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The map label for this gene is frmA [H]

Identifier: 119947132

GI number: 119947132

Start: 4348364

End: 4349494

Strand: Direct

Name: frmA [H]

Synonym: Ping_3530

Alternate gene names: 119947132

Gene position: 4348364-4349494 (Clockwise)

Preceding gene: 119947130

Following gene: 119947133

Centisome position: 95.37

GC content: 43.24

Gene sequence:

>1131_bases
ATGACAGAGAAATATATTAAATCCAAAGCAGCAATAGCATGGGGACCTAATCAGCCATTAAGCATTGAAGAAATTGATGT
CATGCTCCCTAAAAAAGGGGAAGTATTAGTGAAAATTATTGCTTCCGGTGTTTGTCATACGGATGCATTTACCTTATCAG
GCGAAGATCCAGAAGGTATATTTCCTTGTGTATTAGGCCATGAAGGTGGCGGTATTGTTGAACAGATTGGCGAAGGAGTG
ACCAGTGTAAAACTCGGCGACCATGTTATTCCGTTATACACACCGGAATGTGGTGAGTGTAAGTTCTGTCTTTCTGGAAA
AACCAACCTTTGTCAGAAAATTCGTGAAACTCAGGGTAAAGGTTTAATGCCCGACGGCACCACTCGCTTTTATAAAGATG
GTCAACCTATCTACCATTACATGGGCTGTTCAACTTTCTCAGAATATACAGTATTGCCTGAAATCTCCTTGGCTAAGGTT
AATAAAGCCGCACCGCTTGAAGAGGTCTGTTTACTCGGTTGCGGAGTGACAACCGGCATGGGCGCTGTTATGAATACGGC
CAAAGTAGAGGAAGGCGCAACCGTTGCCATCTTTGGCTTAGGCGGCATTGGCCTTTCAGCTGTGATCGGTGCAACCATGG
CAAAAGCAAGCCGAATCATCGCCATCGATATTAATGAAAGTAAATTTGAGCTGGCAAAAAAATTGGGTGCAACGGATTGT
ATTAATCCGAAAGATTTCGATAAAGCCATTCAAGATGTGATTGTTGAAATGACTGACGGCGGTGTGGATTATTCCTTTGA
ATGTATCGGCAATGTGGATGTGATGCGTAGCGCACTGGAATGCTGCCATAAAGGCTGGGGTGAATCGATTATTATTGGTG
TTGCCGGTGCAGGGAAAGAAATATCAACCCGTCCATTCCAATTGGTGACCGGGCGAGTATGGAAAGGCAGTGCATTTGGT
GGTGTCAAAGGACGTACTGAATTGCCTGATTATGTTGAGCGCTATTTACAGGGGGAATTTAAATTATCGGATTTTATTAC
TCACACTATGCCATTAGAAGATGTCAATGAAGCCTTTGAGCTGATGCATAAAGGTGAAAGTATCCGCAGCGTTATTCACT
TTGCTAAATAA

Upstream 100 bases:

>100_bases
AAGTTAAATAAAACAGTAACACTCAGACCAAGTTAAGCAGCAGATTCGTATGCTAAGATAATATACCTACTGAAACACAC
CAAAAATCACCGGAGCTCAT

Downstream 100 bases:

>100_bases
TCTCATTTCGGAATAAGCAACACAACTGAGGTTAAATAACCATCCTGATATTAATCGTTTCTAAATTTTTAGAAACGGTT
TTTTAACAATCTGGGAAAAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTEKYIKSKAAIAWGPNQPLSIEEIDVMLPKKGEVLVKIIASGVCHTDAFTLSGEDPEGIFPCVLGHEGGGIVEQIGEGV
TSVKLGDHVIPLYTPECGECKFCLSGKTNLCQKIRETQGKGLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKV
NKAAPLEEVCLLGCGVTTGMGAVMNTAKVEEGATVAIFGLGGIGLSAVIGATMAKASRIIAIDINESKFELAKKLGATDC
INPKDFDKAIQDVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESIIIGVAGAGKEISTRPFQLVTGRVWKGSAFG
GVKGRTELPDYVERYLQGEFKLSDFITHTMPLEDVNEAFELMHKGESIRSVIHFAK

Sequences:

>Translated_376_residues
MTEKYIKSKAAIAWGPNQPLSIEEIDVMLPKKGEVLVKIIASGVCHTDAFTLSGEDPEGIFPCVLGHEGGGIVEQIGEGV
TSVKLGDHVIPLYTPECGECKFCLSGKTNLCQKIRETQGKGLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKV
NKAAPLEEVCLLGCGVTTGMGAVMNTAKVEEGATVAIFGLGGIGLSAVIGATMAKASRIIAIDINESKFELAKKLGATDC
INPKDFDKAIQDVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESIIIGVAGAGKEISTRPFQLVTGRVWKGSAFG
GVKGRTELPDYVERYLQGEFKLSDFITHTMPLEDVNEAFELMHKGESIRSVIHFAK
>Mature_375_residues
TEKYIKSKAAIAWGPNQPLSIEEIDVMLPKKGEVLVKIIASGVCHTDAFTLSGEDPEGIFPCVLGHEGGGIVEQIGEGVT
SVKLGDHVIPLYTPECGECKFCLSGKTNLCQKIRETQGKGLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKVN
KAAPLEEVCLLGCGVTTGMGAVMNTAKVEEGATVAIFGLGGIGLSAVIGATMAKASRIIAIDINESKFELAKKLGATDCI
NPKDFDKAIQDVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESIIIGVAGAGKEISTRPFQLVTGRVWKGSAFGG
VKGRTELPDYVERYLQGEFKLSDFITHTMPLEDVNEAFELMHKGESIRSVIHFAK

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=64.247311827957, Blast_Score=500, Evalue=1e-142,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=51.4824797843666, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=50.1347708894879, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=50.1347708894879, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=51.4666666666667, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=49.5956873315364, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=49.5934959349593, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=47.9784366576819, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=48.2191780821918, Blast_Score=369, Evalue=1e-102,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=69.3766937669377, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1790045, Length=360, Percent_Identity=27.5, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082125, Length=369, Percent_Identity=25.4742547425474, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788073, Length=382, Percent_Identity=26.9633507853403, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787863, Length=361, Percent_Identity=24.9307479224377, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87081918, Length=349, Percent_Identity=30.0859598853868, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786825, Length=398, Percent_Identity=24.6231155778894, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788407, Length=230, Percent_Identity=28.2608695652174, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=374, Percent_Identity=24.0641711229947, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI226510992, Length=365, Percent_Identity=23.013698630137, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=377, Percent_Identity=60.2122015915119, Blast_Score=478, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI71997431, Length=379, Percent_Identity=59.8944591029024, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=59.4752186588921, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17562582, Length=363, Percent_Identity=28.099173553719, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=361, Percent_Identity=27.9778393351801, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=362, Percent_Identity=27.0718232044199, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=60.0536193029491, Blast_Score=477, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6323099, Length=376, Percent_Identity=28.9893617021277, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319621, Length=378, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=367, Percent_Identity=29.4277929155313, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=377, Percent_Identity=28.1167108753316, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=368, Percent_Identity=29.6195652173913, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=29.0055248618785, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=29.0055248618785, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=226, Percent_Identity=27.4336283185841, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=276, Percent_Identity=25, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=64.0750670241287, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI17137530, Length=348, Percent_Identity=26.4367816091954, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17737897, Length=373, Percent_Identity=24.6648793565684, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 40419; Mature: 40288

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKYIKSKAAIAWGPNQPLSIEEIDVMLPKKGEVLVKIIASGVCHTDAFTLSGEDPEGI
CCCHHHHCCCEEEECCCCCCCHHHEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCCCC
FPCVLGHEGGGIVEQIGEGVTSVKLGDHVIPLYTPECGECKFCLSGKTNLCQKIRETQGK
EEEEEECCCCCHHHHHCCCCEEEEECCEEEEEECCCCCCEEEEECCCHHHHHHHHHHCCC
GLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKVNKAAPLEEVCLLGCGVTTGM
CCCCCCCCHHCCCCCCEEEEECCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHH
GAVMNTAKVEEGATVAIFGLGGIGLSAVIGATMAKASRIIAIDINESKFELAKKLGATDC
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHCCCCCC
INPKDFDKAIQDVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESIIIGVAGAGKE
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
ISTRPFQLVTGRVWKGSAFGGVKGRTELPDYVERYLQGEFKLSDFITHTMPLEDVNEAFE
CCCCCEEEEECCEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
LMHKGESIRSVIHFAK
HHHCCHHHHHHHHHCC
>Mature Secondary Structure 
TEKYIKSKAAIAWGPNQPLSIEEIDVMLPKKGEVLVKIIASGVCHTDAFTLSGEDPEGI
CCHHHHCCCEEEECCCCCCCHHHEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCCCC
FPCVLGHEGGGIVEQIGEGVTSVKLGDHVIPLYTPECGECKFCLSGKTNLCQKIRETQGK
EEEEEECCCCCHHHHHCCCCEEEEECCEEEEEECCCCCCEEEEECCCHHHHHHHHHHCCC
GLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKVNKAAPLEEVCLLGCGVTTGM
CCCCCCCCHHCCCCCCEEEEECCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHH
GAVMNTAKVEEGATVAIFGLGGIGLSAVIGATMAKASRIIAIDINESKFELAKKLGATDC
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHCCCCCC
INPKDFDKAIQDVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESIIIGVAGAGKE
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
ISTRPFQLVTGRVWKGSAFGGVKGRTELPDYVERYLQGEFKLSDFITHTMPLEDVNEAFE
CCCCCEEEEECCEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
LMHKGESIRSVIHFAK
HHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]