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The map label for this gene is maeA

Identifier: 119944310

GI number: 119944310

Start: 686245

End: 687927

Strand: Reverse

Name: maeA

Synonym: Ping_0537

Alternate gene names: 119944310

Gene position: 687927-686245 (Counterclockwise)

Preceding gene: 119944311

Following gene: 119944308

Centisome position: 15.09

GC content: 43.85

Gene sequence:

>1683_bases
ATGACATTTCAACGACCTTTATATATCCCCTTTGCCGGTCCGGCATTATTAGAAAGCCCTTTACTTAATAAAGGCAGCGC
TTTTTCCCAGGAAGAAAGGAACAACTTCAACTTAACCGGCCTGCTGCCACATAATATCGAAACCATTGAATCGCAATCGA
CGAGAGCCTATCAACAGCTTAGTTCATTTAAATCTGATTTAGATAAACATATCTACCTGCGAAATATCCAGGATACTAAT
GAGACCTTATTTCATCATCTGATAGAAAATCATCTCGAAGAAGTTATGCCGCTTATTTATACACCAACGGTCGGGCTTGC
TTGTGAGCAATTTTCTAAAATATACCGGCGTAAAAGAGGATTGTTTGTTTCCTACCCTGAGCGTCATAAAATTGATGATA
TGTTACAAAATGCCACCAAACAAAACGTAAAAGTCATTGTAGTGACCGATGGTGAGCGCATATTGGGGTTAGGCGATCAG
GGCATAGGCGGCATGGGCATTCCAATAGGTAAACTCGCTTTATATACTGCCTGCGGAGGTATCAGTCCCGCTTATTGTTT
GCCAATCGTACTGGATGTTGGTACAAATAACAGTCAGTTACTGGCAGATCCTATGTATATGGGCTGGCGTAATCCCCGTA
TTACGGGCGAAGAATATAATGAATTTGTAGATCTCTTTATTCAGGCGGTCAAACGCCGCTGGCCTGAGGTACTACTGCAG
TTTGAAGATTTTGCACAGACTAATGCAACTCCTCTATTAAATAAATACCGCGATCAGATATGCTGCTTTAATGACGATAT
TCAAGGTACTGCAGCCGTTTCCGTCGGTACACTTATTGCGGCTTGCCAGAATAAAGGTGAAAAACTCAGTGATCAGCGTA
TTGCTTTCCTGGGGTCGGGATCTGCGGGTTGCGGTATTGCCCAGCACATCGTAAGACAAATGCAGCGTGAAGGTTTGACC
CAAGAGCAGGCACGCCAGCGAGTATTCATGGTTGACCGTTATGGCCTGTTAACTGATCAAATGACCAACCTGCAGGCGTT
TCAACAGCCTCTGATACAATATACAAAGGATCTTAGTCACTGGGATATAAGCTCCCATATTGGACTAGAGCAGGTCATCA
AACAGGGCAATATCAGCGTATTATTTGGTGTAAGTGGTCAACCTGGCCTATTTACTCAAGAGGTTGTTGAAAGTTTGTGT
GCTAACGTTGATCATCCGATTGTATTGCCTTTATCAAATCCCACCTCAAGGGTTGAAGCCACTCCAAAGGATATAACCAC
CTGGAGTCATGGTCAGGCGATTGTTGCAACCGGCAGTCCATTTCCGCCCACTTTATATGAAAATGAGTATATTGAAGTAT
CCCAGTGTAACAATAGTTACATATTCCCAGGGATCGGGCTGGGGGTCTTAGCGGCGCGGGCGACGGCAATTAGCGATAAT
ATGTTAATGGCCGCCAGTCAGGCATTAGCAGATGCATCTATGCAGTATGAAAAAGTAAAAGGCGCACTATTACCGCCATT
GGGTGAAATAAGACCAATAAGTAAATCAATCGCTTATGCAGTTGCCAAACAAGCAATTGCCGATGGGTTGGCTTTGCCTG
TGTCTGAAGAAACCATGCAGCGCCGATTAGTTGATAATTTCTGGGCACCTAAATACAGAACCTATAGACGCACCTCTTTT
TAG

Upstream 100 bases:

>100_bases
TTAAATATGTGGTCATGCATTGGACACGAAAAATTAATCTGCAATGCTGATCACATCATTAATTTTTTGGTATAACTTCA
AGACGTAAAAACGAGAAACT

Downstream 100 bases:

>100_bases
ATACTCACCCTTGATATGAGATTACTGTCTGTTTAAAACAGGCAGTAATGTATTACAAACCCATTGCATATTTCATGACT
TTATTCTTAAGCGGCCCGCC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MTFQRPLYIPFAGPALLESPLLNKGSAFSQEERNNFNLTGLLPHNIETIESQSTRAYQQLSSFKSDLDKHIYLRNIQDTN
ETLFHHLIENHLEEVMPLIYTPTVGLACEQFSKIYRRKRGLFVSYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQ
GIGGMGIPIGKLALYTACGGISPAYCLPIVLDVGTNNSQLLADPMYMGWRNPRITGEEYNEFVDLFIQAVKRRWPEVLLQ
FEDFAQTNATPLLNKYRDQICCFNDDIQGTAAVSVGTLIAACQNKGEKLSDQRIAFLGSGSAGCGIAQHIVRQMQREGLT
QEQARQRVFMVDRYGLLTDQMTNLQAFQQPLIQYTKDLSHWDISSHIGLEQVIKQGNISVLFGVSGQPGLFTQEVVESLC
ANVDHPIVLPLSNPTSRVEATPKDITTWSHGQAIVATGSPFPPTLYENEYIEVSQCNNSYIFPGIGLGVLAARATAISDN
MLMAASQALADASMQYEKVKGALLPPLGEIRPISKSIAYAVAKQAIADGLALPVSEETMQRRLVDNFWAPKYRTYRRTSF

Sequences:

>Translated_560_residues
MTFQRPLYIPFAGPALLESPLLNKGSAFSQEERNNFNLTGLLPHNIETIESQSTRAYQQLSSFKSDLDKHIYLRNIQDTN
ETLFHHLIENHLEEVMPLIYTPTVGLACEQFSKIYRRKRGLFVSYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQ
GIGGMGIPIGKLALYTACGGISPAYCLPIVLDVGTNNSQLLADPMYMGWRNPRITGEEYNEFVDLFIQAVKRRWPEVLLQ
FEDFAQTNATPLLNKYRDQICCFNDDIQGTAAVSVGTLIAACQNKGEKLSDQRIAFLGSGSAGCGIAQHIVRQMQREGLT
QEQARQRVFMVDRYGLLTDQMTNLQAFQQPLIQYTKDLSHWDISSHIGLEQVIKQGNISVLFGVSGQPGLFTQEVVESLC
ANVDHPIVLPLSNPTSRVEATPKDITTWSHGQAIVATGSPFPPTLYENEYIEVSQCNNSYIFPGIGLGVLAARATAISDN
MLMAASQALADASMQYEKVKGALLPPLGEIRPISKSIAYAVAKQAIADGLALPVSEETMQRRLVDNFWAPKYRTYRRTSF
>Mature_559_residues
TFQRPLYIPFAGPALLESPLLNKGSAFSQEERNNFNLTGLLPHNIETIESQSTRAYQQLSSFKSDLDKHIYLRNIQDTNE
TLFHHLIENHLEEVMPLIYTPTVGLACEQFSKIYRRKRGLFVSYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQG
IGGMGIPIGKLALYTACGGISPAYCLPIVLDVGTNNSQLLADPMYMGWRNPRITGEEYNEFVDLFIQAVKRRWPEVLLQF
EDFAQTNATPLLNKYRDQICCFNDDIQGTAAVSVGTLIAACQNKGEKLSDQRIAFLGSGSAGCGIAQHIVRQMQREGLTQ
EQARQRVFMVDRYGLLTDQMTNLQAFQQPLIQYTKDLSHWDISSHIGLEQVIKQGNISVLFGVSGQPGLFTQEVVESLCA
NVDHPIVLPLSNPTSRVEATPKDITTWSHGQAIVATGSPFPPTLYENEYIEVSQCNNSYIFPGIGLGVLAARATAISDNM
LMAASQALADASMQYEKVKGALLPPLGEIRPISKSIAYAVAKQAIADGLALPVSEETMQRRLVDNFWAPKYRTYRRTSF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family

Homologues:

Organism=Homo sapiens, GI4505143, Length=521, Percent_Identity=42.6103646833013, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI62420882, Length=562, Percent_Identity=39.6797153024911, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI62420880, Length=562, Percent_Identity=39.6797153024911, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI239049447, Length=562, Percent_Identity=39.6797153024911, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI4505145, Length=552, Percent_Identity=40.036231884058, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI270265879, Length=463, Percent_Identity=42.3326133909287, Blast_Score=376, Evalue=1e-104,
Organism=Escherichia coli, GI87081919, Length=558, Percent_Identity=64.336917562724, Blast_Score=740, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=545, Percent_Identity=40.7339449541284, Blast_Score=390, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322823, Length=534, Percent_Identity=43.2584269662921, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI281362674, Length=533, Percent_Identity=43.7148217636023, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI21356279, Length=533, Percent_Identity=43.7148217636023, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI281362672, Length=533, Percent_Identity=43.7148217636023, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24646388, Length=510, Percent_Identity=42.9411764705882, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24646386, Length=510, Percent_Identity=42.9411764705882, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI78707242, Length=511, Percent_Identity=36.5949119373777, Blast_Score=352, Evalue=5e-97,
Organism=Drosophila melanogaster, GI78707238, Length=511, Percent_Identity=36.5949119373777, Blast_Score=352, Evalue=5e-97,
Organism=Drosophila melanogaster, GI78707240, Length=512, Percent_Identity=36.5234375, Blast_Score=352, Evalue=5e-97,
Organism=Drosophila melanogaster, GI78707232, Length=508, Percent_Identity=34.8425196850394, Blast_Score=347, Evalue=9e-96,
Organism=Drosophila melanogaster, GI281363505, Length=510, Percent_Identity=34.7058823529412, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI78707236, Length=510, Percent_Identity=34.7058823529412, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI281363503, Length=508, Percent_Identity=34.4488188976378, Blast_Score=342, Evalue=6e-94,
Organism=Drosophila melanogaster, GI19922384, Length=544, Percent_Identity=28.8602941176471, Blast_Score=251, Evalue=9e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MAO1_PSYIN (A1SSC6)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941990.1
- ProteinModelPortal:   A1SSC6
- SMR:   A1SSC6
- STRING:   A1SSC6
- GeneID:   4623724
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0537
- eggNOG:   COG0281
- HOGENOM:   HBG289821
- OMA:   IQDNNET
- PhylomeDB:   A1SSC6
- ProtClustDB:   PRK13529
- BioCyc:   PING357804:PING_0537-MONOMER
- HAMAP:   MF_01619
- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000106
- PRINTS:   PR00072
- SMART:   SM00919

Pfam domain/function: PF00390 malic; PF03949 Malic_M

EC number: =1.1.1.38

Molecular weight: Translated: 62300; Mature: 62169

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: ACT_SITE 100-100 ACT_SITE 171-171 BINDING 153-153 BINDING 266-266 BINDING 413-413

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFQRPLYIPFAGPALLESPLLNKGSAFSQEERNNFNLTGLLPHNIETIESQSTRAYQQL
CCCCCCEEECCCCHHHHHCCCCCCCCCCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
SSFKSDLDKHIYLRNIQDTNETLFHHLIENHLEEVMPLIYTPTVGLACEQFSKIYRRKRG
HHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
LFVSYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACGG
CEEECCCCCCHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHCC
ISPAYCLPIVLDVGTNNSQLLADPMYMGWRNPRITGEEYNEFVDLFIQAVKRRWPEVLLQ
CCHHEEEEEEEECCCCCCCEEECHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FEDFAQTNATPLLNKYRDQICCFNDDIQGTAAVSVGTLIAACQNKGEKLSDQRIAFLGSG
HHHHHCCCCCHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
SAGCGIAQHIVRQMQREGLTQEQARQRVFMVDRYGLLTDQMTNLQAFQQPLIQYTKDLSH
CCCCHHHHHHHHHHHHCCCCHHHHHHHEEEEHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
WDISSHIGLEQVIKQGNISVLFGVSGQPGLFTQEVVESLCANVDHPIVLPLSNPTSRVEA
CCCHHCCCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHCCC
TPKDITTWSHGQAIVATGSPFPPTLYENEYIEVSQCNNSYIFPGIGLGVLAARATAISDN
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCEECCCCHHHHHHHHHHHHCCC
MLMAASQALADASMQYEKVKGALLPPLGEIRPISKSIAYAVAKQAIADGLALPVSEETMQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RRLVDNFWAPKYRTYRRTSF
HHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TFQRPLYIPFAGPALLESPLLNKGSAFSQEERNNFNLTGLLPHNIETIESQSTRAYQQL
CCCCCEEECCCCHHHHHCCCCCCCCCCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
SSFKSDLDKHIYLRNIQDTNETLFHHLIENHLEEVMPLIYTPTVGLACEQFSKIYRRKRG
HHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
LFVSYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACGG
CEEECCCCCCHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHCC
ISPAYCLPIVLDVGTNNSQLLADPMYMGWRNPRITGEEYNEFVDLFIQAVKRRWPEVLLQ
CCHHEEEEEEEECCCCCCCEEECHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FEDFAQTNATPLLNKYRDQICCFNDDIQGTAAVSVGTLIAACQNKGEKLSDQRIAFLGSG
HHHHHCCCCCHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
SAGCGIAQHIVRQMQREGLTQEQARQRVFMVDRYGLLTDQMTNLQAFQQPLIQYTKDLSH
CCCCHHHHHHHHHHHHCCCCHHHHHHHEEEEHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
WDISSHIGLEQVIKQGNISVLFGVSGQPGLFTQEVVESLCANVDHPIVLPLSNPTSRVEA
CCCHHCCCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHCCC
TPKDITTWSHGQAIVATGSPFPPTLYENEYIEVSQCNNSYIFPGIGLGVLAARATAISDN
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCEECCCCHHHHHHHHHHHHCCC
MLMAASQALADASMQYEKVKGALLPPLGEIRPISKSIAYAVAKQAIADGLALPVSEETMQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RRLVDNFWAPKYRTYRRTSF
HHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA