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The map label for this gene is fadB [H]

Identifier: 120611736

GI number: 120611736

Start: 3388994

End: 3389773

Strand: Direct

Name: fadB [H]

Synonym: Aave_3074

Alternate gene names: 120611736

Gene position: 3388994-3389773 (Clockwise)

Preceding gene: 120611735

Following gene: 120611737

Centisome position: 63.31

GC content: 72.31

Gene sequence:

>780_bases
ATGCCCGCAAGACTCGAGAGCACCAGCCACGGCCAGACCCTCGTGCTGACCATCCACAACCCGGAGATGCGCAACGCGCT
CGATCCGGCCATCTACGCGGCCGGCGTGGAGGCGCTCAACGGCGCCGAGCGCACGGCCGAAGTGCGTTCGGTCGTCATCA
CGGGCGCCGGAGGGCACTTCTGCGCAGGCGGCGACCTGAAAGGCCTGCAGGCGCTCCGGCAGCAGGGCGCCGAGGCGCAG
GGGCGTGCCGTGGAAGGGCTGCACCACTGGATCGAGGCCATCCGCACCTATCCCAAGCCGGTCATCGCCGCGGTGGAGGG
TGCCGCCGCGGGCGCCGGATTCTCGCTGGCGCTGGCCTGCGACATGGTGGTGGCCGCGCGCGATGCCGTCTTCGTGATGG
CCTACGCGGGCATCGGCCTGTCGCCGGACGGCGGCGCGAGCTGGAGCCTCGCGCAGGCGCTGCCGCGCCAGCTCGCCGCC
GAACTGCTGCTGTGCGGCGAGCGCATCGGCGCGGAACGCCTGCATGCGCTGGGCGTGGTCAACCGGCTGGCGCGCCCCCA
GGAAGCGCTGGCCTGCGCGCTCGCCCTGGCCGAGACGCTCAATGCCCGCGCGCCCAATGCGCTGGCCGGCACCAAGGAAC
TGCTCTCGGAAGCGCCCCTGCACACGCTGGCCCGGCAGCTGGAGAAAGAGCGCGACCAGTTCGTGCGCAACCTGCAGCAC
CCGAACGCGGGCGAAGGCATCGCCGCCTTCCTCGAAAAGCGCACGCCGCGCTATCGCTGA

Upstream 100 bases:

>100_bases
CTGCGACGCCGCGGCGCGATCGGACTGAGCCTGCTCCACGAGGAGGCCTGACGGCCGCCCCTCCCTCCCCTCCACCGCCC
GCAGCCCGGAACCGCCTCAC

Downstream 100 bases:

>100_bases
GCGCGCCCCGGCCGGTCGCCGTAGCCTTCCTTTGCCGTAGCCTTCGCCGTTGTCCCGCGCCGCACGCGCGGGCGTGCACA
GACACGCGCGCGACATCCGC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MPARLESTSHGQTLVLTIHNPEMRNALDPAIYAAGVEALNGAERTAEVRSVVITGAGGHFCAGGDLKGLQALRQQGAEAQ
GRAVEGLHHWIEAIRTYPKPVIAAVEGAAAGAGFSLALACDMVVAARDAVFVMAYAGIGLSPDGGASWSLAQALPRQLAA
ELLLCGERIGAERLHALGVVNRLARPQEALACALALAETLNARAPNALAGTKELLSEAPLHTLARQLEKERDQFVRNLQH
PNAGEGIAAFLEKRTPRYR

Sequences:

>Translated_259_residues
MPARLESTSHGQTLVLTIHNPEMRNALDPAIYAAGVEALNGAERTAEVRSVVITGAGGHFCAGGDLKGLQALRQQGAEAQ
GRAVEGLHHWIEAIRTYPKPVIAAVEGAAAGAGFSLALACDMVVAARDAVFVMAYAGIGLSPDGGASWSLAQALPRQLAA
ELLLCGERIGAERLHALGVVNRLARPQEALACALALAETLNARAPNALAGTKELLSEAPLHTLARQLEKERDQFVRNLQH
PNAGEGIAAFLEKRTPRYR
>Mature_258_residues
PARLESTSHGQTLVLTIHNPEMRNALDPAIYAAGVEALNGAERTAEVRSVVITGAGGHFCAGGDLKGLQALRQQGAEAQG
RAVEGLHHWIEAIRTYPKPVIAAVEGAAAGAGFSLALACDMVVAARDAVFVMAYAGIGLSPDGGASWSLAQALPRQLAAE
LLLCGERIGAERLHALGVVNRLARPQEALACALALAETLNARAPNALAGTKELLSEAPLHTLARQLEKERDQFVRNLQHP
NAGEGIAAFLEKRTPRYR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=245, Percent_Identity=30.2040816326531, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI70995211, Length=258, Percent_Identity=30.2325581395349, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI31542718, Length=246, Percent_Identity=28.4552845528455, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI116235487, Length=177, Percent_Identity=31.0734463276836, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4757966, Length=171, Percent_Identity=29.8245614035088, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI51538581, Length=171, Percent_Identity=29.8245614035088, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI25453481, Length=171, Percent_Identity=29.8245614035088, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI51538573, Length=171, Percent_Identity=29.8245614035088, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4757968, Length=171, Percent_Identity=29.8245614035088, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI49355787, Length=171, Percent_Identity=29.8245614035088, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI45643119, Length=210, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI260275230, Length=210, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI260274832, Length=210, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4502327, Length=260, Percent_Identity=30.3846153846154, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI221307494, Length=178, Percent_Identity=26.9662921348315, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI221136756, Length=178, Percent_Identity=26.9662921348315, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI221136753, Length=178, Percent_Identity=26.9662921348315, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI20127408, Length=187, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI68989263, Length=179, Percent_Identity=30.1675977653631, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1787660, Length=247, Percent_Identity=36.0323886639676, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI221142681, Length=264, Percent_Identity=34.469696969697, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787659, Length=248, Percent_Identity=33.0645161290323, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI87082183, Length=241, Percent_Identity=28.6307053941909, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788597, Length=187, Percent_Identity=31.5508021390374, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=244, Percent_Identity=29.9180327868852, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17554946, Length=256, Percent_Identity=29.296875, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17535521, Length=253, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17540306, Length=249, Percent_Identity=31.7269076305221, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=208, Percent_Identity=31.7307692307692, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=222, Percent_Identity=27.027027027027, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17549921, Length=206, Percent_Identity=25.2427184466019, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=256, Percent_Identity=23.828125, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=253, Percent_Identity=22.9249011857708, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=181, Percent_Identity=27.6243093922652, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=184, Percent_Identity=27.7173913043478, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17508951, Length=184, Percent_Identity=27.7173913043478, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=29.2682926829268, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=29.2682926829268, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19920382, Length=216, Percent_Identity=32.4074074074074, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24654903, Length=247, Percent_Identity=25.5060728744939, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19922422, Length=247, Percent_Identity=28.3400809716599, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653139, Length=261, Percent_Identity=29.5019157088123, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24667722, Length=196, Percent_Identity=27.0408163265306, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357171, Length=190, Percent_Identity=27.8947368421053, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24650670, Length=219, Percent_Identity=28.7671232876712, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27267; Mature: 27135

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARLESTSHGQTLVLTIHNPEMRNALDPAIYAAGVEALNGAERTAEVRSVVITGAGGHF
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCE
CAGGDLKGLQALRQQGAEAQGRAVEGLHHWIEAIRTYPKPVIAAVEGAAAGAGFSLALAC
ECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHH
DMVVAARDAVFVMAYAGIGLSPDGGASWSLAQALPRQLAAELLLCGERIGAERLHALGVV
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRLARPQEALACALALAETLNARAPNALAGTKELLSEAPLHTLARQLEKERDQFVRNLQH
HHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
PNAGEGIAAFLEKRTPRYR
CCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PARLESTSHGQTLVLTIHNPEMRNALDPAIYAAGVEALNGAERTAEVRSVVITGAGGHF
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCE
CAGGDLKGLQALRQQGAEAQGRAVEGLHHWIEAIRTYPKPVIAAVEGAAAGAGFSLALAC
ECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHH
DMVVAARDAVFVMAYAGIGLSPDGGASWSLAQALPRQLAAELLLCGERIGAERLHALGVV
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRLARPQEALACALALAETLNARAPNALAGTKELLSEAPLHTLARQLEKERDQFVRNLQH
HHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
PNAGEGIAAFLEKRTPRYR
CCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]