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The map label for this gene is hmrR2 [H]

Identifier: 120610496

GI number: 120610496

Start: 1970987

End: 1971451

Strand: Direct

Name: hmrR2 [H]

Synonym: Aave_1816

Alternate gene names: 120610496

Gene position: 1970987-1971451 (Clockwise)

Preceding gene: 120610488

Following gene: 120610497

Centisome position: 36.82

GC content: 72.26

Gene sequence:

>465_bases
GTGCCCGCCGCAAGCCCCCACCACCGTATCGGCGATGCCGCCCGCCTCTCCGGCGTGCCCACCGCCAACATCCGCTACTA
CGAGAAGGAGGGGCTGCTGCCCGCGCAGGCCCGCGCCGACAACCGCTACCGCCTCTACAGCGACGACGAAATCCACCGCC
TGCGGTTCATCCGCCTGTGCCGCGCCATGGACATGTCGCTGGACGAAGTGCGCACGCTGCTCTCGCTCGGCCGGGGCATG
GACACCGCCGCAGACCATGCGGCCTGCGCCACCGTGGACGAGCACCTGCTGCACGTACGCACCCGCCTGCGGGAGCTGCA
GGCGCTGGAGGCCCAGCTGCTGTCGCTGCGAGGGCGCTGCGACGGCACCGACGGCAGCCGCTGCCACGTGATCGAGGCCC
TCCATGACCGTGCCGATGCCGATCCCCTGCCGCTGCCCGATCCGCCGGCGCGCCGGCATGTGTGA

Upstream 100 bases:

>100_bases
TGCCATGGTGTGTTGTCCTTGCTTGGGGTGAATTCCGACAGGGGTCCGCAGCCGGACCGTGCCATCATTGGAAACCTTCA
AGCCGCTTCAAGGTCAAGCC

Downstream 100 bases:

>100_bases
CCGCCTTCCGTCGATGTCCCCGCAGCCGTCCCTGACCAAAACCCCGACCGCCCGCCGCTTGACGGAGGAGGGCGCATGAG
CACCGCAGCGGGCGCCCTCC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MPAASPHHRIGDAARLSGVPTANIRYYEKEGLLPAQARADNRYRLYSDDEIHRLRFIRLCRAMDMSLDEVRTLLSLGRGM
DTAADHAACATVDEHLLHVRTRLRELQALEAQLLSLRGRCDGTDGSRCHVIEALHDRADADPLPLPDPPARRHV

Sequences:

>Translated_154_residues
MPAASPHHRIGDAARLSGVPTANIRYYEKEGLLPAQARADNRYRLYSDDEIHRLRFIRLCRAMDMSLDEVRTLLSLGRGM
DTAADHAACATVDEHLLHVRTRLRELQALEAQLLSLRGRCDGTDGSRCHVIEALHDRADADPLPLPDPPARRHV
>Mature_153_residues
PAASPHHRIGDAARLSGVPTANIRYYEKEGLLPAQARADNRYRLYSDDEIHRLRFIRLCRAMDMSLDEVRTLLSLGRGMD
TAADHAACATVDEHLLHVRTRLRELQALEAQLLSLRGRCDGTDGSRCHVIEALHDRADADPLPLPDPPARRHV

Specific function: Transcriptional regulator involved in acid tolerance. Binds copper [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=139, Percent_Identity=34.5323741007194, Blast_Score=81, Evalue=3e-17,
Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=30.7086614173228, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 17275; Mature: 17144

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAASPHHRIGDAARLSGVPTANIRYYEKEGLLPAQARADNRYRLYSDDEIHRLRFIRLC
CCCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCHHCCCCCEEECCCCHHHHHHHHHHH
RAMDMSLDEVRTLLSLGRGMDTAADHAACATVDEHLLHVRTRLRELQALEAQLLSLRGRC
HHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGTDGSRCHVIEALHDRADADPLPLPDPPARRHV
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAASPHHRIGDAARLSGVPTANIRYYEKEGLLPAQARADNRYRLYSDDEIHRLRFIRLC
CCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCHHCCCCCEEECCCCHHHHHHHHHHH
RAMDMSLDEVRTLLSLGRGMDTAADHAACATVDEHLLHVRTRLRELQALEAQLLSLRGRC
HHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGTDGSRCHVIEALHDRADADPLPLPDPPARRHV
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431 [H]