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The map label for this gene is zraR [H]

Identifier: 119945448

GI number: 119945448

Start: 2126548

End: 2127954

Strand: Direct

Name: zraR [H]

Synonym: Ping_1745

Alternate gene names: 119945448

Gene position: 2126548-2127954 (Clockwise)

Preceding gene: 119945446

Following gene: 119945449

Centisome position: 46.64

GC content: 44.21

Gene sequence:

>1407_bases
GTGAATGCTGAATTTAAGGGAAATTTCAAAGATGCCCCAACTGTTCTGATTGTTGACGATGATCCAGATATCTGTTCATT
GCTGTCCTATTTGATGAAACGGGAAGGGTATGTTGTACAAATTGTTCATGATGGTATGGCTGCTCTCGACCTAACACGTA
ACCGGGCACCCGATATTATACTAACTGATTTACGAATGCCCCGTATGGATGGCTTCGAGTTACTAAAGCAGGTAAAGCTG
ATCAAACAGGATCTACCCGTTGTGATACTCACCGCCTATGCTGGTATTAACGGGGCTGTCGAATCAATCAAGGCGGGGGC
TGATGATTACTTACCCAAACCTTTTGATAACAGTAAAGTGGTGATGCTGGTTCACAGAATCCTTCTTCAGCATCACTGTT
ATAAAATTGATGAGCAGCCAATTGAGGGGGGTGTTCATGATATTGTTACTGTGATGGGACCCAGTGCTATTATTCACACC
TTGGCCGCTCAGGTTAAGCTGGTCGCGCAATCCAATTTCAATGTTATTATTCAAGGTGCCACTGGCGTCGGTAAAGAGGT
GGTGGCCCAAGCTATCCATGCTCAGAGTCCATACGCTTCGGGTCCCTTTGTGCCGGTGGATTGTGGCGCGATCCCGGAAA
TGCTATTGGAGAGTGAACTTTTTGGCCACGAAAAGGGCGCTTTTACGGGTGCGTACCGAGCAAAGCAAGGCAAGTTCGAA
GCTGCTCGAGGTGGCACCTTGTTTCTGGATGAAATTGCCAATATGCCACTGACTTCTCAGGCTAAAATTCTGCGAGTTAT
GCAGGAAAAAATTATTTTTCCGGTAGGGTCAAACCAGCCTATTAAAATTGATGTGCGCCTTATAGTGGCTAGCCATGAAA
ATTTAGAAGCTAAGGTGGCTGATGGAACTTTTCGAGAAGACCTCTATTACCGATTCAATGAATTCACTATAAAAGTACCG
CTGTTGTCTGAACGAAAGGAAGATCAGATTTATCTTGCTAAGCGATTTATGAACGAGACTAACCGAGAGCTTGGCAAAAA
CGTGACTCTTTCGATAGGCGCGATTAACAAAATGCAGACCTATGAATGGCGAGGAAATGTGCGCGAATTGCGTGCGGTGA
TCCGCCGTGCGGTTCTCTTGGCGCAAACCGAAATTAGGGAAGAGCATCTTGCCATTATAAATAAAAGCAGCAAGAGGAAT
GAATCTGGTCAGCTAAATGGTATCAATTTTACAACCGCATCTTCCCCACCTTTGAAGGAAATAGTTCGTGATTGCAGCGA
GAGAGTAGAAAAGAAGACCTTAACGCAGGTACTGAGTCAAACCAATGGTAACAAGGCTGAAGCAGCACGTATCCTGAAAA
TAGATTATAAAACGCTACTTAACAAAGTAAAGTATTATGAATTATAA

Upstream 100 bases:

>100_bases
CCGAAACCTAGATTCGGAATGGAATGCTACCTTGTCTGAATGGACTAGAGAAAGTTTGTAGTTTTGACTCAATTAGGCTA
TTTCATAAGGGATTTTATAA

Downstream 100 bases:

>100_bases
ACAGTAAAGATATAAAGATGAAGAAAAAAAATAATTCAAAAAACAGTGAAATTAACGGCTTAAATGGAGCCTTGCATGAA
GTGATGGAAGTCGATGTAGG

Product: two component, sigma54 specific, transcriptional regulator, Fis family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MNAEFKGNFKDAPTVLIVDDDPDICSLLSYLMKREGYVVQIVHDGMAALDLTRNRAPDIILTDLRMPRMDGFELLKQVKL
IKQDLPVVILTAYAGINGAVESIKAGADDYLPKPFDNSKVVMLVHRILLQHHCYKIDEQPIEGGVHDIVTVMGPSAIIHT
LAAQVKLVAQSNFNVIIQGATGVGKEVVAQAIHAQSPYASGPFVPVDCGAIPEMLLESELFGHEKGAFTGAYRAKQGKFE
AARGGTLFLDEIANMPLTSQAKILRVMQEKIIFPVGSNQPIKIDVRLIVASHENLEAKVADGTFREDLYYRFNEFTIKVP
LLSERKEDQIYLAKRFMNETNRELGKNVTLSIGAINKMQTYEWRGNVRELRAVIRRAVLLAQTEIREEHLAIINKSSKRN
ESGQLNGINFTTASSPPLKEIVRDCSERVEKKTLTQVLSQTNGNKAEAARILKIDYKTLLNKVKYYEL

Sequences:

>Translated_468_residues
MNAEFKGNFKDAPTVLIVDDDPDICSLLSYLMKREGYVVQIVHDGMAALDLTRNRAPDIILTDLRMPRMDGFELLKQVKL
IKQDLPVVILTAYAGINGAVESIKAGADDYLPKPFDNSKVVMLVHRILLQHHCYKIDEQPIEGGVHDIVTVMGPSAIIHT
LAAQVKLVAQSNFNVIIQGATGVGKEVVAQAIHAQSPYASGPFVPVDCGAIPEMLLESELFGHEKGAFTGAYRAKQGKFE
AARGGTLFLDEIANMPLTSQAKILRVMQEKIIFPVGSNQPIKIDVRLIVASHENLEAKVADGTFREDLYYRFNEFTIKVP
LLSERKEDQIYLAKRFMNETNRELGKNVTLSIGAINKMQTYEWRGNVRELRAVIRRAVLLAQTEIREEHLAIINKSSKRN
ESGQLNGINFTTASSPPLKEIVRDCSERVEKKTLTQVLSQTNGNKAEAARILKIDYKTLLNKVKYYEL
>Mature_468_residues
MNAEFKGNFKDAPTVLIVDDDPDICSLLSYLMKREGYVVQIVHDGMAALDLTRNRAPDIILTDLRMPRMDGFELLKQVKL
IKQDLPVVILTAYAGINGAVESIKAGADDYLPKPFDNSKVVMLVHRILLQHHCYKIDEQPIEGGVHDIVTVMGPSAIIHT
LAAQVKLVAQSNFNVIIQGATGVGKEVVAQAIHAQSPYASGPFVPVDCGAIPEMLLESELFGHEKGAFTGAYRAKQGKFE
AARGGTLFLDEIANMPLTSQAKILRVMQEKIIFPVGSNQPIKIDVRLIVASHENLEAKVADGTFREDLYYRFNEFTIKVP
LLSERKEDQIYLAKRFMNETNRELGKNVTLSIGAINKMQTYEWRGNVRELRAVIRRAVLLAQTEIREEHLAIINKSSKRN
ESGQLNGINFTTASSPPLKEIVRDCSERVEKKTLTQVLSQTNGNKAEAARILKIDYKTLLNKVKYYEL

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=456, Percent_Identity=41.2280701754386, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=37.8205128205128, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1788550, Length=461, Percent_Identity=37.7440347071584, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1788905, Length=455, Percent_Identity=38.6813186813187, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI87082117, Length=344, Percent_Identity=39.5348837209302, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=41.0094637223975, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789087, Length=318, Percent_Identity=41.5094339622642, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1789233, Length=341, Percent_Identity=36.6568914956012, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786524, Length=334, Percent_Identity=36.5269461077844, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87081872, Length=309, Percent_Identity=36.8932038834951, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1787583, Length=351, Percent_Identity=32.4786324786325, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1789828, Length=232, Percent_Identity=35.7758620689655, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87081858, Length=303, Percent_Identity=26.4026402640264, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790860, Length=115, Percent_Identity=34.7826086956522, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082012, Length=119, Percent_Identity=32.7731092436975, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI2367329, Length=119, Percent_Identity=40.3361344537815, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788394, Length=119, Percent_Identity=32.7731092436975, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786784, Length=125, Percent_Identity=27.2, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=33.6538461538462, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786599, Length=119, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52244; Mature: 52244

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAEFKGNFKDAPTVLIVDDDPDICSLLSYLMKREGYVVQIVHDGMAALDLTRNRAPDII
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCEE
LTDLRMPRMDGFELLKQVKLIKQDLPVVILTAYAGINGAVESIKAGADDYLPKPFDNSKV
EECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHH
VMLVHRILLQHHCYKIDEQPIEGGVHDIVTVMGPSAIIHTLAAQVKLVAQSNFNVIIQGA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHEEEEECCCEEEEECC
TGVGKEVVAQAIHAQSPYASGPFVPVDCGAIPEMLLESELFGHEKGAFTGAYRAKQGKFE
CCCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCC
AARGGTLFLDEIANMPLTSQAKILRVMQEKIIFPVGSNQPIKIDVRLIVASHENLEAKVA
CCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHEEECCCCCCEEEEEEEEEECCCCCEEEEC
DGTFREDLYYRFNEFTIKVPLLSERKEDQIYLAKRFMNETNRELGKNVTLSIGAINKMQT
CCCHHHHHHEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEE
YEWRGNVRELRAVIRRAVLLAQTEIREEHLAIINKSSKRNESGQLNGINFTTASSPPLKE
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHH
IVRDCSERVEKKTLTQVLSQTNGNKAEAARILKIDYKTLLNKVKYYEL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MNAEFKGNFKDAPTVLIVDDDPDICSLLSYLMKREGYVVQIVHDGMAALDLTRNRAPDII
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCEE
LTDLRMPRMDGFELLKQVKLIKQDLPVVILTAYAGINGAVESIKAGADDYLPKPFDNSKV
EECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHH
VMLVHRILLQHHCYKIDEQPIEGGVHDIVTVMGPSAIIHTLAAQVKLVAQSNFNVIIQGA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHEEEEECCCEEEEECC
TGVGKEVVAQAIHAQSPYASGPFVPVDCGAIPEMLLESELFGHEKGAFTGAYRAKQGKFE
CCCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCC
AARGGTLFLDEIANMPLTSQAKILRVMQEKIIFPVGSNQPIKIDVRLIVASHENLEAKVA
CCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHEEECCCCCCEEEEEEEEEECCCCCEEEEC
DGTFREDLYYRFNEFTIKVPLLSERKEDQIYLAKRFMNETNRELGKNVTLSIGAINKMQT
CCCHHHHHHEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEE
YEWRGNVRELRAVIRRAVLLAQTEIREEHLAIINKSSKRNESGQLNGINFTTASSPPLKE
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHH
IVRDCSERVEKKTLTQVLSQTNGNKAEAARILKIDYKTLLNKVKYYEL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]