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The map label for this gene is lpxD

Identifier: 120610513

GI number: 120610513

Start: 1987937

End: 1988938

Strand: Direct

Name: lpxD

Synonym: Aave_1833

Alternate gene names: 120610513

Gene position: 1987937-1988938 (Clockwise)

Preceding gene: 120610512

Following gene: 120610514

Centisome position: 37.14

GC content: 69.66

Gene sequence:

>1002_bases
GTGAGCGTGCGTCTCAGGCAGATTGTTGAGGCGCTGGGCGGAACGATCGAAGGAGGCGGCGGCGACGTCGAGATTCTTCG
CATCGCCCCGCTCGAATCGGCGGAGCCGGGCGACCTGGCCTTCCTGAGCAATCCGCGCTACCGCCAACAACTGGCCGCCT
CCCGGGCGGCCTGTGTCATTGTGGCTCCCGCGATGCGCGAGGAAGCGCTGGCGCGCGGCGCGTGCATCGTGGCGGAGGAT
CCCTACGCCTATTTCGCGCGCGCGACGCAGCTCTGGAAGCGCCTGCACGGCCGCACGCCCGCTGCGGGCGTCCATCCGTC
CGCAGTGGTGGATCCGGACGCCTTCGTCGATCCCTCGGCGCACATCGGCCCGCTCTGCGTGGTCGAGCGCGGCGCGCGCA
TCGGCGCAGGCACGGTGCTGACCTCGCGCATCACCGTGGGCGAAGGCTGCCGCATCGGCGAGCGCTGCCTGCTGCACCCG
GGCGTGGTGATCGGCGCGGACGGTTTCGGCTTCGCGGCCGAGGGTGGCGCCTGGACCAAGATCGAGCAGCTCGGCGCCGT
GCGCATCGGCGACGACGTGGAGATCGGGGCCAACACCTGCATCGACCGCGGGGCGCTGGACGACACCGTCATCGAGGACG
GCGTCAAGCTCGACAACCTCGTGCAGATCGGCCACAACGTGCACATCGGGCGGCACACGGCCGTGGCCGGCTGCACCGGC
GTGTCCGGCAGCACGCGCATCGGCGCCCGCTGCATGATCGGCGGCGCGGCGATGATCCTCGGGCATCTGGAGATCGCCGA
CGGCGTGCAGGTATCGCCCGGCACGGCCATCACGCGCTCCGTCCTGAAGCCGGGGCTCTACTCCGGCATGTTTCCCTTCG
ACGAGAATGCGAAGTGGGAAAAGAACGCGGCCACGCTGCGCCAGCTCCACGGGCTGCGCGCGCGCATCATGGCCCTCGAA
GAACAGATACGAAAAGACGGTCCCACCGCACATATCCAATGA

Upstream 100 bases:

>100_bases
CGACATCACCGACAAGGTGATCAAGGCGCTGAATGCGGGCGCTGGCGCCGGTGCGAAGTGATCGCAGCGGCTGCGGGGCG
GCGCGCACGGGGCATCCTGC

Downstream 100 bases:

>100_bases
TGGACATCCACCAAATCCTCAAGCTCCTGCCGCACCGCTATCCCTTCCTGCTGGTGGACCGTGTCGTCGAACTCGAAAGG
GGCGAGCGCATCCAGGCGAT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSVRLRQIVEALGGTIEGGGGDVEILRIAPLESAEPGDLAFLSNPRYRQQLAASRAACVIVAPAMREEALARGACIVAED
PYAYFARATQLWKRLHGRTPAAGVHPSAVVDPDAFVDPSAHIGPLCVVERGARIGAGTVLTSRITVGEGCRIGERCLLHP
GVVIGADGFGFAAEGGAWTKIEQLGAVRIGDDVEIGANTCIDRGALDDTVIEDGVKLDNLVQIGHNVHIGRHTAVAGCTG
VSGSTRIGARCMIGGAAMILGHLEIADGVQVSPGTAITRSVLKPGLYSGMFPFDENAKWEKNAATLRQLHGLRARIMALE
EQIRKDGPTAHIQ

Sequences:

>Translated_333_residues
MSVRLRQIVEALGGTIEGGGGDVEILRIAPLESAEPGDLAFLSNPRYRQQLAASRAACVIVAPAMREEALARGACIVAED
PYAYFARATQLWKRLHGRTPAAGVHPSAVVDPDAFVDPSAHIGPLCVVERGARIGAGTVLTSRITVGEGCRIGERCLLHP
GVVIGADGFGFAAEGGAWTKIEQLGAVRIGDDVEIGANTCIDRGALDDTVIEDGVKLDNLVQIGHNVHIGRHTAVAGCTG
VSGSTRIGARCMIGGAAMILGHLEIADGVQVSPGTAITRSVLKPGLYSGMFPFDENAKWEKNAATLRQLHGLRARIMALE
EQIRKDGPTAHIQ
>Mature_332_residues
SVRLRQIVEALGGTIEGGGGDVEILRIAPLESAEPGDLAFLSNPRYRQQLAASRAACVIVAPAMREEALARGACIVAEDP
YAYFARATQLWKRLHGRTPAAGVHPSAVVDPDAFVDPSAHIGPLCVVERGARIGAGTVLTSRITVGEGCRIGERCLLHPG
VVIGADGFGFAAEGGAWTKIEQLGAVRIGDDVEIGANTCIDRGALDDTVIEDGVKLDNLVQIGHNVHIGRHTAVAGCTGV
SGSTRIGARCMIGGAAMILGHLEIADGVQVSPGTAITRSVLKPGLYSGMFPFDENAKWEKNAATLRQLHGLRARIMALEE
QIRKDGPTAHIQ

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=342, Percent_Identity=39.1812865497076, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1786378, Length=180, Percent_Identity=30.5555555555556, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_ACIAC (A1TN79)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970191.1
- ProteinModelPortal:   A1TN79
- STRING:   A1TN79
- GeneID:   4665538
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1833
- NMPDR:   fig|397945.5.peg.1587
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- PhylomeDB:   A1TN79
- ProtClustDB:   PRK00892
- BioCyc:   AAVE397945:AAVE_1833-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 34968; Mature: 34836

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRLRQIVEALGGTIEGGGGDVEILRIAPLESAEPGDLAFLSNPRYRQQLAASRAACVI
CCCHHHHHHHHHCCEEECCCCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHCCCEEEE
VAPAMREEALARGACIVAEDPYAYFARATQLWKRLHGRTPAAGVHPSAVVDPDAFVDPSA
ECCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCC
HIGPLCVVERGARIGAGTVLTSRITVGEGCRIGERCLLHPGVVIGADGFGFAAEGGAWTK
CCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCEEEECCCEEEECCCCCEECCCCCHHH
IEQLGAVRIGDDVEIGANTCIDRGALDDTVIEDGVKLDNLVQIGHNVHIGRHTAVAGCTG
HHHCCCEEECCCCEECCHHHHCCCCCCHHHHHCCCCHHHHHHHCCEEEECCCEEEEECCC
VSGSTRIGARCMIGGAAMILGHLEIADGVQVSPGTAITRSVLKPGLYSGMFPFDENAKWE
CCCCCCCCCEEEECCHHHHHEEEECCCCCEECCCHHHHHHHHCCCHHCCCCCCCCCCCCC
KNAATLRQLHGLRARIMALEEQIRKDGPTAHIQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SVRLRQIVEALGGTIEGGGGDVEILRIAPLESAEPGDLAFLSNPRYRQQLAASRAACVI
CCHHHHHHHHHCCEEECCCCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHCCCEEEE
VAPAMREEALARGACIVAEDPYAYFARATQLWKRLHGRTPAAGVHPSAVVDPDAFVDPSA
ECCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCC
HIGPLCVVERGARIGAGTVLTSRITVGEGCRIGERCLLHPGVVIGADGFGFAAEGGAWTK
CCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCEEEECCCEEEECCCCCEECCCCCHHH
IEQLGAVRIGDDVEIGANTCIDRGALDDTVIEDGVKLDNLVQIGHNVHIGRHTAVAGCTG
HHHCCCEEECCCCEECCHHHHCCCCCCHHHHHCCCCHHHHHHHCCEEEECCCEEEEECCC
VSGSTRIGARCMIGGAAMILGHLEIADGVQVSPGTAITRSVLKPGLYSGMFPFDENAKWE
CCCCCCCCCEEEECCHHHHHEEEECCCCCEECCCHHHHHHHHCCCHHCCCCCCCCCCCCC
KNAATLRQLHGLRARIMALEEQIRKDGPTAHIQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA