Click here to switch to the map view.

The map label for this gene is paaH [H]

Identifier: 120611735

GI number: 120611735

Start: 3387424

End: 3388944

Strand: Direct

Name: paaH [H]

Synonym: Aave_3073

Alternate gene names: 120611735

Gene position: 3387424-3388944 (Clockwise)

Preceding gene: 120611733

Following gene: 120611736

Centisome position: 63.28

GC content: 70.94

Gene sequence:

>1521_bases
ATGACCAACCCCTTCCCTATCGTAGGCATCATAGGCACGGGCGCCATGGGCCAGGGCATCGCCCAGGTGGCGGCGCAGGC
CGGCAGCCAGGTGCTGCTGCTCGACAACCGGCCAGGCGCCGCCGAGGCCGCGCAAGGCAACATCCGGCAGCAGTGGGAAC
GCCTCGCCGCCAAGGGCCGCATCTCCGGCGACGAGGCCACGGCCCTGGCCGGCCGGCTGGCTCCGGCCGCTGCGCTGCAG
GATCTCGCCGGGTGCCACCTCATCATAGAAGCGATCGTGGAGCGCCTGGACGCCAAACAGGCGCTTTTTCGCGAACTCGA
AGACATCGTCGCGCAGGCGACGGTGCTTGCCACCAACACTTCCTCGCTGTCCGTGACAGCCATCGGCGCGGCGCTGCGGC
ATCCGGAACGCCTCGCGGGCTTCCACTTCTTCAATCCCGTCCCGCTCATGAAGGTGGTCGAGGTGATCGCCGGACTGAAG
ACCGACACGGCCGTGTGCGACCGCCTCGCCGGCCTCGCGCGCGCCATGGGCCACACCCCGGTACGCGCGCAGGACACGCC
CGGATTCATCGTCAACCACGCCGGGCGCGGATTCGGTACCGAAGCGCTGCGCATCGTCAGCGAGGGCGTGGCCGATTTCG
CCACGGTGGACCGCATCCTGCGCGACCAGGTCGGATTCCGGCTGGGCCCGTTCGAGCTGATGGACCTGACCGCGCTCGAC
GTGTCGCAGCCGGTCATGGAGTCCGTTTATCGACAGTATTACGAAGAGCCGCGGTATCGCCCCAGCGCCCTGGCCGCGCA
GCGTCTGGCCGCCGGCCTGCTCGGCCGCAAGACCGGCGAAGGCTTCTACCGCTACGTGGACGGGCAGGCGCAGGTGCCGG
CCGAGCCGCCCGCGCCCACGGTCGCGGAAATCCCTCCGGTGTGGGTGTCGTCGCGCGCCGCGCGGCGCGCCGAGGTGTTC
CAGCTGCTCAAGGACCTGGGCGCCCGGATCGAGACCGGCACGTCCCCGTCGCCGCAGGCGATCTCCCTCGTGGCGCCCCT
GGGCTTCGACGTCACCACCGTGGCCGTGGTCGAACGGCTGGACCCGGCCCGCACCATCGGCATCGACATGCTGGTGGAGG
ACGCCGCCACCCGCCGCCGCGTGCTGGCCACCAACCCGGCCACGCGCATCGACATCCGCGACGCCGCGCACGCCCTCTTC
GCGCGCGACGGCAAGGCCGTGAGCGTGATCCGCGACAGCGGCGGCTTCGTGACGCAGCGCGTGGTGGCAACCATCGTGAA
CATCGCCAGCGACATCTGCCAGCAGGGCATCTGCAGCCCGGCCGACCTGGAATCCGCCGTCACGCTGGGCCTGGGCTATC
CCCTGGGCCCGCTGGCCATGGGCAACCGCTGGGGGCCGGCGAACATGCTGGAGGTGCTGTTCAACCTGCAGACGGTGTAC
GGCGATCCGCGCTACCGCCCCAGCCCCTGGCTGCGACGCCGCGGCGCGATCGGACTGAGCCTGCTCCACGAGGAGGCCTG
A

Upstream 100 bases:

>100_bases
TCCGAGTATCGCGTTACTTAACTTCACAATAGTTACATTCTTATTCGGTTCATTCTTGCACATAAAGCCGCCTGCTCCCT
CACCGCCATAATCGCGCTCC

Downstream 100 bases:

>100_bases
CGGCCGCCCCTCCCTCCCCTCCACCGCCCGCAGCCCGGAACCGCCTCACATGCCCGCAAGACTCGAGAGCACCAGCCACG
GCCAGACCCTCGTGCTGACC

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MTNPFPIVGIIGTGAMGQGIAQVAAQAGSQVLLLDNRPGAAEAAQGNIRQQWERLAAKGRISGDEATALAGRLAPAAALQ
DLAGCHLIIEAIVERLDAKQALFRELEDIVAQATVLATNTSSLSVTAIGAALRHPERLAGFHFFNPVPLMKVVEVIAGLK
TDTAVCDRLAGLARAMGHTPVRAQDTPGFIVNHAGRGFGTEALRIVSEGVADFATVDRILRDQVGFRLGPFELMDLTALD
VSQPVMESVYRQYYEEPRYRPSALAAQRLAAGLLGRKTGEGFYRYVDGQAQVPAEPPAPTVAEIPPVWVSSRAARRAEVF
QLLKDLGARIETGTSPSPQAISLVAPLGFDVTTVAVVERLDPARTIGIDMLVEDAATRRRVLATNPATRIDIRDAAHALF
ARDGKAVSVIRDSGGFVTQRVVATIVNIASDICQQGICSPADLESAVTLGLGYPLGPLAMGNRWGPANMLEVLFNLQTVY
GDPRYRPSPWLRRRGAIGLSLLHEEA

Sequences:

>Translated_506_residues
MTNPFPIVGIIGTGAMGQGIAQVAAQAGSQVLLLDNRPGAAEAAQGNIRQQWERLAAKGRISGDEATALAGRLAPAAALQ
DLAGCHLIIEAIVERLDAKQALFRELEDIVAQATVLATNTSSLSVTAIGAALRHPERLAGFHFFNPVPLMKVVEVIAGLK
TDTAVCDRLAGLARAMGHTPVRAQDTPGFIVNHAGRGFGTEALRIVSEGVADFATVDRILRDQVGFRLGPFELMDLTALD
VSQPVMESVYRQYYEEPRYRPSALAAQRLAAGLLGRKTGEGFYRYVDGQAQVPAEPPAPTVAEIPPVWVSSRAARRAEVF
QLLKDLGARIETGTSPSPQAISLVAPLGFDVTTVAVVERLDPARTIGIDMLVEDAATRRRVLATNPATRIDIRDAAHALF
ARDGKAVSVIRDSGGFVTQRVVATIVNIASDICQQGICSPADLESAVTLGLGYPLGPLAMGNRWGPANMLEVLFNLQTVY
GDPRYRPSPWLRRRGAIGLSLLHEEA
>Mature_505_residues
TNPFPIVGIIGTGAMGQGIAQVAAQAGSQVLLLDNRPGAAEAAQGNIRQQWERLAAKGRISGDEATALAGRLAPAAALQD
LAGCHLIIEAIVERLDAKQALFRELEDIVAQATVLATNTSSLSVTAIGAALRHPERLAGFHFFNPVPLMKVVEVIAGLKT
DTAVCDRLAGLARAMGHTPVRAQDTPGFIVNHAGRGFGTEALRIVSEGVADFATVDRILRDQVGFRLGPFELMDLTALDV
SQPVMESVYRQYYEEPRYRPSALAAQRLAAGLLGRKTGEGFYRYVDGQAQVPAEPPAPTVAEIPPVWVSSRAARRAEVFQ
LLKDLGARIETGTSPSPQAISLVAPLGFDVTTVAVVERLDPARTIGIDMLVEDAATRRRVLATNPATRIDIRDAAHALFA
RDGKAVSVIRDSGGFVTQRVVATIVNIASDICQQGICSPADLESAVTLGLGYPLGPLAMGNRWGPANMLEVLFNLQTVYG
DPRYRPSPWLRRRGAIGLSLLHEEA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=286, Percent_Identity=37.7622377622378, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI296179427, Length=303, Percent_Identity=35.6435643564356, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=30.7420494699647, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI68989263, Length=368, Percent_Identity=26.9021739130435, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI261878539, Length=368, Percent_Identity=26.9021739130435, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI115430219, Length=245, Percent_Identity=28.9795918367347, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1787661, Length=490, Percent_Identity=37.5510204081633, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1790281, Length=263, Percent_Identity=33.8403041825095, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788682, Length=268, Percent_Identity=32.8358208955224, Blast_Score=122, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=40.2097902097902, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17553560, Length=283, Percent_Identity=36.3957597173145, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17563036, Length=295, Percent_Identity=34.5762711864407, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=29.7872340425532, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI25144276, Length=286, Percent_Identity=30.4195804195804, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17508951, Length=286, Percent_Identity=30.4195804195804, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17508953, Length=286, Percent_Identity=30.4195804195804, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17558304, Length=287, Percent_Identity=30.3135888501742, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=27.8571428571429, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193203623, Length=207, Percent_Identity=25.6038647342995, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=207, Percent_Identity=25.6038647342995, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=31.8493150684932, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=31.8493150684932, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=31.8493150684932, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=28.8702928870293, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20129993, Length=241, Percent_Identity=28.2157676348548, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 54005; Mature: 53873

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPFPIVGIIGTGAMGQGIAQVAAQAGSQVLLLDNRPGAAEAAQGNIRQQWERLAAKGR
CCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCHHHHHHHHHHCCC
ISGDEATALAGRLAPAAALQDLAGCHLIIEAIVERLDAKQALFRELEDIVAQATVLATNT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
SSLSVTAIGAALRHPERLAGFHFFNPVPLMKVVEVIAGLKTDTAVCDRLAGLARAMGHTP
CCEEHHHHHHHHHCHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
VRAQDTPGFIVNHAGRGFGTEALRIVSEGVADFATVDRILRDQVGFRLGPFELMDLTALD
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VSQPVMESVYRQYYEEPRYRPSALAAQRLAAGLLGRKTGEGFYRYVDGQAQVPAEPPAPT
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCC
VAEIPPVWVSSRAARRAEVFQLLKDLGARIETGTSPSPQAISLVAPLGFDVTTVAVVERL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHC
DPARTIGIDMLVEDAATRRRVLATNPATRIDIRDAAHALFARDGKAVSVIRDSGGFVTQR
CCHHHHHHHHHHHHHHHHCCEEECCCCCEEEHHHHHHHHHHCCCCEEEEEECCCCHHHHH
VVATIVNIASDICQQGICSPADLESAVTLGLGYPLGPLAMGNRWGPANMLEVLFNLQTVY
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GDPRYRPSPWLRRRGAIGLSLLHEEA
CCCCCCCCHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure 
TNPFPIVGIIGTGAMGQGIAQVAAQAGSQVLLLDNRPGAAEAAQGNIRQQWERLAAKGR
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCHHHHHHHHHHCCC
ISGDEATALAGRLAPAAALQDLAGCHLIIEAIVERLDAKQALFRELEDIVAQATVLATNT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
SSLSVTAIGAALRHPERLAGFHFFNPVPLMKVVEVIAGLKTDTAVCDRLAGLARAMGHTP
CCEEHHHHHHHHHCHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
VRAQDTPGFIVNHAGRGFGTEALRIVSEGVADFATVDRILRDQVGFRLGPFELMDLTALD
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VSQPVMESVYRQYYEEPRYRPSALAAQRLAAGLLGRKTGEGFYRYVDGQAQVPAEPPAPT
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCC
VAEIPPVWVSSRAARRAEVFQLLKDLGARIETGTSPSPQAISLVAPLGFDVTTVAVVERL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHC
DPARTIGIDMLVEDAATRRRVLATNPATRIDIRDAAHALFARDGKAVSVIRDSGGFVTQR
CCHHHHHHHHHHHHHHHHCCEEECCCCCEEEHHHHHHHHHHCCCCEEEEEECCCCHHHHH
VVATIVNIASDICQQGICSPADLESAVTLGLGYPLGPLAMGNRWGPANMLEVLFNLQTVY
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GDPRYRPSPWLRRRGAIGLSLLHEEA
CCCCCCCCHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]