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The map label for this gene is tas [H]

Identifier: 120610529

GI number: 120610529

Start: 2005758

End: 2006819

Strand: Direct

Name: tas [H]

Synonym: Aave_1849

Alternate gene names: 120610529

Gene position: 2005758-2006819 (Clockwise)

Preceding gene: 120610522

Following gene: 120610530

Centisome position: 37.47

GC content: 69.21

Gene sequence:

>1062_bases
ATGCAAAAAGTCACGTTGGGCGCGAGCGCGCTCCAGGTCTCTCCCATCTGCCTCGGAACCATGACCTTCGGCGAGCAGGT
GGGTGAAGCCGACGCCCATGCCATCCTCGACCGCTCGCTGGCGGCCGGCATCGACTTCATCGACACGGCCGAGATGTACG
CCGTGCCGGCGCGTGCCGAAACCTATGGCGCGACCGAATCCATCATCGGCCGCTGGTTCGCGAAGAACCCGGGCGTCCGT
AGCAAGGTCGTGCTCGCCACCAAGGTGGCCGGCCCTTCGCGCGGCATGCCCTGGGTGCGCGAAGGCAAGGGGATGACGGC
GGCCGACATCCAGGCCTCCTGCGAGGGCAGCCTGCGCCGCCTGCAGACGGACGTGATCGACCTCTACCAGATCCACTGGC
CCGAGCGCCACGTGCCCGCGTTCGGCACCCTGTACTACGACCCGCAGAAGGAAACCTCGGCGACGCCCATCCGGGAACAG
CTCGAAGCCCTCGCAAAGCTGGTGCAGGCCGGCAAGGTGCGCTACGTGGGCCTGTCCAACGAGACGCCCTACGGCGTGCA
CGAGTTCGTGCGTCTGGCCGAGGCGCACGGCCTGCCGCGCGTGGCGACGGTGCAGAACCCGTACTGCCTGATCAACCGCA
CCTGGGACAACGCGATGGACGAAACCTGCCATCGCCTGGGCGTGTCGCTGCTGGCCTATTCGCCGCTGGGCTTCGGCCTG
CTGACCGGAAAGTACGACCAGCACGCACCGACCGACCCGGGTGCGCCGCAGGGTGCGCGCATCGCCCGCTACGAGTCGGT
GCGCAAGCAGCGCTGGGGCCGGCCCGAGGCGCTGGCCGCCGCGCGCCGCTACAACCAGCTCGCCCGCGACAACGGCCTGA
CGCCCACGCAGATGGCGCTGGCCTTCTGCTACCGCAACTGGCGGGTGGCCAGCACCATCATCGGCGTGACCTCCCTGGCC
CAGCTGGAGGAGGACATCGCCGCCTGGAACACGCAGCTTTCGCCCGAACTGCTGGCGGCCATCGACGCGATCCGCTGGGA
CATCCGGGACCCCGCGCTGTGA

Upstream 100 bases:

>100_bases
GCAGGACGAGGGATGGGCCTTCGGGCATGGGGCGGTCTGCGGCGTTCGTGAAAATCCATTATTCTCCCCAGCCACTTTCG
CAGCTTGTAGGCCTTATTCC

Downstream 100 bases:

>100_bases
GCCGCAAGGACCGGGCCGCCGCCCACGTCGGCGAGACGCCGGCCACGCAGTTCCTGCGCCGCCACGGCGTGGCGTTCACC
GAGCACCCGTACGAGTACGT

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MQKVTLGASALQVSPICLGTMTFGEQVGEADAHAILDRSLAAGIDFIDTAEMYAVPARAETYGATESIIGRWFAKNPGVR
SKVVLATKVAGPSRGMPWVREGKGMTAADIQASCEGSLRRLQTDVIDLYQIHWPERHVPAFGTLYYDPQKETSATPIREQ
LEALAKLVQAGKVRYVGLSNETPYGVHEFVRLAEAHGLPRVATVQNPYCLINRTWDNAMDETCHRLGVSLLAYSPLGFGL
LTGKYDQHAPTDPGAPQGARIARYESVRKQRWGRPEALAAARRYNQLARDNGLTPTQMALAFCYRNWRVASTIIGVTSLA
QLEEDIAAWNTQLSPELLAAIDAIRWDIRDPAL

Sequences:

>Translated_353_residues
MQKVTLGASALQVSPICLGTMTFGEQVGEADAHAILDRSLAAGIDFIDTAEMYAVPARAETYGATESIIGRWFAKNPGVR
SKVVLATKVAGPSRGMPWVREGKGMTAADIQASCEGSLRRLQTDVIDLYQIHWPERHVPAFGTLYYDPQKETSATPIREQ
LEALAKLVQAGKVRYVGLSNETPYGVHEFVRLAEAHGLPRVATVQNPYCLINRTWDNAMDETCHRLGVSLLAYSPLGFGL
LTGKYDQHAPTDPGAPQGARIARYESVRKQRWGRPEALAAARRYNQLARDNGLTPTQMALAFCYRNWRVASTIIGVTSLA
QLEEDIAAWNTQLSPELLAAIDAIRWDIRDPAL
>Mature_353_residues
MQKVTLGASALQVSPICLGTMTFGEQVGEADAHAILDRSLAAGIDFIDTAEMYAVPARAETYGATESIIGRWFAKNPGVR
SKVVLATKVAGPSRGMPWVREGKGMTAADIQASCEGSLRRLQTDVIDLYQIHWPERHVPAFGTLYYDPQKETSATPIREQ
LEALAKLVQAGKVRYVGLSNETPYGVHEFVRLAEAHGLPRVATVQNPYCLINRTWDNAMDETCHRLGVSLLAYSPLGFGL
LTGKYDQHAPTDPGAPQGARIARYESVRKQRWGRPEALAAARRYNQLARDNGLTPTQMALAFCYRNWRVASTIIGVTSLA
QLEEDIAAWNTQLSPELLAAIDAIRWDIRDPAL

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI4504825, Length=352, Percent_Identity=27.8409090909091, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI27436969, Length=352, Percent_Identity=27.8409090909091, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI27436962, Length=352, Percent_Identity=26.4204545454545, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI27436964, Length=356, Percent_Identity=26.4044943820225, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI27436966, Length=352, Percent_Identity=26.4204545454545, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI27436971, Length=362, Percent_Identity=27.3480662983425, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI41327764, Length=337, Percent_Identity=28.7833827893175, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI223718702, Length=337, Percent_Identity=27.0029673590504, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI41152114, Length=336, Percent_Identity=26.4880952380952, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789199, Length=353, Percent_Identity=45.3257790368272, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87081735, Length=354, Percent_Identity=32.2033898305085, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789375, Length=351, Percent_Identity=30.1994301994302, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788070, Length=352, Percent_Identity=28.9772727272727, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788081, Length=236, Percent_Identity=29.6610169491525, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787674, Length=343, Percent_Identity=25.9475218658892, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6325169, Length=365, Percent_Identity=23.5616438356164, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323998, Length=359, Percent_Identity=24.7910863509749, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319958, Length=325, Percent_Identity=25.2307692307692, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319951, Length=355, Percent_Identity=23.6619718309859, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322615, Length=272, Percent_Identity=22.0588235294118, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 38791; Mature: 38791

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVTLGASALQVSPICLGTMTFGEQVGEADAHAILDRSLAAGIDFIDTAEMYAVPARAE
CCEEECCCHHEEECCCEEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHH
TYGATESIIGRWFAKNPGVRSKVVLATKVAGPSRGMPWVREGKGMTAADIQASCEGSLRR
HCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHHHHH
LQTDVIDLYQIHWPERHVPAFGTLYYDPQKETSATPIREQLEALAKLVQAGKVRYVGLSN
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCC
ETPYGVHEFVRLAEAHGLPRVATVQNPYCLINRTWDNAMDETCHRLGVSLLAYSPLGFGL
CCCCCHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHH
LTGKYDQHAPTDPGAPQGARIARYESVRKQRWGRPEALAAARRYNQLARDNGLTPTQMAL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
AFCYRNWRVASTIIGVTSLAQLEEDIAAWNTQLSPELLAAIDAIRWDIRDPAL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQKVTLGASALQVSPICLGTMTFGEQVGEADAHAILDRSLAAGIDFIDTAEMYAVPARAE
CCEEECCCHHEEECCCEEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHH
TYGATESIIGRWFAKNPGVRSKVVLATKVAGPSRGMPWVREGKGMTAADIQASCEGSLRR
HCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHHHHH
LQTDVIDLYQIHWPERHVPAFGTLYYDPQKETSATPIREQLEALAKLVQAGKVRYVGLSN
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCC
ETPYGVHEFVRLAEAHGLPRVATVQNPYCLINRTWDNAMDETCHRLGVSLLAYSPLGFGL
CCCCCHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHH
LTGKYDQHAPTDPGAPQGARIARYESVRKQRWGRPEALAAARRYNQLARDNGLTPTQMAL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
AFCYRNWRVASTIIGVTSLAQLEEDIAAWNTQLSPELLAAIDAIRWDIRDPAL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9560382; 9278503 [H]