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The map label for this gene is rnc

Identifier: 119944412

GI number: 119944412

Start: 825315

End: 826001

Strand: Direct

Name: rnc

Synonym: Ping_0640

Alternate gene names: 119944412

Gene position: 825315-826001 (Clockwise)

Preceding gene: 119944411

Following gene: 119944413

Centisome position: 18.1

GC content: 40.9

Gene sequence:

>687_bases
ATGATGATCAAACAGGCAGAATTAAAACGTTTAGAAAGACGTGTTGATTATACTTTTTCAGATTTTTCACTGCTTCAACA
GGCATTAACCCATCGCAGTGCCTTGGGAAATCATAATGAGCGTTTAGAGTTTTTAGGTGACTCTATTCTAAGTTATGCTA
TTTCAACAGATCTTTATGCTCGTTTCCCAAAGGTCGACGAGGGTGACTTAAGCCGCATGCGGGCAACCTTAGTTTGCGGA
AAAATGCTGGCTGAAATTGGACGAGAATTCCAACTCGGCGATTGTTTGATTTTAGGGCCGGGAGAATTAAAAAGTGGTGG
CTTTCGACGCGATTCGATTATCGCCGATGGTGTAGAAGCGATTATTGGTGCCGCTTTTTTAGATTCAGATATTGATACGG
TCAAAAAACTCATTTTAAAATGGTTTGATAGTCGTTTAAATACAATCGAGCCTGGTATCAGCCAAAAAGATCCTAAAACC
CGCCTGCAGGAGCATTTGCAGTCCCGTAAACAGCCTTTACCGATTTATGAGGTGCTGGAAATTAAAGGTGAAGCGCATAA
TCAGCGTTTTACCATGAGCTGTTCAATAGACGGTTTAAAATCAGTACAAGGACAGGGCACCAGTCGTCGTAAAGCAGAAC
AAATAGCGGCAAATAAAATGTTAGATAGCTTATCAGGAGCTAAATAA

Upstream 100 bases:

>100_bases
TTGCTATTTGGATTAGTTTTGAATTTCAGCGTAGCAGCCGCAGTATTCTCCCTTCTTGGGTCCCAAGTGGTGTGCGTTTT
GACCGAGTTGGTGGGATAAA

Downstream 100 bases:

>100_bases
TGATCCAGAAATGTGAATGTGCTGCACTGGCAGAACGTCTTGAAATATTAATAGAAATCAATGTTGAATTTCTAATGTTG
GGAGAAAAATAATGACTCAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MMIKQAELKRLERRVDYTFSDFSLLQQALTHRSALGNHNERLEFLGDSILSYAISTDLYARFPKVDEGDLSRMRATLVCG
KMLAEIGREFQLGDCLILGPGELKSGGFRRDSIIADGVEAIIGAAFLDSDIDTVKKLILKWFDSRLNTIEPGISQKDPKT
RLQEHLQSRKQPLPIYEVLEIKGEAHNQRFTMSCSIDGLKSVQGQGTSRRKAEQIAANKMLDSLSGAK

Sequences:

>Translated_228_residues
MMIKQAELKRLERRVDYTFSDFSLLQQALTHRSALGNHNERLEFLGDSILSYAISTDLYARFPKVDEGDLSRMRATLVCG
KMLAEIGREFQLGDCLILGPGELKSGGFRRDSIIADGVEAIIGAAFLDSDIDTVKKLILKWFDSRLNTIEPGISQKDPKT
RLQEHLQSRKQPLPIYEVLEIKGEAHNQRFTMSCSIDGLKSVQGQGTSRRKAEQIAANKMLDSLSGAK
>Mature_228_residues
MMIKQAELKRLERRVDYTFSDFSLLQQALTHRSALGNHNERLEFLGDSILSYAISTDLYARFPKVDEGDLSRMRATLVCG
KMLAEIGREFQLGDCLILGPGELKSGGFRRDSIIADGVEAIIGAAFLDSDIDTVKKLILKWFDSRLNTIEPGISQKDPKT
RLQEHLQSRKQPLPIYEVLEIKGEAHNQRFTMSCSIDGLKSVQGQGTSRRKAEQIAANKMLDSLSGAK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=27.9475982532751, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=27.9475982532751, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI1788920, Length=205, Percent_Identity=66.8292682926829, Blast_Score=288, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=30.6666666666667, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=30.6666666666667, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=27.3913043478261, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_PSYIN (A1SSM8)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942092.1
- ProteinModelPortal:   A1SSM8
- SMR:   A1SSM8
- STRING:   A1SSM8
- GeneID:   4626838
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0640
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   A1SSM8
- BioCyc:   PING357804:PING_0640-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25517; Mature: 25517

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIKQAELKRLERRVDYTFSDFSLLQQALTHRSALGNHNERLEFLGDSILSYAISTDLYA
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RFPKVDEGDLSRMRATLVCGKMLAEIGREFQLGDCLILGPGELKSGGFRRDSIIADGVEA
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHH
IIGAAFLDSDIDTVKKLILKWFDSRLNTIEPGISQKDPKTRLQEHLQSRKQPLPIYEVLE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
IKGEAHNQRFTMSCSIDGLKSVQGQGTSRRKAEQIAANKMLDSLSGAK
HCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMIKQAELKRLERRVDYTFSDFSLLQQALTHRSALGNHNERLEFLGDSILSYAISTDLYA
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RFPKVDEGDLSRMRATLVCGKMLAEIGREFQLGDCLILGPGELKSGGFRRDSIIADGVEA
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHH
IIGAAFLDSDIDTVKKLILKWFDSRLNTIEPGISQKDPKTRLQEHLQSRKQPLPIYEVLE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
IKGEAHNQRFTMSCSIDGLKSVQGQGTSRRKAEQIAANKMLDSLSGAK
HCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA