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The map label for this gene is aceA [H]

Identifier: 120611524

GI number: 120611524

Start: 3151735

End: 3153054

Strand: Reverse

Name: aceA [H]

Synonym: Aave_2860

Alternate gene names: 120611524

Gene position: 3153054-3151735 (Counterclockwise)

Preceding gene: 120611525

Following gene: 120611523

Centisome position: 58.91

GC content: 65.38

Gene sequence:

>1320_bases
ATGCCCCAAACCTTCAATGAGCAACTGAGCCGTGAACAGCAAATCGCCGCCCTGGAAAAAGACTGGGCGCAGAACCCCCG
CTGGAAGGGGATCAAGCGCGGCTACGGCGCCGCCGATGTCGTGCGGCTCCGCGGCTCCTTCCAGGTCGAACACACGCTGG
CGCGCCGCGGCGCCGAAAAGCTGTGGAACCTCGTCCACAACGAACCCTACGTGAACTGCCTCGGCGCGCTGACCGGCGGC
CAGGCCATGCAGCAGGTCAAGGCCGGCATCAAGGCGATCTACCTGTCCGGCTGGCAGGTGGCCGCCGACAACAACGAGTA
CGCCGCGATGTACCCCGACCAGTCGCTGTACCCCGTGGACTCGGTGCCGAAGGTCGTGGAACGCATCAACAACAGCTTCA
CCCGTGCCGACGAGATCCAGTGGGCCAAGGGCGTGAACCCCGGCGACGCGGGCTTCATCGACTACCACGCCCCGATCGTG
GCCGATGCCGAGGCCGGCTTCGGCGGCGTGCTCAACGCCTATGAACTCATGAAGGCCATGATCCGCGCCGGCGCCGCGGG
CGTGCACTTCGAAGACCAGCTCGCCTCGGTCAAGAAGTGCGGCCACATGGGCGGCAAGGTGCTGGTGCCCACGCAGGAAG
CCGTGCAGAAGCTCATCGCCGCGCGCATGGCTGCCGACGTGTACGGCGTGCCCACCCTGGTCATCGCCCGCACCGACGCC
GAGGCCGCGGACCTCATCACCAGCGATTACGACGAGAACGACAAGCCCTTCCTGACCGGCGAGCGCACCGCCGAAGGCTT
CTACAAAACCCGCAAGGGCATCGACCAGGCCATCAGCCGTGCCGTGGCCTACGCCGACTACGCGGATCTCGTCTGGTGCG
AAACCGGCACGCCGGACCTGGAGTTCGCCCGCAAGTTCGCCGAGGCCGTGCATGCCAAGCACCCGGGCAAGCTGCTCGCT
TACAACTGCTCGCCGTCGTTCAACTGGAAGAAGAACCTCGACGACGCGACCATCGCCAAGTTCCAGCGCGAACTGGGCGC
CATGGGCTACAAGTACCAGTTCATCACGCTGGCCGGCATCCACAGCATGTGGTTCAACATGTTCGACCTGGCGCAGGACT
ACGTGAAGCGCGGCATGTCCGCCTATGTGGAAAAGGTGCAGGAGCCCGAATTCGCGGCCCGCGAGCGCGGCTATACCTTC
GTGTCGCACCAGCAGGAGGTGGGCACGGGCTACTTCGACGAGGTGACCACCGTGATCCAGGGCGGAAAGTCCAGCGTGAC
CGCGCTGACCGGCTCCACCGAGGAAGAGCAGTTCCACTGA

Upstream 100 bases:

>100_bases
AAGACATAAGAGCTTGCGCGGGTCTTCTACAAGACCTAAAGTTGTCTCCAAGGACGGCACACACCGCCTTCGTGTTTTCA
CCCACTTCCTGGAGATGACC

Downstream 100 bases:

>100_bases
CGGGCCCGGTGACCGGCCGCCGCGGGCCGGCCCTTGCGGCCCGCCCGCGGGCACGGGTTAGAATGCCTGCATCAACCACT
TGCAAGGGCGAGAAAGGCAT

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MPQTFNEQLSREQQIAALEKDWAQNPRWKGIKRGYGAADVVRLRGSFQVEHTLARRGAEKLWNLVHNEPYVNCLGALTGG
QAMQQVKAGIKAIYLSGWQVAADNNEYAAMYPDQSLYPVDSVPKVVERINNSFTRADEIQWAKGVNPGDAGFIDYHAPIV
ADAEAGFGGVLNAYELMKAMIRAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLIAARMAADVYGVPTLVIARTDA
EAADLITSDYDENDKPFLTGERTAEGFYKTRKGIDQAISRAVAYADYADLVWCETGTPDLEFARKFAEAVHAKHPGKLLA
YNCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGIHSMWFNMFDLAQDYVKRGMSAYVEKVQEPEFAARERGYTF
VSHQQEVGTGYFDEVTTVIQGGKSSVTALTGSTEEEQFH

Sequences:

>Translated_439_residues
MPQTFNEQLSREQQIAALEKDWAQNPRWKGIKRGYGAADVVRLRGSFQVEHTLARRGAEKLWNLVHNEPYVNCLGALTGG
QAMQQVKAGIKAIYLSGWQVAADNNEYAAMYPDQSLYPVDSVPKVVERINNSFTRADEIQWAKGVNPGDAGFIDYHAPIV
ADAEAGFGGVLNAYELMKAMIRAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLIAARMAADVYGVPTLVIARTDA
EAADLITSDYDENDKPFLTGERTAEGFYKTRKGIDQAISRAVAYADYADLVWCETGTPDLEFARKFAEAVHAKHPGKLLA
YNCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGIHSMWFNMFDLAQDYVKRGMSAYVEKVQEPEFAARERGYTF
VSHQQEVGTGYFDEVTTVIQGGKSSVTALTGSTEEEQFH
>Mature_438_residues
PQTFNEQLSREQQIAALEKDWAQNPRWKGIKRGYGAADVVRLRGSFQVEHTLARRGAEKLWNLVHNEPYVNCLGALTGGQ
AMQQVKAGIKAIYLSGWQVAADNNEYAAMYPDQSLYPVDSVPKVVERINNSFTRADEIQWAKGVNPGDAGFIDYHAPIVA
DAEAGFGGVLNAYELMKAMIRAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLIAARMAADVYGVPTLVIARTDAE
AADLITSDYDENDKPFLTGERTAEGFYKTRKGIDQAISRAVAYADYADLVWCETGTPDLEFARKFAEAVHAKHPGKLLAY
NCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGIHSMWFNMFDLAQDYVKRGMSAYVEKVQEPEFAARERGYTFV
SHQQEVGTGYFDEVTTVIQGGKSSVTALTGSTEEEQFH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=74.5958429561201, Blast_Score=677, Evalue=0.0,
Organism=Escherichia coli, GI1786525, Length=264, Percent_Identity=29.5454545454545, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71982926, Length=416, Percent_Identity=59.6153846153846, Blast_Score=504, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17561814, Length=416, Percent_Identity=59.6153846153846, Blast_Score=503, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6320908, Length=291, Percent_Identity=37.4570446735395, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6325263, Length=252, Percent_Identity=36.1111111111111, Blast_Score=149, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 48590; Mature: 48459

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQTFNEQLSREQQIAALEKDWAQNPRWKGIKRGYGAADVVRLRGSFQVEHTLARRGAEK
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
LWNLVHNEPYVNCLGALTGGQAMQQVKAGIKAIYLSGWQVAADNNEYAAMYPDQSLYPVD
HHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHEEEECCEEEEECCCCEEEECCCCCCCCCH
SVPKVVERINNSFTRADEIQWAKGVNPGDAGFIDYHAPIVADAEAGFGGVLNAYELMKAM
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHH
IRAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLIAARMAADVYGVPTLVIARTDA
HHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCC
EAADLITSDYDENDKPFLTGERTAEGFYKTRKGIDQAISRAVAYADYADLVWCETGTPDL
HHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCH
EFARKFAEAVHAKHPGKLLAYNCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGI
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHH
HSMWFNMFDLAQDYVKRGMSAYVEKVQEPEFAARERGYTFVSHQQEVGTGYFDEVTTVIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEECCHHHHCCCHHHHHHHHHH
GGKSSVTALTGSTEEEQFH
CCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
PQTFNEQLSREQQIAALEKDWAQNPRWKGIKRGYGAADVVRLRGSFQVEHTLARRGAEK
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
LWNLVHNEPYVNCLGALTGGQAMQQVKAGIKAIYLSGWQVAADNNEYAAMYPDQSLYPVD
HHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHEEEECCEEEEECCCCEEEECCCCCCCCCH
SVPKVVERINNSFTRADEIQWAKGVNPGDAGFIDYHAPIVADAEAGFGGVLNAYELMKAM
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHH
IRAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLIAARMAADVYGVPTLVIARTDA
HHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCC
EAADLITSDYDENDKPFLTGERTAEGFYKTRKGIDQAISRAVAYADYADLVWCETGTPDL
HHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCH
EFARKFAEAVHAKHPGKLLAYNCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGI
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHH
HSMWFNMFDLAQDYVKRGMSAYVEKVQEPEFAARERGYTFVSHQQEVGTGYFDEVTTVIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEECCHHHHCCCHHHHHHHHHH
GGKSSVTALTGSTEEEQFH
CCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]