Click here to switch to the map view.

The map label for this gene is purM [H]

Identifier: 120599230

GI number: 120599230

Start: 2799031

End: 2800068

Strand: Direct

Name: purM [H]

Synonym: Sputw3181_2426

Alternate gene names: 120599230

Gene position: 2799031-2800068 (Clockwise)

Preceding gene: 120599228

Following gene: 120599231

Centisome position: 59.45

GC content: 46.92

Gene sequence:

>1038_bases
GTGAGCACTCCTACCCCACTGAGCTATAAAGATGCCGGCGTTGATATTGATGCAGGTAATGCACTGGTAAGTAACATTAA
AGCCGCCGTAAAACGTACCCGTCGTCCAGAAGTTATGGGCAACTTAGGTGGTTTTGGCGCTCTGTGTGAAATCCCCACTA
AATACAAACAACCCGTTTTAGTTTCTGGCACCGACGGTGTTGGGACTAAATTACGTTTAGCTATCGACTATAAAAAACAT
GACACTGTCGGCATCGATTTAGTTGCCATGTGTGTGAACGATCTTATCGTTCAAGGCGCTGAGCCACTGTTTTTCCTCGA
TTACTATGCAACGGGCAAACTCGATGTTGAAACTGCAACCTCTGTAGTGAATGGCATCGGCGAAGGTTGTTTCCAATCTG
GTTGTGCGTTAATTGGCGGTGAAACCGCTGAAATGCCAGGCATGTATGAAGGTGAAGATTACGACCTAGCGGGTTTCTGC
GTCGGTGTAGTTGAAAAAGCCGACATCATTGACGGTAGCAAAGTGGCAGCGGGTGATGCACTTATTGCATTAGCCTCAAG
CGGCCCTCATTCAAATGGTTACTCTTTAGTCCGTAAGGTATTAGAAGTAAGCCAAGCAGACCCTCAGCAAGATCTCAATG
GCAAACCGCTAATTGAACATCTCCTTGAGCCAACCAAAATTTACGTAAAATCATTGCTCAAACTGATTGAAGCATCTGAT
ATCCATGCGATGGCGCACATTACTGGCGGTGGCTTCTGGGAGAATATCCCCCGCGTATTGCCAGATAATTGCAAAGCGGT
TATCCAAGGCGACTCATGGCAATGGCCTGCTGTTTTCAGTTGGTTAATGGAAAATGGCAATATTGCCCAGTACGAAATGT
ATCGTACCTTCAACTGTGGCGTCGGCATGATAGTCGCGCTACCTGCCGATAAAGTGGATGCAGCACTTGCATTACTGGCA
GCAGAAGGCGAACAAGCATGGCTTATCGGTGCTATTGCACATCGAGAAGGCAATGAAGAGCAAGTGGAGATCCTGTAA

Upstream 100 bases:

>100_bases
AAATGGGATAAATCCAAATCATGGCTTTCGACCCCTAGCACAAGCTGATAGAATACCGCCGCATAAAATCCAATAACGAT
GTACCCGAGAGGATCCCTCC

Downstream 100 bases:

>100_bases
TGCCCCAGCGCTGTCGTGTAGTAGTCTTAATTTCCGGAAATGGCAGTAACCTGCAAGCGATTATCGACGGTTGTGACGAT
AATCTGCAGGCCGAAGTTGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSTPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVLVSGTDGVGTKLRLAIDYKKH
DTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFC
VGVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIEASD
IHAMAHITGGGFWENIPRVLPDNCKAVIQGDSWQWPAVFSWLMENGNIAQYEMYRTFNCGVGMIVALPADKVDAALALLA
AEGEQAWLIGAIAHREGNEEQVEIL

Sequences:

>Translated_345_residues
MSTPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVLVSGTDGVGTKLRLAIDYKKH
DTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFC
VGVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIEASD
IHAMAHITGGGFWENIPRVLPDNCKAVIQGDSWQWPAVFSWLMENGNIAQYEMYRTFNCGVGMIVALPADKVDAALALLA
AEGEQAWLIGAIAHREGNEEQVEIL
>Mature_344_residues
STPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVLVSGTDGVGTKLRLAIDYKKHD
TVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCV
GVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIEASDI
HAMAHITGGGFWENIPRVLPDNCKAVIQGDSWQWPAVFSWLMENGNIAQYEMYRTFNCGVGMIVALPADKVDAALALLAA
EGEQAWLIGAIAHREGNEEQVEIL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=350, Percent_Identity=46.8571428571429, Blast_Score=325, Evalue=3e-89,
Organism=Homo sapiens, GI209869995, Length=350, Percent_Identity=46.8571428571429, Blast_Score=325, Evalue=3e-89,
Organism=Homo sapiens, GI209869993, Length=350, Percent_Identity=46.8571428571429, Blast_Score=325, Evalue=3e-89,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=74.6355685131195, Blast_Score=541, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17567511, Length=348, Percent_Identity=41.0919540229885, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=342, Percent_Identity=49.1228070175439, Blast_Score=318, Evalue=6e-88,
Organism=Drosophila melanogaster, GI24582400, Length=318, Percent_Identity=42.7672955974843, Blast_Score=238, Evalue=4e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36816; Mature: 36685

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVL
CCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCEECCCCCCCCCEE
VSGTDGVGTKLRLAIDYKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETAT
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEHHHHH
SVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKADIIDGSKVAAGDA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCE
LIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIEASD
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCC
IHAMAHITGGGFWENIPRVLPDNCKAVIQGDSWQWPAVFSWLMENGNIAQYEMYRTFNCG
CEEEEEECCCCHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEEECCC
VGMIVALPADKVDAALALLAAEGEQAWLIGAIAHREGNEEQVEIL
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEC
>Mature Secondary Structure 
STPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCEIPTKYKQPVL
CCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCEECCCCCCCCCEE
VSGTDGVGTKLRLAIDYKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETAT
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEHHHHH
SVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKADIIDGSKVAAGDA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCE
LIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIEHLLEPTKIYVKSLLKLIEASD
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCC
IHAMAHITGGGFWENIPRVLPDNCKAVIQGDSWQWPAVFSWLMENGNIAQYEMYRTFNCG
CEEEEEECCCCHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEEECCC
VGMIVALPADKVDAALALLAAEGEQAWLIGAIAHREGNEEQVEIL
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]