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The map label for this gene is guaB [H]

Identifier: 120598184

GI number: 120598184

Start: 1541929

End: 1543395

Strand: Direct

Name: guaB [H]

Synonym: Sputw3181_1361

Alternate gene names: 120598184

Gene position: 1541929-1543395 (Clockwise)

Preceding gene: 120598182

Following gene: 120598185

Centisome position: 32.75

GC content: 47.72

Gene sequence:

>1467_bases
ATGCTACGTTTAATTAAAGAAGCGCTTACTTTTGACGATGTGTTACTTGTTCCTGCGCATTCTACTGTACTCCCAAATAC
CGCAGTTCTTAAAACTCGCCTAACCAATACTATCGAACTCAACATTCCGCTTGTGTCTGCCGCTATGGACACAGTTACCG
AAGCTCGCCTTGCGATTGCGATGGCGCAGGAAGGTGGCTTAGGTTTTATTCACAAAAACATGAGTATTGAGAAACAAGCC
GAAGAAGTGCGTAAAGTAAAAATTTACGAAGCTGGCGTGGTTCAACAACCTGTGACAGTGACTCCTTCAACGACACTTGC
TGATCTGAAAGTGTTAACCCTGAAAAACGGTTTTGCCGGTTACCCCGTGGTTAACGAAGCGAATGAGCTTGTCGGTATCA
TTACTGGCCGTGACGTGCGCTTTGTGACGGATTGGAGCAAAACGGTAGAGGAAGTGATGACGCCTAAGTCGCGTTTAGTC
ACCGTTGCTGAAGGCACTAAGTTAGATGAAGTGCAAAAATTAATGCACTCTAACCGTATTGAAAAAGTGCTGGTTGTCGA
TGATAACTTTAAATTAAAAGGGTTGATTACCGTTAAAGACTTCGAGAAAGCCGAGCGTAAACCTAACGCCTGTAAAGATG
AGTTAGGCCGTTTACGCGTGGGCGCCGCCGTTGGTGCGGGTGCCGGCAACGAAGAGCGCGTTGATGCGCTGGTTAAGGCC
GGTGTTGACGTACTGTTGATCGACTCTTCCCATGGACATTCTGAAGGCGTATTACAACGTATTCGCGAAACCCGTGCCAA
GTACCCAGATTTACAAATTGTGGGTGGTAACGTCGCCACGGCTGAAGGTGCTTTAGCCTTAGTTGAAGCGGGTGTTAACG
CTGTTAAAGTGGGTATTGGTCCTGGTTCTATCTGTACAACCCGTATCGTAACCGGTGTTGGTGTGCCCCAAATTACCGCA
GTTTCCGATGCCGCCGAAGCCGTAAAAGGCTTAGGTATTCCTGTGATTGCCGATGGTGGTGTGCGTTTTTCTGGCGACTT
AGCCAAAGCCCTTGCCGCGGGTGCATCTTGTATTATGGCGGGTTCAATGTTTGCTGGTACCGATGAAGCACCAGGCGAAA
CTGAACTCTATCAAGGGCGTGCATATAAATCATACCGTGGTATGGGGTCATTAGGCGCTATGTCTCAAGGCTCTTCTGAT
CGTTATTTCCAATCTGACAATGCTGCCGACAAACTGGTGCCAGAAGGCATTGAAGGCCGCGTGCCTTATAAAGGCAAGCT
TAAGGAAATCATCCATCAACATATGGGTGGTTTACGTTCATGCATGGGCTTAACAGGCTGTGCAACCATTAGCGAGCTGA
ATGAAAAAGCGCAATTTGTAAAAGTGACTTCTGCGGGTATGGGCGAGTCCCATGTACACGATGTGACTATCACTAAAGAA
GCGCCGAACTACCGTTCTGGTTCATAA

Upstream 100 bases:

>100_bases
GGATATTTGCTATTTTCCATTTACCGCGCCCCATATGCAAGGTATAATCCCGCCGCAATATTTCACCTCTAAATCCTACT
CAACTGGGGAGATGTTGCTA

Downstream 100 bases:

>100_bases
ATGTTTGATGTAGTGGGGCGGCAATAAGCCGCCCCACTAACAATATGTGTGATGCTCTCAAGCTTGACGTTGTCAGTTTT
GAGCCAAGTTAAACAATAGA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNTIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEKQA
EEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKSRLV
TVAEGTKLDEVQKLMHSNRIEKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRVPYKGKLKEIIHQHMGGLRSCMGLTGCATISELNEKAQFVKVTSAGMGESHVHDVTITKE
APNYRSGS

Sequences:

>Translated_488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNTIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEKQA
EEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKSRLV
TVAEGTKLDEVQKLMHSNRIEKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRVPYKGKLKEIIHQHMGGLRSCMGLTGCATISELNEKAQFVKVTSAGMGESHVHDVTITKE
APNYRSGS
>Mature_488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNTIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEKQA
EEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKSRLV
TVAEGTKLDEVQKLMHSNRIEKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMAGSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRVPYKGKLKEIIHQHMGGLRSCMGLTGCATISELNEKAQFVKVTSAGMGESHVHDVTITKE
APNYRSGS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=40, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=39.8340248962656, Blast_Score=332, Evalue=6e-91,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=40, Blast_Score=332, Evalue=7e-91,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=40, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=40, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=40.084388185654, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=38.9583333333333, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=36.6666666666667, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=38.2113821138211, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=36.8421052631579, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=36.8421052631579, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=36.8421052631579, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=36.8421052631579, Blast_Score=163, Evalue=4e-40,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=80.327868852459, Blast_Score=745, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=36.1990950226244, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=36.2105263157895, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=38.3886255924171, Blast_Score=258, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=36.9747899159664, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=40.1656314699793, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=39.3004115226337, Blast_Score=332, Evalue=6e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=482, Percent_Identity=40.0414937759336, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.9356725146199, Blast_Score=256, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=122, Percent_Identity=39.344262295082, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=38.9233954451346, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=38.9233954451346, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.4557823129252, Blast_Score=289, Evalue=4e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51677; Mature: 51677

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLIKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNTIELNIPLVSAAMDTVTEARLAIA
CHHHHHHHCCCCCEEEEECCCCCCCCHHHHHEECCCEEEEECCHHHHHHHHHHHHHHEEE
MAQEGGLGFIHKNMSIEKQAEEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAG
EECCCCEEEEECCCCHHHHHHHHHHEEEEECCCCCCCEEECCCCCHHCEEEEEEECCCCC
YPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKSRLVTVAEGTKLDEVQKLMHSNRI
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHCCCC
EKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
CEEEEECCCEEEEEEEEECCHHHHHCCCCHHHHHHCCEEECEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATAEGALALVEAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
CCEECCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
VPYKGKLKEIIHQHMGGLRSCMGLTGCATISELNEKAQFVKVTSAGMGESHVHDVTITKE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEEC
APNYRSGS
CCCCCCCC
>Mature Secondary Structure
MLRLIKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNTIELNIPLVSAAMDTVTEARLAIA
CHHHHHHHCCCCCEEEEECCCCCCCCHHHHHEECCCEEEEECCHHHHHHHHHHHHHHEEE
MAQEGGLGFIHKNMSIEKQAEEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAG
EECCCCEEEEECCCCHHHHHHHHHHEEEEECCCCCCCEEECCCCCHHCEEEEEEECCCCC
YPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKSRLVTVAEGTKLDEVQKLMHSNRI
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHCCCC
EKVLVVDDNFKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
CEEEEECCCEEEEEEEEECCHHHHHCCCCHHHHHHCCEEECEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATAEGALALVEAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAEAVKGLGIPVIADGGVRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTDEAPGETELYQGRAYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
CCEECCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
VPYKGKLKEIIHQHMGGLRSCMGLTGCATISELNEKAQFVKVTSAGMGESHVHDVTITKE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEEC
APNYRSGS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]