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The map label for this gene is gor [H]

Identifier: 119944281

GI number: 119944281

Start: 643291

End: 644649

Strand: Reverse

Name: gor [H]

Synonym: Ping_0507

Alternate gene names: 119944281

Gene position: 644649-643291 (Counterclockwise)

Preceding gene: 119944282

Following gene: 119944278

Centisome position: 14.14

GC content: 43.19

Gene sequence:

>1359_bases
ATGAATAATAATAAATTCGATTTTGACTATATCTGTATTGGCGGCGGCAGTGGCGGCATTGCCTCGGCTAATCGGGCATC
GAAGTATGGACAAAAGGTAGCAATCATTGAAGCAAAAGCATTGGGCGGCACTTGTGTCAATGTTGGCTGCGTGCCTAAAA
AAGCGATGTGGTATGCCGGACAAATTGCAGATGCGCTACGCTATGCGCCTGATTATGGTTTTGATGCACCGCTTAAAAAT
TTCAGCTGGGCAAAATTAATTGAAAGCCGCGAAGCTTATATTGCGCGTATTCATCAATCATATGAACGGGTTTTGGGTAA
CAATAATATTACTGTGATTGACGGTTTTGCTAAGTTTATTGATAATCATACGGTTGAAGTCAATGGAAAAACCTATACAG
CACCTCATATTACGGTTGCAACGGGCGGTGCTCCAACTGTTCCAGCAATTGAGGGAGCAGAACACGGTATTACATCCGAT
GGTTTTTTTGCCCTTAATGAGCAACCCAAACGAGTCGCCGTTGTTGGTGCAGGTTATATCGCGGTGGAAATAGCCGGTGT
CTTTAATGCCTTGGGCAGTGAAACCCATTTACTTTGCCGTCGCCATACTTTTTTGCGTGACTTCGATCATATGCTTTCCT
CCACATTGGTTGAAGTGATGCAGGAAGAAGGCCCGACACTGCATACTCACTCGACCCCTAAATCAGTACATAAAAATGAG
GATGGCAGCCTTACCTTACATTTAGAAAATGAAAAATCGCTGACTGTTGACTGTTTGGTTTGGGCTATTGGTCGTAACCC
GGCCAATACTGATATCGGTCTGGAAAATACCGATATTGAACTTAATAAACATAAATTTATCAATGTTGATAAATACCAAA
ATACAACAGCTCAAGGTATTTATGCCGTAGGCGATAATACTGGTGAGATCCAATTAACCCCGGTTGCGATCAAGGCCGGT
AGATTTTTGTCAGAGCGTTTATTTAACGGACAACTGGATGCGCATTTAGATGCTAAATTAGTGCCGACAGTGGTCTTTAG
CCACCCGCCGATAGGAACAATAGGCTTGACTGAGCTTGAGGCGGAAGAAAAATACGGTAAAAGCAAGCTGAAGGTTTATA
CCTCACAATTTACCAGTATGTATACCGCCATGACGACCATGCGCCAACCAACACGAATGAAATTAGTTTGTGCCGGGGAA
AACCAAAAAGTGGTTGGTTTACATTGTATTGGTTTAGCATCTGATGAGATTTTGCAGGGTTTTGCGGTGGCCATGAAAAT
GGGTGCAACCAAAGCAGATTTTGATAGCTGTGTCGCGATTCACCCAACCAGTGCAGAAGAATTTGTAACGATGACTTAA

Upstream 100 bases:

>100_bases
GCACAGTAGAAAAACACGATTTACAAGCTTTATTGCCTTGGCTAACTTGGGCTTACCAAGAAGTCACCGTATAACAGCAC
AACAAAATTTAAGGGTACTC

Downstream 100 bases:

>100_bases
GTAATAAAGAAGCAACAAAAAGCCCCGCTTAATGTCTTGTATTAAGCGGGGCTTTTCTATTAATACGCTTTAAAAATTAA
ACAGAAAAAGGATATTTAAT

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MNNNKFDFDYICIGGGSGGIASANRASKYGQKVAIIEAKALGGTCVNVGCVPKKAMWYAGQIADALRYAPDYGFDAPLKN
FSWAKLIESREAYIARIHQSYERVLGNNNITVIDGFAKFIDNHTVEVNGKTYTAPHITVATGGAPTVPAIEGAEHGITSD
GFFALNEQPKRVAVVGAGYIAVEIAGVFNALGSETHLLCRRHTFLRDFDHMLSSTLVEVMQEEGPTLHTHSTPKSVHKNE
DGSLTLHLENEKSLTVDCLVWAIGRNPANTDIGLENTDIELNKHKFINVDKYQNTTAQGIYAVGDNTGEIQLTPVAIKAG
RFLSERLFNGQLDAHLDAKLVPTVVFSHPPIGTIGLTELEAEEKYGKSKLKVYTSQFTSMYTAMTTMRQPTRMKLVCAGE
NQKVVGLHCIGLASDEILQGFAVAMKMGATKADFDSCVAIHPTSAEEFVTMT

Sequences:

>Translated_452_residues
MNNNKFDFDYICIGGGSGGIASANRASKYGQKVAIIEAKALGGTCVNVGCVPKKAMWYAGQIADALRYAPDYGFDAPLKN
FSWAKLIESREAYIARIHQSYERVLGNNNITVIDGFAKFIDNHTVEVNGKTYTAPHITVATGGAPTVPAIEGAEHGITSD
GFFALNEQPKRVAVVGAGYIAVEIAGVFNALGSETHLLCRRHTFLRDFDHMLSSTLVEVMQEEGPTLHTHSTPKSVHKNE
DGSLTLHLENEKSLTVDCLVWAIGRNPANTDIGLENTDIELNKHKFINVDKYQNTTAQGIYAVGDNTGEIQLTPVAIKAG
RFLSERLFNGQLDAHLDAKLVPTVVFSHPPIGTIGLTELEAEEKYGKSKLKVYTSQFTSMYTAMTTMRQPTRMKLVCAGE
NQKVVGLHCIGLASDEILQGFAVAMKMGATKADFDSCVAIHPTSAEEFVTMT
>Mature_452_residues
MNNNKFDFDYICIGGGSGGIASANRASKYGQKVAIIEAKALGGTCVNVGCVPKKAMWYAGQIADALRYAPDYGFDAPLKN
FSWAKLIESREAYIARIHQSYERVLGNNNITVIDGFAKFIDNHTVEVNGKTYTAPHITVATGGAPTVPAIEGAEHGITSD
GFFALNEQPKRVAVVGAGYIAVEIAGVFNALGSETHLLCRRHTFLRDFDHMLSSTLVEVMQEEGPTLHTHSTPKSVHKNE
DGSLTLHLENEKSLTVDCLVWAIGRNPANTDIGLENTDIELNKHKFINVDKYQNTTAQGIYAVGDNTGEIQLTPVAIKAG
RFLSERLFNGQLDAHLDAKLVPTVVFSHPPIGTIGLTELEAEEKYGKSKLKVYTSQFTSMYTAMTTMRQPTRMKLVCAGE
NQKVVGLHCIGLASDEILQGFAVAMKMGATKADFDSCVAIHPTSAEEFVTMT

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=457, Percent_Identity=50.109409190372, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=37.0762711864407, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI148277065, Length=475, Percent_Identity=34.3157894736842, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=34.3157894736842, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=34.3157894736842, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=34.3157894736842, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=34.3157894736842, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=32.7004219409283, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI291045268, Length=474, Percent_Identity=29.746835443038, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=27.3118279569892, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1789915, Length=445, Percent_Identity=66.7415730337079, Blast_Score=594, Evalue=1e-171,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=27.8260869565217, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=27.5938189845475, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=26.2806236080178, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71983429, Length=447, Percent_Identity=53.6912751677852, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71983419, Length=447, Percent_Identity=53.6912751677852, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17557007, Length=476, Percent_Identity=33.1932773109244, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=33.9583333333333, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=27.6824034334764, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=52.03426124197, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321091, Length=467, Percent_Identity=26.1241970021413, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=27.7185501066098, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24640553, Length=473, Percent_Identity=35.9408033826639, Blast_Score=274, Evalue=9e-74,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=35.9574468085106, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=35.9574468085106, Blast_Score=271, Evalue=8e-73,
Organism=Drosophila melanogaster, GI17737741, Length=477, Percent_Identity=33.5429769392034, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=27.7056277056277, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49081; Mature: 49081

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNKFDFDYICIGGGSGGIASANRASKYGQKVAIIEAKALGGTCVNVGCVPKKAMWYAG
CCCCCEEEEEEEEECCCCCCCCCCHHHHCCCEEEEEEEECCCCEEEEECCCCCHHHHHHH
QIADALRYAPDYGFDAPLKNFSWAKLIESREAYIARIHQSYERVLGNNNITVIDGFAKFI
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHH
DNHTVEVNGKTYTAPHITVATGGAPTVPAIEGAEHGITSDGFFALNEQPKRVAVVGAGYI
CCCEEEECCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCEE
AVEIAGVFNALGSETHLLCRRHTFLRDFDHMLSSTLVEVMQEEGPTLHTHSTPKSVHKNE
EEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCC
DGSLTLHLENEKSLTVDCLVWAIGRNPANTDIGLENTDIELNKHKFINVDKYQNTTAQGI
CCEEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCEE
YAVGDNTGEIQLTPVAIKAGRFLSERLFNGQLDAHLDAKLVPTVVFSHPPIGTIGLTELE
EEECCCCCEEEEEEEEEECCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEC
AEEKYGKSKLKVYTSQFTSMYTAMTTMRQPTRMKLVCAGENQKVVGLHCIGLASDEILQG
CHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEEECCCHHHHHH
FAVAMKMGATKADFDSCVAIHPTSAEEFVTMT
HHHHHHCCCCCCCCCCEEEECCCCCCCEEEEC
>Mature Secondary Structure
MNNNKFDFDYICIGGGSGGIASANRASKYGQKVAIIEAKALGGTCVNVGCVPKKAMWYAG
CCCCCEEEEEEEEECCCCCCCCCCHHHHCCCEEEEEEEECCCCEEEEECCCCCHHHHHHH
QIADALRYAPDYGFDAPLKNFSWAKLIESREAYIARIHQSYERVLGNNNITVIDGFAKFI
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHH
DNHTVEVNGKTYTAPHITVATGGAPTVPAIEGAEHGITSDGFFALNEQPKRVAVVGAGYI
CCCEEEECCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCEE
AVEIAGVFNALGSETHLLCRRHTFLRDFDHMLSSTLVEVMQEEGPTLHTHSTPKSVHKNE
EEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCC
DGSLTLHLENEKSLTVDCLVWAIGRNPANTDIGLENTDIELNKHKFINVDKYQNTTAQGI
CCEEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCEE
YAVGDNTGEIQLTPVAIKAGRFLSERLFNGQLDAHLDAKLVPTVVFSHPPIGTIGLTELE
EEECCCCCEEEEEEEEEECCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEC
AEEKYGKSKLKVYTSQFTSMYTAMTTMRQPTRMKLVCAGENQKVVGLHCIGLASDEILQG
CHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEEECCCHHHHHH
FAVAMKMGATKADFDSCVAIHPTSAEEFVTMT
HHHHHHCCCCCCCCCCEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]