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The map label for this gene is gnd [H]

Identifier: 119946378

GI number: 119946378

Start: 3376040

End: 3377488

Strand: Reverse

Name: gnd [H]

Synonym: Ping_2752

Alternate gene names: 119946378

Gene position: 3377488-3376040 (Counterclockwise)

Preceding gene: 119946379

Following gene: 119946376

Centisome position: 74.07

GC content: 42.72

Gene sequence:

>1449_bases
ATGAATGCTGATATTGCAGTAATAGGTCTGGCCGTGATGGGGCAGAATTTAATTTTAAATATGAACGATCATGGTTTTAA
AGTTGTCGCATTTAACCGCACCGTCGCAAAGGTTGATCAGTTTCTTGAGGGGGCAGCAAAAGATACAGATGTTATCGCTG
CGCACTCTCTTGAAGAAATGGTGAGTTTACTGGGATTGCCGCGTAAAATTATGCTGATGGTCAAGGCAGGGGAGGTCGTC
GATGATTTTATTGATAAGTTAATCCCTTTATTGTCTAAAGGCGATATTATTATTGACGGCGGCAATTCCAATTTTATCGA
TACCAACCGCCGTGTTGAGAAGTTAAGCAAACTGAATTTACATTATGTCGGTGCAGGTGTATCTGGTGGGGAAGAGGGGG
CTCGCTATGGGCCGTCAATTATGCCCGGAGGAGATGTACAGGCATGGCCTTCTATTAAAGCTATTTTTCAAGGGATTTCA
GCTAAAACAGAGAAAGGGGAGCCTTGTTGTGACTGGGTTGGCCATGGCGGCTCGGGTCATTTTGTTAAGATGATTCACAA
CGGCATAGAATATGGCGATATGCAGTTAATTAGTGAAGCTTACCATTTTATGAAGGATGTTTTACGGATGTCCCACGAAG
AGATGCAGGCGACCTTCAGGGATTGGAACAAAACAGAGTTAAATAGCTACTTAGTTGAAATAACAGCCGATATTTTGGCT
TATAAGGATATCGACGGGAATCCCCTGGTTGAAAAAATAATGGATACCGCAGGGCAAAAAGGAACTGGTAAATGGACTGG
AATCAATGCATTAGATGCTGGCATTCCGTTAACCTTAATCACCGAATCTGTGTTTGCCCGTTGTCTGTCTGCATTAAAGC
TACAGCGTGTGGAGGCACAAAAACTATTTAATAAATCCATTGGCGAAATTCATGACGATAAACAGCAATGGATAGCGGCA
TTACATGACGCATTGCTTGCGAGTAAAATAATTTCCTATGCGCAGGGTTTTATGCTGATGAAGCAGGCATCAGAAGATAA
TAATTGGGATCTTAATTATGGTAACGTAGCACTGCTGTGGCGCGGTGGTTGTATTATACGCAGTGCATTTTTAGGCAATA
TTCGTGATGCTTTTGCAGCGAAACCCGAATTAGATTTTCTGGTCTTAGATCCCTACTTTAAAAATATTTTAGAACGCTGT
ATGCCGGCCTGGCGAAAAATTGCCGCCACCTCTTTTGAGACCGGATTACCTATGCCCTGCATGACCTCCGCATTGTCTTT
TCTGGACGGTTATACAACAGCAAGATCATCTGCAAATATGATCCAAGCGCAGCGAGATTATTTTGGTGCGCATACTTATG
AAAGGGTAGATAAAAAACCCGGTGAATTTTTCCATACCAACTGGACTGGACAGGGTGGAAATACCGCTTCAACAACCTAT
GATGCTTAA

Upstream 100 bases:

>100_bases
AGCGAACGCTATCCAGCGGGCAAAATAAAAGCTAAAGCAGGGCTAACCCAATGGTATTTAGATTCAGGATCCGCAATGTT
ATTAATAGAGGAAAAAAGTG

Downstream 100 bases:

>100_bases
CCGTTCAGCAAAGTTGTACATTGTGTAATGTATTCATTTAAAAAACAGCGCCAACGGGGTATTAGACTTTTGGCGCTGTT
TTTTTCGGGTCAATTCCTCT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MNADIAVIGLAVMGQNLILNMNDHGFKVVAFNRTVAKVDQFLEGAAKDTDVIAAHSLEEMVSLLGLPRKIMLMVKAGEVV
DDFIDKLIPLLSKGDIIIDGGNSNFIDTNRRVEKLSKLNLHYVGAGVSGGEEGARYGPSIMPGGDVQAWPSIKAIFQGIS
AKTEKGEPCCDWVGHGGSGHFVKMIHNGIEYGDMQLISEAYHFMKDVLRMSHEEMQATFRDWNKTELNSYLVEITADILA
YKDIDGNPLVEKIMDTAGQKGTGKWTGINALDAGIPLTLITESVFARCLSALKLQRVEAQKLFNKSIGEIHDDKQQWIAA
LHDALLASKIISYAQGFMLMKQASEDNNWDLNYGNVALLWRGGCIIRSAFLGNIRDAFAAKPELDFLVLDPYFKNILERC
MPAWRKIAATSFETGLPMPCMTSALSFLDGYTTARSSANMIQAQRDYFGAHTYERVDKKPGEFFHTNWTGQGGNTASTTY
DA

Sequences:

>Translated_482_residues
MNADIAVIGLAVMGQNLILNMNDHGFKVVAFNRTVAKVDQFLEGAAKDTDVIAAHSLEEMVSLLGLPRKIMLMVKAGEVV
DDFIDKLIPLLSKGDIIIDGGNSNFIDTNRRVEKLSKLNLHYVGAGVSGGEEGARYGPSIMPGGDVQAWPSIKAIFQGIS
AKTEKGEPCCDWVGHGGSGHFVKMIHNGIEYGDMQLISEAYHFMKDVLRMSHEEMQATFRDWNKTELNSYLVEITADILA
YKDIDGNPLVEKIMDTAGQKGTGKWTGINALDAGIPLTLITESVFARCLSALKLQRVEAQKLFNKSIGEIHDDKQQWIAA
LHDALLASKIISYAQGFMLMKQASEDNNWDLNYGNVALLWRGGCIIRSAFLGNIRDAFAAKPELDFLVLDPYFKNILERC
MPAWRKIAATSFETGLPMPCMTSALSFLDGYTTARSSANMIQAQRDYFGAHTYERVDKKPGEFFHTNWTGQGGNTASTTY
DA
>Mature_482_residues
MNADIAVIGLAVMGQNLILNMNDHGFKVVAFNRTVAKVDQFLEGAAKDTDVIAAHSLEEMVSLLGLPRKIMLMVKAGEVV
DDFIDKLIPLLSKGDIIIDGGNSNFIDTNRRVEKLSKLNLHYVGAGVSGGEEGARYGPSIMPGGDVQAWPSIKAIFQGIS
AKTEKGEPCCDWVGHGGSGHFVKMIHNGIEYGDMQLISEAYHFMKDVLRMSHEEMQATFRDWNKTELNSYLVEITADILA
YKDIDGNPLVEKIMDTAGQKGTGKWTGINALDAGIPLTLITESVFARCLSALKLQRVEAQKLFNKSIGEIHDDKQQWIAA
LHDALLASKIISYAQGFMLMKQASEDNNWDLNYGNVALLWRGGCIIRSAFLGNIRDAFAAKPELDFLVLDPYFKNILERC
MPAWRKIAATSFETGLPMPCMTSALSFLDGYTTARSSANMIQAQRDYFGAHTYERVDKKPGEFFHTNWTGQGGNTASTTY
DA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=482, Percent_Identity=63.2780082987552, Blast_Score=621, Evalue=1e-178,
Organism=Escherichia coli, GI1788341, Length=465, Percent_Identity=50.752688172043, Blast_Score=478, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17542558, Length=483, Percent_Identity=58.1780538302277, Blast_Score=591, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6321695, Length=492, Percent_Identity=56.0975609756098, Blast_Score=563, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6321977, Length=490, Percent_Identity=56.9387755102041, Blast_Score=545, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24639279, Length=482, Percent_Identity=60.7883817427386, Blast_Score=582, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53125; Mature: 53125

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNADIAVIGLAVMGQNLILNMNDHGFKVVAFNRTVAKVDQFLEGAAKDTDVIAAHSLEEM
CCCCEEEEEHHHHCCCEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHH
VSLLGLPRKIMLMVKAGEVVDDFIDKLIPLLSKGDIIIDGGNSNFIDTNRRVEKLSKLNL
HHHHCCCHHHEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCE
HYVGAGVSGGEEGARYGPSIMPGGDVQAWPSIKAIFQGISAKTEKGEPCCDWVGHGGSGH
EEEECCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCC
FVKMIHNGIEYGDMQLISEAYHFMKDVLRMSHEEMQATFRDWNKTELNSYLVEITADILA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
YKDIDGNPLVEKIMDTAGQKGTGKWTGINALDAGIPLTLITESVFARCLSALKLQRVEAQ
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLFNKSIGEIHDDKQQWIAALHDALLASKIISYAQGFMLMKQASEDNNWDLNYGNVALLW
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
RGGCIIRSAFLGNIRDAFAAKPELDFLVLDPYFKNILERCMPAWRKIAATSFETGLPMPC
ECCHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
MTSALSFLDGYTTARSSANMIQAQRDYFGAHTYERVDKKPGEFFHTNWTGQGGNTASTTY
HHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCC
DA
CC
>Mature Secondary Structure
MNADIAVIGLAVMGQNLILNMNDHGFKVVAFNRTVAKVDQFLEGAAKDTDVIAAHSLEEM
CCCCEEEEEHHHHCCCEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHH
VSLLGLPRKIMLMVKAGEVVDDFIDKLIPLLSKGDIIIDGGNSNFIDTNRRVEKLSKLNL
HHHHCCCHHHEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCE
HYVGAGVSGGEEGARYGPSIMPGGDVQAWPSIKAIFQGISAKTEKGEPCCDWVGHGGSGH
EEEECCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCC
FVKMIHNGIEYGDMQLISEAYHFMKDVLRMSHEEMQATFRDWNKTELNSYLVEITADILA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
YKDIDGNPLVEKIMDTAGQKGTGKWTGINALDAGIPLTLITESVFARCLSALKLQRVEAQ
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLFNKSIGEIHDDKQQWIAALHDALLASKIISYAQGFMLMKQASEDNNWDLNYGNVALLW
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
RGGCIIRSAFLGNIRDAFAAKPELDFLVLDPYFKNILERCMPAWRKIAATSFETGLPMPC
ECCHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
MTSALSFLDGYTTARSSANMIQAQRDYFGAHTYERVDKKPGEFFHTNWTGQGGNTASTTY
HHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCC
DA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]