Click here to switch to the map view.

The map label for this gene is 120597438

Identifier: 120597438

GI number: 120597438

Start: 663502

End: 664938

Strand: Direct

Name: 120597438

Synonym: Sputw3181_0607

Alternate gene names: NA

Gene position: 663502-664938 (Clockwise)

Preceding gene: 120597437

Following gene: 120597439

Centisome position: 14.09

GC content: 44.47

Gene sequence:

>1437_bases
ATGACACTGCAGTTTTTAGGGGCAACGAGAGAAGTGACAGGTTCGTGCCATTTACTCTCGGTCGATCATGAACATTTATT
ACTCGATTGTGGGTTGATACAGGGCGGTAAAGAAGATGAATTGCGTAATCACGACCCTTTCACTTTCGAGCCCGAGTCTA
TTTCCGCTGTCGTGCTGAGTCATGCCCATATCGATCACTCTGGACGTTTACCTCTGTTAGTCAAATCGGGGTTTGATGGG
CCTATTTATACTCATAAAGCGACGGCTGAACTTTGTGCCATTATGCTTAAAGATGCTGCTATGCTGCAGAGCAGAGATAC
GGAACGTACTAATAAAAAACGGACTAAGCACGATCTTGAGCCTTTAGAACCCTTATTTACCGTTGAAGATGTCGAACAAG
TGATGAGGCAATTTATTCCCTTAGAATACGGCCAAGTGATAAACGTGATCCCCCATGTGGATATTTGTTTGTCGGATGCG
GGGCATATTTTAGGTTCGGCTTTAGTTGAAATTTGGTTAGGTGAAGGTAAGTCGCAGAAAAAAATTGTTTTCAGTGGTGA
TCTTGGCCGTGCAGGTATGCCGATTTTACATAATCCAACCTTAGTTGATACGGCCGATTTAGTGCTAATGGAAAGTACCT
ATGGTGATCGTTTTCACCGGAGTTGGACTGATACCTTAGCAGAGTTGAAAGCCATTTTTACGAAGGCGGTGACAGAAAGC
CACGGTAATATTTTGTTACCCGCATTCTCAGTCGGACGAGCACAAGAGTTACTCTATCTTTTTCATTTATATGCCAAGGA
ATGGGATCTATCCCGTTGGAGAATTTGCCTTGATAGCCCAATGGCGATTGAAGCGACTCGCGTCTATGTTAATAACTACC
AGTTGATGGATGAAGACTTTAAGCATTTTACTCGCCAGTCACCAGGGAAGCATCCACTGCTGTCAAACGTTGAATTTATT
CAAACCACCGAAGAATCAATAGCATTAAATGATATACACAAGGGGCTGATTATTATTGCAGGGAGCGGGATGTGTAATGG
TGGGCGTATTCGTAGCCATTTTGAACATAATCTATGGCGCCCTGAATGTGATGTGATTATTTGTGGCTATCAAGCCAGAG
GCACTCCTGGGCGTGCTTTAGTCGATGGCGCAGAAGAGCTAACCATTCACGGTAACAGTATTAAAGTCGCCGCTAAGCTA
CATACGGTAGGTGGGCTATCTGCCCATGCGGATCAGGCTGAGTTATTACATTGGTATCACCACTTTGATGATCAGCCCCC
CTTAGTTCTCGTCCATGGCGAACCCGAGGCACAGCAGGGGTTAGTCGATGTCATTAACCAAGATCCTAAAACTAGACCTA
AGGATATTGCGATAGCTGCATATGGTGATAAGTTGGATTTAACTGCATTGCCGCGGTTAATGTGGATCACCTCTTAA

Upstream 100 bases:

>100_bases
GACATTACTCGTATGTGATTAATTAATCCTTTTTGTTTTAGGAATAAGGGCATAGTCTATCTTTAATAAGAGGTAAACAC
GGTGGAGGGACACTATGCGA

Downstream 100 bases:

>100_bases
GTTTATGCCCTTCTTTGTAACGCCCTATTTAGTAAGAATAGGGCGTCTTATTTGCTTATAAATCAACGCGCCTTAGGTAT
GGTACCGAATAAATTTATCC

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTLQFLGATREVTGSCHLLSVDHEHLLLDCGLIQGGKEDELRNHDPFTFEPESISAVVLSHAHIDHSGRLPLLVKSGFDG
PIYTHKATAELCAIMLKDAAMLQSRDTERTNKKRTKHDLEPLEPLFTVEDVEQVMRQFIPLEYGQVINVIPHVDICLSDA
GHILGSALVEIWLGEGKSQKKIVFSGDLGRAGMPILHNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFTKAVTES
HGNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRICLDSPMAIEATRVYVNNYQLMDEDFKHFTRQSPGKHPLLSNVEFI
QTTEESIALNDIHKGLIIIAGSGMCNGGRIRSHFEHNLWRPECDVIICGYQARGTPGRALVDGAEELTIHGNSIKVAAKL
HTVGGLSAHADQAELLHWYHHFDDQPPLVLVHGEPEAQQGLVDVINQDPKTRPKDIAIAAYGDKLDLTALPRLMWITS

Sequences:

>Translated_478_residues
MTLQFLGATREVTGSCHLLSVDHEHLLLDCGLIQGGKEDELRNHDPFTFEPESISAVVLSHAHIDHSGRLPLLVKSGFDG
PIYTHKATAELCAIMLKDAAMLQSRDTERTNKKRTKHDLEPLEPLFTVEDVEQVMRQFIPLEYGQVINVIPHVDICLSDA
GHILGSALVEIWLGEGKSQKKIVFSGDLGRAGMPILHNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFTKAVTES
HGNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRICLDSPMAIEATRVYVNNYQLMDEDFKHFTRQSPGKHPLLSNVEFI
QTTEESIALNDIHKGLIIIAGSGMCNGGRIRSHFEHNLWRPECDVIICGYQARGTPGRALVDGAEELTIHGNSIKVAAKL
HTVGGLSAHADQAELLHWYHHFDDQPPLVLVHGEPEAQQGLVDVINQDPKTRPKDIAIAAYGDKLDLTALPRLMWITS
>Mature_477_residues
TLQFLGATREVTGSCHLLSVDHEHLLLDCGLIQGGKEDELRNHDPFTFEPESISAVVLSHAHIDHSGRLPLLVKSGFDGP
IYTHKATAELCAIMLKDAAMLQSRDTERTNKKRTKHDLEPLEPLFTVEDVEQVMRQFIPLEYGQVINVIPHVDICLSDAG
HILGSALVEIWLGEGKSQKKIVFSGDLGRAGMPILHNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFTKAVTESH
GNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRICLDSPMAIEATRVYVNNYQLMDEDFKHFTRQSPGKHPLLSNVEFIQ
TTEESIALNDIHKGLIIIAGSGMCNGGRIRSHFEHNLWRPECDVIICGYQARGTPGRALVDGAEELTIHGNSIKVAAKLH
TVGGLSAHADQAELLHWYHHFDDQPPLVLVHGEPEAQQGLVDVINQDPKTRPKDIAIAAYGDKLDLTALPRLMWITS

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=484, Percent_Identity=26.0330578512397, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI7706427, Length=442, Percent_Identity=26.4705882352941, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI32564696, Length=488, Percent_Identity=25.2049180327869, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI32566029, Length=449, Percent_Identity=26.9487750556793, Blast_Score=107, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323307, Length=450, Percent_Identity=25.1111111111111, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24648013, Length=449, Percent_Identity=28.5077951002227, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI21358523, Length=446, Percent_Identity=28.9237668161435, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 53328; Mature: 53196

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQFLGATREVTGSCHLLSVDHEHLLLDCGLIQGGKEDELRNHDPFTFEPESISAVVLS
CEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCEEEEEE
HAHIDHSGRLPLLVKSGFDGPIYTHKATAELCAIMLKDAAMLQSRDTERTNKKRTKHDLE
EEECCCCCCCEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
PLEPLFTVEDVEQVMRQFIPLEYGQVINVIPHVDICLSDAGHILGSALVEIWLGEGKSQK
CCCHHEEHHHHHHHHHHHCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCC
KIVFSGDLGRAGMPILHNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFTKAVTES
EEEEECCCCCCCCCEECCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
HGNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRICLDSPMAIEATRVYVNNYQLMDEDF
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEECEEEHHHHH
KHFTRQSPGKHPLLSNVEFIQTTEESIALNDIHKGLIIIAGSGMCNGGRIRSHFEHNLWR
HHHHHCCCCCCCCCCCCHHEEECCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCCC
PECDVIICGYQARGTPGRALVDGAEELTIHGNSIKVAAKLHTVGGLSAHADQAELLHWYH
CCCCEEEECCCCCCCCCCHHHCCCCEEEEECCEEEEEEEEEECCCCCCCCCHHHHHHHHH
HFDDQPPLVLVHGEPEAQQGLVDVINQDPKTRPKDIAIAAYGDKLDLTALPRLMWITS
HCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHCCCEEEECC
>Mature Secondary Structure 
TLQFLGATREVTGSCHLLSVDHEHLLLDCGLIQGGKEDELRNHDPFTFEPESISAVVLS
EEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCEEEEEE
HAHIDHSGRLPLLVKSGFDGPIYTHKATAELCAIMLKDAAMLQSRDTERTNKKRTKHDLE
EEECCCCCCCEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
PLEPLFTVEDVEQVMRQFIPLEYGQVINVIPHVDICLSDAGHILGSALVEIWLGEGKSQK
CCCHHEEHHHHHHHHHHHCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCC
KIVFSGDLGRAGMPILHNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFTKAVTES
EEEEECCCCCCCCCEECCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
HGNILLPAFSVGRAQELLYLFHLYAKEWDLSRWRICLDSPMAIEATRVYVNNYQLMDEDF
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEECEEEHHHHH
KHFTRQSPGKHPLLSNVEFIQTTEESIALNDIHKGLIIIAGSGMCNGGRIRSHFEHNLWR
HHHHHCCCCCCCCCCCCHHEEECCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCCC
PECDVIICGYQARGTPGRALVDGAEELTIHGNSIKVAAKLHTVGGLSAHADQAELLHWYH
CCCCEEEECCCCCCCCCCHHHCCCCEEEEECCEEEEEEEEEECCCCCCCCCHHHHHHHHH
HFDDQPPLVLVHGEPEAQQGLVDVINQDPKTRPKDIAIAAYGDKLDLTALPRLMWITS
HCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA