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The map label for this gene is prs [H]

Identifier: 120598498

GI number: 120598498

Start: 1939460

End: 1940347

Strand: Direct

Name: prs [H]

Synonym: Sputw3181_1681

Alternate gene names: 120598498

Gene position: 1939460-1940347 (Clockwise)

Preceding gene: 120598497

Following gene: 120598499

Centisome position: 41.19

GC content: 46.51

Gene sequence:

>888_bases
ATGTCTCAACGTATTCAAACGTCTCAAGATGCTTCTCACGCTCAATGTTCGCAAGCCGATTTTTATCGGTTACCCGCAGC
TAGCGATGAGGCTCACTACCGTTTATTTCAATTTGGTGCGGGGGAAAACCATGTTCAAATACTTGTTCCTCCTGCTAAAC
GAGTAACGATCTTTTTCAGTTATCGGGGCGATCATTCCATCATGCAGCTCTTGTTGTTAACTGATGCACTGCGTCGCAGC
GGTGCAGAGCAAATCGATCTGTTACTGCCTTATATGCCTGGCGCTCGCCAAGATAGGGTGTGTAATCTGGGTGAAGCCTT
GTCGGTAAAAGTCTATGCTAGCCTGATTAATCAGCAGCAATATGCTTCTGTCAGCGTTTTTGACCCTCACAGCGATGTCA
CCGCCGCATTGTTAGACCGAGTTCGGGTAATAGATAACCACAGTTTTGTTGCCGCGATCGCAGCCCAATTAACGGGGGAG
CTAGTGTTAGTCTCGCCCGATGCGGGGGCGAATAAAAAAGTATTCGGCTTAGCTAAAGCGTTACAGGGAATGCCTGTGAT
CAGGGCCGATAAACATCGTGATGTGGTCAATGGCCATATTATCGCTACCGAAGTGTTCTGTGATGACTTGTCGGGTAAAA
CCTGCTTAATCGTTGACGATATTTGCGCAGGTGGCAGAACCTTTATTGAACTTGCCATCAAATTAAAGCAAAAGGGGGCC
CAAAGCGTCATTTTGATCGTGTCACATTATGAAGATAAGGCCAGTGAGTTGGCACTGCGAGAGGCGGGCATAGACAGATT
ATTTTGTACCGATAGTTTAGGTGTCCCTACACATATTTCGAGCGAGTTCTGCCATTGCCATGCTGTTTTGAGTTATATGA
ATCATTAA

Upstream 100 bases:

>100_bases
AAATCAACTTTACATGATAATGTCTTTAAGACACTATTGTTCATGTAGACAACAAGGGCGCCGTCAATTTCGGCAATCTT
GCCACAGACAGGAGGTTACT

Downstream 100 bases:

>100_bases
GGAAAATATTATGTACTTGAATCCCGTTACCGCCATTGATGGCTATAAAGTCGACCACCGTCGTCAATATCCCGATAATA
CTCAAGTGATTTTTAGTAAC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSQRIQTSQDASHAQCSQADFYRLPAASDEAHYRLFQFGAGENHVQILVPPAKRVTIFFSYRGDHSIMQLLLLTDALRRS
GAEQIDLLLPYMPGARQDRVCNLGEALSVKVYASLINQQQYASVSVFDPHSDVTAALLDRVRVIDNHSFVAAIAAQLTGE
LVLVSPDAGANKKVFGLAKALQGMPVIRADKHRDVVNGHIIATEVFCDDLSGKTCLIVDDICAGGRTFIELAIKLKQKGA
QSVILIVSHYEDKASELALREAGIDRLFCTDSLGVPTHISSEFCHCHAVLSYMNH

Sequences:

>Translated_295_residues
MSQRIQTSQDASHAQCSQADFYRLPAASDEAHYRLFQFGAGENHVQILVPPAKRVTIFFSYRGDHSIMQLLLLTDALRRS
GAEQIDLLLPYMPGARQDRVCNLGEALSVKVYASLINQQQYASVSVFDPHSDVTAALLDRVRVIDNHSFVAAIAAQLTGE
LVLVSPDAGANKKVFGLAKALQGMPVIRADKHRDVVNGHIIATEVFCDDLSGKTCLIVDDICAGGRTFIELAIKLKQKGA
QSVILIVSHYEDKASELALREAGIDRLFCTDSLGVPTHISSEFCHCHAVLSYMNH
>Mature_294_residues
SQRIQTSQDASHAQCSQADFYRLPAASDEAHYRLFQFGAGENHVQILVPPAKRVTIFFSYRGDHSIMQLLLLTDALRRSG
AEQIDLLLPYMPGARQDRVCNLGEALSVKVYASLINQQQYASVSVFDPHSDVTAALLDRVRVIDNHSFVAAIAAQLTGEL
VLVSPDAGANKKVFGLAKALQGMPVIRADKHRDVVNGHIIATEVFCDDLSGKTCLIVDDICAGGRTFIELAIKLKQKGAQ
SVILIVSHYEDKASELALREAGIDRLFCTDSLGVPTHISSEFCHCHAVLSYMNH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Escherichia coli, GI1787458, Length=230, Percent_Identity=28.695652173913, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319403, Length=218, Percent_Identity=29.3577981651376, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320946, Length=232, Percent_Identity=28.448275862069, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321776, Length=232, Percent_Identity=27.1551724137931, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 32317; Mature: 32186

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRIQTSQDASHAQCSQADFYRLPAASDEAHYRLFQFGAGENHVQILVPPAKRVTIFFS
CCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEE
YRGDHSIMQLLLLTDALRRSGAEQIDLLLPYMPGARQDRVCNLGEALSVKVYASLINQQQ
ECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHH
YASVSVFDPHSDVTAALLDRVRVIDNHSFVAAIAAQLTGELVLVSPDAGANKKVFGLAKA
HCEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHH
LQGMPVIRADKHRDVVNGHIIATEVFCDDLSGKTCLIVDDICAGGRTFIELAIKLKQKGA
HCCCCCEECCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
QSVILIVSHYEDKASELALREAGIDRLFCTDSLGVPTHISSEFCHCHAVLSYMNH
CEEEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQRIQTSQDASHAQCSQADFYRLPAASDEAHYRLFQFGAGENHVQILVPPAKRVTIFFS
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEE
YRGDHSIMQLLLLTDALRRSGAEQIDLLLPYMPGARQDRVCNLGEALSVKVYASLINQQQ
ECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHH
YASVSVFDPHSDVTAALLDRVRVIDNHSFVAAIAAQLTGELVLVSPDAGANKKVFGLAKA
HCEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHH
LQGMPVIRADKHRDVVNGHIIATEVFCDDLSGKTCLIVDDICAGGRTFIELAIKLKQKGA
HCCCCCEECCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
QSVILIVSHYEDKASELALREAGIDRLFCTDSLGVPTHISSEFCHCHAVLSYMNH
CEEEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA