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The map label for this gene is lpsI [H]

Identifier: 120611787

GI number: 120611787

Start: 3450801

End: 3451613

Strand: Reverse

Name: lpsI [H]

Synonym: Aave_3127

Alternate gene names: 120611787

Gene position: 3451613-3450801 (Counterclockwise)

Preceding gene: 120611790

Following gene: 120611786

Centisome position: 64.48

GC content: 67.04

Gene sequence:

>813_bases
GTGAACAAGCTTTTCCCCTCCGCGGTCGAGGCGCTCAAGGGCGTCGTGGCCGACGGCCAGTTGCTGGCCGTCGGCGGTTT
CGGGCTCTGCGGCATTCCCGAAGCGCTGATCGACGCCCTGCGCGACAGCGGCGTGAAGGGCCTCACCGTGATTTCCAACA
ATGCCGGCGTGGACGGCTTCGGCCTCGGCAAGCTGCTGGAGACGCGGCAGATCAAAAAGATGATCTCCTCCTACGTGGGC
GAGAACAAGGAGTTCGAGCGCCAGTACCTCGCGGGCGAGCTGGAACTGGAGTTCACGCCCCAGGGCACGCTGGCCGAGAA
GCTGCGTGCCGGCGGCGCGGGCATCCCGGCCTTCTTCACCAGGACCGGTGTCGGCACCATCGTGGCCGAGGGCAAGGAGT
TGCGCGAGTTCGATGGCGGGACCTACGTGATGGAGCGCTCCCTCGTGCCCGACGTGTCGCTGGTCAAGGCGCACCGTGCC
GACAAGTCGGGCAACCTGCAGTTCCGCCTCACGGCGCGCAACTTCAATCCGGCAGCGGCCACGGCGGGCAAGCTCTGCAT
CGTCGAGGTGGAAGAGATCGTCGAAACCGGGGAGATCGCACCCGACGACGTGCACCTGCCCGGCATCTACGTGCACCGCA
TCGTGCACAACCCCAACCCTGAAAAGCGCATCGAAAAACGCACCGTGAGCGCCGCCGCGCCCGTCGATGCCGTCGCCGCC
AAGGTCGAGGCCCAGGCCGTGATCGCCCAGGCCGCCGTCGCGGCAGACCCCGTGGTGCCCACCGTACCCGCCAACAAGAA
AGAAGGAGCCTGA

Upstream 100 bases:

>100_bases
GCGGTAATCGGCGACATCCATGGAAGTATTTAGGGAGAACTACGTAACGATATACGTAGTATCGTAGCGGCCATCCACCT
TGTTGTTGAGGAGTCTCCAA

Downstream 100 bases:

>100_bases
GATGCCCTGGACCCAAGACCAGATGGCCGCGCGCGCGGCGCAGGAACTGGAAGACGGTTTCTACGTGAACCTCGGCATCG
GCATTCCCACGCTGGTGGCC

Product: 3-oxoacid CoA-transferase subunit A

Products: NA

Alternate protein names: Succinyl CoA:3-oxoacid CoA-transferase; OXCT A [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MNKLFPSAVEALKGVVADGQLLAVGGFGLCGIPEALIDALRDSGVKGLTVISNNAGVDGFGLGKLLETRQIKKMISSYVG
ENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFTRTGVGTIVAEGKELREFDGGTYVMERSLVPDVSLVKAHRA
DKSGNLQFRLTARNFNPAAATAGKLCIVEVEEIVETGEIAPDDVHLPGIYVHRIVHNPNPEKRIEKRTVSAAAPVDAVAA
KVEAQAVIAQAAVAADPVVPTVPANKKEGA

Sequences:

>Translated_270_residues
MNKLFPSAVEALKGVVADGQLLAVGGFGLCGIPEALIDALRDSGVKGLTVISNNAGVDGFGLGKLLETRQIKKMISSYVG
ENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFTRTGVGTIVAEGKELREFDGGTYVMERSLVPDVSLVKAHRA
DKSGNLQFRLTARNFNPAAATAGKLCIVEVEEIVETGEIAPDDVHLPGIYVHRIVHNPNPEKRIEKRTVSAAAPVDAVAA
KVEAQAVIAQAAVAADPVVPTVPANKKEGA
>Mature_270_residues
MNKLFPSAVEALKGVVADGQLLAVGGFGLCGIPEALIDALRDSGVKGLTVISNNAGVDGFGLGKLLETRQIKKMISSYVG
ENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFTRTGVGTIVAEGKELREFDGGTYVMERSLVPDVSLVKAHRA
DKSGNLQFRLTARNFNPAAATAGKLCIVEVEEIVETGEIAPDDVHLPGIYVHRIVHNPNPEKRIEKRTVSAAAPVDAVAA
KVEAQAVIAQAAVAADPVVPTVPANKKEGA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=258, Percent_Identity=53.8759689922481, Blast_Score=279, Evalue=2e-75,
Organism=Homo sapiens, GI11545841, Length=269, Percent_Identity=47.9553903345725, Blast_Score=228, Evalue=3e-60,
Organism=Escherichia coli, GI1788551, Length=202, Percent_Identity=44.5544554455446, Blast_Score=188, Evalue=3e-49,
Organism=Escherichia coli, GI1787985, Length=241, Percent_Identity=25.3112033195021, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17531517, Length=271, Percent_Identity=54.9815498154982, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI21358325, Length=246, Percent_Identity=50, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24655794, Length=246, Percent_Identity=50, Blast_Score=245, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.5 [H]

Molecular weight: Translated: 28450; Mature: 28450

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLFPSAVEALKGVVADGQLLAVGGFGLCGIPEALIDALRDSGVKGLTVISNNAGVDGF
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
GLGKLLETRQIKKMISSYVGENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFT
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCCCCHHHH
RTGVGTIVAEGKELREFDGGTYVMERSLVPDVSLVKAHRADKSGNLQFRLTARNFNPAAA
HCCCEEEEECCHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHH
TAGKLCIVEVEEIVETGEIAPDDVHLPGIYVHRIVHNPNPEKRIEKRTVSAAAPVDAVAA
CCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHH
KVEAQAVIAQAAVAADPVVPTVPANKKEGA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNKLFPSAVEALKGVVADGQLLAVGGFGLCGIPEALIDALRDSGVKGLTVISNNAGVDGF
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
GLGKLLETRQIKKMISSYVGENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFT
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCCCCHHHH
RTGVGTIVAEGKELREFDGGTYVMERSLVPDVSLVKAHRADKSGNLQFRLTARNFNPAAA
HCCCEEEEECCHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHH
TAGKLCIVEVEEIVETGEIAPDDVHLPGIYVHRIVHNPNPEKRIEKRTVSAAAPVDAVAA
CCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHH
KVEAQAVIAQAAVAADPVVPTVPANKKEGA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9385134; 11589581 [H]