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The map label for this gene is lpxH

Identifier: 119945846

GI number: 119945846

Start: 2660088

End: 2660825

Strand: Direct

Name: lpxH

Synonym: Ping_2186

Alternate gene names: 119945846

Gene position: 2660088-2660825 (Clockwise)

Preceding gene: 119945845

Following gene: 119945849

Centisome position: 58.34

GC content: 34.69

Gene sequence:

>738_bases
ATGCGCACACTCTTCATCGCCGATCTGCATCTCAGTGAAAAGCATCCGCAAATAAGCCATGCATTTTTTGAGTTTCTGCA
AAATGAAACTGAAAATGTGGATGCCTTATATATTTTGGGTGATTTATTTGAAGTTTGGATCGGGGATGATGAGCGCACTC
TCTTAATGAATGAAGTTGCTCTTAAATTATCAGAATATGCACTGAAAAATAATATATTACTGTATTACATTCATGGTAAC
CGTGATTTTATGATTGGCAAAAAATATGCAAAACAATCATCAATGCAATTGTTACCGGAACACTGTGAAATAAATTTGTA
TGGCAAAAAAATACTGATTTTACACGGTGATACACTTTGTTTAGCAGATAAAAATTATCAAAAAATGCGTACGCTGCTCC
ATAACCCTCTCATACAATTAGTTTTTAATCTTTTACCACTCTTTCTACGTAAAAAAATAGGCTGGAAAATTCGTCATGCA
AGCCAGTCCAAAAAAGTCTATAAAAATCGAGAAGTGATGGATGTCACTAAAGATGAAGTAGTACGTTTAATGGAGAAACA
TCATGTCCAGACTTTAATTCACGGACATACCCATCGAGTAGCTTGTCATGAGATGTTAGTTAAAGGGCAAGCTGCACAAC
GATATGATGTCGGCGATTGGCGTCATAATTTAAGTTATGTCGAAGTTCAAAAAGATAAAATCAATTTAGTTATCCGCCCG
ATTAATTTCTATAACTAA

Upstream 100 bases:

>100_bases
GTGGCAACAGGCAACTCTGGTTATGTGCATCAAGATGTTCCTCTGGAAGATGTGATCATCAAAAGTGTCACTATTGTTTA
ACGGTTAACTGGTGTCTTCT

Downstream 100 bases:

>100_bases
CCTAATGCCAAACTTGCGCAGTTAAAATTAACCGAAGTAAATTCACAACCTGTCGTTTGTTAATACTACAAACATAAAAA
AGCCGGCTAGATAGCCGGCC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MRTLFIADLHLSEKHPQISHAFFEFLQNETENVDALYILGDLFEVWIGDDERTLLMNEVALKLSEYALKNNILLYYIHGN
RDFMIGKKYAKQSSMQLLPEHCEINLYGKKILILHGDTLCLADKNYQKMRTLLHNPLIQLVFNLLPLFLRKKIGWKIRHA
SQSKKVYKNREVMDVTKDEVVRLMEKHHVQTLIHGHTHRVACHEMLVKGQAAQRYDVGDWRHNLSYVEVQKDKINLVIRP
INFYN

Sequences:

>Translated_245_residues
MRTLFIADLHLSEKHPQISHAFFEFLQNETENVDALYILGDLFEVWIGDDERTLLMNEVALKLSEYALKNNILLYYIHGN
RDFMIGKKYAKQSSMQLLPEHCEINLYGKKILILHGDTLCLADKNYQKMRTLLHNPLIQLVFNLLPLFLRKKIGWKIRHA
SQSKKVYKNREVMDVTKDEVVRLMEKHHVQTLIHGHTHRVACHEMLVKGQAAQRYDVGDWRHNLSYVEVQKDKINLVIRP
INFYN
>Mature_245_residues
MRTLFIADLHLSEKHPQISHAFFEFLQNETENVDALYILGDLFEVWIGDDERTLLMNEVALKLSEYALKNNILLYYIHGN
RDFMIGKKYAKQSSMQLLPEHCEINLYGKKILILHGDTLCLADKNYQKMRTLLHNPLIQLVFNLLPLFLRKKIGWKIRHA
SQSKKVYKNREVMDVTKDEVVRLMEKHHVQTLIHGHTHRVACHEMLVKGQAAQRYDVGDWRHNLSYVEVQKDKINLVIRP
INFYN

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=240, Percent_Identity=47.0833333333333, Blast_Score=236, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_PSYIN (A1SWR2)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943526.1
- ProteinModelPortal:   A1SWR2
- STRING:   A1SWR2
- GeneID:   4625341
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2186
- eggNOG:   COG2908
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- PhylomeDB:   A1SWR2
- BioCyc:   PING357804:PING_2186-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 28933; Mature: 28933

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLFIADLHLSEKHPQISHAFFEFLQNETENVDALYILGDLFEVWIGDDERTLLMNEVA
CCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHH
LKLSEYALKNNILLYYIHGNRDFMIGKKYAKQSSMQLLPEHCEINLYGKKILILHGDTLC
HHHHHHHHHCCEEEEEEECCEEEEECHHHHHHHHHHHCCCCCEEEEECCEEEEEECCEEE
LADKNYQKMRTLLHNPLIQLVFNLLPLFLRKKIGWKIRHASQSKKVYKNREVMDVTKDEV
EECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCCEECCHHHH
VRLMEKHHVQTLIHGHTHRVACHEMLVKGQAAQRYDVGDWRHNLSYVEVQKDKINLVIRP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCEEEEEECCEEEEEEEE
INFYN
CCCCC
>Mature Secondary Structure
MRTLFIADLHLSEKHPQISHAFFEFLQNETENVDALYILGDLFEVWIGDDERTLLMNEVA
CCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHH
LKLSEYALKNNILLYYIHGNRDFMIGKKYAKQSSMQLLPEHCEINLYGKKILILHGDTLC
HHHHHHHHHCCEEEEEEECCEEEEECHHHHHHHHHHHCCCCCEEEEECCEEEEEECCEEE
LADKNYQKMRTLLHNPLIQLVFNLLPLFLRKKIGWKIRHASQSKKVYKNREVMDVTKDEV
EECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCCEECCHHHH
VRLMEKHHVQTLIHGHTHRVACHEMLVKGQAAQRYDVGDWRHNLSYVEVQKDKINLVIRP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCEEEEEECCEEEEEEEE
INFYN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA