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The map label for this gene is fabB [H]

Identifier: 120598381

GI number: 120598381

Start: 1780012

End: 1781247

Strand: Direct

Name: fabB [H]

Synonym: Sputw3181_1563

Alternate gene names: 120598381

Gene position: 1780012-1781247 (Clockwise)

Preceding gene: 120598379

Following gene: 120598382

Centisome position: 37.81

GC content: 47.73

Gene sequence:

>1236_bases
ATGTACACAATGGATAGCAATAAAATGAAAAGAGTCGTGATCACCGGAATGGGTGTTGTTTCAAGTATCGGTAATAACAA
GCAAGAAGTGACCGAGTCACTGAAAGCGGGCCGCAGTGGTATTACGCATTCAGCTCAGTTTGAAGAGATGCAATTACGTA
GCCATGTATGGGGTGACATCAAGTTAAACCCTGCTGAGCATATCGATCGTAAGGCATTGCGTTTTATGGGTGATGCGGCA
GCTTATGCCTACATTGCTATGCAAGAAGCGGTTGCCGATGCCAATTTAACCGAAGAGCAGTATTCAGATCCGCGCGTAGG
TTTGATTGTGGGTACAGGCGGCGCATCATCGTCTAACCAAGTTCAATCTGCCGATACACTGCGTGAAAAAGGCGTTAAAC
GTGTTGGTCCGTATATTGTGCCTCGCATCATGTCGAGCACGGCCAGCGCCTGTTTAGCCACGCCATTTAAAATTAAAGGC
ATGAACTATTCTATCAGTTCAGCCTGTGCAACCAGCGCCCATTGTATTGGTCACGCCGTTGAACTTATCCAAATGGGTAA
GCAAGACATGGTGTTTGCCGGTGGTGCTGAAGAAGTGGATTGGACGCTGACCATGGGCTTTGATGCTATGGGCGCACTGT
CAACTAAGTACAATGCCACACCCGAAAAAGCTTCTCGTACCTATGATGCTGACCGTGATGGTTTTGTGATTTCTGGCGGC
GGCGGTATTTTAGTGGTTGAAGAGTTAGAGCATGCTCTGGCTCGCGGCGCAAAAATTTACGCTGAAGTCATTGGTTATGG
CGCGTCTTCAGACGGTTATGACATGGTGGCTCCATCGGGTGAAGGCGCTGTGCGTTGTATGCAAATGGCGATGATGGATG
TCGACACCCCAATCGATTACATCAATACTCACGGCACTTCAACGCCAGTGGGCGACGTGCGTGAATTAGAAGCGCTACGT
GAAGTCTTTAAAGACAAGTGCCCACCGATTGCATCGACTAAGTCTATGACAGGTCATGCATTAGGCGCCGCAGGCGTACA
TGAAGCGATTTACAGCTTAATTATGATGGAAAACAGCTTTATTGCCCCAAGCATCAATATCGAAAATCTGGACGAAGCGG
CGAAAGATATGCCTATCGTGCGTGAATATCGCGATGCTGAGCTGAATACAGTCATGAGTAACAGCTTTGGTTTTGGTGGT
ACAAACGCCACGCTAGTGATGCGTAAATTCAAATAA

Upstream 100 bases:

>100_bases
GGTCTCATAATTGGCATTATTTTACTCGCCTTTATGGAAAGCTGACCACTTAATTGAGTCAAAACAGATACTATTGGCTC
AGCGAAAAGTAGGTACTGAC

Downstream 100 bases:

>100_bases
GTTTGTTTATCAGATACGATAGAAGGGAAGCTTAGGCTTCCCTTTTTTATGAGCATTTTTTGTAAACCTGTTGCATCGAC
AAGGATTTATCCCATTAGTC

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDIKLNPAEHIDRKALRFMGDAA
AYAYIAMQEAVADANLTEEQYSDPRVGLIVGTGGASSSNQVQSADTLREKGVKRVGPYIVPRIMSSTASACLATPFKIKG
MNYSISSACATSAHCIGHAVELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKYNATPEKASRTYDADRDGFVISGG
GGILVVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMAMMDVDTPIDYINTHGTSTPVGDVRELEALR
EVFKDKCPPIASTKSMTGHALGAAGVHEAIYSLIMMENSFIAPSINIENLDEAAKDMPIVREYRDAELNTVMSNSFGFGG
TNATLVMRKFK

Sequences:

>Translated_411_residues
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDIKLNPAEHIDRKALRFMGDAA
AYAYIAMQEAVADANLTEEQYSDPRVGLIVGTGGASSSNQVQSADTLREKGVKRVGPYIVPRIMSSTASACLATPFKIKG
MNYSISSACATSAHCIGHAVELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKYNATPEKASRTYDADRDGFVISGG
GGILVVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMAMMDVDTPIDYINTHGTSTPVGDVRELEALR
EVFKDKCPPIASTKSMTGHALGAAGVHEAIYSLIMMENSFIAPSINIENLDEAAKDMPIVREYRDAELNTVMSNSFGFGG
TNATLVMRKFK
>Mature_411_residues
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDIKLNPAEHIDRKALRFMGDAA
AYAYIAMQEAVADANLTEEQYSDPRVGLIVGTGGASSSNQVQSADTLREKGVKRVGPYIVPRIMSSTASACLATPFKIKG
MNYSISSACATSAHCIGHAVELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKYNATPEKASRTYDADRDGFVISGG
GGILVVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMAMMDVDTPIDYINTHGTSTPVGDVRELEALR
EVFKDKCPPIASTKSMTGHALGAAGVHEAIYSLIMMENSFIAPSINIENLDEAAKDMPIVREYRDAELNTVMSNSFGFGG
TNATLVMRKFK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=35.3080568720379, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI223972627, Length=139, Percent_Identity=41.726618705036, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI41872631, Length=338, Percent_Identity=26.6272189349112, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=70.3703703703704, Blast_Score=591, Evalue=1e-170,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=37.956204379562, Blast_Score=254, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI71983541, Length=418, Percent_Identity=35.4066985645933, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=40, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI212642053, Length=354, Percent_Identity=25.9887005649718, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=356, Percent_Identity=26.123595505618, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=30.9576837416481, Blast_Score=192, Evalue=9e-50,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=37.7403846153846, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI221330659, Length=342, Percent_Identity=27.1929824561404, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19920632, Length=342, Percent_Identity=27.1929824561404, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24581345, Length=345, Percent_Identity=22.3188405797101, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 44115; Mature: 44115

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDI
CCCCCCCCCEEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCE
KLNPAEHIDRKALRFMGDAAAYAYIAMQEAVADANLTEEQYSDPRVGLIVGTGGASSSNQ
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCCCCCC
VQSADTLREKGVKRVGPYIVPRIMSSTASACLATPFKIKGMNYSISSACATSAHCIGHAV
HHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
ELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKYNATPEKASRTYDADRDGFVISGG
HHHHCCCCCEEEECCCCCEEEEEEECCCHHHHCCCCCCCCHHHHHCCCCCCCCCEEEECC
GGILVVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMAMMDVDTPIDY
CCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCHHH
INTHGTSTPVGDVRELEALREVFKDKCPPIASTKSMTGHALGAAGVHEAIYSLIMMENSF
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHCCCC
IAPSINIENLDEAAKDMPIVREYRDAELNTVMSNSFGFGGTNATLVMRKFK
CCCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGDI
CCCCCCCCCEEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCE
KLNPAEHIDRKALRFMGDAAAYAYIAMQEAVADANLTEEQYSDPRVGLIVGTGGASSSNQ
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCCCCCC
VQSADTLREKGVKRVGPYIVPRIMSSTASACLATPFKIKGMNYSISSACATSAHCIGHAV
HHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
ELIQMGKQDMVFAGGAEEVDWTLTMGFDAMGALSTKYNATPEKASRTYDADRDGFVISGG
HHHHCCCCCEEEECCCCCEEEEEEECCCHHHHCCCCCCCCHHHHHCCCCCCCCCEEEECC
GGILVVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMAMMDVDTPIDY
CCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCHHH
INTHGTSTPVGDVRELEALREVFKDKCPPIASTKSMTGHALGAAGVHEAIYSLIMMENSF
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHCCCC
IAPSINIENLDEAAKDMPIVREYRDAELNTVMSNSFGFGGTNATLVMRKFK
CCCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]