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The map label for this gene is lepB [H]

Identifier: 119944411

GI number: 119944411

Start: 824413

End: 825318

Strand: Direct

Name: lepB [H]

Synonym: Ping_0639

Alternate gene names: 119944411

Gene position: 824413-825318 (Clockwise)

Preceding gene: 119944410

Following gene: 119944412

Centisome position: 18.08

GC content: 41.94

Gene sequence:

>906_bases
ATGGCAAATACTTTTGCTCTTATTTTAGTTATTGCAACCTTTGTAACCGGTATTATTTGGATTATAGATAAAATAAAATG
GGGACCTGCACGACGGGCCGCTCAAAAGGCTGCACAGGAAAAAGCGACGGTTAAACTTGATGAAGAGGTGCTTGCGACCA
TTCATCCTGAAAATGTAGTGATTGAAAATGCACGTTCACTTTTTCCAGTGATCCTGATTGTTTTTATACTGCGTTCGTTT
ATTTATGAGCCCTTTCAAATTCCATCTGGATCGATGATGCCAACGCTTTTAGTGGGTGATTTTATACTGGTGGAAAAATT
TTCCTACGGTGTAAAAGAGCCCGTATGGCAAAATACCTTAATCCCCATGGGCAAGGTAAAACGCGGTGATGTTGCCGTCT
TTAAATACCCGGAAGATATCCGTGTTGATTTTATCAAACGTGTTGTCGGTCTACCTGGGGATCATATTGTTTATAAAGAT
AAACAGTTATATTTATGCGCAAGCGAGCCATGTGCTTCATACAAAGCGTTAGAGATGAATTTTATCGGTGAGCAGGAATT
CGTTGATGAAGAAAGCACAATGCAGGTTTACAACGAAATGTTAGGCCAAGTGGCACATCAGATACTGATTAACCCAATGC
GCATTGATCAACCTGCCCGTTATTACCAACAGCCCGAGACTGTCGCTTATGAGTGGATTGTGCCAGAAGGGCATTATTTT
ATGATGGGTGATAACCGTGATAACAGCAGAGACAGTCGTTACTGGGGATTTGTGCCGGAACAAAATTTAGTCGGTAAAGC
CGTTGCTATTTGGATTAGTTTTGAATTTCAGCGTAGCAGCCGCAGTATTCTCCCTTCTTGGGTCCCAAGTGGTGTGCGTT
TTGACCGAGTTGGTGGGATAAAATGA

Upstream 100 bases:

>100_bases
CTGACCAGTCATATTAGTTAAACCGATATTGAACCAATTGATTCAATTATGTCCGCTTAAATAATGTGATTTTGACATAC
CCATTTTTATAGGAATTAAC

Downstream 100 bases:

>100_bases
TGATCAAACAGGCAGAATTAAAACGTTTAGAAAGACGTGTTGATTATACTTTTTCAGATTTTTCACTGCTTCAACAGGCA
TTAACCCATCGCAGTGCCTT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MANTFALILVIATFVTGIIWIIDKIKWGPARRAAQKAAQEKATVKLDEEVLATIHPENVVIENARSLFPVILIVFILRSF
IYEPFQIPSGSMMPTLLVGDFILVEKFSYGVKEPVWQNTLIPMGKVKRGDVAVFKYPEDIRVDFIKRVVGLPGDHIVYKD
KQLYLCASEPCASYKALEMNFIGEQEFVDEESTMQVYNEMLGQVAHQILINPMRIDQPARYYQQPETVAYEWIVPEGHYF
MMGDNRDNSRDSRYWGFVPEQNLVGKAVAIWISFEFQRSSRSILPSWVPSGVRFDRVGGIK

Sequences:

>Translated_301_residues
MANTFALILVIATFVTGIIWIIDKIKWGPARRAAQKAAQEKATVKLDEEVLATIHPENVVIENARSLFPVILIVFILRSF
IYEPFQIPSGSMMPTLLVGDFILVEKFSYGVKEPVWQNTLIPMGKVKRGDVAVFKYPEDIRVDFIKRVVGLPGDHIVYKD
KQLYLCASEPCASYKALEMNFIGEQEFVDEESTMQVYNEMLGQVAHQILINPMRIDQPARYYQQPETVAYEWIVPEGHYF
MMGDNRDNSRDSRYWGFVPEQNLVGKAVAIWISFEFQRSSRSILPSWVPSGVRFDRVGGIK
>Mature_300_residues
ANTFALILVIATFVTGIIWIIDKIKWGPARRAAQKAAQEKATVKLDEEVLATIHPENVVIENARSLFPVILIVFILRSFI
YEPFQIPSGSMMPTLLVGDFILVEKFSYGVKEPVWQNTLIPMGKVKRGDVAVFKYPEDIRVDFIKRVVGLPGDHIVYKDK
QLYLCASEPCASYKALEMNFIGEQEFVDEESTMQVYNEMLGQVAHQILINPMRIDQPARYYQQPETVAYEWIVPEGHYFM
MGDNRDNSRDSRYWGFVPEQNLVGKAVAIWISFEFQRSSRSILPSWVPSGVRFDRVGGIK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=330, Percent_Identity=50.3030303030303, Blast_Score=304, Evalue=4e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 34448; Mature: 34317

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTFALILVIATFVTGIIWIIDKIKWGPARRAAQKAAQEKATVKLDEEVLATIHPENVV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEECHHHHHEECCCCEE
IENARSLFPVILIVFILRSFIYEPFQIPSGSMMPTLLVGDFILVEKFSYGVKEPVWQNTL
EHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
IPMGKVKRGDVAVFKYPEDIRVDFIKRVVGLPGDHIVYKDKQLYLCASEPCASYKALEMN
CCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCEEEEEECCCCCCCEEEEEE
FIGEQEFVDEESTMQVYNEMLGQVAHQILINPMRIDQPARYYQQPETVAYEWIVPEGHYF
ECCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEEECCCCEE
MMGDNRDNSRDSRYWGFVPEQNLVGKAVAIWISFEFQRSSRSILPSWVPSGVRFDRVGGI
EEECCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEECCCCCC
K
C
>Mature Secondary Structure 
ANTFALILVIATFVTGIIWIIDKIKWGPARRAAQKAAQEKATVKLDEEVLATIHPENVV
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEECHHHHHEECCCCEE
IENARSLFPVILIVFILRSFIYEPFQIPSGSMMPTLLVGDFILVEKFSYGVKEPVWQNTL
EHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
IPMGKVKRGDVAVFKYPEDIRVDFIKRVVGLPGDHIVYKDKQLYLCASEPCASYKALEMN
CCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCEEEEEECCCCCCCEEEEEE
FIGEQEFVDEESTMQVYNEMLGQVAHQILINPMRIDQPARYYQQPETVAYEWIVPEGHYF
ECCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEEECCCCEE
MMGDNRDNSRDSRYWGFVPEQNLVGKAVAIWISFEFQRSSRSILPSWVPSGVRFDRVGGI
EEECCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEECCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]