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The map label for this gene is pgl [H]

Identifier: 119946379

GI number: 119946379

Start: 3377478

End: 3378212

Strand: Reverse

Name: pgl [H]

Synonym: Ping_2753

Alternate gene names: 119946379

Gene position: 3378212-3377478 (Counterclockwise)

Preceding gene: 119946380

Following gene: 119946378

Centisome position: 74.09

GC content: 41.09

Gene sequence:

>735_bases
ATGAATTATACAATTTTTTCTGCAACCCAATTACTGCTAGATAAACTGGCCGAGGATTTTTTGCTCTTAAGTCAAAAAGA
GACCGTAAGCCATATCTCTTTATCCGGTGGCTCAACCCCGATCCTTCTGTTTAAATATTTAGCCAACTCTCCCTATGCAC
AGAAAATAAACTGGCAAAAGTTGCATTTTTGGTGGGGGGATGAACGCTGTGTTGCAGCGACTGATTCAGAAAGTAACTTT
GGGCAGTGTAAACAATTTTTATTCGACCAAATTATTATTCCGGCAGAAAATATTCATCGCATTCGAGGGGAAAACTCCCC
ACAGCAGGAAGCGATTCGCTATGCACAGGAAATAAGAAATTATATTGATAGCGTTAATGGCATTCCACAGTTTGACTGGA
TTCTTTTAGGCGTGGGCAATGACGGTCATACCGCCTCACTTTTTCCCGGACAAACAAACTATCAGGATGCTCATTTAACC
TTTGTGGCAACACAGCCGCAAAGCGGGCAATTACGGGTATCTAAAACAGCCGGCTTAATTGAAAACAGCCGGCGTATTAC
TTATCTGGTACTAGGTGAAAATAAAGCCGATATTATTCATAAAATTAACAGTGAAAAAGCGGGCAGCGAACGCTATCCAG
CGGGCAAAATAAAAGCTAAAGCAGGGCTAACCCAATGGTATTTAGATTCAGGATCCGCAATGTTATTAATAGAGGAAAAA
AGTGATGAATGCTGA

Upstream 100 bases:

>100_bases
TGGGGGCCGATTGAAGCGGAAAAATTATTAAACCGAGATAACCATGAATGGCGCTTCCCCTGTAAAAATTTAACCGATAC
AGATTACTGTGAGTTATAAA

Downstream 100 bases:

>100_bases
TATTGCAGTAATAGGTCTGGCCGTGATGGGGCAGAATTTAATTTTAAATATGAACGATCATGGTTTTAAAGTTGTCGCAT
TTAACCGCACCGTCGCAAAG

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MNYTIFSATQLLLDKLAEDFLLLSQKETVSHISLSGGSTPILLFKYLANSPYAQKINWQKLHFWWGDERCVAATDSESNF
GQCKQFLFDQIIIPAENIHRIRGENSPQQEAIRYAQEIRNYIDSVNGIPQFDWILLGVGNDGHTASLFPGQTNYQDAHLT
FVATQPQSGQLRVSKTAGLIENSRRITYLVLGENKADIIHKINSEKAGSERYPAGKIKAKAGLTQWYLDSGSAMLLIEEK
SDEC

Sequences:

>Translated_244_residues
MNYTIFSATQLLLDKLAEDFLLLSQKETVSHISLSGGSTPILLFKYLANSPYAQKINWQKLHFWWGDERCVAATDSESNF
GQCKQFLFDQIIIPAENIHRIRGENSPQQEAIRYAQEIRNYIDSVNGIPQFDWILLGVGNDGHTASLFPGQTNYQDAHLT
FVATQPQSGQLRVSKTAGLIENSRRITYLVLGENKADIIHKINSEKAGSERYPAGKIKAKAGLTQWYLDSGSAMLLIEEK
SDEC
>Mature_244_residues
MNYTIFSATQLLLDKLAEDFLLLSQKETVSHISLSGGSTPILLFKYLANSPYAQKINWQKLHFWWGDERCVAATDSESNF
GQCKQFLFDQIIIPAENIHRIRGENSPQQEAIRYAQEIRNYIDSVNGIPQFDWILLGVGNDGHTASLFPGQTNYQDAHLT
FVATQPQSGQLRVSKTAGLIENSRRITYLVLGENKADIIHKINSEKAGSERYPAGKIKAKAGLTQWYLDSGSAMLLIEEK
SDEC

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=231, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI6912586, Length=246, Percent_Identity=28.0487804878049, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115533058, Length=221, Percent_Identity=27.6018099547511, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115533060, Length=221, Percent_Identity=27.6018099547511, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324362, Length=210, Percent_Identity=33.8095238095238, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321957, Length=242, Percent_Identity=27.6859504132231, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321687, Length=236, Percent_Identity=27.5423728813559, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319918, Length=213, Percent_Identity=31.924882629108, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24641119, Length=206, Percent_Identity=28.1553398058252, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 27415; Mature: 27415

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYTIFSATQLLLDKLAEDFLLLSQKETVSHISLSGGSTPILLFKYLANSPYAQKINWQK
CCEEEHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCHHHHHHHHHCCCCHHCCCEEE
LHFWWGDERCVAATDSESNFGQCKQFLFDQIIIPAENIHRIRGENSPQQEAIRYAQEIRN
EEEEECCCEEEEECCCCCCHHHHHHHHHHHEECCHHHHHHHCCCCCCHHHHHHHHHHHHH
YIDSVNGIPQFDWILLGVGNDGHTASLFPGQTNYQDAHLTFVATQPQSGQLRVSKTAGLI
HHHHCCCCCCEEEEEEEECCCCCEEEECCCCCCCCCEEEEEEEECCCCCCEEEECCCCHH
ENSRRITYLVLGENKADIIHKINSEKAGSERYPAGKIKAKAGLTQWYLDSGSAMLLIEEK
CCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCEEEEEECC
SDEC
CCCC
>Mature Secondary Structure
MNYTIFSATQLLLDKLAEDFLLLSQKETVSHISLSGGSTPILLFKYLANSPYAQKINWQK
CCEEEHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCHHHHHHHHHCCCCHHCCCEEE
LHFWWGDERCVAATDSESNFGQCKQFLFDQIIIPAENIHRIRGENSPQQEAIRYAQEIRN
EEEEECCCEEEEECCCCCCHHHHHHHHHHHEECCHHHHHHHCCCCCCHHHHHHHHHHHHH
YIDSVNGIPQFDWILLGVGNDGHTASLFPGQTNYQDAHLTFVATQPQSGQLRVSKTAGLI
HHHHCCCCCCEEEEEEEECCCCCEEEECCCCCCCCCEEEEEEEECCCCCCEEEECCCCHH
ENSRRITYLVLGENKADIIHKINSEKAGSERYPAGKIKAKAGLTQWYLDSGSAMLLIEEK
CCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCEEEEEECC
SDEC
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]