Click here to switch to the map view.

The map label for this gene is rnr [H]

Identifier: 120611651

GI number: 120611651

Start: 3286902

End: 3289217

Strand: Reverse

Name: rnr [H]

Synonym: Aave_2988

Alternate gene names: 120611651

Gene position: 3289217-3286902 (Counterclockwise)

Preceding gene: 120611652

Following gene: 120611650

Centisome position: 61.45

GC content: 69.91

Gene sequence:

>2316_bases
TTGTATATCAAAAAAACCAAAGCCGTTGCAAACGTCGCGCACTCCGATGACGAAATCGAAGGCAGCGTGCAGGGCCACCG
CGACGGCCACGGATTCGTGCAGCGCGACGACGGCGATGCCGACATCTATATCCCCGCCAACGAGATGCGGGCGGTGCTCC
ACAAGGACCGCGTGCGCGTGCGCATCGCGCGGCACGACCGGCGCGGCCGGCCAGAGGGCCGCATCGTCGAGATCATCGAA
CGCCCCCAGCACCCGATCATCGGGCGCCTGCTGCAGGAAAGCGGTGTGTGGCTGGTGGCGCCGGAAGACAAGCGCTACGG
CCAGGACGTGCTGATCCCCAAGGGCGCGACCGGCTCGGCCAAGACCGGGCAGGTCGTGGTGGTGGAGCTGACGGAGCCGC
CCGCGCTGTTCGGGCAGCCCGTGGGCCGCGTCACGGAAGTGCTGGGCGAGGTGGACGATCCCGGCATGGAGATCGAGATC
GCCGTGCGCAAGTACGGCGTGCCGCACGAGTTCTCGCAGGAGGCGCTGGCGCAGGCCAAGGCCCTGCCCGACAAGGTGCG
CGCGCAGGACAAGCGCCACCGCATCGACCTGACCGACGTGCCCCTGGTGACCATCGACGGCGAAGATGCCCGTGACTTCG
ACGACGCCGTGTATTGCGAGCCGGCGCGCGTCGGCCGCACCAAGGGCTGGCGCCTGCTGGTCGCGATCGCCGACGTGAGC
CACTATGTGGAGACGGGCAGCCCCATCGACGTGGACGCCTATGACCGGGCCACCAGCGTCTATTTCCCGCGCCGCGTCAT
CCCGATGCTGCCCGAGAAGCTGTCCAACGGGCTGTGCTCGCTCAATCCGGAGGTGGAGCGCCTGTGCATGGTGTGCGACA
TGCTGGTCACCGCCAAGGGCGAAGTGCACGCCTACCAGTTCTATCCGGCCGTCATGTTCAGCCACGCGCGCTTCACCTAT
ACGGAAGTGGCCGCGATCCTCGCGAACACGCGGGGGCCCGAGGCGACGAAGCGCCGCGCGCGCGTGCAGGACCTGCTGAA
CCTGCACGACGTGTACCGTGCGCTGCTGTCGTCGCGGCACGCGCGGGGGGCGGTGGATTTCGAGACCACCGAGACGCAGA
TCGTCTGCGACGACAACGGACGCATCGAGAAGATCGTGCCGCGCACGCGCAACGATGCCCACCGGCTGATCGAGGAAGCC
ATGCTCGCGGCCAACGTGTGCAGCGCGGACTTCATCGCCCAGGGCGGGCAGCCCGGGCTGTACCGCGTGCACGAGGGCCC
CACGCCGGAGAAGCAGGAAATCCTGCGCAATTACCTGAAGGCCATGGCGGTGGGCATGACGATCGGTGACGATCCGAAGC
CCGGCGACTTCCAGGCCATCGCGGAGGCCACGAAGGACCGCCCGGACGCGCAGCAGATCCACACGATGCTGCTGCGCTCC
ATGCAGCAGGCCATCTACACCCCTGTGAACAGCGGCCATTTCGGGCTGGCCTACGAGGCCTACACGCATTTCACCAGCCC
GATCCGGCGCTACCCCGACCTGCTGGTGCACCGCGTCATCAAGGCCATCCTGGGCCAGACCAAATACCGGCTGCCGGCAC
TGCCCGTGCCGGGCGAGGCGCACGCCAAGCTCGCCAAGCGCCTCGCCGCGCGGCTGCCGGCGCCGACGCAGCAGCCGCGC
AAGCCGCTGTCCGCCGCCGCGGTCCGCGAGGTGCAGGCCTGGGAGGCCGCCGGCCTGCACTGCAGCGCCAACGAGCGCCG
GGCCGACGAGGCCAGTCGCGACGTCGAGGCGTGGTTGAAGTGCAAGTACATGCGCGAGCACCTGGGCGAGGAGTTCAGCG
GCCTGGTCACGGCCGCGACCAGTTTCGGCATCTTCGTGACGCTGGACGCGATGTATGTCGAGGGGCTGGTGCACATCACG
GAGCTGGGGGGCGAGTACTTCAAGTTCGACGAGGCGCGTCAGGAGCTGCGTGGCGAGCGCACGGGCATCCGCTATGCCAT
CGGCACGCGGGTGCGCGTGCAGGTCAGCCGCGTGGACCTGGATGGGCGACGCATCGACTTCCGGCTGGTGCGCGAGGGCG
AGGAGTCGCTGCCGCCCGCGCGCGCTTCCCGCGGCCGCGGAGGGCGCGAGCCGGCGGAGCCCATGCTCCCGGCATCCGCC
GACGGAGCGGGGGCGGAGCGCAGCCGCAACAAGGCCCGCAAGGGCGCTTCGAGGGCTGCCCGGCCGCAGGACGCCCCCGC
GGCGCCGCGCAAGGCGGCGGCCAAGGGCTCCGGACGCCGCTCCGGAGCGGCCAAGCGGGGCAAGTCGCGCCGCTGA

Upstream 100 bases:

>100_bases
GCCCAGGAGAGGACTCGAACCTCCACGATGTTACTCGCTAGTACCTGAAACTAGTGCGTCTACCAATTCCGCCACCTGGG
CATTTCAGGAAAGACTCAGA

Downstream 100 bases:

>100_bases
GCCCTGGCGGGGCGCCGGGATGCCGCGAGCGTCCGGCCCCGCCCCGGGGTTGTGCATTCAGCAAAGGGACAGGATCGATG
AAGGTTTCGAACGGAACGCC

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 771; Mature: 771

Protein sequence:

>771_residues
MYIKKTKAVANVAHSDDEIEGSVQGHRDGHGFVQRDDGDADIYIPANEMRAVLHKDRVRVRIARHDRRGRPEGRIVEIIE
RPQHPIIGRLLQESGVWLVAPEDKRYGQDVLIPKGATGSAKTGQVVVVELTEPPALFGQPVGRVTEVLGEVDDPGMEIEI
AVRKYGVPHEFSQEALAQAKALPDKVRAQDKRHRIDLTDVPLVTIDGEDARDFDDAVYCEPARVGRTKGWRLLVAIADVS
HYVETGSPIDVDAYDRATSVYFPRRVIPMLPEKLSNGLCSLNPEVERLCMVCDMLVTAKGEVHAYQFYPAVMFSHARFTY
TEVAAILANTRGPEATKRRARVQDLLNLHDVYRALLSSRHARGAVDFETTETQIVCDDNGRIEKIVPRTRNDAHRLIEEA
MLAANVCSADFIAQGGQPGLYRVHEGPTPEKQEILRNYLKAMAVGMTIGDDPKPGDFQAIAEATKDRPDAQQIHTMLLRS
MQQAIYTPVNSGHFGLAYEAYTHFTSPIRRYPDLLVHRVIKAILGQTKYRLPALPVPGEAHAKLAKRLAARLPAPTQQPR
KPLSAAAVREVQAWEAAGLHCSANERRADEASRDVEAWLKCKYMREHLGEEFSGLVTAATSFGIFVTLDAMYVEGLVHIT
ELGGEYFKFDEARQELRGERTGIRYAIGTRVRVQVSRVDLDGRRIDFRLVREGEESLPPARASRGRGGREPAEPMLPASA
DGAGAERSRNKARKGASRAARPQDAPAAPRKAAAKGSGRRSGAAKRGKSRR

Sequences:

>Translated_771_residues
MYIKKTKAVANVAHSDDEIEGSVQGHRDGHGFVQRDDGDADIYIPANEMRAVLHKDRVRVRIARHDRRGRPEGRIVEIIE
RPQHPIIGRLLQESGVWLVAPEDKRYGQDVLIPKGATGSAKTGQVVVVELTEPPALFGQPVGRVTEVLGEVDDPGMEIEI
AVRKYGVPHEFSQEALAQAKALPDKVRAQDKRHRIDLTDVPLVTIDGEDARDFDDAVYCEPARVGRTKGWRLLVAIADVS
HYVETGSPIDVDAYDRATSVYFPRRVIPMLPEKLSNGLCSLNPEVERLCMVCDMLVTAKGEVHAYQFYPAVMFSHARFTY
TEVAAILANTRGPEATKRRARVQDLLNLHDVYRALLSSRHARGAVDFETTETQIVCDDNGRIEKIVPRTRNDAHRLIEEA
MLAANVCSADFIAQGGQPGLYRVHEGPTPEKQEILRNYLKAMAVGMTIGDDPKPGDFQAIAEATKDRPDAQQIHTMLLRS
MQQAIYTPVNSGHFGLAYEAYTHFTSPIRRYPDLLVHRVIKAILGQTKYRLPALPVPGEAHAKLAKRLAARLPAPTQQPR
KPLSAAAVREVQAWEAAGLHCSANERRADEASRDVEAWLKCKYMREHLGEEFSGLVTAATSFGIFVTLDAMYVEGLVHIT
ELGGEYFKFDEARQELRGERTGIRYAIGTRVRVQVSRVDLDGRRIDFRLVREGEESLPPARASRGRGGREPAEPMLPASA
DGAGAERSRNKARKGASRAARPQDAPAAPRKAAAKGSGRRSGAAKRGKSRR
>Mature_771_residues
MYIKKTKAVANVAHSDDEIEGSVQGHRDGHGFVQRDDGDADIYIPANEMRAVLHKDRVRVRIARHDRRGRPEGRIVEIIE
RPQHPIIGRLLQESGVWLVAPEDKRYGQDVLIPKGATGSAKTGQVVVVELTEPPALFGQPVGRVTEVLGEVDDPGMEIEI
AVRKYGVPHEFSQEALAQAKALPDKVRAQDKRHRIDLTDVPLVTIDGEDARDFDDAVYCEPARVGRTKGWRLLVAIADVS
HYVETGSPIDVDAYDRATSVYFPRRVIPMLPEKLSNGLCSLNPEVERLCMVCDMLVTAKGEVHAYQFYPAVMFSHARFTY
TEVAAILANTRGPEATKRRARVQDLLNLHDVYRALLSSRHARGAVDFETTETQIVCDDNGRIEKIVPRTRNDAHRLIEEA
MLAANVCSADFIAQGGQPGLYRVHEGPTPEKQEILRNYLKAMAVGMTIGDDPKPGDFQAIAEATKDRPDAQQIHTMLLRS
MQQAIYTPVNSGHFGLAYEAYTHFTSPIRRYPDLLVHRVIKAILGQTKYRLPALPVPGEAHAKLAKRLAARLPAPTQQPR
KPLSAAAVREVQAWEAAGLHCSANERRADEASRDVEAWLKCKYMREHLGEEFSGLVTAATSFGIFVTLDAMYVEGLVHIT
ELGGEYFKFDEARQELRGERTGIRYAIGTRVRVQVSRVDLDGRRIDFRLVREGEESLPPARASRGRGGREPAEPMLPASA
DGAGAERSRNKARKGASRAARPQDAPAAPRKAAAKGSGRRSGAAKRGKSRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=484, Percent_Identity=30.3719008264463, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI190014623, Length=484, Percent_Identity=30.3719008264463, Blast_Score=186, Evalue=9e-47,
Organism=Homo sapiens, GI134288890, Length=418, Percent_Identity=29.4258373205742, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI19115966, Length=501, Percent_Identity=28.1437125748503, Blast_Score=137, Evalue=5e-32,
Organism=Homo sapiens, GI219521928, Length=501, Percent_Identity=28.1437125748503, Blast_Score=136, Evalue=7e-32,
Organism=Escherichia coli, GI87082383, Length=676, Percent_Identity=44.6745562130178, Blast_Score=600, Evalue=1e-172,
Organism=Escherichia coli, GI1787542, Length=521, Percent_Identity=28.2149712092131, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI212645896, Length=415, Percent_Identity=30.6024096385542, Blast_Score=161, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17553506, Length=422, Percent_Identity=30.0947867298578, Blast_Score=146, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324552, Length=534, Percent_Identity=24.9063670411985, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323943, Length=386, Percent_Identity=22.279792746114, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24649634, Length=483, Percent_Identity=29.399585921325, Blast_Score=174, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19922976, Length=440, Percent_Identity=29.5454545454545, Blast_Score=138, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24654597, Length=440, Percent_Identity=29.5454545454545, Blast_Score=138, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24654592, Length=440, Percent_Identity=29.5454545454545, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 85405; Mature: 85405

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIKKTKAVANVAHSDDEIEGSVQGHRDGHGFVQRDDGDADIYIPANEMRAVLHKDRVRV
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECHHHHHHHHHHHHHEE
RIARHDRRGRPEGRIVEIIERPQHPIIGRLLQESGVWLVAPEDKRYGQDVLIPKGATGSA
EEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCC
KTGQVVVVELTEPPALFGQPVGRVTEVLGEVDDPGMEIEIAVRKYGVPHEFSQEALAQAK
CCCCEEEEEECCCCHHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
ALPDKVRAQDKRHRIDLTDVPLVTIDGEDARDFDDAVYCEPARVGRTKGWRLLVAIADVS
CCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEECHHHCCCCCCCEEEEEEHHHH
HYVETGSPIDVDAYDRATSVYFPRRVIPMLPEKLSNGLCSLNPEVERLCMVCDMLVTAKG
HHHHCCCCCCCCCCCCCHHCCCCHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
EVHAYQFYPAVMFSHARFTYTEVAAILANTRGPEATKRRARVQDLLNLHDVYRALLSSRH
CEEEEEEHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARGAVDFETTETQIVCDDNGRIEKIVPRTRNDAHRLIEEAMLAANVCSADFIAQGGQPGL
CCCCEEEECCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCCE
YRVHEGPTPEKQEILRNYLKAMAVGMTIGDDPKPGDFQAIAEATKDRPDAQQIHTMLLRS
EEECCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
MQQAIYTPVNSGHFGLAYEAYTHFTSPIRRYPDLLVHRVIKAILGQTKYRLPALPVPGEA
HHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
HAKLAKRLAARLPAPTQQPRKPLSAAAVREVQAWEAAGLHCSANERRADEASRDVEAWLK
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
CKYMREHLGEEFSGLVTAATSFGIFVTLDAMYVEGLVHITELGGEYFKFDEARQELRGER
HHHHHHHHCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
TGIRYAIGTRVRVQVSRVDLDGRRIDFRLVREGEESLPPARASRGRGGREPAEPMLPASA
CCEEEEECCEEEEEEEEECCCCCEEEEEEEECCHHHCCCCHHHCCCCCCCCCCCCCCCCC
DGAGAERSRNKARKGASRAARPQDAPAAPRKAAAKGSGRRSGAAKRGKSRR
CCCCCHHHHHHHHHCHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYIKKTKAVANVAHSDDEIEGSVQGHRDGHGFVQRDDGDADIYIPANEMRAVLHKDRVRV
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECHHHHHHHHHHHHHEE
RIARHDRRGRPEGRIVEIIERPQHPIIGRLLQESGVWLVAPEDKRYGQDVLIPKGATGSA
EEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCC
KTGQVVVVELTEPPALFGQPVGRVTEVLGEVDDPGMEIEIAVRKYGVPHEFSQEALAQAK
CCCCEEEEEECCCCHHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
ALPDKVRAQDKRHRIDLTDVPLVTIDGEDARDFDDAVYCEPARVGRTKGWRLLVAIADVS
CCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEECHHHCCCCCCCEEEEEEHHHH
HYVETGSPIDVDAYDRATSVYFPRRVIPMLPEKLSNGLCSLNPEVERLCMVCDMLVTAKG
HHHHCCCCCCCCCCCCCHHCCCCHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
EVHAYQFYPAVMFSHARFTYTEVAAILANTRGPEATKRRARVQDLLNLHDVYRALLSSRH
CEEEEEEHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARGAVDFETTETQIVCDDNGRIEKIVPRTRNDAHRLIEEAMLAANVCSADFIAQGGQPGL
CCCCEEEECCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCCE
YRVHEGPTPEKQEILRNYLKAMAVGMTIGDDPKPGDFQAIAEATKDRPDAQQIHTMLLRS
EEECCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
MQQAIYTPVNSGHFGLAYEAYTHFTSPIRRYPDLLVHRVIKAILGQTKYRLPALPVPGEA
HHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
HAKLAKRLAARLPAPTQQPRKPLSAAAVREVQAWEAAGLHCSANERRADEASRDVEAWLK
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
CKYMREHLGEEFSGLVTAATSFGIFVTLDAMYVEGLVHITELGGEYFKFDEARQELRGER
HHHHHHHHCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
TGIRYAIGTRVRVQVSRVDLDGRRIDFRLVREGEESLPPARASRGRGGREPAEPMLPASA
CCEEEEECCEEEEEEEEECCCCCEEEEEEEECCHHHCCCCHHHCCCCCCCCCCCCCCCCC
DGAGAERSRNKARKGASRAARPQDAPAAPRKAAAKGSGRRSGAAKRGKSRR
CCCCCHHHHHHHHHCHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]