Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 120611523

GI number: 120611523

Start: 3149538

End: 3151457

Strand: Reverse

Name: thrS

Synonym: Aave_2859

Alternate gene names: 120611523

Gene position: 3151457-3149538 (Counterclockwise)

Preceding gene: 120611524

Following gene: 120611522

Centisome position: 58.88

GC content: 63.7

Gene sequence:

>1920_bases
ATGATCCGGATCACGCTTCCCGACAACTCCCAACGCGAATACGCCGGCCCCGTCTCCGTGGCCGACGTGGCCCAGTCCAT
CGGGCCGGGGCTCGCCAAGATGACCGTGGCCGGCAAGGTCGATGGCCGCCTGGTGGATGCCAGCGACGTGATCGACCACG
ACGCGCGCCTGCAGATCATCACTCCCTGGGACCAGGAGGGCGTGGAAATCATCCGCCACTCCTGCGCCCACCTGGTGGGC
CATGCCGTCAAGCAGCTGTACCCGACGGCGAAGATGGTGATCGGCCCGGTGATCGAAGAGGGCTTCTATTACGACATCGC
CTATGAGCGCCCGTTCACGCCCGAAGACCTCGCGGCGATCGAGCAGCGCATGAAGGAGCTCATCGCGCAGGACTACGACG
TCGTCAAGAAGATGACGCCGCGCGACGAGGTGATCCAGGTCTTCCGCGAGCGCGGCGAGGAATACAAGCTGCGCCTCGTG
GAAGACATGCCCGACGAGAAGGCCATGGGCCTGTACTACCACCAGGAATACGTGGACATGTGCCGCGGCCCGCACGTGCC
GAACACCCGCTTCCTGAAGGTGTTCAAGCTCACGCGCGTCTCCGGCGCCTACTGGCGCGGCGATGCCAGGAACGAGCAGC
TGCAGCGCATCTACGGCACCGCCTGGGCCGACAAGAAGGACCTGGAGGCGTACGTCAAGCGCATCGAGGAAGCCGAAAAG
CGCGACCACCGTCGCCTCGGCCGCGAGCTCGACCTGTTCCACATCGACGAGCACTCCCCCGGCACGGTCTTCTGGCATCC
GAAGGGCTGGACGATCTGGCAGGGCGTGGAGCAGTACATGCGCCAGGTGTACCGCGACAACGGCTACCAGGAGGTCAAGG
GCCCGCAGATCCTCGACAAGCACCTCTGGGAGAAAACGGGCCACTGGGACAAGTACCGCGAGAACATGTTCACGACCGAG
AGCGAGAAGCACGACTACGCCCTCAAGCCGATGAACTGCCCCGGCCACATCCTGATCTTCAACCAGGGCGTGAAGAGCTA
CCGCGACCTGCCGCTGCGCTACGGCGAGTTCGGCCAGTGCCACCGCAACGAGCCCACGGGCGGCCTGCACGGCATCATGC
GCGTGCGCGCCTTCACGCAGGACGACGGACACATCTTCTGCACCGAAGACCAGATCCAGCAGGAGTGCATCAACTTCACG
GCCCTGCTGCAGAAGGTGTACAAGGATTTCGGCTTCACCGACATCATCTACAAGGTGGCGACGCGCCCCGAAAAGCGCAT
CGGCTCGGAAGAAAGCTGGGACAAGGCCGAGAATGCCCTCATCGAGAGCCTGAAGGCCTCGGGCTGCGATTACCAGATCG
CGGTGGGCGACGGCGCGTTCTACGGCCCGAAGCTCGAGTACACGCTGCGCGATGCGATCGGCCGCCACTGGCAGTGCGGC
ACGATCCAGGTGGACCCGTCCATGCCGGAGCGCCTGGGGGCGGAATATGTAGGAGAAGATGGCCAGCGCCACCGCCCCAT
CGTGCTGCACCGCGCCATCGTCGGAAGCCTGGAGCGTTTCATCGGCATCCTGATCGAGCAGCACGCCGGTGCACTGCCCG
TCTGGCTGGCCCCGGTGCAGGTGGCGGTGCTCAACATTACCGGCGCGCAGGACGATTACTGTCGCGAAATTGCCGCAAAG
CTCCAAAAAGCGCTGCCGAATCAAGGCCTTAGGGTGGAGCTGGATCTGCGCAACGAGAAGATTACGTATAAAATACGAGA
GCATTCGTTGCAAAAGCTGCCCTATATCCTCGTCGTGGGCGACAAGGAAAAGGCGGCTGGAGCCGTTGCCGTGCGGGCGC
GGGGTAACCGTGATCTGGGTGTGATGCCGCTGGAGGCCTTCATTTCCCTGATCGGGCAGGACATCGCCGACAAGGTCTGA

Upstream 100 bases:

>100_bases
ACTGTTGCCTGCACCCCCGAAAAAGCGCGGACATCGTTCCGCGTTTTTTTTCGCCTTCGCTTTTCTCGCGCATCCTCCCG
TCGAACCAAGGCCCCATCAC

Downstream 100 bases:

>100_bases
TGGATTGCCGGGTACGCCGCAGGATGCCCGCCATGCTGCGGCGTATCGCCACATTTTTCGTGGCTTGTTGATTGAAGGAA
TACAGCCATCGCTACTGAAT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MIRITLPDNSQREYAGPVSVADVAQSIGPGLAKMTVAGKVDGRLVDASDVIDHDARLQIITPWDQEGVEIIRHSCAHLVG
HAVKQLYPTAKMVIGPVIEEGFYYDIAYERPFTPEDLAAIEQRMKELIAQDYDVVKKMTPRDEVIQVFRERGEEYKLRLV
EDMPDEKAMGLYYHQEYVDMCRGPHVPNTRFLKVFKLTRVSGAYWRGDARNEQLQRIYGTAWADKKDLEAYVKRIEEAEK
RDHRRLGRELDLFHIDEHSPGTVFWHPKGWTIWQGVEQYMRQVYRDNGYQEVKGPQILDKHLWEKTGHWDKYRENMFTTE
SEKHDYALKPMNCPGHILIFNQGVKSYRDLPLRYGEFGQCHRNEPTGGLHGIMRVRAFTQDDGHIFCTEDQIQQECINFT
ALLQKVYKDFGFTDIIYKVATRPEKRIGSEESWDKAENALIESLKASGCDYQIAVGDGAFYGPKLEYTLRDAIGRHWQCG
TIQVDPSMPERLGAEYVGEDGQRHRPIVLHRAIVGSLERFIGILIEQHAGALPVWLAPVQVAVLNITGAQDDYCREIAAK
LQKALPNQGLRVELDLRNEKITYKIREHSLQKLPYILVVGDKEKAAGAVAVRARGNRDLGVMPLEAFISLIGQDIADKV

Sequences:

>Translated_639_residues
MIRITLPDNSQREYAGPVSVADVAQSIGPGLAKMTVAGKVDGRLVDASDVIDHDARLQIITPWDQEGVEIIRHSCAHLVG
HAVKQLYPTAKMVIGPVIEEGFYYDIAYERPFTPEDLAAIEQRMKELIAQDYDVVKKMTPRDEVIQVFRERGEEYKLRLV
EDMPDEKAMGLYYHQEYVDMCRGPHVPNTRFLKVFKLTRVSGAYWRGDARNEQLQRIYGTAWADKKDLEAYVKRIEEAEK
RDHRRLGRELDLFHIDEHSPGTVFWHPKGWTIWQGVEQYMRQVYRDNGYQEVKGPQILDKHLWEKTGHWDKYRENMFTTE
SEKHDYALKPMNCPGHILIFNQGVKSYRDLPLRYGEFGQCHRNEPTGGLHGIMRVRAFTQDDGHIFCTEDQIQQECINFT
ALLQKVYKDFGFTDIIYKVATRPEKRIGSEESWDKAENALIESLKASGCDYQIAVGDGAFYGPKLEYTLRDAIGRHWQCG
TIQVDPSMPERLGAEYVGEDGQRHRPIVLHRAIVGSLERFIGILIEQHAGALPVWLAPVQVAVLNITGAQDDYCREIAAK
LQKALPNQGLRVELDLRNEKITYKIREHSLQKLPYILVVGDKEKAAGAVAVRARGNRDLGVMPLEAFISLIGQDIADKV
>Mature_639_residues
MIRITLPDNSQREYAGPVSVADVAQSIGPGLAKMTVAGKVDGRLVDASDVIDHDARLQIITPWDQEGVEIIRHSCAHLVG
HAVKQLYPTAKMVIGPVIEEGFYYDIAYERPFTPEDLAAIEQRMKELIAQDYDVVKKMTPRDEVIQVFRERGEEYKLRLV
EDMPDEKAMGLYYHQEYVDMCRGPHVPNTRFLKVFKLTRVSGAYWRGDARNEQLQRIYGTAWADKKDLEAYVKRIEEAEK
RDHRRLGRELDLFHIDEHSPGTVFWHPKGWTIWQGVEQYMRQVYRDNGYQEVKGPQILDKHLWEKTGHWDKYRENMFTTE
SEKHDYALKPMNCPGHILIFNQGVKSYRDLPLRYGEFGQCHRNEPTGGLHGIMRVRAFTQDDGHIFCTEDQIQQECINFT
ALLQKVYKDFGFTDIIYKVATRPEKRIGSEESWDKAENALIESLKASGCDYQIAVGDGAFYGPKLEYTLRDAIGRHWQCG
TIQVDPSMPERLGAEYVGEDGQRHRPIVLHRAIVGSLERFIGILIEQHAGALPVWLAPVQVAVLNITGAQDDYCREIAAK
LQKALPNQGLRVELDLRNEKITYKIREHSLQKLPYILVVGDKEKAAGAVAVRARGNRDLGVMPLEAFISLIGQDIADKV

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=636, Percent_Identity=38.9937106918239, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI38570111, Length=598, Percent_Identity=39.4648829431438, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI20070344, Length=643, Percent_Identity=36.3919129082426, Blast_Score=400, Evalue=1e-111,
Organism=Escherichia coli, GI1788013, Length=639, Percent_Identity=57.7464788732394, Blast_Score=797, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=632, Percent_Identity=38.7658227848101, Blast_Score=478, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI71984184, Length=632, Percent_Identity=38.7658227848101, Blast_Score=477, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322112, Length=633, Percent_Identity=38.0726698262243, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322654, Length=393, Percent_Identity=39.9491094147583, Blast_Score=302, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24583839, Length=640, Percent_Identity=40, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24583842, Length=640, Percent_Identity=40, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI28574141, Length=640, Percent_Identity=40, Blast_Score=487, Evalue=1e-137,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_ACIAC (A1TR39)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971201.1
- ProteinModelPortal:   A1TR39
- SMR:   A1TR39
- STRING:   A1TR39
- GeneID:   4666402
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2859
- NMPDR:   fig|397945.5.peg.2429
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   A1TR39
- ProtClustDB:   PRK00413
- BioCyc:   AAVE397945:AAVE_2859-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73116; Mature: 73116

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRITLPDNSQREYAGPVSVADVAQSIGPGLAKMTVAGKVDGRLVDASDVIDHDARLQII
CEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEECHHHHHCCCCEEEEE
TPWDQEGVEIIRHSCAHLVGHAVKQLYPTAKMVIGPVIEEGFYYDIAYERPFTPEDLAAI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHH
EQRMKELIAQDYDVVKKMTPRDEVIQVFRERGEEYKLRLVEDMPDEKAMGLYYHQEYVDM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
CRGPHVPNTRFLKVFKLTRVSGAYWRGDARNEQLQRIYGTAWADKKDLEAYVKRIEEAEK
HCCCCCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RDHRRLGRELDLFHIDEHSPGTVFWHPKGWTIWQGVEQYMRQVYRDNGYQEVKGPQILDK
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
HLWEKTGHWDKYRENMFTTESEKHDYALKPMNCPGHILIFNQGVKSYRDLPLRYGEFGQC
HHHHHCCCHHHHHHHCCCCCCCCCCCEECCCCCCCEEEEECCCHHHHHCCCCCCCCCCCC
HRNEPTGGLHGIMRVRAFTQDDGHIFCTEDQIQQECINFTALLQKVYKDFGFTDIIYKVA
CCCCCCCHHHHHHHHHEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TRPEKRIGSEESWDKAENALIESLKASGCDYQIAVGDGAFYGPKLEYTLRDAIGRHWQCG
CCHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEHHHHHCCCCEECC
TIQVDPSMPERLGAEYVGEDGQRHRPIVLHRAIVGSLERFIGILIEQHAGALPVWLAPVQ
EEEECCCCHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEE
VAVLNITGAQDDYCREIAAKLQKALPNQGLRVELDLRNEKITYKIREHSLQKLPYILVVG
EEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEHHHHHHHCCEEEEEC
DKEKAAGAVAVRARGNRDLGVMPLEAFISLIGQDIADKV
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRITLPDNSQREYAGPVSVADVAQSIGPGLAKMTVAGKVDGRLVDASDVIDHDARLQII
CEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEECHHHHHCCCCEEEEE
TPWDQEGVEIIRHSCAHLVGHAVKQLYPTAKMVIGPVIEEGFYYDIAYERPFTPEDLAAI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHH
EQRMKELIAQDYDVVKKMTPRDEVIQVFRERGEEYKLRLVEDMPDEKAMGLYYHQEYVDM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
CRGPHVPNTRFLKVFKLTRVSGAYWRGDARNEQLQRIYGTAWADKKDLEAYVKRIEEAEK
HCCCCCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RDHRRLGRELDLFHIDEHSPGTVFWHPKGWTIWQGVEQYMRQVYRDNGYQEVKGPQILDK
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
HLWEKTGHWDKYRENMFTTESEKHDYALKPMNCPGHILIFNQGVKSYRDLPLRYGEFGQC
HHHHHCCCHHHHHHHCCCCCCCCCCCEECCCCCCCEEEEECCCHHHHHCCCCCCCCCCCC
HRNEPTGGLHGIMRVRAFTQDDGHIFCTEDQIQQECINFTALLQKVYKDFGFTDIIYKVA
CCCCCCCHHHHHHHHHEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TRPEKRIGSEESWDKAENALIESLKASGCDYQIAVGDGAFYGPKLEYTLRDAIGRHWQCG
CCHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEHHHHHCCCCEECC
TIQVDPSMPERLGAEYVGEDGQRHRPIVLHRAIVGSLERFIGILIEQHAGALPVWLAPVQ
EEEECCCCHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEE
VAVLNITGAQDDYCREIAAKLQKALPNQGLRVELDLRNEKITYKIREHSLQKLPYILVVG
EEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEHHHHHHHCCEEEEEC
DKEKAAGAVAVRARGNRDLGVMPLEAFISLIGQDIADKV
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA