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The map label for this gene is ppiB [H]

Identifier: 119945845

GI number: 119945845

Start: 2659574

End: 2660068

Strand: Direct

Name: ppiB [H]

Synonym: Ping_2185

Alternate gene names: 119945845

Gene position: 2659574-2660068 (Clockwise)

Preceding gene: 119945841

Following gene: 119945846

Centisome position: 58.33

GC content: 35.96

Gene sequence:

>495_bases
ATGGTTACTTTACATACAAACTTTGGTGATATTAAACTTGATTTAAATGCAGAAAAGGCACCTAAAACTGTTGCTAACTT
TATTAAATATGTTGAATCAGGTCATTATGACAATACTATTTTTCATCGCGTTATCGATGGTTTTATGATTCAAGGTGGTG
GCTTTGCGGCAGGGATGGAAGAAAAACCAACCAATAAACCGGTGAAAAATGAAGCAAATAACGGTCTGTCAAATACAAAA
TATTCCGTCGCAATGGCAAGAACAATGGAGCCCCATTCTGCGTCTGCACAATTCTTTATTAATCTTAACGACAATAAGTT
TTTAGATTTTAAATCGGAAACAACTGATGGTTGGGGATATTGCGTATTTGCACAAGTTGTTGAAGGAGTCGATGTTGTTG
ATAAGATAAGAAATGTGGCAACAGGCAACTCTGGTTATGTGCATCAAGATGTTCCTCTGGAAGATGTGATCATCAAAAGT
GTCACTATTGTTTAA

Upstream 100 bases:

>100_bases
TAGAAATTCACCCTTTGTATTTAATGAATATCATGCTTTAGGGTATGATATAAGCAGACCCTAAGGGGATTTATTATTTT
TTCAATAACAGGAACTAAAA

Downstream 100 bases:

>100_bases
CGGTTAACTGGTGTCTTCTATGCGCACACTCTTCATCGCCGATCTGCATCTCAGTGAAAAGCATCCGCAAATAAGCCATG
CATTTTTTGAGTTTCTGCAA

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVTLHTNFGDIKLDLNAEKAPKTVANFIKYVESGHYDNTIFHRVIDGFMIQGGGFAAGMEEKPTNKPVKNEANNGLSNTK
YSVAMARTMEPHSASAQFFINLNDNKFLDFKSETTDGWGYCVFAQVVEGVDVVDKIRNVATGNSGYVHQDVPLEDVIIKS
VTIV

Sequences:

>Translated_164_residues
MVTLHTNFGDIKLDLNAEKAPKTVANFIKYVESGHYDNTIFHRVIDGFMIQGGGFAAGMEEKPTNKPVKNEANNGLSNTK
YSVAMARTMEPHSASAQFFINLNDNKFLDFKSETTDGWGYCVFAQVVEGVDVVDKIRNVATGNSGYVHQDVPLEDVIIKS
VTIV
>Mature_164_residues
MVTLHTNFGDIKLDLNAEKAPKTVANFIKYVESGHYDNTIFHRVIDGFMIQGGGFAAGMEEKPTNKPVKNEANNGLSNTK
YSVAMARTMEPHSASAQFFINLNDNKFLDFKSETTDGWGYCVFAQVVEGVDVVDKIRNVATGNSGYVHQDVPLEDVIIKS
VTIV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=35.5421686746988, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=34.1463414634146, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=34.1463414634146, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=34.1463414634146, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI7706339, Length=163, Percent_Identity=33.1288343558282, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=33.7423312883436, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI64276486, Length=105, Percent_Identity=41.9047619047619, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=66.2576687116564, Blast_Score=227, Evalue=3e-61,
Organism=Escherichia coli, GI1789763, Length=163, Percent_Identity=52.1472392638037, Blast_Score=168, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17532641, Length=160, Percent_Identity=35, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=165, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=145, Percent_Identity=33.7931034482759, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=164, Percent_Identity=32.3170731707317, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=31.4814814814815, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=158, Percent_Identity=32.9113924050633, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=151, Percent_Identity=34.4370860927152, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17551284, Length=151, Percent_Identity=34.4370860927152, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=32.7272727272727, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17986117, Length=143, Percent_Identity=32.8671328671329, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24652460, Length=172, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18079; Mature: 18079

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLHTNFGDIKLDLNAEKAPKTVANFIKYVESGHYDNTIFHRVIDGFMIQGGGFAAGME
CEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCEEECCCCEECCCC
EKPTNKPVKNEANNGLSNTKYSVAMARTMEPHSASAQFFINLNDNKFLDFKSETTDGWGY
CCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCEEEEECCCCCCCCHH
CVFAQVVEGVDVVDKIRNVATGNSGYVHQDVPLEDVIIKSVTIV
HHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHEECC
>Mature Secondary Structure
MVTLHTNFGDIKLDLNAEKAPKTVANFIKYVESGHYDNTIFHRVIDGFMIQGGGFAAGME
CEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCEEECCCCEECCCC
EKPTNKPVKNEANNGLSNTKYSVAMARTMEPHSASAQFFINLNDNKFLDFKSETTDGWGY
CCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCEEEEECCCCCCCCHH
CVFAQVVEGVDVVDKIRNVATGNSGYVHQDVPLEDVIIKSVTIV
HHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]