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The map label for this gene is hutH

Identifier: 120611628

GI number: 120611628

Start: 3255187

End: 3256725

Strand: Reverse

Name: hutH

Synonym: Aave_2965

Alternate gene names: 120611628

Gene position: 3256725-3255187 (Counterclockwise)

Preceding gene: 120611629

Following gene: 120611627

Centisome position: 60.84

GC content: 71.67

Gene sequence:

>1539_bases
ATGAGCGCCATGCCCACCCTCGTACTGCACCCCGGCCGGGTCACCCTGGCCGAACTGCGCGCCATCGCCGCCGGCGGCCA
GCGGCTGGCACTGGATGCCTCCGCCCTGGCCGGCATGCGGGCTTCCCAGGCGACGGTGGACCGCATCGCCCTGGAAGAAC
AGGTGGTCTATGGCATCAACACCGGCTTCGGCAAGCTCGCCAGCACGAAGATCGCGCACGACCGGCTGGCCGAGCTGCAG
CGCAACCTGGTGCTCTCGCACAGCGTGGGCACGGGCGATCCGCTGCCGGACGGCGTGGTCCGCATGGTGTTGGCCACCAA
AGCCGTGAGCCTGGCGCGCGGCCATTCGGGCGTGCGCCCGGCCCTGGTCGATGCGCTGCTGGCGCTGGCCAATGCCGACG
TGCTGCCGGTGATTCCCGCCAAGGGCTCGGTGGGGGCTTCGGGCGATCTCGCGCCCCTGGCGCACCTGGCCTGCGTGCTG
ATCGGCGAGGGCGCGGCCCAGGTCGGTGGCCGGATCGTCACCGGGCGCGAGGCCATGGCCGCCGTGGGGCTGGAGCCGTT
CGTGCTGGGTCCCAAGGAAGGCCTGGCCCTGCTCAATGGCACGCAGGTGTCCACCGCGCTGGCGCTGGCGGGACTGTTCG
CGGCCGAGAACGTGTTCGCCGCCGGCCTGGTGTCGGGCTGCCTCACGCTGGAGGCCATCAAGGGCTCGGTCAAGCCCTTC
GACGCGCGCATCCACGAAGCGCGCGGGCAGGCCGGCCAGATCGCCGTCGCCGCCGCCGTGCGCGCGCTGCTGGAAGGCAG
CGCCATCGATCCCTCCCACCCGGACTGCGGCCGCGTGCAGGACCCGTATTCCATCCGCTGCGTGCCCCAGGTCATGGGCG
CCTGCCTGGACAACCTTTCGCATGCCGCCCGCGTGTTGCAGATCGAGGCCAATGCCGCGTCGGACAACCCGCTGGTGTTC
ACGGACACGGGCGAGGTGATCTCCGGCGGCAACTTCCATGCCGAACCGGTCGCCTTCGCGGCGGACATCATCGCTCTGGC
GCTGTCGGAGATCGGCGCCATCTCGGAGCGCCGCCTCGCGCTGCTGCTCGACACGGGCCTGTCGGGCCTGCCGGCCTTCC
TGATCCGGGACAGCGGCGTCAACTCCGGCTTCATGATCGCCCAGGTCACGGCCGCGGCCCTGGCCGCCGAGAACCAGTGC
CTGGCCCACCCCAGCAGCGTGACCAGCCTGCCCACCTCGGCCAACCAGGAAGACCACGTCTCCATGGCCACCTACGCCGC
GCGGCGCCTGCTGGACATGGCGCGCAACACGGCGGTGATCGTGGGCATCGAGGCCATGGCCGCCGCGCAGGGCATGGAGT
TCGACCGCAGCCTGAAATCATCCCCGCTGATCGAGGCGCAGTTCGCCGCCATCCGCGGGCGCGTGGCCTTCCTTGAGCAG
GACCGCTACCTCGCGCCCGACATCGAGGCCATGCGCCTGTGGGCCAGCACCTCGGCGTGGCCCGCGCCGCTCGCGGCCTG
CCTGCCCAGCTTCCAGTAA

Upstream 100 bases:

>100_bases
GCCTGTATATACAAGTTGGTGATTCCGTGGTTCAATGCGCCCGCCGCCGAGAAAAACCGTCGGCCCAGTTGTAGATTGAC
TTGTATATACAGGAAAAGCC

Downstream 100 bases:

>100_bases
TCCCGGTCCGTACACGAACGCCCAAGGAGCGATGCCATGAACGCCAACGACGCCATCCTGCCCGCTGCCACCCACGCAGA
CCCCCGCCACGATCCCGCGC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSAMPTLVLHPGRVTLAELRAIAAGGQRLALDASALAGMRASQATVDRIALEEQVVYGINTGFGKLASTKIAHDRLAELQ
RNLVLSHSVGTGDPLPDGVVRMVLATKAVSLARGHSGVRPALVDALLALANADVLPVIPAKGSVGASGDLAPLAHLACVL
IGEGAAQVGGRIVTGREAMAAVGLEPFVLGPKEGLALLNGTQVSTALALAGLFAAENVFAAGLVSGCLTLEAIKGSVKPF
DARIHEARGQAGQIAVAAAVRALLEGSAIDPSHPDCGRVQDPYSIRCVPQVMGACLDNLSHAARVLQIEANAASDNPLVF
TDTGEVISGGNFHAEPVAFAADIIALALSEIGAISERRLALLLDTGLSGLPAFLIRDSGVNSGFMIAQVTAAALAAENQC
LAHPSSVTSLPTSANQEDHVSMATYAARRLLDMARNTAVIVGIEAMAAAQGMEFDRSLKSSPLIEAQFAAIRGRVAFLEQ
DRYLAPDIEAMRLWASTSAWPAPLAACLPSFQ

Sequences:

>Translated_512_residues
MSAMPTLVLHPGRVTLAELRAIAAGGQRLALDASALAGMRASQATVDRIALEEQVVYGINTGFGKLASTKIAHDRLAELQ
RNLVLSHSVGTGDPLPDGVVRMVLATKAVSLARGHSGVRPALVDALLALANADVLPVIPAKGSVGASGDLAPLAHLACVL
IGEGAAQVGGRIVTGREAMAAVGLEPFVLGPKEGLALLNGTQVSTALALAGLFAAENVFAAGLVSGCLTLEAIKGSVKPF
DARIHEARGQAGQIAVAAAVRALLEGSAIDPSHPDCGRVQDPYSIRCVPQVMGACLDNLSHAARVLQIEANAASDNPLVF
TDTGEVISGGNFHAEPVAFAADIIALALSEIGAISERRLALLLDTGLSGLPAFLIRDSGVNSGFMIAQVTAAALAAENQC
LAHPSSVTSLPTSANQEDHVSMATYAARRLLDMARNTAVIVGIEAMAAAQGMEFDRSLKSSPLIEAQFAAIRGRVAFLEQ
DRYLAPDIEAMRLWASTSAWPAPLAACLPSFQ
>Mature_511_residues
SAMPTLVLHPGRVTLAELRAIAAGGQRLALDASALAGMRASQATVDRIALEEQVVYGINTGFGKLASTKIAHDRLAELQR
NLVLSHSVGTGDPLPDGVVRMVLATKAVSLARGHSGVRPALVDALLALANADVLPVIPAKGSVGASGDLAPLAHLACVLI
GEGAAQVGGRIVTGREAMAAVGLEPFVLGPKEGLALLNGTQVSTALALAGLFAAENVFAAGLVSGCLTLEAIKGSVKPFD
ARIHEARGQAGQIAVAAAVRALLEGSAIDPSHPDCGRVQDPYSIRCVPQVMGACLDNLSHAARVLQIEANAASDNPLVFT
DTGEVISGGNFHAEPVAFAADIIALALSEIGAISERRLALLLDTGLSGLPAFLIRDSGVNSGFMIAQVTAAALAAENQCL
AHPSSVTSLPTSANQEDHVSMATYAARRLLDMARNTAVIVGIEAMAAAQGMEFDRSLKSSPLIEAQFAAIRGRVAFLEQD
RYLAPDIEAMRLWASTSAWPAPLAACLPSFQ

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=494, Percent_Identity=45.1417004048583, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567831, Length=471, Percent_Identity=43.312101910828, Blast_Score=355, Evalue=2e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_ACIAC (A1TRE4)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971306.1
- ProteinModelPortal:   A1TRE4
- SMR:   A1TRE4
- STRING:   A1TRE4
- GeneID:   4669246
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2965
- NMPDR:   fig|397945.5.peg.2523
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   HIEGDER
- ProtClustDB:   PRK09367
- BioCyc:   AAVE397945:AAVE_2965-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 52711; Mature: 52580

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAMPTLVLHPGRVTLAELRAIAAGGQRLALDASALAGMRASQATVDRIALEEQVVYGIN
CCCCCCEEECCCCEEHHHHHHHHCCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHEEEECC
TGFGKLASTKIAHDRLAELQRNLVLSHSVGTGDPLPDGVVRMVLATKAVSLARGHSGVRP
CCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCH
ALVDALLALANADVLPVIPAKGSVGASGDLAPLAHLACVLIGEGAAQVGGRIVTGREAMA
HHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEECCHHHH
AVGLEPFVLGPKEGLALLNGTQVSTALALAGLFAAENVFAAGLVSGCLTLEAIKGSVKPF
HCCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DARIHEARGQAGQIAVAAAVRALLEGSAIDPSHPDCGRVQDPYSIRCVPQVMGACLDNLS
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHH
HAARVLQIEANAASDNPLVFTDTGEVISGGNFHAEPVAFAADIIALALSEIGAISERRLA
HHEEEEEEEECCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
LLLDTGLSGLPAFLIRDSGVNSGFMIAQVTAAALAAENQCLAHPSSVTSLPTSANQEDHV
EEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHCCCCHHCCCCCCCCCCHHH
SMATYAARRLLDMARNTAVIVGIEAMAAAQGMEFDRSLKSSPLIEAQFAAIRGRVAFLEQ
HHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHCEEEEEEC
DRYLAPDIEAMRLWASTSAWPAPLAACLPSFQ
CCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCC
>Mature Secondary Structure 
SAMPTLVLHPGRVTLAELRAIAAGGQRLALDASALAGMRASQATVDRIALEEQVVYGIN
CCCCCEEECCCCEEHHHHHHHHCCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHEEEECC
TGFGKLASTKIAHDRLAELQRNLVLSHSVGTGDPLPDGVVRMVLATKAVSLARGHSGVRP
CCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCH
ALVDALLALANADVLPVIPAKGSVGASGDLAPLAHLACVLIGEGAAQVGGRIVTGREAMA
HHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEECCHHHH
AVGLEPFVLGPKEGLALLNGTQVSTALALAGLFAAENVFAAGLVSGCLTLEAIKGSVKPF
HCCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DARIHEARGQAGQIAVAAAVRALLEGSAIDPSHPDCGRVQDPYSIRCVPQVMGACLDNLS
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHH
HAARVLQIEANAASDNPLVFTDTGEVISGGNFHAEPVAFAADIIALALSEIGAISERRLA
HHEEEEEEEECCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
LLLDTGLSGLPAFLIRDSGVNSGFMIAQVTAAALAAENQCLAHPSSVTSLPTSANQEDHV
EEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHCCCCHHCCCCCCCCCCHHH
SMATYAARRLLDMARNTAVIVGIEAMAAAQGMEFDRSLKSSPLIEAQFAAIRGRVAFLEQ
HHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHCEEEEEEC
DRYLAPDIEAMRLWASTSAWPAPLAACLPSFQ
CCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA