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The map label for this gene is hutU [H]

Identifier: 120611627

GI number: 120611627

Start: 3253426

End: 3255150

Strand: Reverse

Name: hutU [H]

Synonym: Aave_2964

Alternate gene names: 120611627

Gene position: 3255150-3253426 (Counterclockwise)

Preceding gene: 120611628

Following gene: 120611626

Centisome position: 60.81

GC content: 68.93

Gene sequence:

>1725_bases
ATGAACGCCAACGACGCCATCCTGCCCGCTGCCACCCACGCAGACCCCCGCCACGATCCCGCGCGCGTGGTCCGAGCCCC
GCGCGGCAGCCAGCTGCATTGCAGGAACTGGCTGGCCGAGGCCGCCTACCGCATGATCCAGAACAACCTGGACCCGGACG
TGGCCGAGAACCCGCAGTCGCTGGTGGTCTATGGCGGCATCGGCCGCGCGGCGCGCAACTGGGAATGCTTCGACCAGATC
CTGGCCTCGCTGCGCACGCTAGAGGCCGACGAATCCCTGCTGATCCAGTCCGGCAAGCCGGTGGGCGTATTCAAGACCCA
CGAGAACGCGCCGCGCGTGCTGCTGGCCAACTCCAACCTCGTGCCCAAGTGGGGCACCTGGGAGCACTTCAACGAACTGG
ACCGCAAGGGCCTCTTCATGTACGGCCAGATGACGGCCGGCAGCTGGATCTACATCGGTGCCCAGGGCATCGTGCAGGGC
ACCTTCGAGACCTTCGTCGAAGCGGGCCGCCAGCATTACGGCAACGACCTGTCCGGCAAGTGGATCCTGACGGCGGGCCT
GGGCGGCATGGGCGGAGCGCAGCCGCTGGCGGGCGTATTGGCGGGGGCCTGCGTGCTGGCCGTCGAATGCAAGCAGTCCA
GCATCGACTTCCGCCTGCGCACGCGCTACGTGGACAAGCAGGCGAGGGACATCGACGATGCGCTGGCGCTCATCGCGCAC
CACACGGCCCGGGGCGAGGCGGTGTCGATCGCGCTGCTGGGCAACGCCGCCGAGGTGCTGCCCGAACTGGCCAGGCGCGC
AAAGGCGGGCGGCCCCCGGCCCGACATCGTGACCGACCAGACCTCGGCCCACGACCTCATCAACGGCTACCTGCCCGTGG
GATGGACCGTGGAGCAATGGCAGGCCGCCGCCGCCGACCCGGCGCAGCATGCCCGCCTGAAGCAGGCCGCCGCCCAGGGC
TGCGCCGTCCACGTGCAGGCCATGCTCGACTTCCAGGCCATGGGCATTCCCACGGTGGACTACGGCAACAACATCCGCCA
GGTGGCGTTCGACCAGGGCGTGAAGAACGCCTTCGATTTCCCCGGCTTCGTGCCGGCCTACATCCGCCCGCTGTTCTGCG
AAGGCAAGGGCCCGTTCCGCTGGGTGGCGCTCTCGGGCGACCCGGAAGACATCTACAGGACCGACGCCAAGATCAAGGAG
CTGTTCCCCGAGAACAAACACACCCACCGCTGGCTCGACATGGCCCGCGAGCGCATCGCCTTCCAGGGCCTGCCCGCGCG
CATCTGCTGGCTGGGCCTGGGCGAGCGCCACAAGGCGGCGCTGGCCTTCAACGAGATGGTGAAAAGCGGCGAGCTGAAGG
CGCCCATCGTCATCGGCCGCGACCACCTGGACACCGGCTCCGTCGCCAGCCCCAACCGCGAAACCGAGGCGATGAAGGAC
GGCACCGACGCGGTGAGCGACTGGCCGCTGCTCAACGCGCTGCTCAACACCGCGGGCGGCGCCACGTGGGTGAGCCTGCA
CCATGGCGGCGGCGTGGGCATGGGCTATTCGCAGCATGCGGGCGTGGTGATCGTGGCCGATGGAACGCCGGAAGCCGCGG
CCCGCCTGGAGCGCGTGCTCTGGAACGATCCGGCCAGTGGCGTCATGCGGCATGCGGACGCTGGCTACGACATAGCCATC
GCCACGGCGAAGAAGCACCAGCTGCACCTGCCGATGGTGAAGTGA

Upstream 100 bases:

>100_bases
CCTGTGGGCCAGCACCTCGGCGTGGCCCGCGCCGCTCGCGGCCTGCCTGCCCAGCTTCCAGTAATCCCGGTCCGTACACG
AACGCCCAAGGAGCGATGCC

Downstream 100 bases:

>100_bases
TGCTGCGCGCCGCCGCCACTGCCGCGATCGCCCGGCGCGTGTCCGAATGTGTGACCGACGAACTCGTGGCCGATTTCGCA
CGCCACGGTGCAGTGTGCCT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MNANDAILPAATHADPRHDPARVVRAPRGSQLHCRNWLAEAAYRMIQNNLDPDVAENPQSLVVYGGIGRAARNWECFDQI
LASLRTLEADESLLIQSGKPVGVFKTHENAPRVLLANSNLVPKWGTWEHFNELDRKGLFMYGQMTAGSWIYIGAQGIVQG
TFETFVEAGRQHYGNDLSGKWILTAGLGGMGGAQPLAGVLAGACVLAVECKQSSIDFRLRTRYVDKQARDIDDALALIAH
HTARGEAVSIALLGNAAEVLPELARRAKAGGPRPDIVTDQTSAHDLINGYLPVGWTVEQWQAAAADPAQHARLKQAAAQG
CAVHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYRTDAKIKE
LFPENKHTHRWLDMARERIAFQGLPARICWLGLGERHKAALAFNEMVKSGELKAPIVIGRDHLDTGSVASPNRETEAMKD
GTDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTPEAAARLERVLWNDPASGVMRHADAGYDIAI
ATAKKHQLHLPMVK

Sequences:

>Translated_574_residues
MNANDAILPAATHADPRHDPARVVRAPRGSQLHCRNWLAEAAYRMIQNNLDPDVAENPQSLVVYGGIGRAARNWECFDQI
LASLRTLEADESLLIQSGKPVGVFKTHENAPRVLLANSNLVPKWGTWEHFNELDRKGLFMYGQMTAGSWIYIGAQGIVQG
TFETFVEAGRQHYGNDLSGKWILTAGLGGMGGAQPLAGVLAGACVLAVECKQSSIDFRLRTRYVDKQARDIDDALALIAH
HTARGEAVSIALLGNAAEVLPELARRAKAGGPRPDIVTDQTSAHDLINGYLPVGWTVEQWQAAAADPAQHARLKQAAAQG
CAVHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYRTDAKIKE
LFPENKHTHRWLDMARERIAFQGLPARICWLGLGERHKAALAFNEMVKSGELKAPIVIGRDHLDTGSVASPNRETEAMKD
GTDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTPEAAARLERVLWNDPASGVMRHADAGYDIAI
ATAKKHQLHLPMVK
>Mature_574_residues
MNANDAILPAATHADPRHDPARVVRAPRGSQLHCRNWLAEAAYRMIQNNLDPDVAENPQSLVVYGGIGRAARNWECFDQI
LASLRTLEADESLLIQSGKPVGVFKTHENAPRVLLANSNLVPKWGTWEHFNELDRKGLFMYGQMTAGSWIYIGAQGIVQG
TFETFVEAGRQHYGNDLSGKWILTAGLGGMGGAQPLAGVLAGACVLAVECKQSSIDFRLRTRYVDKQARDIDDALALIAH
HTARGEAVSIALLGNAAEVLPELARRAKAGGPRPDIVTDQTSAHDLINGYLPVGWTVEQWQAAAADPAQHARLKQAAAQG
CAVHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYRTDAKIKE
LFPENKHTHRWLDMARERIAFQGLPARICWLGLGERHKAALAFNEMVKSGELKAPIVIGRDHLDTGSVASPNRETEAMKD
GTDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTPEAAARLERVLWNDPASGVMRHADAGYDIAI
ATAKKHQLHLPMVK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=580, Percent_Identity=33.6206896551724, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI260306182, Length=220, Percent_Identity=38.1818181818182, Blast_Score=157, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71997891, Length=568, Percent_Identity=35.7394366197183, Blast_Score=312, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 62293; Mature: 62293

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANDAILPAATHADPRHDPARVVRAPRGSQLHCRNWLAEAAYRMIQNNLDPDVAENPQS
CCCCCCEEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
LVVYGGIGRAARNWECFDQILASLRTLEADESLLIQSGKPVGVFKTHENAPRVLLANSNL
EEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCCEEEEECCCC
VPKWGTWEHFNELDRKGLFMYGQMTAGSWIYIGAQGIVQGTFETFVEAGRQHYGNDLSGK
CCCCCCHHHHHHHCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WILTAGLGGMGGAQPLAGVLAGACVLAVECKQSSIDFRLRTRYVDKQARDIDDALALIAH
EEEEECCCCCCCCHHHHHHHHHHHHEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
HTARGEAVSIALLGNAAEVLPELARRAKAGGPRPDIVTDQTSAHDLINGYLPVGWTVEQW
HCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCCCCHHHH
QAAAADPAQHARLKQAAAQGCAVHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDF
HHHCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEECCCCCHHHHHHHHCHHHHCCC
PGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYRTDAKIKELFPENKHTHRWLDMARERIA
CCCCHHHHCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FQGLPARICWLGLGERHKAALAFNEMVKSGELKAPIVIGRDHLDTGSVASPNRETEAMKD
HCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHC
GTDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTPEAAARLERVL
CCCHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
WNDPASGVMRHADAGYDIAIATAKKHQLHLPMVK
HCCCHHHHHHHCCCCCEEEEEECCCCEEECCCCC
>Mature Secondary Structure
MNANDAILPAATHADPRHDPARVVRAPRGSQLHCRNWLAEAAYRMIQNNLDPDVAENPQS
CCCCCCEEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
LVVYGGIGRAARNWECFDQILASLRTLEADESLLIQSGKPVGVFKTHENAPRVLLANSNL
EEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCCEEEEECCCC
VPKWGTWEHFNELDRKGLFMYGQMTAGSWIYIGAQGIVQGTFETFVEAGRQHYGNDLSGK
CCCCCCHHHHHHHCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WILTAGLGGMGGAQPLAGVLAGACVLAVECKQSSIDFRLRTRYVDKQARDIDDALALIAH
EEEEECCCCCCCCHHHHHHHHHHHHEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
HTARGEAVSIALLGNAAEVLPELARRAKAGGPRPDIVTDQTSAHDLINGYLPVGWTVEQW
HCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCCCCHHHH
QAAAADPAQHARLKQAAAQGCAVHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDF
HHHCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEECCCCCHHHHHHHHCHHHHCCC
PGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYRTDAKIKELFPENKHTHRWLDMARERIA
CCCCHHHHCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FQGLPARICWLGLGERHKAALAFNEMVKSGELKAPIVIGRDHLDTGSVASPNRETEAMKD
HCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHC
GTDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTPEAAARLERVL
CCCHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
WNDPASGVMRHADAGYDIAIATAKKHQLHLPMVK
HCCCHHHHHHHCCCCCEEEEEECCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]