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The map label for this gene is guaA

Identifier: 120598185

GI number: 120598185

Start: 1543513

End: 1545090

Strand: Direct

Name: guaA

Synonym: Sputw3181_1362

Alternate gene names: 120598185

Gene position: 1543513-1545090 (Clockwise)

Preceding gene: 120598184

Following gene: 120598186

Centisome position: 32.78

GC content: 47.72

Gene sequence:

>1578_bases
ATGAGCGATATTCATGAGCACAAGATACTGATCCTCGATTTTGGATCCCAGTACACTCAACTGATTGCCCGTCGTATCCG
TGAAATTGGCGTTTACTGCGAATTATGGGCATGGGATGTGACCGAAGCCCAAATCCGTGAGTTTGCCCCTAACGGTATTA
TCCTAGCGGGCGGCCCTGAAAGTGTGACGGCTGAAAATTCTCCCCGTGCACCTGAATATGTCTTTAACGCTGGCATACCT
GTTTTAGGTATTTGCTACGGCATGCAGACTATGTCTGAGCAGTTAGGTGGTAAAGTTATTCAAGGTGTGGGCGAAGGTGA
ATTTGGCTACGCTCAAATTGAAATGCTGACAAAATCTGCGCTGTTCAAAGATATTGAAGATGCAGTCAATAGCGAAGGGA
AACCTCTGCTCGATGTATGGATGAGCCACGGTGATAAAGTCTCTGCGATCCCTGAGGGATTTGTGGCGGTAGCTAAAACC
GATACTTGCCCATTTGCTGCTATGGCTAATGAAGAAAAACGCTTCTATGGCGTACAGTTCCACCCAGAAGTGACCCACAC
TCGTCAAGGCATGCGGATGTTATCGCATTTTGCCTTAGACATCTGTGGCTGTGCCGCCAACTGGAAACCCTCATCGATTA
TTGAAGATGCGATTGAGCGTTTGAAGAAGCAAATCGGCGATGATGAAGTGATTTTAGGCTTGTCTGGTGGTGTCGATTCT
TCGGTTGTAGCTATGTTGCTACACCGCGCGATTGGTAAAAAACTGACCTGCGTATTCGTTGATAACGGTTTATTGCGATT
GAATGAAGCTGCACAAGTGATGGAAATGTTTGGCGATCATTTCGGCCTGAATATCATCCACGTTGATGCGGAAAACCGTT
TCCTCGATGCGATGAAGGGCGTTGCAGATCCAGAAGCAAAACGCAAAATCATCGGCCGTGTATTTGTGGAAATTTTCGAT
GAAGAATCGAAAAAATGCGCCAATGCTAAATGGTTAGCCCAAGGGACTATCTACCCCGATGTGATTGAATCTGCTGGCAG
CGCCACAGGTAAAGCCCATGTGATTAAATCACACCATAACGTCGGCGGTTTGCCAGACGATATGGCGCTCGGCTTAGTTG
AGCCACTGCGTGAACTCTTTAAAGATGAAGTGCGCAAAATTGGTCTTGAGTTAGGTCTGCCTTACAATATGCTTTATCGT
CACCCGTTCCCAGGTCCAGGCTTAGGGGTGCGTGTACTCGGTGAAGTGAAGAAAGAATACTGTGACTTGTTGCGCCGCGC
CGATGCTATCTTCATCGAAGAACTGCATAAAGCCGACTTATACAATAAAGTCAGCCAAGCCTTTACCGTGTTCTTACCTG
TGCGCTCTGTTGGCGTGATGGGCGATGGCCGTAAATATGACTGGGTTGTATCACTGCGCGCAGTGGAAACCATCGATTTT
ATGACGGCACATTGGGCACATCTACCCTATGATTTCTTGGGGCGAGTGTCGAACCGCATCATCAACGAAGTCGATGGCAT
TTCCCGTGTGGTTTACGATATCTCTGGCAAGCCGCCAGCGACTATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GCGGCAATAAGCCGCCCCACTAACAATATGTGTGATGCTCTCAAGCTTGACGTTGTCAGTTTTGAGCCAAGTTAAACAAT
AGATAAAATAAAGGTTATCC

Downstream 100 bases:

>100_bases
GTTAATTATTTGAATTAACGATTAAAAGGCGCCGAGTGCGCCTTTTTTGTTGTTTGATGGATTAACTTAGGCTGAATGAC
TCAGCTGTGAAATATCTGTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPESVTAENSPRAPEYVFNAGIP
VLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTKSALFKDIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKT
DTCPFAAMANEEKRFYGVQFHPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDS
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAAQVMEMFGDHFGLNIIHVDAENRFLDAMKGVADPEAKRKIIGRVFVEIFD
EESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMALGLVEPLRELFKDEVRKIGLELGLPYNMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE

Sequences:

>Translated_525_residues
MSDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPESVTAENSPRAPEYVFNAGIP
VLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTKSALFKDIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKT
DTCPFAAMANEEKRFYGVQFHPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDS
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAAQVMEMFGDHFGLNIIHVDAENRFLDAMKGVADPEAKRKIIGRVFVEIFD
EESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMALGLVEPLRELFKDEVRKIGLELGLPYNMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
>Mature_524_residues
SDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPESVTAENSPRAPEYVFNAGIPV
LGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTKSALFKDIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKTD
TCPFAAMANEEKRFYGVQFHPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDSS
VVAMLLHRAIGKKLTCVFVDNGLLRLNEAAQVMEMFGDHFGLNIIHVDAENRFLDAMKGVADPEAKRKIIGRVFVEIFDE
ESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMALGLVEPLRELFKDEVRKIGLELGLPYNMLYRH
PFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFM
TAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=574, Percent_Identity=34.8432055749129, Blast_Score=289, Evalue=4e-78,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=81.8355640535373, Blast_Score=911, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=579, Percent_Identity=33.8514680483592, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI71992710, Length=579, Percent_Identity=33.8514680483592, Blast_Score=277, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI133901714, Length=579, Percent_Identity=33.8514680483592, Blast_Score=277, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=524, Percent_Identity=49.4274809160305, Blast_Score=531, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=564, Percent_Identity=36.1702127659575, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58193; Mature: 58061

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCEEEECCCC
SVTAENSPRAPEYVFNAGIPVLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTKSA
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHH
LFKDIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKTDTCPFAAMANEEKRFYGVQF
HHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCCCEEEEECCCCCCHHHCCCCCCEEEEEE
HPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAAQVMEMFGDHFGLNIIHVDAENRFLDAMKG
HHHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCC
VADPEAKRKIIGRVFVEIFDEESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPDDMALGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC
>Mature Secondary Structure 
SDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPE
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCEEEECCCC
SVTAENSPRAPEYVFNAGIPVLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTKSA
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHH
LFKDIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKTDTCPFAAMANEEKRFYGVQF
HHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCCCEEEEECCCCCCHHHCCCCCCEEEEEE
HPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAAQVMEMFGDHFGLNIIHVDAENRFLDAMKG
HHHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCC
VADPEAKRKIIGRVFVEIFDEESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPDDMALGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA