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The map label for this gene is (rmlA1 [H]

Identifier: 120598286

GI number: 120598286

Start: 1655105

End: 1655968

Strand: Direct

Name: (rmlA1 [H]

Synonym: Sputw3181_1464

Alternate gene names: 120598286

Gene position: 1655105-1655968 (Clockwise)

Preceding gene: 120598285

Following gene: 120598287

Centisome position: 35.15

GC content: 38.77

Gene sequence:

>864_bases
ATGAAAGGAATTATTTTAGCTGGGGGCTCTGGTACTCGTTTATATCCATTAACACGCGGAGTATCAAAACAGTTATTACC
GATTTATGATAAGCCGATGATTTATTATCCCTTATCAACGCTTATGTTAGCGGGAATTCGGGATATATTAATTATCACAA
CCCCAGAAGATAATGACAGCTTCAAACGTTTACTTGGTAATGGGTCAGATTTTGGTATTAAGTTAAGTTATGCGGTGCAA
CCATCACCTGATGGTTTAGCACAAGCCTTTATCATTGGTGAAGAATTTATCGGTAATTCAAATGTTTGTTTAGTGCTTGG
TGATAATATTTTCTATGGTCAGTCTTTTTCCAAAACACTCAAAAATGCTGCTTCGCGTGAATCAGGAGCAACAGTGTTTG
GCTATCAAGTTAAAGATCCAGAACGTTTTGGCGTAGTCGAATTTGATGCTGATATGAAGGCTATTTCTATTGAAGAAAAG
CCTACAAAACCTAAATCAAACTATGCGGTCACAGGACTTTATTTTTACGACAACAAAGTGGTGGAATTAGCCAAACAGGT
TAAACCTTCCCATCGTGGTGAGCTTGAAATCACCACACTCAATGAGATGTATCTTAATGCTGGCGAGCTTAATGTTGAAT
TATTAGGACGTGGTTTTGCTTGGTTAGATACTGGTACACACGAGAGTTTGCATGAGGCGTCGTCATTTGTACAAACCATT
GAGCATGTTCAAGGGTTAAAGGTGGCTTGTTTAGAAGAAATTTCCTATCGCAATGGCTGGTTAACCGCTGACGAACTTAA
AGAACTCGCCAAACCCATGCTCAAAAATGACTATGGGCAGTATTTAAACCAGTTAGCGCAATAA

Upstream 100 bases:

>100_bases
GCACTTACCAACGCGAGCGTTTAGGCATTTAATCTATTTTATTTTAATGTCCTAGTGTTTCATAAACCTAGGGCCTATTT
ATCTAGGAACTGATTTTACT

Downstream 100 bases:

>100_bases
TTAACGTTATTTCGTAGCCAGCGCACAACTTACACCCTTTATTTGTCATTCCCGCGAAAGCGGAAATCCATTCTTTTACA
TTGTGCTTATATGTTGAACC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNDSFKRLLGNGSDFGIKLSYAVQ
PSPDGLAQAFIIGEEFIGNSNVCLVLGDNIFYGQSFSKTLKNAASRESGATVFGYQVKDPERFGVVEFDADMKAISIEEK
PTKPKSNYAVTGLYFYDNKVVELAKQVKPSHRGELEITTLNEMYLNAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
EHVQGLKVACLEEISYRNGWLTADELKELAKPMLKNDYGQYLNQLAQ

Sequences:

>Translated_287_residues
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNDSFKRLLGNGSDFGIKLSYAVQ
PSPDGLAQAFIIGEEFIGNSNVCLVLGDNIFYGQSFSKTLKNAASRESGATVFGYQVKDPERFGVVEFDADMKAISIEEK
PTKPKSNYAVTGLYFYDNKVVELAKQVKPSHRGELEITTLNEMYLNAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
EHVQGLKVACLEEISYRNGWLTADELKELAKPMLKNDYGQYLNQLAQ
>Mature_287_residues
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNDSFKRLLGNGSDFGIKLSYAVQ
PSPDGLAQAFIIGEEFIGNSNVCLVLGDNIFYGQSFSKTLKNAASRESGATVFGYQVKDPERFGVVEFDADMKAISIEEK
PTKPKSNYAVTGLYFYDNKVVELAKQVKPSHRGELEITTLNEMYLNAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
EHVQGLKVACLEEISYRNGWLTADELKELAKPMLKNDYGQYLNQLAQ

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=247, Percent_Identity=25.1012145748988, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI11761621, Length=247, Percent_Identity=25.1012145748988, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=74.3859649122807, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1788351, Length=286, Percent_Identity=67.8321678321678, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI133931050, Length=226, Percent_Identity=26.5486725663717, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=228, Percent_Identity=26.7543859649123, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21355443, Length=225, Percent_Identity=25.3333333333333, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644084, Length=225, Percent_Identity=25.3333333333333, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 31795; Mature: 31795

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNDS
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FKRLLGNGSDFGIKLSYAVQPSPDGLAQAFIIGEEFIGNSNVCLVLGDNIFYGQSFSKTL
HHHHHCCCCCCCEEEEEEECCCCCHHHEEEEEHHHHCCCCCEEEEECCCEEECCHHHHHH
KNAASRESGATVFGYQVKDPERFGVVEFDADMKAISIEEKPTKPKSNYAVTGLYFYDNKV
HHHHCCCCCCEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCHH
VELAKQVKPSHRGELEITTLNEMYLNAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
HHHHHHCCCCCCCEEEEEEEHHHHCCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHH
EHVQGLKVACLEEISYRNGWLTADELKELAKPMLKNDYGQYLNQLAQ
HHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNDS
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FKRLLGNGSDFGIKLSYAVQPSPDGLAQAFIIGEEFIGNSNVCLVLGDNIFYGQSFSKTL
HHHHHCCCCCCCEEEEEEECCCCCHHHEEEEEHHHHCCCCCEEEEECCCEEECCHHHHHH
KNAASRESGATVFGYQVKDPERFGVVEFDADMKAISIEEKPTKPKSNYAVTGLYFYDNKV
HHHHCCCCCCEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCHH
VELAKQVKPSHRGELEITTLNEMYLNAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
HHHHHHCCCCCCCEEEEEEEHHHHCCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHH
EHVQGLKVACLEEISYRNGWLTADELKELAKPMLKNDYGQYLNQLAQ
HHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]