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The map label for this gene is czcD [H]

Identifier: 119945640

GI number: 119945640

Start: 2374175

End: 2375071

Strand: Direct

Name: czcD [H]

Synonym: Ping_1952

Alternate gene names: 119945640

Gene position: 2374175-2375071 (Clockwise)

Preceding gene: 119945639

Following gene: 119945644

Centisome position: 52.07

GC content: 34.0

Gene sequence:

>897_bases
ATGTCAGAACACCATCACCATCACCCAGTAAGCGGTAAAAATCTTTTTATCACTATTGTGTTAAATATCATTATCACTCT
CTCGCAAATAGTTGGCGGAATACTCTCAGGTTCGCTTGCACTGTTAAGTGATGCGATGCATAACCTGAGTGATGTGGTCG
CTTTATTAATTGCCTATTGGGCAAATAAAATTTCATCAAAACCAAAAAACAATCAAAAGACGTTTGGCTATAAAAGGGCT
GAGATCATAGCGGCACTTTTTAACGCATCGGCACTTTTTGGTATCGCACTTTTTCTTATCATAGAAGCTATCCATAAATT
CTTAAATCCAGAGACCATAGATTCTATACTCGTTATTGCGTTAGGATTTTTAAGTATCGTTTTAAATGCCATCAGCGTAC
TTCTCATAAAAGATGATGCCAAGCACAACATGAATATGAAAGCTGCTTATGTTCACCTACTTACCGATGTGATGACATCG
GTTGCAGTGGTTGTTGGCGGGCTATTGATGTACTATTTTAACTTGTTTTGGATAGATTCAATTATCACGGTTTTAATTGC
AGGTTATCTTATAAAAGCATCTTATGCTTTGATTGTAGAGTCCATCTCAATATTAATGCAAAGTGTTCCAGACGACATCA
ATATAGATGAGCTAAAAATAGACATAGAAAAGTATGAACCCATTGATAATATTCACCATCTTCATATTTGGAAATTAGAC
GATCACGATATACATTTAGAGGCGCATATTGATTTCAATGAAAATTTAGCATTAAAAGAGGTAACAAAAATTTGCGATGA
AATTTCTGATGCTATCAAAAAGAAATATCATATCACCCATATGACGATACAACCTGAATATGAAAAAAATGATAATAAAG
AATTGATTTATTCTTAG

Upstream 100 bases:

>100_bases
GCCCTATTTATTGGGGTAATAAGTTGAGGTCTTATCAGTATTGGTGAATTTTTTAATACGATTTAATGATAATATAAGAA
AAAAAATAAAGGTCTATCCT

Downstream 100 bases:

>100_bases
GAGCAGAAGATAAAAAGACAGGCCGGGCTTCGAACTTTCGGGCTTCGAACTTTCGAGCTTCGAGCTTCGAGCTTTGAGCT
TCGAGCTTTCGAGCTGCGAG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSEHHHHHPVSGKNLFITIVLNIIITLSQIVGGILSGSLALLSDAMHNLSDVVALLIAYWANKISSKPKNNQKTFGYKRA
EIIAALFNASALFGIALFLIIEAIHKFLNPETIDSILVIALGFLSIVLNAISVLLIKDDAKHNMNMKAAYVHLLTDVMTS
VAVVVGGLLMYYFNLFWIDSIITVLIAGYLIKASYALIVESISILMQSVPDDINIDELKIDIEKYEPIDNIHHLHIWKLD
DHDIHLEAHIDFNENLALKEVTKICDEISDAIKKKYHITHMTIQPEYEKNDNKELIYS

Sequences:

>Translated_298_residues
MSEHHHHHPVSGKNLFITIVLNIIITLSQIVGGILSGSLALLSDAMHNLSDVVALLIAYWANKISSKPKNNQKTFGYKRA
EIIAALFNASALFGIALFLIIEAIHKFLNPETIDSILVIALGFLSIVLNAISVLLIKDDAKHNMNMKAAYVHLLTDVMTS
VAVVVGGLLMYYFNLFWIDSIITVLIAGYLIKASYALIVESISILMQSVPDDINIDELKIDIEKYEPIDNIHHLHIWKLD
DHDIHLEAHIDFNENLALKEVTKICDEISDAIKKKYHITHMTIQPEYEKNDNKELIYS
>Mature_297_residues
SEHHHHHPVSGKNLFITIVLNIIITLSQIVGGILSGSLALLSDAMHNLSDVVALLIAYWANKISSKPKNNQKTFGYKRAE
IIAALFNASALFGIALFLIIEAIHKFLNPETIDSILVIALGFLSIVLNAISVLLIKDDAKHNMNMKAAYVHLLTDVMTSV
AVVVGGLLMYYFNLFWIDSIITVLIAGYLIKASYALIVESISILMQSVPDDINIDELKIDIEKYEPIDNIHHLHIWKLDD
HDIHLEAHIDFNENLALKEVTKICDEISDAIKKKYHITHMTIQPEYEKNDNKELIYS

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=306, Percent_Identity=24.8366013071895, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI289803013, Length=285, Percent_Identity=27.719298245614, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI289803009, Length=285, Percent_Identity=27.719298245614, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI289803007, Length=285, Percent_Identity=27.719298245614, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI289803003, Length=285, Percent_Identity=27.719298245614, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI64762489, Length=285, Percent_Identity=28.7719298245614, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI20070323, Length=322, Percent_Identity=22.9813664596273, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI21359890, Length=254, Percent_Identity=24.8031496062992, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI21361112, Length=334, Percent_Identity=21.2574850299401, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI52351208, Length=134, Percent_Identity=35.0746268656716, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI222080086, Length=127, Percent_Identity=29.9212598425197, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI40255009, Length=127, Percent_Identity=29.9212598425197, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI52352803, Length=129, Percent_Identity=34.1085271317829, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI14210520, Length=228, Percent_Identity=21.9298245614035, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786966, Length=265, Percent_Identity=30.9433962264151, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1790349, Length=247, Percent_Identity=20.6477732793522, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193210990, Length=307, Percent_Identity=24.4299674267101, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32564488, Length=303, Percent_Identity=25.7425742574257, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17555794, Length=315, Percent_Identity=22.8571428571429, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17555796, Length=305, Percent_Identity=23.2786885245902, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17550440, Length=118, Percent_Identity=27.9661016949153, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17550442, Length=118, Percent_Identity=27.9661016949153, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=133, Percent_Identity=34.5864661654135, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=142, Percent_Identity=30.9859154929577, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=167, Percent_Identity=29.940119760479, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583858, Length=316, Percent_Identity=23.7341772151899, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24656728, Length=344, Percent_Identity=24.7093023255814, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24656724, Length=344, Percent_Identity=24.7093023255814, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24656720, Length=344, Percent_Identity=24.7093023255814, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24656715, Length=344, Percent_Identity=24.7093023255814, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357035, Length=344, Percent_Identity=24.7093023255814, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24584409, Length=145, Percent_Identity=28.2758620689655, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574430, Length=145, Percent_Identity=28.2758620689655, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33515; Mature: 33383

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHHHHHPVSGKNLFITIVLNIIITLSQIVGGILSGSLALLSDAMHNLSDVVALLIAYW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANKISSKPKNNQKTFGYKRAEIIAALFNASALFGIALFLIIEAIHKFLNPETIDSILVIA
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGFLSIVLNAISVLLIKDDAKHNMNMKAAYVHLLTDVMTSVAVVVGGLLMYYFNLFWIDS
HHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IITVLIAGYLIKASYALIVESISILMQSVPDDINIDELKIDIEKYEPIDNIHHLHIWKLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEHHHCCCCCCCCEEEEEEEC
DHDIHLEAHIDFNENLALKEVTKICDEISDAIKKKYHITHMTIQPEYEKNDNKELIYS
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEHHHHHPVSGKNLFITIVLNIIITLSQIVGGILSGSLALLSDAMHNLSDVVALLIAYW
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANKISSKPKNNQKTFGYKRAEIIAALFNASALFGIALFLIIEAIHKFLNPETIDSILVIA
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGFLSIVLNAISVLLIKDDAKHNMNMKAAYVHLLTDVMTSVAVVVGGLLMYYFNLFWIDS
HHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IITVLIAGYLIKASYALIVESISILMQSVPDDINIDELKIDIEKYEPIDNIHHLHIWKLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEHHHCCCCCCCCEEEEEEEC
DHDIHLEAHIDFNENLALKEVTKICDEISDAIKKKYHITHMTIQPEYEKNDNKELIYS
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]