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The map label for this gene is lpxB

Identifier: 119946584

GI number: 119946584

Start: 3655140

End: 3656285

Strand: Reverse

Name: lpxB

Synonym: Ping_2963

Alternate gene names: 119946584

Gene position: 3656285-3655140 (Counterclockwise)

Preceding gene: 119946585

Following gene: 119946583

Centisome position: 80.19

GC content: 41.97

Gene sequence:

>1146_bases
ATGAATAAACCATTAAGAATAGGTTTAATTGCCGGTGAAGCTTCAGGTGACATCCTAGGTGAAGGTTTAATTAAAGCATT
AAAAATACATTATCCCGATGCTGTTTTCGAAGGGATCGCCGGGCCAAAAATGATTGCGCAGGGCTGTACGGCTTTGCACC
CGCTGGAGGCCTTGTCGGTGATGGGATTTGTTGAAGTGCTGGGCAAATTAGGCAGTATTTTACGTATTCGTAAGTCTATT
ATTAACCATTTTATCGCTAACCCACCGGATATTTTTATTGGTATTGATGCACCAGATTTTAACCTGACCGTCGAGCTTAA
ATTAAAACAACATAATATCAAAACAATCCATTATGTAAGCCCTTCTGTCTGGGCTTGGAAGCAGTGGCGTATTCATAAAA
TTGCAAAAGCCACGGATCTGGTCTTAGCTTTTTTGCCCTTCGAAAAAGCGTTTTATGATAGATTTGATGTGCCTTGCCGG
TTTATTGGCCATACGCTTGCGGATCAATTACCGCTTGAACCTGAAAAGCAACAAGCTAGGCAAAGCTTAGGTCTTCAGGC
CGATGCTAAATTACTGGCTATTTTACCCGGTAGCCGAAAAGCCGAAGTTGAAATTTTAGGTCCCATATTTTTACAGTCGG
CAGCGTTAATCAGCAGACAATACCCGGACTACAAATTTATTGTCCCTATGGTCAATGGGGCACGTAAAAAACAACTTTTA
GAACAACAACAGCAATATGCACCTGATTTACCCCTACAAATTTTTGACGGTCAGGCAAGCGCTGTTCTACAGTCAGCTGA
TGCTGTACTGCTTGCTTCGGGCACGGCAGCATTAGAGGCAATGCTCGCTAAAGTGCCGATGGTGGTTGCCTATAAAGTGA
ACCTTCTTACTTATGTTATTGCCAAAGCCTTAGTAAAGGTTAAATATACGTCATTGCCGAACTTAATCGCCGATAAAGAA
ATTGTAAAAGAGCTCAGTCAATATAATTGTACTGTGGAAAATATCGTCGCAGCATTACAGCCCTTATTGGGCCAAGACAA
CCACCAGATGATCAATACTTTTATCCGCCTGCACAAGTTGATTCGTTGCGATGCTGATCGGCAAGCAGCCCAGGCTGTGG
TTGATGTGTTAAATAATAAAAAATAA

Upstream 100 bases:

>100_bases
GTGAAGAAAGTCGCGGCATTGTTCGTTAAGCATTTTGTGCTTTAGTTTTATATTTAAAATAGGCTCATTAGAGCCTTTTT
TTTTAAGAGCGAATTAAAAT

Downstream 100 bases:

>100_bases
TAAATAGTAATAGAGCATAATATGAGTAAATTGAAAATTGACTTTCCAGCTGTTGTGTATCCCGATTTTACTTTGATTGC
CGGTGTTGATGAGGTGGGTC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MNKPLRIGLIAGEASGDILGEGLIKALKIHYPDAVFEGIAGPKMIAQGCTALHPLEALSVMGFVEVLGKLGSILRIRKSI
INHFIANPPDIFIGIDAPDFNLTVELKLKQHNIKTIHYVSPSVWAWKQWRIHKIAKATDLVLAFLPFEKAFYDRFDVPCR
FIGHTLADQLPLEPEKQQARQSLGLQADAKLLAILPGSRKAEVEILGPIFLQSAALISRQYPDYKFIVPMVNGARKKQLL
EQQQQYAPDLPLQIFDGQASAVLQSADAVLLASGTAALEAMLAKVPMVVAYKVNLLTYVIAKALVKVKYTSLPNLIADKE
IVKELSQYNCTVENIVAALQPLLGQDNHQMINTFIRLHKLIRCDADRQAAQAVVDVLNNKK

Sequences:

>Translated_381_residues
MNKPLRIGLIAGEASGDILGEGLIKALKIHYPDAVFEGIAGPKMIAQGCTALHPLEALSVMGFVEVLGKLGSILRIRKSI
INHFIANPPDIFIGIDAPDFNLTVELKLKQHNIKTIHYVSPSVWAWKQWRIHKIAKATDLVLAFLPFEKAFYDRFDVPCR
FIGHTLADQLPLEPEKQQARQSLGLQADAKLLAILPGSRKAEVEILGPIFLQSAALISRQYPDYKFIVPMVNGARKKQLL
EQQQQYAPDLPLQIFDGQASAVLQSADAVLLASGTAALEAMLAKVPMVVAYKVNLLTYVIAKALVKVKYTSLPNLIADKE
IVKELSQYNCTVENIVAALQPLLGQDNHQMINTFIRLHKLIRCDADRQAAQAVVDVLNNKK
>Mature_381_residues
MNKPLRIGLIAGEASGDILGEGLIKALKIHYPDAVFEGIAGPKMIAQGCTALHPLEALSVMGFVEVLGKLGSILRIRKSI
INHFIANPPDIFIGIDAPDFNLTVELKLKQHNIKTIHYVSPSVWAWKQWRIHKIAKATDLVLAFLPFEKAFYDRFDVPCR
FIGHTLADQLPLEPEKQQARQSLGLQADAKLLAILPGSRKAEVEILGPIFLQSAALISRQYPDYKFIVPMVNGARKKQLL
EQQQQYAPDLPLQIFDGQASAVLQSADAVLLASGTAALEAMLAKVPMVVAYKVNLLTYVIAKALVKVKYTSLPNLIADKE
IVKELSQYNCTVENIVAALQPLLGQDNHQMINTFIRLHKLIRCDADRQAAQAVVDVLNNKK

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=377, Percent_Identity=56.763925729443, Blast_Score=433, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_PSYIN (A1SYV0)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944264.1
- STRING:   A1SYV0
- GeneID:   4623479
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2963
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   A1SYV0
- BioCyc:   PING357804:PING_2963-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42088; Mature: 42088

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPLRIGLIAGEASGDILGEGLIKALKIHYPDAVFEGIAGPKMIAQGCTALHPLEALSV
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCHHHHHHHHHHH
MGFVEVLGKLGSILRIRKSIINHFIANPPDIFIGIDAPDFNLTVELKLKQHNIKTIHYVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCEEEEEC
PSVWAWKQWRIHKIAKATDLVLAFLPFEKAFYDRFDVPCRFIGHTLADQLPLEPEKQQAR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHH
QSLGLQADAKLLAILPGSRKAEVEILGPIFLQSAALISRQYPDYKFIVPMVNGARKKQLL
HHCCCCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
EQQQQYAPDLPLQIFDGQASAVLQSADAVLLASGTAALEAMLAKVPMVVAYKVNLLTYVI
HHHHHHCCCCCEEEECCCHHHHHHHCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHH
AKALVKVKYTSLPNLIADKEIVKELSQYNCTVENIVAALQPLLGQDNHQMINTFIRLHKL
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IRCDADRQAAQAVVDVLNNKK
HHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKPLRIGLIAGEASGDILGEGLIKALKIHYPDAVFEGIAGPKMIAQGCTALHPLEALSV
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCHHHHHHHHHHH
MGFVEVLGKLGSILRIRKSIINHFIANPPDIFIGIDAPDFNLTVELKLKQHNIKTIHYVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCEEEEEC
PSVWAWKQWRIHKIAKATDLVLAFLPFEKAFYDRFDVPCRFIGHTLADQLPLEPEKQQAR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHH
QSLGLQADAKLLAILPGSRKAEVEILGPIFLQSAALISRQYPDYKFIVPMVNGARKKQLL
HHCCCCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
EQQQQYAPDLPLQIFDGQASAVLQSADAVLLASGTAALEAMLAKVPMVVAYKVNLLTYVI
HHHHHHCCCCCEEEECCCHHHHHHHCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHH
AKALVKVKYTSLPNLIADKEIVKELSQYNCTVENIVAALQPLLGQDNHQMINTFIRLHKL
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IRCDADRQAAQAVVDVLNNKK
HHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA