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The map label for this gene is ndh [H]

Identifier: 120611790

GI number: 120611790

Start: 3453249

End: 3454529

Strand: Reverse

Name: ndh [H]

Synonym: Aave_3130

Alternate gene names: 120611790

Gene position: 3454529-3453249 (Counterclockwise)

Preceding gene: 120611791

Following gene: 120611787

Centisome position: 64.54

GC content: 68.7

Gene sequence:

>1281_bases
ATGCATTCCGACATCGTGATCGTGGGCGGAGGGGCCGGCGGGCTGGAACTGGCTGCGCGCCTCGGGCGCAGCCTCGGTGC
GAAGCAGGGCCGCGAACGGGTGCTGCTGGTGGACCGTTCCCCCTTCCATATCTGGAAGCCCACGCTGCACGAGGTGGCCG
CCGGCACGCTGGACGTCCACCAGGAAGGACTGTCCTACCCCGTACTGGCGCGGCGCAACCATTTCGGCTTCGCCATCGGA
GACCTGGTAGGGCTGGACGCCGCGCGCAAGACCATCGAGCTGGGCGAGATACGCAACGCCGAGGGCGAACTGCTGGTGCC
GCGCCGCACGGTGAGCTACACCCGCCTGGTGCTGGCCATCGGCAGCGGCTCCAACGCCTTCGGCACGCCCGGCATCGAGC
ATGCCTACCTGCTGGAGAACGTGCGCGATGCGCAGCGCTTCCATACCGACTGGCTGGGCGCCTGCGCGCGGGCCTCGTTT
TCCGAAAGCCGGGCGCTGTCGATCGCCATCGTGGGCGCGGGCGCGACGGGCGTGGAACTGTCCGCCGAATTGCTGGAAGC
CTATGCCGAGCTGCTCGAAAGCCTGGGCAGCAGCCAGCGCTTTCGCCTGGACATCACCCTGGTCGAAGGCGGCAGCCGCA
TCCTGGGCGGCCTGCCGGAAAAGATCTCCGCGCAGGCCGAAGTGGCGCTGCGCCGCAAGCAGGTGCAGGTGCTCACCGGC
ACGCGCGTGACCGAGATCCGCCGCGGCGCCCTGGTCACCCCTGCCGGGGAGATCCCGGCCGACATGGTGGTCTGGGCCGC
GGGCATCAAGGCTGCCGAAGGCAATGCCCGCATGGGCCTGGAAGTGAACCGCCTCAACCAGTTCATCGTGGACGACCGCC
TGCGCACCTCGGCGCCCGACGTGCTGGCTTTAGGCGACTGCGCTGCCTGCCCGTGGGTCGATGGCAAGACCGTGCCCGCC
CGAGCGCAGGCCGCGCACCAGCAGGCCGACTACCTGGCCAAGGTGCTGGGCGCGCTGCTGCGCGAGCGGGAGATGACGGA
ACCGTTCATCTACAAGGATTTCGGCTCGCTGGTTTCGCTGGGCGACAACAAGGGCGTAGGCAACCTCATGGGAGGCCTGG
GCGGGCGCAACTTCTTCGTCGAGGGCCTGATCGCCAAGTGGATGTATATCTCCCTGCACCTGAATCACCACCGCGCCATC
CTGGGTACCGGCAAGACGGTGGTGCTGGCGCTGGCGCGGCTGCTGCAGCAGCGCGTGTCCGGCCGGCTCAAGCTCCATTG
A

Upstream 100 bases:

>100_bases
GGCGCTTGTCCTTCTGCATCGGCAGGCCATGGCCGCCGTGGATGGCAGATCAGGGTTTGCCGCAATAGACTCGGACATTG
AATTATTGGAGAGCCATTTC

Downstream 100 bases:

>100_bases
CGCGGCCCGGGCCCGGCCCGGGCCCGCAGCCTGCGATCACTTCGATGTGTAGGTGATTTTCGTCATCTCGGTCGTCGAGG
CGGCCCCGTTCGACGAAGAG

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MHSDIVIVGGGAGGLELAARLGRSLGAKQGRERVLLVDRSPFHIWKPTLHEVAAGTLDVHQEGLSYPVLARRNHFGFAIG
DLVGLDAARKTIELGEIRNAEGELLVPRRTVSYTRLVLAIGSGSNAFGTPGIEHAYLLENVRDAQRFHTDWLGACARASF
SESRALSIAIVGAGATGVELSAELLEAYAELLESLGSSQRFRLDITLVEGGSRILGGLPEKISAQAEVALRRKQVQVLTG
TRVTEIRRGALVTPAGEIPADMVVWAAGIKAAEGNARMGLEVNRLNQFIVDDRLRTSAPDVLALGDCAACPWVDGKTVPA
RAQAAHQQADYLAKVLGALLREREMTEPFIYKDFGSLVSLGDNKGVGNLMGGLGGRNFFVEGLIAKWMYISLHLNHHRAI
LGTGKTVVLALARLLQQRVSGRLKLH

Sequences:

>Translated_426_residues
MHSDIVIVGGGAGGLELAARLGRSLGAKQGRERVLLVDRSPFHIWKPTLHEVAAGTLDVHQEGLSYPVLARRNHFGFAIG
DLVGLDAARKTIELGEIRNAEGELLVPRRTVSYTRLVLAIGSGSNAFGTPGIEHAYLLENVRDAQRFHTDWLGACARASF
SESRALSIAIVGAGATGVELSAELLEAYAELLESLGSSQRFRLDITLVEGGSRILGGLPEKISAQAEVALRRKQVQVLTG
TRVTEIRRGALVTPAGEIPADMVVWAAGIKAAEGNARMGLEVNRLNQFIVDDRLRTSAPDVLALGDCAACPWVDGKTVPA
RAQAAHQQADYLAKVLGALLREREMTEPFIYKDFGSLVSLGDNKGVGNLMGGLGGRNFFVEGLIAKWMYISLHLNHHRAI
LGTGKTVVLALARLLQQRVSGRLKLH
>Mature_426_residues
MHSDIVIVGGGAGGLELAARLGRSLGAKQGRERVLLVDRSPFHIWKPTLHEVAAGTLDVHQEGLSYPVLARRNHFGFAIG
DLVGLDAARKTIELGEIRNAEGELLVPRRTVSYTRLVLAIGSGSNAFGTPGIEHAYLLENVRDAQRFHTDWLGACARASF
SESRALSIAIVGAGATGVELSAELLEAYAELLESLGSSQRFRLDITLVEGGSRILGGLPEKISAQAEVALRRKQVQVLTG
TRVTEIRRGALVTPAGEIPADMVVWAAGIKAAEGNARMGLEVNRLNQFIVDDRLRTSAPDVLALGDCAACPWVDGKTVPA
RAQAAHQQADYLAKVLGALLREREMTEPFIYKDFGSLVSLGDNKGVGNLMGGLGGRNFFVEGLIAKWMYISLHLNHHRAI
LGTGKTVVLALARLLQQRVSGRLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=435, Percent_Identity=46.6666666666667, Blast_Score=318, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6323794, Length=458, Percent_Identity=24.0174672489083, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320118, Length=463, Percent_Identity=25.2699784017279, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323515, Length=459, Percent_Identity=22.4400871459695, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 45771; Mature: 45771

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSDIVIVGGGAGGLELAARLGRSLGAKQGRERVLLVDRSPFHIWKPTLHEVAAGTLDVH
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCHHHHHHCCHHHHH
QEGLSYPVLARRNHFGFAIGDLVGLDAARKTIELGEIRNAEGELLVPRRTVSYTRLVLAI
HCCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHCEEEEEEEE
GSGSNAFGTPGIEHAYLLENVRDAQRFHTDWLGACARASFSESRALSIAIVGAGATGVEL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHH
SAELLEAYAELLESLGSSQRFRLDITLVEGGSRILGGLPEKISAQAEVALRRKQVQVLTG
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHEEEECC
TRVTEIRRGALVTPAGEIPADMVVWAAGIKAAEGNARMGLEVNRLNQFIVDDRLRTSAPD
CHHHHHHCCCEECCCCCCCHHHHHHCCCCEECCCCCCCCEEHHHHHHHHHHCHHHCCCCC
VLALGDCAACPWVDGKTVPARAQAAHQQADYLAKVLGALLREREMTEPFIYKDFGSLVSL
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
GDNKGVGNLMGGLGGRNFFVEGLIAKWMYISLHLNHHRAILGTGKTVVLALARLLQQRVS
CCCCCHHHHHHCCCCCHHHHHHHHHHEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHC
GRLKLH
CCEECC
>Mature Secondary Structure
MHSDIVIVGGGAGGLELAARLGRSLGAKQGRERVLLVDRSPFHIWKPTLHEVAAGTLDVH
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCHHHHHHCCHHHHH
QEGLSYPVLARRNHFGFAIGDLVGLDAARKTIELGEIRNAEGELLVPRRTVSYTRLVLAI
HCCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHCEEEEEEEE
GSGSNAFGTPGIEHAYLLENVRDAQRFHTDWLGACARASFSESRALSIAIVGAGATGVEL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHH
SAELLEAYAELLESLGSSQRFRLDITLVEGGSRILGGLPEKISAQAEVALRRKQVQVLTG
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHEEEECC
TRVTEIRRGALVTPAGEIPADMVVWAAGIKAAEGNARMGLEVNRLNQFIVDDRLRTSAPD
CHHHHHHCCCEECCCCCCCHHHHHHCCCCEECCCCCCCCEEHHHHHHHHHHCHHHCCCCC
VLALGDCAACPWVDGKTVPARAQAAHQQADYLAKVLGALLREREMTEPFIYKDFGSLVSL
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
GDNKGVGNLMGGLGGRNFFVEGLIAKWMYISLHLNHHRAILGTGKTVVLALARLLQQRVS
CCCCCHHHHHHCCCCCHHHHHHHHHHEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHC
GRLKLH
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]