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The map label for this gene is lpxA

Identifier: 119946585

GI number: 119946585

Start: 3656357

End: 3657145

Strand: Reverse

Name: lpxA

Synonym: Ping_2964

Alternate gene names: 119946585

Gene position: 3657145-3656357 (Counterclockwise)

Preceding gene: 119946586

Following gene: 119946584

Centisome position: 80.21

GC content: 40.94

Gene sequence:

>789_bases
ATGACTAAAAAAATAGCAATGATTCATCCAACGGCGATTGTGCATGAAAATGCCATCATTGGAAAGGATGTAGAAATTGG
ACCTTATACAATTATTGGCGATCGCGTTGAAATTGGTGATAATTGCTGGATTGCACCGCATGTTGTGATCAAAGGTCCGA
CTAAAATGGGTAAAGGTAATAAAATTTACCAGTTTGCTTCAATCGGAGAAGATTGCCAGGATCTGAAATATAACGGTGAA
GAAACTTTCCTGGAGATTGGCGACAATAATGTTTTTCGTGAAAGTTGCACTGTCCACCGCGGAACGGCTCAGGATCAGGG
GACGACGCGCATTGGTAATAATAATTTATTGATGGCTTATGTGCATGTGGCGCATGATTGTGTGCTAGGTAATAACATTA
TTTTATCAAATAATGCCACTTTAGCCGGCCATACTAAGCTTGCTAATAATGTAATTATAGGCGGCCTTTCTGCACTGCAT
CAATTTACCCGTGTGGGTGAGTTTGCCATGATTGGCGGCTGCTCTGCCGTCAACAAAGACATTCCTCCGTACTTTATGGC
AACGGGAAATTATGTGGAAGCGCAAGGTGTTAACTCGGTCGGTTTAAAACGCAGTGGTTTTAACAGCAAAGCGATTATGG
AAATAAAACGTGCCTATAAAATACTTTGCCGCGAAGGTAATTCCCTTGAGCAGGCAAAAATTAAAATTGCAGAAAAACTA
GAAGGTTGTCCGGAATTACAGGTTTTATACGATTTTATCTGTGAAGAAAGTCGCGGCATTGTTCGTTAA

Upstream 100 bases:

>100_bases
TTAAGGATCGCCGTGGCATGGGTAAATTTGAGTGTGTTGCAAAAGTGGATGGACAAGTCGCCTGTGAAGCGATGATCATG
TGTGCAAGAAGAGAGATTTA

Downstream 100 bases:

>100_bases
GCATTTTGTGCTTTAGTTTTATATTTAAAATAGGCTCATTAGAGCCTTTTTTTTTAAGAGCGAATTAAAATATGAATAAA
CCATTAAGAATAGGTTTAAT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MTKKIAMIHPTAIVHENAIIGKDVEIGPYTIIGDRVEIGDNCWIAPHVVIKGPTKMGKGNKIYQFASIGEDCQDLKYNGE
ETFLEIGDNNVFRESCTVHRGTAQDQGTTRIGNNNLLMAYVHVAHDCVLGNNIILSNNATLAGHTKLANNVIIGGLSALH
QFTRVGEFAMIGGCSAVNKDIPPYFMATGNYVEAQGVNSVGLKRSGFNSKAIMEIKRAYKILCREGNSLEQAKIKIAEKL
EGCPELQVLYDFICEESRGIVR

Sequences:

>Translated_262_residues
MTKKIAMIHPTAIVHENAIIGKDVEIGPYTIIGDRVEIGDNCWIAPHVVIKGPTKMGKGNKIYQFASIGEDCQDLKYNGE
ETFLEIGDNNVFRESCTVHRGTAQDQGTTRIGNNNLLMAYVHVAHDCVLGNNIILSNNATLAGHTKLANNVIIGGLSALH
QFTRVGEFAMIGGCSAVNKDIPPYFMATGNYVEAQGVNSVGLKRSGFNSKAIMEIKRAYKILCREGNSLEQAKIKIAEKL
EGCPELQVLYDFICEESRGIVR
>Mature_261_residues
TKKIAMIHPTAIVHENAIIGKDVEIGPYTIIGDRVEIGDNCWIAPHVVIKGPTKMGKGNKIYQFASIGEDCQDLKYNGEE
TFLEIGDNNVFRESCTVHRGTAQDQGTTRIGNNNLLMAYVHVAHDCVLGNNIILSNNATLAGHTKLANNVIIGGLSALHQ
FTRVGEFAMIGGCSAVNKDIPPYFMATGNYVEAQGVNSVGLKRSGFNSKAIMEIKRAYKILCREGNSLEQAKIKIAEKLE
GCPELQVLYDFICEESRGIVR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=52.2900763358779, Blast_Score=285, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_PSYIN (A1SYV1)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944265.1
- ProteinModelPortal:   A1SYV1
- SMR:   A1SYV1
- STRING:   A1SYV1
- GeneID:   4623480
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2964
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- PhylomeDB:   A1SYV1
- ProtClustDB:   PRK05289
- BioCyc:   PING357804:PING_2964-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28641; Mature: 28510

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKIAMIHPTAIVHENAIIGKDVEIGPYTIIGDRVEIGDNCWIAPHVVIKGPTKMGKGN
CCCEEEEECCEEEEECCCEECCCCCCCCEEEECCEEEECCCEEECCEEEEECCCCCCCCC
KIYQFASIGEDCQDLKYNGEETFLEIGDNNVFRESCTVHRGTAQDQGTTRIGNNNLLMAY
EEEEEHHCCCCHHHCCCCCCEEEEEECCCCEECCCCCEECCCCCCCCCEEECCCCEEEEE
VHVAHDCVLGNNIILSNNATLAGHTKLANNVIIGGLSALHQFTRVGEFAMIGGCSAVNKD
EEEHHHEEECCCEEEECCCEEEECHHHHCCEEEECHHHHHHHHHCCCEEEECCCHHCCCC
IPPYFMATGNYVEAQGVNSVGLKRSGFNSKAIMEIKRAYKILCREGNSLEQAKIKIAEKL
CCCEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
EGCPELQVLYDFICEESRGIVR
CCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TKKIAMIHPTAIVHENAIIGKDVEIGPYTIIGDRVEIGDNCWIAPHVVIKGPTKMGKGN
CCEEEEECCEEEEECCCEECCCCCCCCEEEECCEEEECCCEEECCEEEEECCCCCCCCC
KIYQFASIGEDCQDLKYNGEETFLEIGDNNVFRESCTVHRGTAQDQGTTRIGNNNLLMAY
EEEEEHHCCCCHHHCCCCCCEEEEEECCCCEECCCCCEECCCCCCCCCEEECCCCEEEEE
VHVAHDCVLGNNIILSNNATLAGHTKLANNVIIGGLSALHQFTRVGEFAMIGGCSAVNKD
EEEHHHEEECCCEEEECCCEEEECHHHHCCEEEECHHHHHHHHHCCCEEEECCCHHCCCC
IPPYFMATGNYVEAQGVNSVGLKRSGFNSKAIMEIKRAYKILCREGNSLEQAKIKIAEKL
CCCEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
EGCPELQVLYDFICEESRGIVR
CCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA