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The map label for this gene is ywrD [H]

Identifier: 119946076

GI number: 119946076

Start: 2973032

End: 2974603

Strand: Reverse

Name: ywrD [H]

Synonym: Ping_2425

Alternate gene names: 119946076

Gene position: 2974603-2973032 (Counterclockwise)

Preceding gene: 119946077

Following gene: 119946075

Centisome position: 65.24

GC content: 46.5

Gene sequence:

>1572_bases
ATGAACTATCAATCAGCATTTAGCGCATCGCATTATCAAGCCACTCAAACAGGTCAAGCTATATTAGATGCAGGAGGCAC
TGCAAGCGAAGCGATGGTTGCAGCCGCTGCAATGATCACCGTGCAATATCCGCATATGAACAGTATTGGCGGAGATAGTT
TTTGGCTGATTTGCCATCCGGGCAAAGCACCGATTGCTATTGATGCCTGTGGTGCGGCGAGCCATTCTATTGATGTAAAT
GCCTACCGTGCCAAGGGCGGTGAACTGCCCGAGAGCGGTGGCGAATCGGCTATTACTATGGCCGGTACTATCTCGGGCTG
GCAAAAAGCATTGCAGATTAACGGCGGTCAGCATTCACTCAGTGAACTGCTTAAGCCTGCTATAGAGGCTGCTGAACAGG
GTATTGAAGTGACGCAAAGTTTTGTTGACGCCAGTGAAAAAACCTTCGATCGTCTGCACGCACTTGATGATTTTGCCAAT
CTTTTTTTAAATCAGTCCAAAACCTTAAAAGTAGGTGACAATTTAGTTAACCCGGAGCTTGCTGCAACGTTAACTCGTCT
TGGCGAAGTGGGATTAGATGACTTTTACCGTGGTGAAATCGCAGAAAAAGCGGCACTGGATTTAAGTAAAGCCGGCAGCC
CGATTACGCTCGATGATTTTCATATCCATCGGGTAAAAGTGATGGAGCCACTGACGGTGGAAATATCCAAAGGACAATTA
TATAACTTTGGTGCACCGACTCAGGGACTGGCTTCGCTGTTGATTATCGCTATTTATGATCAACTGGTAAGTACCACCGG
TAATGAATTTGAGCACATGCATTTGCTGGTTGAAGCAACCAAACAGGCATTTATTATTCGTGACCGATTGATTACCGATG
AGGCCTGTTTAAGCCAACCATTACAAGATTTACTCAGTGAAAAAATGATTCGTGAGTGTGCCGATCGTATCTCATTAGAG
AAAGCACAACCTTGGCCGCATCAGGCAAAAGTGGGTGATACGGTTTGGATGGGAGCGACGGACAAGTACGGTACTATGGT
GAGCTTTATTCAAAGTATCTATTGGGAATTTGGTTCGGGAGTGGTATTACCAAGCACCGGTATTTTATGGAATATCCGCG
GCAAAAGTTTCTCCCTTGATGCCGATCACCATAATGTTTTAGCGCCAGGTAAAAAACCCTTTCATACCCTTAATCCTGCC
TATGCAGAGCTGCATGATGGCAGGCGCATGGTGTATGGAACCATGGGCGGTGAAGGGCAGCCGCAGACTCAAGCCTGTCT
GTTTAGCCGTTATATCTATCAAGGGTTGAATCTCCAGGATGCGATCGCAAAACCGCGTTGGTTACTGGGCCGCACTTGGG
GAGATACGACCAATAATTTACGTTTAGAATACAGCCTTTATAAAGCTCACGCGGCGCAGCTAAGTAAGCTTGGTCATGAC
GTCACTTATGTGACAGATAATAATGAATTAATGGGGCACGCCGGTGCAATTGTTATAGACTCGCAAGGTCTAGCCTGTGC
AAGCAGCGATCCCCGCAGTGATGGAAGCAGTTTACTTGGAGATGTTTTATGA

Upstream 100 bases:

>100_bases
GCCTAGAAGAAGGGCCCTGCGGAATATCACTGTTAGGTCTGCCGGACAGTGAAGGAGATCTGTTCGCTACCGCGCAACAG
TTAATTCAAGGAAAACAATT

Downstream 100 bases:

>100_bases
GCACCAGCGACCTTTTTGAAACCCTTGATCCACCGCAGCGTTTACTAATGGGGCCTGGCCCAATTAATGCTTATCCGCGT
GTACATCAAGCTATTTCAGC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MNYQSAFSASHYQATQTGQAILDAGGTASEAMVAAAAMITVQYPHMNSIGGDSFWLICHPGKAPIAIDACGAASHSIDVN
AYRAKGGELPESGGESAITMAGTISGWQKALQINGGQHSLSELLKPAIEAAEQGIEVTQSFVDASEKTFDRLHALDDFAN
LFLNQSKTLKVGDNLVNPELAATLTRLGEVGLDDFYRGEIAEKAALDLSKAGSPITLDDFHIHRVKVMEPLTVEISKGQL
YNFGAPTQGLASLLIIAIYDQLVSTTGNEFEHMHLLVEATKQAFIIRDRLITDEACLSQPLQDLLSEKMIRECADRISLE
KAQPWPHQAKVGDTVWMGATDKYGTMVSFIQSIYWEFGSGVVLPSTGILWNIRGKSFSLDADHHNVLAPGKKPFHTLNPA
YAELHDGRRMVYGTMGGEGQPQTQACLFSRYIYQGLNLQDAIAKPRWLLGRTWGDTTNNLRLEYSLYKAHAAQLSKLGHD
VTYVTDNNELMGHAGAIVIDSQGLACASSDPRSDGSSLLGDVL

Sequences:

>Translated_523_residues
MNYQSAFSASHYQATQTGQAILDAGGTASEAMVAAAAMITVQYPHMNSIGGDSFWLICHPGKAPIAIDACGAASHSIDVN
AYRAKGGELPESGGESAITMAGTISGWQKALQINGGQHSLSELLKPAIEAAEQGIEVTQSFVDASEKTFDRLHALDDFAN
LFLNQSKTLKVGDNLVNPELAATLTRLGEVGLDDFYRGEIAEKAALDLSKAGSPITLDDFHIHRVKVMEPLTVEISKGQL
YNFGAPTQGLASLLIIAIYDQLVSTTGNEFEHMHLLVEATKQAFIIRDRLITDEACLSQPLQDLLSEKMIRECADRISLE
KAQPWPHQAKVGDTVWMGATDKYGTMVSFIQSIYWEFGSGVVLPSTGILWNIRGKSFSLDADHHNVLAPGKKPFHTLNPA
YAELHDGRRMVYGTMGGEGQPQTQACLFSRYIYQGLNLQDAIAKPRWLLGRTWGDTTNNLRLEYSLYKAHAAQLSKLGHD
VTYVTDNNELMGHAGAIVIDSQGLACASSDPRSDGSSLLGDVL
>Mature_523_residues
MNYQSAFSASHYQATQTGQAILDAGGTASEAMVAAAAMITVQYPHMNSIGGDSFWLICHPGKAPIAIDACGAASHSIDVN
AYRAKGGELPESGGESAITMAGTISGWQKALQINGGQHSLSELLKPAIEAAEQGIEVTQSFVDASEKTFDRLHALDDFAN
LFLNQSKTLKVGDNLVNPELAATLTRLGEVGLDDFYRGEIAEKAALDLSKAGSPITLDDFHIHRVKVMEPLTVEISKGQL
YNFGAPTQGLASLLIIAIYDQLVSTTGNEFEHMHLLVEATKQAFIIRDRLITDEACLSQPLQDLLSEKMIRECADRISLE
KAQPWPHQAKVGDTVWMGATDKYGTMVSFIQSIYWEFGSGVVLPSTGILWNIRGKSFSLDADHHNVLAPGKKPFHTLNPA
YAELHDGRRMVYGTMGGEGQPQTQACLFSRYIYQGLNLQDAIAKPRWLLGRTWGDTTNNLRLEYSLYKAHAAQLSKLGHD
VTYVTDNNELMGHAGAIVIDSQGLACASSDPRSDGSSLLGDVL

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=470, Percent_Identity=25.9574468085106, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI73915090, Length=470, Percent_Identity=25.9574468085106, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI73915096, Length=470, Percent_Identity=25.9574468085106, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI73915094, Length=470, Percent_Identity=25.9574468085106, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI113429324, Length=469, Percent_Identity=25.3731343283582, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI113429326, Length=476, Percent_Identity=24.7899159663866, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI153266885, Length=474, Percent_Identity=25.3164556962025, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI153266901, Length=475, Percent_Identity=25.6842105263158, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI109148539, Length=516, Percent_Identity=25.1937984496124, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789856, Length=535, Percent_Identity=27.2897196261682, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI72000294, Length=478, Percent_Identity=25.1046025104602, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI212646519, Length=478, Percent_Identity=25.1046025104602, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17542894, Length=465, Percent_Identity=23.4408602150538, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161077878, Length=473, Percent_Identity=25.369978858351, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551474, Length=473, Percent_Identity=25.369978858351, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI161077880, Length=473, Percent_Identity=25.369978858351, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24642670, Length=473, Percent_Identity=25.369978858351, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24642666, Length=473, Percent_Identity=25.369978858351, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI18859893, Length=461, Percent_Identity=24.9457700650759, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI18859741, Length=509, Percent_Identity=24.5579567779961, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56656; Mature: 56656

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYQSAFSASHYQATQTGQAILDAGGTASEAMVAAAAMITVQYPHMNSIGGDSFWLICHP
CCCCHHCCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECC
GKAPIAIDACGAASHSIDVNAYRAKGGELPESGGESAITMAGTISGWQKALQINGGQHSL
CCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEHHHHHHHHEECCCHHHH
SELLKPAIEAAEQGIEVTQSFVDASEKTFDRLHALDDFANLFLNQSKTLKVGDNLVNPEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHH
AATLTRLGEVGLDDFYRGEIAEKAALDLSKAGSPITLDDFHIHRVKVMEPLTVEISKGQL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEEECCEEEEEECCEE
YNFGAPTQGLASLLIIAIYDQLVSTTGNEFEHMHLLVEATKQAFIIRDRLITDEACLSQP
EECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQDLLSEKMIRECADRISLEKAQPWPHQAKVGDTVWMGATDKYGTMVSFIQSIYWEFGSG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCC
VVLPSTGILWNIRGKSFSLDADHHNVLAPGKKPFHTLNPAYAELHDGRRMVYGTMGGEGQ
EEECCCCEEEEECCCEEEECCCCCCEECCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
PQTQACLFSRYIYQGLNLQDAIAKPRWLLGRTWGDTTNNLRLEYSLYKAHAAQLSKLGHD
CHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCCCC
VTYVTDNNELMGHAGAIVIDSQGLACASSDPRSDGSSLLGDVL
EEEEECCCCEECCCCEEEECCCCCEECCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MNYQSAFSASHYQATQTGQAILDAGGTASEAMVAAAAMITVQYPHMNSIGGDSFWLICHP
CCCCHHCCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECC
GKAPIAIDACGAASHSIDVNAYRAKGGELPESGGESAITMAGTISGWQKALQINGGQHSL
CCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEHHHHHHHHEECCCHHHH
SELLKPAIEAAEQGIEVTQSFVDASEKTFDRLHALDDFANLFLNQSKTLKVGDNLVNPEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHH
AATLTRLGEVGLDDFYRGEIAEKAALDLSKAGSPITLDDFHIHRVKVMEPLTVEISKGQL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEEECCEEEEEECCEE
YNFGAPTQGLASLLIIAIYDQLVSTTGNEFEHMHLLVEATKQAFIIRDRLITDEACLSQP
EECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQDLLSEKMIRECADRISLEKAQPWPHQAKVGDTVWMGATDKYGTMVSFIQSIYWEFGSG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCC
VVLPSTGILWNIRGKSFSLDADHHNVLAPGKKPFHTLNPAYAELHDGRRMVYGTMGGEGQ
EEECCCCEEEEECCCEEEECCCCCCEECCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
PQTQACLFSRYIYQGLNLQDAIAKPRWLLGRTWGDTTNNLRLEYSLYKAHAAQLSKLGHD
CHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCCCC
VTYVTDNNELMGHAGAIVIDSQGLACASSDPRSDGSSLLGDVL
EEEEECCCCEECCCCEEEECCCCCEECCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]