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The map label for this gene is rnb [H]

Identifier: 119945930

GI number: 119945930

Start: 2756575

End: 2758545

Strand: Direct

Name: rnb [H]

Synonym: Ping_2270

Alternate gene names: 119945930

Gene position: 2756575-2758545 (Clockwise)

Preceding gene: 119945929

Following gene: 119945931

Centisome position: 60.46

GC content: 39.37

Gene sequence:

>1971_bases
ATGTTTCAGAACAATCCGTTGCTAAGTCAATTAAAAAAACAAATTCAAGAAGATATTCCCAAACGTCAGGGAAAGGTTAA
AGCAACTGATCGTGGTTATGGCTTTTTAGAAACAGATAAAGGTAAACGTTTTTTTATCCCGCCAAGTGAGATGAAAAAAG
TATTACACGGCGATCAAATTAATGCATTTATTCGTGGTAAAGGTGATAAATCAACTGCGGAGCCAAATCAACTCAAAAAA
ACAGGTTCAGCTGTTTTTATTGCACGGTTAGTTATCAAGCAAAAAAATATCTCTATTATTCCAAAAAATCCCCTGCTTAA
AGGATTTTTTAAAATAAAAGGCAGCCAATCTTTGCAATCCAGAGGATATCAAGATGGTGATTGGGTTAAAGTTGAATTAG
TAAGCCATGCGCTCGAAGGAAATGGTTTTTTAACTCAGATTATCGAAAAAATAGCCGATGCCAGTGATCCTTTTGCCTAT
CGTTTATTAACCGTCGCAACTCATAACCTAGCCAACAAAGCCCCTGAATTTGATCATCCATGGAAAATTATTGATCCACA
ATTATCCCGTAGCGATTTAACTAAAACCCCCTTTTTTACTATTGATGGTGTTAACACCCAAGATATGGACGATGCACTGT
ACATCGAAGCTGATGAGAATGGTTGGAAATTGACCGTCGCGATCTCAGATCCATCCGCCTACGTACCAGAAAATAGCGAC
ATGGATGCTGAAGCTAAACGTCGTGCCTTTACGTTATATCTACCTAATTTTAATGTGCCCATGTTGCCGCGTGATTTGAG
TGACAGTCTTTGCTCATTAAAAGAGGGCGAAAAACGGGCAACACTCTGCTGTACTATCCATATTAATAAAAAGGGTGAAA
TTGAGGGTGAACCCGCATTTTATGGCGCATGGATAAAATCTCATTATCGCCTTAACTATACGGATGTTTCCAATTATCTC
GAAAATGAAGAGCTCAGCAATGATTGTTGGAAACCCAGTACACAACTTGCCGAGCAACTGCGCACTTTGGATTCGCTCTC
CCTAAAGCGTCTACAATGGCGAACTGATAATAATGCTGTCTTTAAAAACCAACCTGATTACACCTTAAAACTAAACAATA
AAGGTGAGATTTCCGAAATACTCTGCGAACCAAGGCGCAGTGCTAATCGCCTGGTAGAGGAATCGATGATTGCCGCCAAT
ATATGTGCAGGTGACTTTTTAGCAAAACATAAACAGCAAGGTGTGTTTAATACCCATTCAGGTTTTTCCAGTGAGCGCCT
GGGAAAAGTAGTCTCTTTACTGAGTGAGTTTGGCATTGAAAGTGATATTCAAACATTAGCCACCGTTACAGGTTATACAA
AAATACGCCAACAAACGAATTTATTGCACAACAGTTATCTGGACCACAGATTGCGTAAACTGCTCAGTTATGCCGATATT
AAAAACACACCAGAAGCACATTTTACCCTTGGGGTCGACCACTACGCGACGTGGACTTCTCCTATCCGCAAGTACGGTGA
TTTACTTAACCATCGTTTGATTAAATCAGTGTTGTTAAAAGAAGATAATATTCAGATCGATAATGAGATCGGGCAGGTGC
TTAATGCAGCCCGTAAATTACAACGTTTAGCCGAAAGAGATGTTAATAATATTCTTTACAGTCAATATCTAAAGAATCAG
GTAGAGTCCAAGTGGCGCTATAAAGCGGAGATTTTTGATATTATTAAAGCGGGTATCCGGGTCAAAATACAAGAAAATGG
GGCGACTTTCTTTATCCCTTGCTCACTACTGTGCAAAGACAGCAGCGATGCCACAAAAATCGACTGCAATCAAGCATTAG
GAAAAGTTATTATTGCACAACAAACCGAATTACAACTCGGGGATGTGATTGATGTGATGCTTAATAATGTCAAAGTGGAA
AGCGGTCAATTAATCGGAAAGCTTGCCGAATCATTGACAATTAGCGAGTAA

Upstream 100 bases:

>100_bases
TAAAACGCAATCACCTTTATATTTAACACTGTCAAACAGCTGAGCTTATTTCCTTTCAAAATAGGCTGTTTATATCGACA
TCTATCTAAGGTTTTATTTT

Downstream 100 bases:

>100_bases
TTTAATCGGTAAAATTTATTTTTCCGATTAAATATCAATCACTTAAAAACCATAAAAACATCATGGTTAAGAAAGCATCG
CAGAGTTTAATTTCTTCTGT

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MFQNNPLLSQLKKQIQEDIPKRQGKVKATDRGYGFLETDKGKRFFIPPSEMKKVLHGDQINAFIRGKGDKSTAEPNQLKK
TGSAVFIARLVIKQKNISIIPKNPLLKGFFKIKGSQSLQSRGYQDGDWVKVELVSHALEGNGFLTQIIEKIADASDPFAY
RLLTVATHNLANKAPEFDHPWKIIDPQLSRSDLTKTPFFTIDGVNTQDMDDALYIEADENGWKLTVAISDPSAYVPENSD
MDAEAKRRAFTLYLPNFNVPMLPRDLSDSLCSLKEGEKRATLCCTIHINKKGEIEGEPAFYGAWIKSHYRLNYTDVSNYL
ENEELSNDCWKPSTQLAEQLRTLDSLSLKRLQWRTDNNAVFKNQPDYTLKLNNKGEISEILCEPRRSANRLVEESMIAAN
ICAGDFLAKHKQQGVFNTHSGFSSERLGKVVSLLSEFGIESDIQTLATVTGYTKIRQQTNLLHNSYLDHRLRKLLSYADI
KNTPEAHFTLGVDHYATWTSPIRKYGDLLNHRLIKSVLLKEDNIQIDNEIGQVLNAARKLQRLAERDVNNILYSQYLKNQ
VESKWRYKAEIFDIIKAGIRVKIQENGATFFIPCSLLCKDSSDATKIDCNQALGKVIIAQQTELQLGDVIDVMLNNVKVE
SGQLIGKLAESLTISE

Sequences:

>Translated_656_residues
MFQNNPLLSQLKKQIQEDIPKRQGKVKATDRGYGFLETDKGKRFFIPPSEMKKVLHGDQINAFIRGKGDKSTAEPNQLKK
TGSAVFIARLVIKQKNISIIPKNPLLKGFFKIKGSQSLQSRGYQDGDWVKVELVSHALEGNGFLTQIIEKIADASDPFAY
RLLTVATHNLANKAPEFDHPWKIIDPQLSRSDLTKTPFFTIDGVNTQDMDDALYIEADENGWKLTVAISDPSAYVPENSD
MDAEAKRRAFTLYLPNFNVPMLPRDLSDSLCSLKEGEKRATLCCTIHINKKGEIEGEPAFYGAWIKSHYRLNYTDVSNYL
ENEELSNDCWKPSTQLAEQLRTLDSLSLKRLQWRTDNNAVFKNQPDYTLKLNNKGEISEILCEPRRSANRLVEESMIAAN
ICAGDFLAKHKQQGVFNTHSGFSSERLGKVVSLLSEFGIESDIQTLATVTGYTKIRQQTNLLHNSYLDHRLRKLLSYADI
KNTPEAHFTLGVDHYATWTSPIRKYGDLLNHRLIKSVLLKEDNIQIDNEIGQVLNAARKLQRLAERDVNNILYSQYLKNQ
VESKWRYKAEIFDIIKAGIRVKIQENGATFFIPCSLLCKDSSDATKIDCNQALGKVIIAQQTELQLGDVIDVMLNNVKVE
SGQLIGKLAESLTISE
>Mature_656_residues
MFQNNPLLSQLKKQIQEDIPKRQGKVKATDRGYGFLETDKGKRFFIPPSEMKKVLHGDQINAFIRGKGDKSTAEPNQLKK
TGSAVFIARLVIKQKNISIIPKNPLLKGFFKIKGSQSLQSRGYQDGDWVKVELVSHALEGNGFLTQIIEKIADASDPFAY
RLLTVATHNLANKAPEFDHPWKIIDPQLSRSDLTKTPFFTIDGVNTQDMDDALYIEADENGWKLTVAISDPSAYVPENSD
MDAEAKRRAFTLYLPNFNVPMLPRDLSDSLCSLKEGEKRATLCCTIHINKKGEIEGEPAFYGAWIKSHYRLNYTDVSNYL
ENEELSNDCWKPSTQLAEQLRTLDSLSLKRLQWRTDNNAVFKNQPDYTLKLNNKGEISEILCEPRRSANRLVEESMIAAN
ICAGDFLAKHKQQGVFNTHSGFSSERLGKVVSLLSEFGIESDIQTLATVTGYTKIRQQTNLLHNSYLDHRLRKLLSYADI
KNTPEAHFTLGVDHYATWTSPIRKYGDLLNHRLIKSVLLKEDNIQIDNEIGQVLNAARKLQRLAERDVNNILYSQYLKNQ
VESKWRYKAEIFDIIKAGIRVKIQENGATFFIPCSLLCKDSSDATKIDCNQALGKVIIAQQTELQLGDVIDVMLNNVKVE
SGQLIGKLAESLTISE

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=455, Percent_Identity=25.7142857142857, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI219521928, Length=506, Percent_Identity=23.5177865612648, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI19115966, Length=453, Percent_Identity=24.7240618101545, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI190014623, Length=347, Percent_Identity=24.4956772334294, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI190014625, Length=347, Percent_Identity=24.4956772334294, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1787542, Length=650, Percent_Identity=41.2307692307692, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI87082383, Length=666, Percent_Identity=27.3273273273273, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17553506, Length=448, Percent_Identity=24.5535714285714, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI212645896, Length=483, Percent_Identity=24.223602484472, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323943, Length=409, Percent_Identity=26.161369193154, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324552, Length=512, Percent_Identity=24.609375, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24649634, Length=367, Percent_Identity=25.8855585831063, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24654592, Length=434, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI19922976, Length=434, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24654597, Length=434, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 74164; Mature: 74164

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQNNPLLSQLKKQIQEDIPKRQGKVKATDRGYGFLETDKGKRFFIPPSEMKKVLHGDQI
CCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEECCCCCEEECCHHHHHHHHCCCCE
NAFIRGKGDKSTAEPNQLKKTGSAVFIARLVIKQKNISIIPKNPLLKGFFKIKGSQSLQS
EEEEECCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCEEECCCCHHHHHHEECCCHHHHH
RGYQDGDWVKVELVSHALEGNGFLTQIIEKIADASDPFAYRLLTVATHNLANKAPEFDHP
CCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
WKIIDPQLSRSDLTKTPFFTIDGVNTQDMDDALYIEADENGWKLTVAISDPSAYVPENSD
CEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCC
MDAEAKRRAFTLYLPNFNVPMLPRDLSDSLCSLKEGEKRATLCCTIHINKKGEIEGEPAF
CCCHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCE
YGAWIKSHYRLNYTDVSNYLENEELSNDCWKPSTQLAEQLRTLDSLSLKRLQWRTDNNAV
EEHHHHHCCEEEHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCE
FKNQPDYTLKLNNKGEISEILCEPRRSANRLVEESMIAANICAGDFLAKHKQQGVFNTHS
ECCCCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GFSSERLGKVVSLLSEFGIESDIQTLATVTGYTKIRQQTNLLHNSYLDHRLRKLLSYADI
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNTPEAHFTLGVDHYATWTSPIRKYGDLLNHRLIKSVLLKEDNIQIDNEIGQVLNAARKL
CCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
QRLAERDVNNILYSQYLKNQVESKWRYKAEIFDIIKAGIRVKIQENGATFFIPCSLLCKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEEEECC
SSDATKIDCNQALGKVIIAQQTELQLGDVIDVMLNNVKVESGQLIGKLAESLTISE
CCCCCEEEHHHHHCCEEEEECCCCHHHHHHHHHHHCCEECCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQNNPLLSQLKKQIQEDIPKRQGKVKATDRGYGFLETDKGKRFFIPPSEMKKVLHGDQI
CCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEECCCCCEEECCHHHHHHHHCCCCE
NAFIRGKGDKSTAEPNQLKKTGSAVFIARLVIKQKNISIIPKNPLLKGFFKIKGSQSLQS
EEEEECCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCEEECCCCHHHHHHEECCCHHHHH
RGYQDGDWVKVELVSHALEGNGFLTQIIEKIADASDPFAYRLLTVATHNLANKAPEFDHP
CCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
WKIIDPQLSRSDLTKTPFFTIDGVNTQDMDDALYIEADENGWKLTVAISDPSAYVPENSD
CEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCC
MDAEAKRRAFTLYLPNFNVPMLPRDLSDSLCSLKEGEKRATLCCTIHINKKGEIEGEPAF
CCCHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCE
YGAWIKSHYRLNYTDVSNYLENEELSNDCWKPSTQLAEQLRTLDSLSLKRLQWRTDNNAV
EEHHHHHCCEEEHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCE
FKNQPDYTLKLNNKGEISEILCEPRRSANRLVEESMIAANICAGDFLAKHKQQGVFNTHS
ECCCCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GFSSERLGKVVSLLSEFGIESDIQTLATVTGYTKIRQQTNLLHNSYLDHRLRKLLSYADI
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNTPEAHFTLGVDHYATWTSPIRKYGDLLNHRLIKSVLLKEDNIQIDNEIGQVLNAARKL
CCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
QRLAERDVNNILYSQYLKNQVESKWRYKAEIFDIIKAGIRVKIQENGATFFIPCSLLCKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEEEECC
SSDATKIDCNQALGKVIIAQQTELQLGDVIDVMLNNVKVESGQLIGKLAESLTISE
CCCCCEEEHHHHHCCEEEEECCCCHHHHHHHHHHHCCEECCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA