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The map label for this gene is zraS [H]

Identifier: 119944208

GI number: 119944208

Start: 542150

End: 544222

Strand: Reverse

Name: zraS [H]

Synonym: Ping_0429

Alternate gene names: 119944208

Gene position: 544222-542150 (Counterclockwise)

Preceding gene: 119944209

Following gene: 119944207

Centisome position: 11.94

GC content: 34.97

Gene sequence:

>2073_bases
ATGAGTGGTTACCCAACGCTAACTATATTTGATTATTTTACCGCAAGCGTTGAAATTGCATTAGCCTTGACCGCGCTGGT
GAAGATAAAAAATTTAAAAATAAAGCTGAGTTTTTTCCTCTTCGCGATGTTAACTGCAATCTGGCATATAACCTTCGCTG
ACAACCCATTTGACCGGTTTCCATCAAGTTACCAATTTCAACTTATTGAAACACTCCGCTATATAGGTTGGTCTTTAATT
CTTATTAATCTGTTAATGTACTCGCAAAAAAAAAGGCTCCCCGTAAATTGGCTTGCTTCAATATATATTACTATTGTGGT
GATTTTAGCTCTCTTAATACAGAGTTTAAACAATCCATTAACATCATTTATGCAGATGACACTCTGGCTCTATATAAAAA
TAATTCTTTGTTTAGCCGGCATAGTCATCGCGGAACAACTGCTCAGGCATGACAATTCTAGTCGCGTTAGCAAGCTAGTA
GCACTTGTTGCAATAACGCAACTTGCCTATGATATGCTCGTTTTTTTAAATTTATTACTTTTTATAAATGAAAACAACAA
CTTGTGGTATGCCAGAGGCATAATTAACAGCGCAACCTCATTAATATTAGCACTTGCAATTATCATCTATCCCTTTCAAC
AACAGCAAGATAGTCAGTTTCAATTATCTCGGTCAATTATTATATTCAATACCAGCTTTATATTAGCTGGGATATTCCTT
GTCTTTATGGCGCTTCTTGGCTTAGCCGTTAATATTTTCAATGTTGAATGGGCGGAGGTTTCAAGAATACTGTTGTATGT
TATGTCAATATTTGCCATAGCAGCACTGTCATGTCTTGAAAAATTCCGTTCACACACCACCGTTTGGATTAGCAAGAATT
TCTTTATTAATAAATATGATTATCAAAAACAATGGATCGAACTAGATTCCCAACTTTCACAGAAAAGAGACGATAACAAT
GGTTATGAAATAGCACTAGCAACGATGACTTCGCTGTTTAACTGCAGTGGTGGAGGGATTTGGCTTAAAGGGCAACAGTT
TTATTCTCCCGTTGCATTAAAAAACTTCGAACTCCCATCATCACGCGCAATTGAAGCAAATAATAGCCATTTTATACAAC
TGATGACTAAAGATGAATGGGTCTTTCAAACACCTAAAAATACAGGCGATCATGATAAAAAAAATAATAAGTACTTACCT
AAATGGTTCATAAATACGAATGATGCATGGACAATTATTCCACTCAATACTCATCAAGGATTAATTGGTTTTGCGGTACT
TTGTAAAAAGTCAGCTAACACCACCTTAACTTGGGAAGACTTAGACATATTAAAACTGACAGGTCGTCAAATAGGCAGCT
ATATTAATAGCCATCAGGCATCAGAAAAGTTAATTCAAAATCAACAGTTCGACCTATTTAATAAAATCACAGCTTTTGCA
ATCCACGATATAAAAAACCTCATAGCACAACAAGGCTTAATGCTTAATAATGCAGAAAAGTTCAGGCATCAACCTGAATT
TATTGATGATGTCATATTAACGATTGGTAACTCAGTTGAAAAAATGAATCAATTATTAGTCAAATTACAAGGAGATTCAC
AGAGTAAAATTGAATCTATCAATATCATAAAACTGCTAGAAAATGCGATAGAAATGAATTCATCCAGTCTCCCAACACCA
ATATTGTCAGTCGTAAAAGGAAATAATGCGTTAGTGATGGCTGACAAAGATAAATTGCAAATGGCACTTTATCATTTAAT
TAAAAATGCACAGGATGCAACCGATGATAGTGGAACCATTGCAATAAAATTAACCACCGAGAATGATGATTTATGGTTAG
AAGTAACGGATACAGGCTGCGGTATGGATGAGTCTTTTATTAAGGAGCAATTATTTAAACCCTTCTCCAGCACCAAAAAA
AATCAGGGAATGGGAATCGGCGCATATCAGATAAGGGAGCTCATTCATTCTTTACAAGGAGAGATCTTTGTTGAGAGTAC
AGTAAAAAAAGGCACTCAATTTTCAATTTATTTACCTTTGAATGGCACTAAAAAAGAAATGAACTACGCTTAA

Upstream 100 bases:

>100_bases
ACGCGGAATATTATAGCCTTATATCAATCTATTTGGGAACAGTAGCTTGCCAGTTTTAATTTACTGACTGTATTGAGACA
AGGAAAATAAAGTGTTTATG

Downstream 100 bases:

>100_bases
AATCATTAACTTAGAGATAAACATTTGTTAATAGACTTTAGAGGATAAAATGATAAAAACTTTACTACTTACTTTCGCCA
TTTACATGCTGGCAAGTTGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 690; Mature: 689

Protein sequence:

>690_residues
MSGYPTLTIFDYFTASVEIALALTALVKIKNLKIKLSFFLFAMLTAIWHITFADNPFDRFPSSYQFQLIETLRYIGWSLI
LINLLMYSQKKRLPVNWLASIYITIVVILALLIQSLNNPLTSFMQMTLWLYIKIILCLAGIVIAEQLLRHDNSSRVSKLV
ALVAITQLAYDMLVFLNLLLFINENNNLWYARGIINSATSLILALAIIIYPFQQQQDSQFQLSRSIIIFNTSFILAGIFL
VFMALLGLAVNIFNVEWAEVSRILLYVMSIFAIAALSCLEKFRSHTTVWISKNFFINKYDYQKQWIELDSQLSQKRDDNN
GYEIALATMTSLFNCSGGGIWLKGQQFYSPVALKNFELPSSRAIEANNSHFIQLMTKDEWVFQTPKNTGDHDKKNNKYLP
KWFINTNDAWTIIPLNTHQGLIGFAVLCKKSANTTLTWEDLDILKLTGRQIGSYINSHQASEKLIQNQQFDLFNKITAFA
IHDIKNLIAQQGLMLNNAEKFRHQPEFIDDVILTIGNSVEKMNQLLVKLQGDSQSKIESINIIKLLENAIEMNSSSLPTP
ILSVVKGNNALVMADKDKLQMALYHLIKNAQDATDDSGTIAIKLTTENDDLWLEVTDTGCGMDESFIKEQLFKPFSSTKK
NQGMGIGAYQIRELIHSLQGEIFVESTVKKGTQFSIYLPLNGTKKEMNYA

Sequences:

>Translated_690_residues
MSGYPTLTIFDYFTASVEIALALTALVKIKNLKIKLSFFLFAMLTAIWHITFADNPFDRFPSSYQFQLIETLRYIGWSLI
LINLLMYSQKKRLPVNWLASIYITIVVILALLIQSLNNPLTSFMQMTLWLYIKIILCLAGIVIAEQLLRHDNSSRVSKLV
ALVAITQLAYDMLVFLNLLLFINENNNLWYARGIINSATSLILALAIIIYPFQQQQDSQFQLSRSIIIFNTSFILAGIFL
VFMALLGLAVNIFNVEWAEVSRILLYVMSIFAIAALSCLEKFRSHTTVWISKNFFINKYDYQKQWIELDSQLSQKRDDNN
GYEIALATMTSLFNCSGGGIWLKGQQFYSPVALKNFELPSSRAIEANNSHFIQLMTKDEWVFQTPKNTGDHDKKNNKYLP
KWFINTNDAWTIIPLNTHQGLIGFAVLCKKSANTTLTWEDLDILKLTGRQIGSYINSHQASEKLIQNQQFDLFNKITAFA
IHDIKNLIAQQGLMLNNAEKFRHQPEFIDDVILTIGNSVEKMNQLLVKLQGDSQSKIESINIIKLLENAIEMNSSSLPTP
ILSVVKGNNALVMADKDKLQMALYHLIKNAQDATDDSGTIAIKLTTENDDLWLEVTDTGCGMDESFIKEQLFKPFSSTKK
NQGMGIGAYQIRELIHSLQGEIFVESTVKKGTQFSIYLPLNGTKKEMNYA
>Mature_689_residues
SGYPTLTIFDYFTASVEIALALTALVKIKNLKIKLSFFLFAMLTAIWHITFADNPFDRFPSSYQFQLIETLRYIGWSLIL
INLLMYSQKKRLPVNWLASIYITIVVILALLIQSLNNPLTSFMQMTLWLYIKIILCLAGIVIAEQLLRHDNSSRVSKLVA
LVAITQLAYDMLVFLNLLLFINENNNLWYARGIINSATSLILALAIIIYPFQQQQDSQFQLSRSIIIFNTSFILAGIFLV
FMALLGLAVNIFNVEWAEVSRILLYVMSIFAIAALSCLEKFRSHTTVWISKNFFINKYDYQKQWIELDSQLSQKRDDNNG
YEIALATMTSLFNCSGGGIWLKGQQFYSPVALKNFELPSSRAIEANNSHFIQLMTKDEWVFQTPKNTGDHDKKNNKYLPK
WFINTNDAWTIIPLNTHQGLIGFAVLCKKSANTTLTWEDLDILKLTGRQIGSYINSHQASEKLIQNQQFDLFNKITAFAI
HDIKNLIAQQGLMLNNAEKFRHQPEFIDDVILTIGNSVEKMNQLLVKLQGDSQSKIESINIIKLLENAIEMNSSSLPTPI
LSVVKGNNALVMADKDKLQMALYHLIKNAQDATDDSGTIAIKLTTENDDLWLEVTDTGCGMDESFIKEQLFKPFSSTKKN
QGMGIGAYQIRELIHSLQGEIFVESTVKKGTQFSIYLPLNGTKKEMNYA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=274, Percent_Identity=24.8175182481752, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78432; Mature: 78301

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGYPTLTIFDYFTASVEIALALTALVKIKNLKIKLSFFLFAMLTAIWHITFADNPFDRF
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHEEEECCCCHHHC
PSSYQFQLIETLRYIGWSLILINLLMYSQKKRLPVNWLASIYITIVVILALLIQSLNNPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
TSFMQMTLWLYIKIILCLAGIVIAEQLLRHDNSSRVSKLVALVAITQLAYDMLVFLNLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
FINENNNLWYARGIINSATSLILALAIIIYPFQQQQDSQFQLSRSIIIFNTSFILAGIFL
EEECCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCEEEEEEHHHHHHHHHH
VFMALLGLAVNIFNVEWAEVSRILLYVMSIFAIAALSCLEKFRSHTTVWISKNFFINKYD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCH
YQKQWIELDSQLSQKRDDNNGYEIALATMTSLFNCSGGGIWLKGQQFYSPVALKNFELPS
HHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCCEEEECHHHCCCHHEECCCCCC
SRAIEANNSHFIQLMTKDEWVFQTPKNTGDHDKKNNKYLPKWFINTNDAWTIIPLNTHQG
CCEEECCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCC
LIGFAVLCKKSANTTLTWEDLDILKLTGRQIGSYINSHQASEKLIQNQQFDLFNKITAFA
HHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IHDIKNLIAQQGLMLNNAEKFRHQPEFIDDVILTIGNSVEKMNQLLVKLQGDSQSKIESI
HHHHHHHHHHCCCEECCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHEEECCCCCHHHHHH
NIIKLLENAIEMNSSSLPTPILSVVKGNNALVMADKDKLQMALYHLIKNAQDATDDSGTI
HHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEE
AIKLTTENDDLWLEVTDTGCGMDESFIKEQLFKPFSSTKKNQGMGIGAYQIRELIHSLQG
EEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHCC
EIFVESTVKKGTQFSIYLPLNGTKKEMNYA
CEEEEHHHCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SGYPTLTIFDYFTASVEIALALTALVKIKNLKIKLSFFLFAMLTAIWHITFADNPFDRF
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHEEEECCCCHHHC
PSSYQFQLIETLRYIGWSLILINLLMYSQKKRLPVNWLASIYITIVVILALLIQSLNNPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
TSFMQMTLWLYIKIILCLAGIVIAEQLLRHDNSSRVSKLVALVAITQLAYDMLVFLNLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
FINENNNLWYARGIINSATSLILALAIIIYPFQQQQDSQFQLSRSIIIFNTSFILAGIFL
EEECCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCEEEEEEHHHHHHHHHH
VFMALLGLAVNIFNVEWAEVSRILLYVMSIFAIAALSCLEKFRSHTTVWISKNFFINKYD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCH
YQKQWIELDSQLSQKRDDNNGYEIALATMTSLFNCSGGGIWLKGQQFYSPVALKNFELPS
HHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCCEEEECHHHCCCHHEECCCCCC
SRAIEANNSHFIQLMTKDEWVFQTPKNTGDHDKKNNKYLPKWFINTNDAWTIIPLNTHQG
CCEEECCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCC
LIGFAVLCKKSANTTLTWEDLDILKLTGRQIGSYINSHQASEKLIQNQQFDLFNKITAFA
HHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IHDIKNLIAQQGLMLNNAEKFRHQPEFIDDVILTIGNSVEKMNQLLVKLQGDSQSKIESI
HHHHHHHHHHCCCEECCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHEEECCCCCHHHHHH
NIIKLLENAIEMNSSSLPTPILSVVKGNNALVMADKDKLQMALYHLIKNAQDATDDSGTI
HHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEE
AIKLTTENDDLWLEVTDTGCGMDESFIKEQLFKPFSSTKKNQGMGIGAYQIRELIHSLQG
EEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHCC
EIFVESTVKKGTQFSIYLPLNGTKKEMNYA
CEEEEHHHCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]