACCGCCGGATCGGGTTGCCCCGCGACTAA

Upstream 100 bases:

>100_bases
TTTAAGGCGTTGCGGCGCTCCGGGCGTTGCAGCTCAATGGTCAGCACGGCTTCTGCCTGGGTGATACCGATCATTGGGTC
AGCCTATATAGCCTCATCGC

Downstream 100 bases:

>100_bases
CCCGCGCGCACCCCGCGAGCAGACACAGAGTCGCACAAAATCGGCGGTTTTGATGCGACTCTGTGTCTGCTCGCCCAGCA
CGCGACCCGGCGGCTCACCC

Product: putative acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) accD3

Products: NA

Alternate protein names: ACCase beta chain

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGV
AAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHL
TVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDV
PTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARR
GMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWL
APLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERL
ATRLQRYRRIGLPRD

Sequences:

>Translated_495_residues
MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGV
AAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHL
TVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDV
PTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARR
GMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWL
APLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERL
ATRLQRYRRIGLPRD
>Mature_494_residues
SRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGVA
AAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLT
VAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDVP
TWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARRG
MALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWLA
PLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLA
TRLQRYRRIGLPRD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0825

COG function: function code I; Acetyl-CoA carboxylase alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AccD/PCCB family

Homologues:

Organism=Homo sapiens, GI119943100, Length=421, Percent_Identity=24.7030878859857, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI295821216, Length=441, Percent_Identity=23.8095238095238, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788655, Length=248, Percent_Identity=38.7096774193548, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1786382, Length=278, Percent_Identity=26.2589928057554, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI25147359, Length=421, Percent_Identity=21.8527315914489, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=421, Percent_Identity=21.8527315914489, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACCD_MYCBO (P63406)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854585.1
- ProteinModelPortal:   P63406
- SMR:   P63406
- EnsemblBacteria:   EBMYCT00000016174
- GeneID:   1092848
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0928c
- GeneTree:   EBGT00050000015716
- HOGENOM:   HBG668219
- OMA:   GASAIVH
- ProtClustDB:   CLSK790823
- BioCyc:   MBOV233413:MB0928C-MONOMER
- BRENDA:   6.4.1.2
- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762
- PRINTS:   PR01070

Pfam domain/function: PF01039 Carboxyl_trans

EC number: =6.4.1.2

Molecular weight: Translated: 51773; Mature: 51642

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50989 COA_CT_CTER; PS50980 COA_CT_NTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVF
CCCCCHHHHHHHHHCCCCEECCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
GRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQ
EEEEEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHH
MVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLTVAEPGALIGFLGPRVYELL
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCEECCCCCCEEEECCCCHHHHHHHHHHHHHH
YGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDV
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCC
PTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQ
CCHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCC
RAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCL
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHH
AELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWLAPLPPEGASAIVFRDTAHAA
HHHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHH
ELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERL
HHHHHHCCCHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ATRLQRYRRIGLPRD
HHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVF
CCCCHHHHHHHHHCCCCEECCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
GRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQ
EEEEEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHH
MVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLTVAEPGALIGFLGPRVYELL
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCEECCCCCCEEEECCCCHHHHHHHHHHHHHH
YGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDV
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCC
PTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQ
CCHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCC
RAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCL
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHH
AELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWLAPLPPEGASAIVFRDTAHAA
HHHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHH
ELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERL
HHHHHHCCCHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ATRLQRYRRIGLPRD
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972